It has been a quarter century since we started work on the first edition of Principles and Practice of Sleep Medicine. At that time there was a great deal of concern from colleagues that there simply wasn't enough information available for a book, and there simply wasn't enough of a market to justify all that effort. In fact, several colleagues whom we respect a great deal tried to talk us out of a textbook because they felt it would have been a waste of time. At that time there were roughly 2000 members of the American Sleep Disorders Association (now the American Academy of Sleep Medicine). Information about sleep medicine was transmitted and shared via telephone (almost everybody knew everybody practicing sleep medicine), articles, scientific meetings and one or two journals that regularly published articles about sleep.How things have changed. In the United States of America, within about 25 miles of anybody's home there are about 5 to 10 accredited sleep disorders centers, and also some unaccredited centers. There are about 1900 accredited sleep disorders centers. The American Academy of Sleep medicine has approximately 9000 members and counting. The number of doctors who practice sleep medicine is unknown, but there are 3,445 who have specialty certification in sleep awarded by the American Board of Sleep Medicine. This has been supplanted by a new certification exam administered by the American Board of Medical Specialties. The first time the exam was given, 724 physicians passed the examination. In addition, doctors from other specialties who may not have had any training in sleep medicine (for example those trained in pulmonary, neurology, otolaryngology) frequently evaluate and manage patients with sleep disorders.There are now eleven journals that publish articles exclusively about sleep. Whereas in 1985 there were about 400 articles published using the keywords “sleep apnea” or “sleep apnoea,” by 2010 about 4000 articles are being published per year. Entirely new fields now have important sleep components including geriatrics, occupational health, women's health, and there has been an explosion of knowledge just in the past few years in the genetics, molecular biology, and neuroanatomy and neurochemistry of sleep.To ensure that the information is up-to-date, this edition has five entirely new sections (“Sleep Medicine in the Elderly,” “Occupational Sleep Medicine,” “Physiology in Sleep,” “Genetics of Sleep,” and “Sleep Mechanisms and Phylogeny”). There are more than 50 brand new chapters and the remaining chapters have all been updated. There are new sleep stage and respiratory event scoring rules and this is perhaps the first major sleep textbook that incorporates these rules. A companion volume, Atlas of Clinical Sleep Medicine, contains hundreds of examples of polysomnographic data, and videos of interviews with patients with sleep disorders.Besides the dramatic increase in content, we had to deal with the changes in the delivery of information. Books were the way to go in the 1980s, content on CDs were the rage in the 1990s, but web-enabled books appear to be what people want beyond 2010. The third edition almost came out solely on a CD. It turned out that CDs were a passing trend and people hated reading large amounts of text on a computer screen. What doctors want now is a book that they can access in their library, via the internet and even on their handheld device and tablet. We have been listening to caregivers who use this content to help them better care for their patients and hope that you will continue to provide feedback.
Book Review
Medicine has only recently discovered the importance of sleep, and how sleep symptoms can be the canary in the mine of serious medical and psychiatric problems that can affect all people. I can attest firsthand about the importance of sleep, and how symptoms affecting sleep can impact a person's life. I was the Canadian Force Commander of the United Nations Assistance Mission for Rwanda between October 1993 and August 1994. During that time, a genocide resulted in the deaths of 800,000 people and I was an eyewitness having heard, smelled, seen, and touched thousands and thousands of mutilated bloated bodies of innocent civilians while trying to arrange a peace during a civil war while much of the world stood idly by. My sleep suffered, my health suffered, and I developed the symptoms of posttraumatic stress disorder. As the mission was winding down …“After prayers, I climbed into my vehicle and took off without telling anyone. It wasn't the first time. I had begun to suffocate in the headquarters, with its endless stream of problems and demands. I had been inventing trips to get me away from it, deciding that I had to see the troops in the field or just tour the country. In every village, along every road, in every church, in every school were unburied corpses. My dreams at night became my reality of the day, and increasingly I could not distinguish between the two.By this point, I wasn't bothering to make excuses anymore to disguise my quest for solitude. I would just sneak away and then drive around thinking all manner of black thoughts that I couldn't permit myself to say to anyone for fear of the effect on the morale of my troops. Without my marking the moment, death became a desired option. I hoped I would hit a mine or run into an ambush and just end it all. I think some part of me wanted to join the legions of the dead, whom I felt I had failed. I could not face the thought of leaving Rwanda alive after so many people had died. On my travels around the country, whole roads and villages were empty, as if they'd been hit by a nuclear bomb or the bubonic plague. You could drive for miles without seeing a single human being or a single living creature. Everything seemed so dead.”
Book Review
Medicine has only recently discovered the importance of sleep, and how sleep symptoms can be the canary in the mine of serious medical and psychiatric problems that can affect all people. I can attest firsthand about the importance of sleep, and how symptoms affecting sleep can impact a person's life. I was the Canadian Force Commander of the United Nations Assistance Mission for Rwanda between October 1993 and August 1994. During that time, a genocide resulted in the deaths of 800,000 people and I was an eyewitness having heard, smelled, seen, and touched thousands and thousands of mutilated bloated bodies of innocent civilians while trying to arrange a peace during a civil war while much of the world stood idly by. My sleep suffered, my health suffered, and I developed the symptoms of posttraumatic stress disorder. As the mission was winding down …“After prayers, I climbed into my vehicle and took off without telling anyone. It wasn't the first time. I had begun to suffocate in the headquarters, with its endless stream of problems and demands. I had been inventing trips to get me away from it, deciding that I had to see the troops in the field or just tour the country. In every village, along every road, in every church, in every school were unburied corpses. My dreams at night became my reality of the day, and increasingly I could not distinguish between the two.By this point, I wasn't bothering to make excuses anymore to disguise my quest for solitude. I would just sneak away and then drive around thinking all manner of black thoughts that I couldn't permit myself to say to anyone for fear of the effect on the morale of my troops. Without my marking the moment, death became a desired option. I hoped I would hit a mine or run into an ambush and just end it all. I think some part of me wanted to join the legions of the dead, whom I felt I had failed. I could not face the thought of leaving Rwanda alive after so many people had died. On my travels around the country, whole roads and villages were empty, as if they'd been hit by a nuclear bomb or the bubonic plague. You could drive for miles without seeing a single human being or a single living creature. Everything seemed so dead.”
—From, Roméo A. Dallaire, Shake Hands with the Devil: The Failure of Humanity in Rwanda. Carroll & Graf Publishers, New York. 2003. pp 499-500.
This is the first medical textbook that focuses on the sleep disorders that affect everyone, and that also includes the problems of first responders and the military and teaches doctors about how post traumatic stress disorder impacts sleep. I congratulate the editors.
—Lt. Gen the Hon. Roméo Dallaire, OC, CMM, GOQ, MSC, CD, (Ret'd), Senator, Canada
It is an honor for us, representing the Sleep Research Society, to help introduce the 5th edition of Principles and Practice of Sleep Medicine. This volume appears nearly fifty years after the first professional sleep research meeting in the United States on March 25 and 26, 1961, a meeting which directly led to the formation of the Sleep Research Society. According to records of Al Rechtschaffen, maintained in the University of Chicago Library, the first meeting was titled the “Conference on Research in EEG, Sleep and Dreams.” Two days of scientific sessions included topics such as: “Methods and Merits of Various Systems of Scoring,” “Equipment and Technical Problems” and “The Relation of EEG to Verbal Report.” As the session titles suggest, in 1961 sleep scientists were necessarily focused upon some of the most basic tenants of research: observation, measurement, standardization, and technology. It seems very unlikely that any of the thirty-six scientists in attendance, including Bill Dement, would have envisioned the exponential growth of knowledge about sleep and its disorders represented in the many pages of the current volume.Sleep research has evolved to include the breadth of modern scientific approaches, and sleep medicine is germane to most medical specialties and public health concerns. In the 149 chapters of this text (including more than 50 new chapters and new sections on Genetics, Occupational Sleep Medicine, Sleep Medicine in Older People) experts describe the intricate mechanisms of biological timing, the genetic polymorphisms conferring risk for sleep disorders, sleep-immune interactions, the morbidity and mortality risks of sleep apnea, and the impact of sleep disturbance on workplace and transportation safety, just to highlight as few areas. We commend the authors on their excellent contributions which will serve to educate and inspire practitioners, researchers and students for years to come.The Sleep Research Society congratulates Drs. Kryger, Roth, and Dement on the publication of this very impressive 5th edition of Principles and Practice of Sleep Medicine and thanks them for undertaking the important service of identifying the latest advances in the field and compiling the body of knowledge represented herein.
—James K. Walsh, PhD
President, Sleep Research Society, Executive Director and Senior Scientist, Sleep Medicine and Research Center, St. Luke's Hospital, Chesterfield, Missouri
President, Sleep Research Society, Executive Director and Senior Scientist, Sleep Medicine and Research Center, St. Luke's Hospital, Chesterfield, Missouri
—Clifford B. Saper, MD, PhD
Past-president, Sleep Research Society, James Jackson Putnam Professor of Neurology and Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts
Past-president, Sleep Research Society, James Jackson Putnam Professor of Neurology and Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts
The success of any field of medicine is often directly proportional to the scope and comprehensiveness of the knowledge base available to physicians, scientists, trainees, and the general public. For the field of sleep medicine, we are fortunate in that there continues to be dramatic growth in this knowledge, derived from both patient care and clinical/basic research. It is revealing when we step back and reflect on how this knowledge base has developed in so short a time: It has been less than 60 years since the discovery of rapid eye movement (REM) sleep, which initiated the organized, scientific study of sleep, and barely 25 years since the invention of continuous positive airway pressure (CPAP), which comprised the first effective treatment for obstructive sleep apnea. In this short time, the sleep field has expanded to the point where we have almost 1,900 accredited sleep centers and laboratories in the United States and over 9,000 members of the American Academy of Sleep Medicine. Our field has blossomed to the point where it is truly interdisciplinary, comprising specialists from the areas of pulmonary medicine, neurology, psychiatry, internal and family medicine, pediatrics, psychology, otolaryngology, and others. Exciting breakthroughs in sleep research have impacted other disciplines of science and research as well, and it is not unusual for sleep medicine specialists to collaborate with other diverse fields of medicine such as cardiology, endocrinology, and immunology.Despite our amazing growth, there are still many questions yet to be answered, including the holy grail of our field: the function of sleep. To explore these questions, the field requires a continued supply of dedicated and talented researchers in both the clinical and basic sciences. In addition, funding from the government, industry, and foundations; support from institutions; and strong mentorship by experienced investigators are important cornerstones to a successful independent research career. As members of the field, we must collectively strive to ensure that funding, support, and mentorship continues in order to ensure success of our field, even in times of economic downturns and increased competition from other fields. For without breakthroughs in research, there won't be new diagnostic tools, medications, or treatments to help us manage the nearly 90 different sleep disorders that we have identified thus far.The growth of our field and the exploration of critical research areas cannot exist without adequate education and training of our young clinicians and investigators. We are indeed privileged that we have excellent resources available that enable trainees to learn more about sleep and sleep medicine. For countless numbers of students, Principles and Practice of Sleep Medicine has served as the primary textbook, study material for the sleep medicine board certification examination, and/or the basic resource for any sleep-related condition or question about sleep. Often fondly referred to simply as “P&P”, it continues to rise in prominence and demand. I've had the great pleasure to learn from and collaborate with Drs. Kryger, Roth, and Dement, and not only are they among the top clinicians and scientists within our field, but they have continued to produce a sleep medicine reference that has remained the gold standard over the span of 20 years. Our field is deeply indebted to their dedication, hard work, and diligence.
—Clete A. Kushida, MD, PhD, RPSGT
President, American Academy of Sleep Medicine, Director, Stanford Center for Human Sleep Research, Stanford University, California
President, American Academy of Sleep Medicine, Director, Stanford Center for Human Sleep Research, Stanford University, California
The American Sleep Apnea Association (ASAA) congratulates the editors of the Principles and Practice of Sleep Medicine on the publication of the fifth edition of this invaluable guide for those practicing sleep medicine. As the field evolves, it has become a key resource for those responsible for diagnosing and treating those with sleep disorders like sleep apnea. The long-term management of patients requires a partnership between the doctor who will learn from this volume the scientific basis of the field and the patient with a chronic illness who must also learn about their condition.For the patient and their families seeking to understand sleep apnea prior to diagnosis, and often once they are treated, they frequently turn to the ASAA, since 1990 the only patient interest organization in the USA dedicated to sleep apnea education, support and advocacy. The ASAA produces educational materials and includes support groups for sleep apnea patients and their families operating under the name A.W.A.K.E. that stands for Alert, Well, And Keep Energetic. The network of the more than 300 A.W.A.K.E. groups has locations around the United States, Canada and overseas.As elucidated in this book sleep apnea is associated with several important comorbidities and thus the ASAA will expand contacts with other patient groups concerned such as heart disease and type 2 diabetes.The fifth edition of Practice and Principles of Sleep Medicine is for the education and support of the caregiver and the American Sleep Apnea Association for the education and support of the apnea patient and their family.
On behalf of the National Sleep Foundation, it is my pleasure and honor to help introduce the fifth edition of Principles and Practice of Sleep Medicine, the latest update to what has over the past 21 years properly come to be regarded as the preeminent reference text on sleep medicine. I congratulate the editors, Drs. Kryger, Roth, and Dement, for this new edition – representing as it does their long-standing and continuing commitment to the expansion of the field of sleep medicine and science, and their collective talent for presentation and dissemination of sleep-related knowledge.When the first edition was published, the discipline of sleep medicine was in its infancy. Today, perusing previous editions of PPSM is akin to marveling over the growth of a child by leafing through old family photo albums: Although it is understood on an intellectual level that growth and maturation have been occurring continuously, the intermittent nature of the photographic record serves to crystallize those changes in startlingly sharp relief. So it is with PPSM and the history of our field. Each successive edition of PPSM has faithfully reflected the progress made in the intervening years, in a narrative manner that makes clear the process by which high-quality scientific research on sleep and its disorders accrues and is translated into the practice of sleep medicine.Perusal of the current edition will, I think, make it apparent that our field has now grown past infancy, spurted through childhood, and entered its adolescence: to be sure, a phase of high energy and escalating complexity with a few early hints of maturity, but a phase primarily characterized by the exhilaration of a future that still seems horizonless. For those wishing an understanding of the roots of sleep science, desiring a comprehensive overview of the current ‘state of the art’ of sleep medicine, or yearning for a glimpse of what the future of sleep science holds, just start turning the pages. …
—Thomas J. Balkin, Ph.D.
Chairman of the Board of Directors, National Sleep Foundation, Washington, DC 
Part I - Principles of Sleep Medicine
Section 1 - Normal Sleep and Its Variations
- Chapter 1 - History of Sleep Physiology and Medicine
- Chapter 2 - Normal Human Sleep: An Overview
- Chapter 3 - Normal Aging
- Chapter 4 - Daytime Sleepiness and Alertness
- Chapter 5 - Acute Sleep Deprivation
- Chapter 6 - Chronic Sleep Deprivation
- Chapter 7 - Neural Control of Sleep in Mammals
- Chapter 8 - REM Sleep
- Chapter 9 - Phylogeny of Sleep Regulation
- Chapter 10 - Sleep in Animals: A State of Adaptive Inactivity
- Chapter 11 - Introduction
- Chapter 12 - Circadian Clock Genes
- Chapter 13 - Genetics of Sleep in a Simple Model Organism: Drosophila
- Chapter 14 - Genetic Basis of Sleep in Rodents
- Chapter 15 - Genetic Basis of Sleep in Healthy Humans
- Chapter 16 - Genetics of Sleep and Sleep Disorders in Humans
- Chapter 17 - Relevance of Sleep Physiology for Sleep Medicine Clinicians
- Chapter 18 - What Brain Imaging Reveals about Sleep Generation and Maintenance
- Chapter 19 - Cardiovascular Physiology: Central and Autonomic Regulation
- Chapter 20 - Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders
- Chapter 21 - Respiratory Physiology: Central Neural Control of Respiratory Neurons and Motoneurons during Sleep
- Chapter 22 - Respiratory Physiology: Understanding the Control of Ventilation
- Chapter 23 - Normal Physiology of the Upper and Lower Airways
- Chapter 24 - Respiratory Physiology: Sleep at High Altitudes
- Chapter 25 - Sleep and Host Defense
- Chapter 26 - Endocrine Physiology in Relation to Sleep and Sleep Disturbances
- Chapter 27 - Gastrointestinal Physiology in Relation to Sleep
- Chapter 28 - Body Temperature, Sleep, and Hibernation
- Chapter 29 - Memory Processing in Relation to Sleep
- Chapter 30 - Sensory and Motor Processing during Sleep and Wakefulness
- Chapter 31 - Introduction: Master Circadian Clock and Master Circadian Rhythm
- Chapter 32 - Circadian Rhythms in Mammals: Formal Properties and Environmental Influences
- Chapter 33 - Anatomy of the Mammalian Circadian System
- Chapter 34 - Physiology of the Mammalian Circadian System
- Chapter 35 - The Human Circadian Timing System and Sleep–Wake Regulation
- Chapter 36 - Melatonin and the Regulation of Sleep and Circadian Rhythms
- Chapter 37 - Sleep Homeostasis and Models of Sleep Regulation
- Chapter 38 - Circadian Rhythms in Sleepiness, Alertness, and Performance
- Chapter 39 - Animal Models for Disorders of Circadian Functions: Whole Organism
- Chapter 40 - Animal Models for Disorders of Chronobiology: Cell and Tissue
- Chapter 41 - Circadian Disorders of the Sleep–Wake Cycle
- Chapter 42 - Hypnotic Medications: Mechanisms of Action and Pharmacologic Effects
- Chapter 43 - Clinical Pharmacology of Other Drugs Used as Hypnotics
- Chapter 44 - Wake-Promoting Medications: Basic Mechanisms and Pharmacology
- Chapter 45 - Wake-Promoting Medications: Efficacy and Adverse Effects
- Chapter 46 - Drugs That Disturb Sleep and Wakefulness
- Chapter 47 - Introduction: The Changing Historical Context of Dream Research
- Chapter 48 - The Neurobiology of Dreaming
- Chapter 49 - Ultradian, Circadian, and Sleep-Dependent Features of Dreaming
- Chapter 50 - Dream Content: Quantitative Findings
- Chapter 51 - Dream Analysis and Classification: The Reality Simulation Perspective
- Chapter 52 - Dreams in Patients with Sleep Disorders
- Chapter 53 - Dreams and Nightmares in Posttraumatic Stress Disorder
- Chapter 54 - Dreaming as a Mood-Regulation System
- Chapter 55 - Why We Dream
Section 8 - Impact, Presentation, and Diagnosis
- Chapter 56 - Approach to the Patient with Disordered Sleep
- Chapter 57 - Cardinal Manifestations of Sleep Disorders
- Chapter 58 - Physical Examination in Sleep Medicine
- Chapter 59 - Use of Clinical Tools and Tests in Sleep Medicine
- Chapter 60 - Classification of Sleep Disorders
- Chapter 61 - Epidemiology of Sleep Disorders
- Chapter 62 - Sleep Medicine, Public Policy, and Public Health
- Chapter 63 - Sleep Forensics
- Chapter 64 - Introduction
- Chapter 65 - Performance Deficits during Sleep Loss: Effects of Time Awake, Time of Day, and Time on Task
- Chapter 66 - Fatigue and Performance Modeling
- Chapter 67 - Fatigue, Performance, Errors, and Accidents
- Chapter 68 - Fatigue Risk Management
- Chapter 69 - Drowsy Driving
- Chapter 70 - Sleep and Performance Monitoring in the Workplace: The Basis for Fatigue Risk Management
- Chapter 71 - Shift Work, Shift-Work Disorder, and Jet Lag
- Chapter 72 - Sleep Problems in First Responders and the Military
- Chapter 73 - Pharmacologic Management of Performance Deficits Resulting from Sleep Loss and Circadian Desynchrony
- Chapter 74 - Sleep, Stress, and Burnout
- Chapter 75 - Insomnia: Recent Developments and Future Directions
- Chapter 76 - Insomnia: Epidemiology and Risk Factors
- Chapter 77 - Insomnia: Diagnosis, Assessment, and Outcomes
- Chapter 78 - Models of Insomnia
- Chapter 79 - Psychological and Behavioral Treatments for Insomnia I: Approaches and Efficacy
- Chapter 80 - Psychological and Behavioral Treatments for Insomnia II: Implementation and Specific Populations
- Chapter 81 - Pharmacologic Treatment of Insomnia: Benzodiazepine Receptor Agonists
- Chapter 82 - Pharmacologic Treatment: Other Medications
- Chapter 83 - Treatment Guidelines for Insomnia
- Chapter 84 - Narcolepsy: Pathophysiology and Genetic Predisposition
- Chapter 85 - Narcolepsy: Diagnosis and Management
- Chapter 86 - Idiopathic Hypersomnia
- Chapter 87 - Parkinsonism
- Chapter 88 - Sleep and Stroke
- Chapter 89 - Sleep and Neuromuscular Diseases
- Chapter 90 - Restless Legs Syndrome and Periodic Limb Movements during Sleep
- Chapter 91 - Alzheimer's Disease and Other Dementias
- Chapter 92 - Epilepsy, Sleep, and Sleep Disorders
- Chapter 93 - Other Neurologic Disorders
- Chapter 94 - Non-REM Arousal Parasomnias
- Chapter 95 - REM Sleep Parasomnias
- Chapter 96 - Other Parasomnias
- Chapter 97 - Idiopathic Nightmares and Dream Disturbances Associated with Sleep–Wake Transitions
- Chapter 98 - Disturbed Dreaming as a Factor in Medical Conditions
- Chapter 99 - Sleep Bruxism
- Chapter 100 - Central Sleep Apnea and Periodic Breathing
- Chapter 101 - Anatomy and Physiology of Upper Airway Obstruction
- Chapter 102 - Snoring
- Chapter 103 - Genetics of Obstructive Sleep Apnea
- Chapter 104 - Cognition and Performance in Patients with Obstructive Sleep Apnea
- Chapter 105 - Clinical Features and Evaluation of Obstructive Sleep Apnea and Upper Airway Resistance Syndrome
- Chapter 106 - Medical Therapy for Obstructive Sleep Apnea
- Chapter 107 - Positive Airway Pressure Treatment for Obstructive Sleep Apnea–Hypopnea Syndrome
- Chapter 108 - Surgical Management for Obstructive Sleep-Disordered Breathing
- Chapter 109 - Oral Appliances for Sleep-Disordered Breathing
- Chapter 110 - Management of Obstructive Sleep Apnea–Hypopnea Syndrome
- Chapter 111 - Sleep in Patients with Asthma and Chronic Obstructive Pulmonary Disease
- Chapter 112 - Restrictive Lung Disorders
- Chapter 113 - Noninvasive Ventilation to Treat Chronic Ventilatory Failure
- Chapter 114 - Obstructive Sleep Apnea and Metabolic Dysfunction
- Chapter 115 - Obstructive Sleep Apnea, Obesity, and Bariatric Surgery
- Chapter 116 - Sleep and Cardiovascular Disease: Present and Future
- Chapter 117 - Sleep-Related Cardiac Risk
- Chapter 118 - Cardiac Arrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy
- Chapter 119 - Cardiovascular Effects of Sleep-Related Breathing Disorders
- Chapter 120 - Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea
- Chapter 121 - Coronary Artery Disease and Obstructive Sleep Apnea
- Chapter 122 - Heart Failure
- Chapter 123 - Sleep and Fatigue in Cancer Patients
- Chapter 124 - Fibromyalgia and Chronic Fatigue Syndromes
- Chapter 125 - Endocrine Disorders
- Chapter 126 - Pain and Sleep
- Chapter 127 - Gastrointestinal Disorders
- Chapter 128 - Sleep in Chronic Kidney Disease
- Chapter 129 - Anxiety Disorders
- Chapter 130 - Mood Disorders
- Chapter 131 - Schizophrenia
- Chapter 132 - Medication and Substance Abuse
- Chapter 133 - Medical and Psychiatric Disorders and the Medications Used to Treat Them
- Chapter 134 - Obstructive Sleep Apnea in the Elderly
- Chapter 135 - Insomnia in Older Adults
- Chapter 136 - Sleep in Independently Living and Institutionalized Elderly
- Chapter 137 - Sex Differences and Menstrual-Related Changes in Sleep and Circadian Rhythms
- Chapter 138 - Sleep Disturbances and Sleep-Related Disorders in Pregnancy
- Chapter 139 - The Postpartum Period
- Chapter 140 - Menopause
- Chapter 141 - Monitoring and Staging Human Sleep
- Chapter 142 - Monitoring Techniques for Evaluating Suspected Sleep-Disordered Breathing
- Chapter 143 - Evaluating Sleepiness
- Chapter 144 - Assessment Techniques for Insomnia
- Chapter 145 - Neurologic Monitoring Techniques
- Chapter 146 - Chronobiologic Monitoring Techniques
- Chapter 147 - Actigraphy
- Chapter 148 - Gastrointestinal Monitoring Techniques
- Chapter 149 - Light Therapy
Product Details
- Hardcover: 1766 pages
- Publisher: Saunders; 5 edition (November 1, 2010)
- Language: English
- ISBN-10: 1416066454
- ISBN-13: 978-1416066453