Many of the cells in our body undergo tightly regulated replication to enable growth to occur and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms. It is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
Now in its second edition, The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics gives a fresh approach to the study of the molecular basis of cancer. Written with the undergraduate student in mind, Lauren Pecorino focuses on how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled and corrupted with the onset of cancer. Within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.
Ideal for courses in the molecular biology of cancer and cancer biology, The Molecular Biology of Cancer, Second Edition, is an invaluable resource for any student wishing to gain insight into the molecular basis of the disease and formulate possible solutions for its effective control.
Contents
Key Features
New to this Edition
Product Details
Now in its second edition, The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics gives a fresh approach to the study of the molecular basis of cancer. Written with the undergraduate student in mind, Lauren Pecorino focuses on how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled and corrupted with the onset of cancer. Within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.
Ideal for courses in the molecular biology of cancer and cancer biology, The Molecular Biology of Cancer, Second Edition, is an invaluable resource for any student wishing to gain insight into the molecular basis of the disease and formulate possible solutions for its effective control.
- 1: Introduction
- 2: DNA structure and stability: mutations vs. repair
- 3: Regulation of gene expression
- 4: Growth factor signaling and oncogenes
- 5: The cell cycle
- 6: Growth inhibition and tumor suppressor genes
- 7: Apoptosis
- 8: Stem cells and differentiation
- 9: Metastasis
- 10: Infections and inflammation
- 11: Nutrients, hormones, and gene interactions
- 12: The Cancer Industry: drug development and clinical trial design
- 13: Cancer in the future: focus on diagnostics and immunotherapy
Key Features
- Show how an understanding of the molecular processes underpinning cancer can be directly applied to the development of new therapeutics, giving students a clear appreciation of how the theory relates to real life scenarios.
- Provides a carefully structured overview of the molecular mechanisms that regulate cell replication, and relates defects in these mechanisms to the onset of cancer, so that students can clearly see the link between the two.
- Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student; clarity is not sacrificed to achieve a contemporary account of the field.
- Online Resource Centre features additional resources for both lecturers and students, enhancing the value of this text as a teaching and learning tool.
New to this Edition
- Three new chapters. 'The Cell Cycle' gives extended treatment of this central aspect of cancer biology. 'Infections and Inflammation' focuses on the relationship between infectious agents and inflammation, and the onset of cancer. 'The Cancer Industry' gives an overview of the process through which drugs are developed and tested, setting the therapeutics theme that runs through the book in a professional context.
- Enhanced coverage of apoptosis.
- Over 25 new figures plus a new colour plate section, to further support and illustrate concepts presented in the written text.
- A new 'How do we know that?' feature, in which experimental methods and results are discussed, giving students an insight into how our understanding of cancer biology is developed.
- An extended glossary, to help those new to the subject grasp the terminology used.
Product Details
- Paperback: 320 pages
- Publisher: Oxford University Press, USA; 2 edition (May 6, 2008)
- Language: English
- ISBN-10: 0199211485
- ISBN-13: 978-0199211487
- Product Dimensions: 9.5 x 7.4 x 0.6 inches