The brain and heart have been used as metaphors for thinking and feeling, for cognition and emotion. These ideas have been demonstrated to have a high scientific value. In fact, complex physiopathological relationships exist between these two organs. This book will deal with several aspects of the cardiovascular and nervous systems from a new viewpoint. It will describe the differences and similarities in their differentiation pathways with a peculiar emphasis on the role of cell cycle regulation and cell differentiation.
Cell cycle exit represents the fundamental step to trigger differentiation of cells and induction of a novel program of gene expression leading to the elaboration of a specialized phenotype. Moreover, there is evidence demonstrating that several components of the cell cycle machinery play a major role also in cell specification and differentiation both in neural and cardiovascular systems. The differentiation process will be evaluated starting from the most early cell precursor, i.e., stem cells. The attention of readers will be focused also on transcription factors with differentiating properties and on their relationship with cell cycle regulators.
In summary, this book will offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another and, therefore, will help us to better understand their biology by providing the tools to dissect the molecular basis of pathological conditions. The book will prompt the scientific community to perceive cell cycle regulation and differentiation under a novel and more comprehensive light.
Contents
Part I Introduction to Cell Cycle and Differentiation
- 1 Short Introduction to the Cell Cycle
- 2 The Basic Helix-Loop-Helix Transcription Factors in Neural Differentiation
- 3 Transcription Factors and Muscle Differentiation
Part II Stem Cells
- 4 The Neural Stem Cells
- 5 Cardiac Stem and Progenitor Cells
- 6 Muscle Stem Cells
- 7 Marrow Stromal Mesenchymal Stem Cells
Part III Cell Cycle and Differentiation in the Nervous System
- 8 Neurogenesis in the Central Nervous System: Cell Cycle Progression/Exit and Differentiation of Neuronal Progenitors
Part IV Cell Cycle and Differentiation in the Cardiovascular System
- 9 Cell Cycle and Differentiation in the Cardiovascular System
- 10 Cell Cycle and Differentiation in Vessels
Part V Cell Cycle and Differentiation in the Muscle
- 11 Cell Cycle Regulation in Myogenesis
Subject Index
About the Editors
- Antonio Giordano, College of Science & Technology, Sbarro Institute for Cancer Research, Temple University, N. 12th Street 1900, 19122 Philadelphia, Pennsylvania, USA. Email: giordano@temple.edu
- Umberto Galderisi, Dipto. Medicina Sperimentale, Università Napoli Federico II, Sezione di Biotecnologia e Biologia Molecolare, Via Costantinopoli 16, 80138 Napoli, Italy. Email: umberto.galderisi@unina2.it
Product Details
- Hardcover: 267 pages
- Publisher: Springer; 1st edition (August 30, 2010)
- Language: English
- ISBN-10: 160327152X
- ISBN-13: 978-1603271523
- Product Dimensions: 9.1 x 6.2 x 0.8 inches
List Price: $189.00