The field of Functional Neurosurgery and Neuromodulation is experiencing a renaissance. The reasons for this are many. First, numerous patients with neurological and psychiatric disorders continue to be disabled despite the best available medical treatments. Second, there have been important advances in the understanding of the pathophysiology of these disorders. Third, there have been significant improvements in both structural and functional brain imaging, which make the identification of potential targets easier. Fourth, there have been significant improvements in the neurosurgical techniques, such as neuronavigation and microelectrode recording, as well as in the equipment, including the stimulating electrodes, the pulse generators, and the drug delivery pumps, that are being used in day-to-day treatment.
There are a large number of circuits in the brain, spinal cord, and peripheral nerves that are amenable to neuromodulation. Both constant electrical stimulation as well as responsive electrical stimulation are possible, in addition to modulation through the delivery of pharmacological agents. As this field evolves, we anticipate the further development and application of novel forms of modulation based upon techniques such as optogenetics and gene therapy, with the latter currently being evaluated in a number of trials in Parkinson's disease. In addition, there is some re-emerging activity in transplantation as an investigational therapy.
The types of pathologies that are being treated with neuromodulation include pain, movement disorders, psychiatric disease, and epilepsy, and the patients that could benefit from these therapies are many. The future is bright for this specialty, and we need to train young neurosurgeons to embark on this fascinating aspect of neurosurgery.
This book compiles a series of works by experts who discuss various aspects of this field. It provides an overview of the entire discipline, tells us where we have been, and also where we are heading.
By Andres Lozano and Francisco Ponce
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
Key Features
- Each chapter offers point-counterpoint commentary for varied perspectives.
- Appendix distills current guidelines in easy accessible format.
- Chapters follow story of patient care, effectively emphasizing general principles with supporting examples.
- Offers outstanding scholarship, with over 20% of chapters involving international contributors.
Contents
Section I: The Neuromodulation Approach
- 1. The Neuromodulation Approach by Jeff Arle
Section II: Regions of Application
- 2. Cerebral - Surface by Sergio Canavero
- 3. Cerebral - Deep by Yakov Gologorsky, Ron Alterman
- 4. Spinal - Extradural by Tim Deer, Mathew Shocket
- 5. Peripheral Nerve by Konstantin Slavin
Section III: The Neuromodulation Therapy Interface
- 6. The Electrode - Materials and Configurations by Daniel Merrill
- 7. The Electrode - Principles of the Neural Interface: Axons and Cell Bodies by Cameron McIntyre
- 8. The Electrode - Principles of the Neural Interface: Circuits by Erwin Montgomery
- 9. The Electrode - Device Materials, Handling and Upgradeability by John Kast, Gabi Molnar, Mark Lent
- 10. The Electrode - Electronics by Emarit Ranu
- 11. The Electrode - Power by Tracy Cameron
Section IV: Placing Neuromodulation in the Human Body
- 12. Surgical Techniques by Jeff Arle
- 13. Trials and Their Applicability by Lou Raso
- 14. Limiting Morbidity by Konstantin Slavin
Section V: Troubleshooting and Repair
- 15. Intraoperative Evaluation by Jay Shils, Jeff Arle
Section VI: Post-Operative Management
- 16. Programming - DBS and other by Jay Shils
- 17. Programming - SCS by Gabi Molnar, Lisa Johanek, Steve Goetz, John Heitman
- 18. Safety and Environmental Constraints by Paul Larson, Alastair J. Martin
Section VII: The End User
- 19. Expectations and Outcomes by Guillermo A. Monsalve, Chad W. Farley, George T. Mandybur
- 20. Future Design Improvements by Alim-Louis Benabid
Appendix
About the Authors
- Jeffrey E. Arle, Director, Functional Neurosurgery and Research, Department of Neurosurgery Lahey Clinic, Burlington, MA; Associate Professor of Neurosurgery, Tufts University School, of Medicine, Boston, MA.
- Jay L. Shils, Director of Intraoperative, Monitoring, Dept of Neurosurgery, Lahey Clinic Burlington, MA.
Product Details
- Hardcover: 504 pages
- Publisher: Academic Press; 1 edition (June 23, 2011)
- Language: English
- ISBN-10: 012381409X
- ISBN-13: 978-0123814098
- Product Dimensions: 9.1 x 6.1 x 1.2 inches
List Price: $125.00