The Molecular Basis of Cancer: with Expert Consult 3rd Edition by John Mendelsohn, Peter M. Howley, Mark A. Israel, Joe W. Gray and Craig B. Thompson explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. A new full-color format expedites reference, and now as an Expert Consult title, it enables you to conveniently search the entire text online, download all of the books images for your personal use, and review periodic updates.
Contents
I - CARCINOGENESIS AND CANCER GENETICS
Book Features
Website Features
About the Author
Product Details
Contents
- 1 - Cancer: A Genetic Disorder
- 2 - Oncogenes and Signal Transduction
- 3 - Tumor Suppressor Genes
- 4 - DNA Repair Pathways and Human Cancer
- 5 - Epigenetics and Cancer
- 6 - Infectious Agents and Cancer
- 7 - Environmental Carcinogenesis
- 8 - Animal Models: Flies, Fish, and Yeast
- 9 - Genetic Mouse Models of Cancer
- 10 - Cancer Stem Cells
- 11 - Signal Transduction by Growth Factor Receptors
- 12 - Cell Growth
- 13 - Regulation of the Cell Cycle
- 14 - Metabolism of Cell Growth and Proliferation
- 15 - Apoptosis, Autophagy, and Necrosis
- 16 - Cellular Senescence
- 17 - The Tumor Microenvironment in Cancer Progression
- 18 - Tumor Angiogenesis
- 19 - Invasion and Metastasis
- 20 - Cancer Genomics
- 21 - Transcriptome Analysis
- 22 - Mass Spectrometry in Cancer Biology
- 23 - Imaging and Cancer
- 24 - Bioinformatics
- 25 - Early Detection of Cancer: Molecular Screening
- 26 - Lymphoma/Myeloma
- 27 - Molecular Genetics of ALL
- 28 - Biology of Chronic and Acute Myeloid Leukemia
- 29 - Molecular Biology of Childhood Neoplasms
- 30 - Molecular Basis of Lung Cancer
- 31 - Molecular Abnormalities in Colon and Rectal Cancer
- 32 - Breast Cancer
- 33 - Molecular Basis of Prostate Cancer
- 34 - Molecular Pathogenesis of Epithelial Ovarian Cancer
- 35 - Molecular Pathogenesis of Pancreatic Adenocarcinoma
- 36 - Molecular Biology of Melanoma
- 37 - Soft-Tissue Sarcomas
- 38 - Head and Neck Squamous Cell Carcinoma
- 39 - Primary Brain Tumors
- 40 - Epithelial Skin Cancer1
- 41 - Endocrine Cancer
- 42 - Gastric and Gastroesophageal Adenocarcinoma
- 43 - From Bench to Bedside with Targeted Therapies
- 44 - Screening Strategies for Targeted Therapeutics
- 45 - Animal Models to Predict Anticancer Efficacy
- 46 - Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics1
- 47 - Phase 1 Trials Today
- 48 - Cancer Therapeutics
- 49 - Natural and Acquired Resistance to Cancer Therapies
- 50 - Molecular Basis of Radiation Therapy
- 51 - Hematopoietic Growth Factors and Cytokines
- 52 - Interferons
- 53 - Cancer and the Cellular Immune Response
- 54 - Cancer-Specific Vaccines
- 55 - Monoclonal Antibody Therapy of Cancer
- 56 - Gene Therapy and Oncolytic Viruses
- 57 - RNA as a Therapeutic Molecule
- 58 - Heat Shock Protein 90 and the Proteasome
- 59 - Cancer Chemoprevention
Book Features
- Offers online access the book's complete contents fully searchable along with periodic updates, and artwork from the text for your personal use.
- Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines... keeping you on the cutting edge of your specialty.
- Offers a new, more user-friendly full-color format so the information that you need is easier to find.
- Presents abundant figures all redrawn in full color illustrating major concepts for easier comprehension.
- Features numerous descriptions of the latest clinical strategies helping you to understand and take advantage of todays state-of-the-art biotechnology advances.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
About the Author
- John Mendelsohn, MD, President, The University of Texas, MD Anderson Cancer Center, Houston, TX;
- Peter Howley, MD, Professor and Chairman, Department of Pathology, Harvard Medical School, Boston, MA;
- Mark A. Israel, MD, Director, Preuss Laboratory of Molecular Neuro-Oncology Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA;
- Lance A. Liotta, MD., PhD, Chief, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, San Francisco, CA.
- Hardcover: 704 pages
- Publisher: Saunders; 3 edition (March 26, 2008)
- Language: English
- ISBN-10: 1416037039
- ISBN-13: 9781416037033
- Dimensions: 11.1 x 8.8 x 1.4 inches