This textbook continues to change and evolve. The incomparable Ted Harris, who was editor-in-chief of the 7th edition, has stepped down, leaving Gary Firestein to fill his shoes. For the first time, a European editor, Iain McInnes, joined the group and helped create a truly international edition. Full color was introduced, new chapter formats were designed to assure a consistent look and feel for each topic, and algorithms for diagnosis and treatment as well as key point boxes were included. In addition, new authors were added to the list of luminaries that already contribute to the book, and there was a major effort to provide greater availability through electronic versions of reference material and on-line access.
While change has been in the air regarding many aspects of the book, some things never vary. The book was initially designed decades ago to provide scholarly rigor to the field of rheumatology and to offer definitive reviews of scientific advances as they apply to clinical medicine. This remained the touchstone of our enterprise for the past 4 years, just as it was for the previous seven editions. The painstaking job of identifying the premier authors to present definitive information on each topic required months of work, culminating in an editors’ meeting in Costa Rica to finalize the chapters (well, it wasn't all work!). The arduous process of guiding, reviewing, and editing the outstanding contributions of our authors was time consuming but paled compared with the efforts that the authors put into creating their chapters. The thread connecting the past to the present was also evident in the continued effort of our valued co-editors John Sergent, Ralph Budd, and Shaun Ruddy. Our trusted colleagues at Elsevier, including Cathy Carroll and Kimberly Murphy, were always available and suffered with us in Costa Rica as well.
The present looks very encouraging indeed. Kelley's Textbook of Rheumatology, 8th edition, is a beautiful tome that is designed to carry on the tradition of being the definitive rheumatology resource. Looking to the future, we expect that this work will continue to evolve and change. New editors, new science, new authors, and new technology will be the rule rather than the exception.
As you begin to use this edition, please know that it is truly a labor of love. We have enjoyed the experience and hope that it is as valuable to you as the previous editions.
While change has been in the air regarding many aspects of the book, some things never vary. The book was initially designed decades ago to provide scholarly rigor to the field of rheumatology and to offer definitive reviews of scientific advances as they apply to clinical medicine. This remained the touchstone of our enterprise for the past 4 years, just as it was for the previous seven editions. The painstaking job of identifying the premier authors to present definitive information on each topic required months of work, culminating in an editors’ meeting in Costa Rica to finalize the chapters (well, it wasn't all work!). The arduous process of guiding, reviewing, and editing the outstanding contributions of our authors was time consuming but paled compared with the efforts that the authors put into creating their chapters. The thread connecting the past to the present was also evident in the continued effort of our valued co-editors John Sergent, Ralph Budd, and Shaun Ruddy. Our trusted colleagues at Elsevier, including Cathy Carroll and Kimberly Murphy, were always available and suffered with us in Costa Rica as well.
The present looks very encouraging indeed. Kelley's Textbook of Rheumatology, 8th edition, is a beautiful tome that is designed to carry on the tradition of being the definitive rheumatology resource. Looking to the future, we expect that this work will continue to evolve and change. New editors, new science, new authors, and new technology will be the rule rather than the exception.
As you begin to use this edition, please know that it is truly a labor of love. We have enjoyed the experience and hope that it is as valuable to you as the previous editions.
The Editors
Contents
VOLUME I
PART 1 - STRUCTURE AND FUNCTION OF BONE, JOINTS AND CONNECTIVE TISSUE
- 1 - Biology of the Normal Joint
- 2 - Synovium
- 3 - Cartilage and Chondrocytes
- 4 - Biology, Physiology, and Morphology of Bone
- Chapter 5 - Muscle: Anatomy, Physiology, and Biochemistry
- 6 - Joint Biomechanics: The Role of Mechanics in Joint Pathology
- 7 - Proteinases and Matrix Degradation
PART 2 - CELLS INVOLVED IN AUTOIMMUNE DISEASES AND INFLAMMATION
- 8 - Mononuclear Phagocytes in Rheumatic Diseases
- 9 - T Lymphocytes
- 10 - B Cells
- 11 - Fibroblasts and Fibroblast-like Synoviocytes
- 12 - Neutrophils and Eosinophils
- 13 - Mast Cells
- 14 - Platelets and Rheumatic Diseases
PART 3 - EFFECTOR MECHANISMS IN AUTOIMMUNITY AND INFLAMMATION
- 15 - Autoimmunity
- 16 - Innate Immunity
- 17 - Adaptive Immunity Including Organization of Lymphoid Tissues
- 18 - Genetics of Rheumatic Diseases
- 19 - Complement System
- 20 - Signal Transduction
- 21 - Prostaglandins, Leukotrienes, and Related Compounds
- 22 - Cell Recruitment and Angiogenesis
- 23 - Cytokines
- 24 - Cell Survival and Death in Rheumatic Diseases
- 25 - Animal Models of Inflammatory Arthritis
- 26 - Neurologic Regulation of Inflammation
- 27 - Atherosclerosis in Rheumatoid Arthritis
PART 4 - BROAD ISSUES IN THE APPROCAH TO RHEUMATIC DISEASES
- 28 - Principles of Epidemiology in Rheumatic Disease
- 29 - Economic Burden of Rheumatic Diseases
- 30 - Clinical Trial Design and Analysis
- 31 - Assessment of Health Outcomes
- 32 - Biologic Markers
- 33 - Occupational and Recreational Musculoskeletal Disorders
- 34 - Integrative Medicine in Rheumatology: An Evidence-Based Approach
PART 5 - EVALUATION OF GENERALIZED AND LOCALIZED SYMPTOMS
- 35 - History and Physical Examination of the Musculoskeletal System
- 36 - Monarticular Arthritis
- 37 - Polyarticular Arthritis
- 38 - Fibromyalgia
PART 6 - DIFFERENTIAL DIAGNOSIS OF REGIONAL MUSCULOSKELETAL PAIN
- 39 - Neck Pain
- 40 - Shoulder Pain
- 41 - Low Back Pain
- 42 - Hip and Knee Pain
- 43 - Foot and Ankle Pain
- 44 - Hand and Wrist Pain
- 45 - Temporomandibular Joint Pain
- 46 - The Eye and Rheumatic Diseases
- 47 - The Skin and Rheumatic Diseases
PART 7 - DIAGNOSTIC TESTS AND PROCEDURES IN RHEUMATIC DISEASES
- 48 - Synovial Fluid Analysis, Synovial Biopsy, and Synovial Pathology
- 49 - Arthrocentesis and Injection of Joints and Soft Tissue
- 50 - Antinuclear Antibodies
- 51 - Rheumatoid Factors and Other Autoantibodies in Rheumatoid Arthritis
- 52 - Acute-Phase Reactants and the Concept of Inflammation
- 53 - Imaging Modalities in Rheumatic Disease
PART 8 - MODALITIES OF THERAPY IN RHEUMATIC DISEASE
- 54 - Nonsteroidal Anti-inflammatory Drug
- 55 - Glucocorticoid Therapy
- 56 - Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies
- 57 - Immunoregulatory Drugs
- 58 - Anticytokine Therapies
- 59 - Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics
- 60 - Chronic Musculoskeletal Pain
- 61 - Arthritis Self-Management
- 62 - Psychosocial Management of Rheumatic Diseases
- 63 - Nutrition and Rheumatic Diseases
- 64 - Introduction to Physical Medicine and Rehabilitation
VOLUME II
PART 9 - RHEUMATOID ARTHRITIS
- 65 - Etiology and Pathogenesis of Rheumatoid Arthritis
- 66 - Clinical Features of Rheumatoid Arthritis
- 67 - Treatment of Rheumatoid Arthritis
- 68 - Felty's Syndrome
- 69 - Sjogren's Syndrome
PART 10 - SPONDYLOARTHROPATHIES
- 70 - Ankylosing Spondylitis
- 71 - Undifferentiated Spondyloarthritis and Reactive Arthritis
- 72 - Psoriatic Arthritis
- 73 - Enteropathic Arthritis
PART 11 - SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES
- 74 - Pathogenesis of Systemic Lupus Erythematosus
- 75 - Clinical Features and Treatment of Systemic Lupus Erythematosus
- 76 - Antiphospholipid Syndrome
PART 12 - SCLERODERMA, INFLAMMATORY MYOPATHIES, AND OVERLAP SYNDROMES
- 77 - Systemic Sclerosis and the Scleroderma-Spectrum Disorders
- 78 - Inflammatory Diseases of Muscle and Other Myopathies
- 79 - Overlap Syndromes
PART 13 - VASCULITIS
- 80 - The Classification and Epidemiology of Systemic Vasculitis
- 81 - Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu's Arteritis
- 82 - Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
- 83 - Polyarteritis and Related Disorders
- 84 - Isolated Angiitis of the Central Nervous System
- 85 - Immune Complex-Mediated Small Vessel Vasculitis
- 86 - Behcet's Disease
PART 14 - CRYSTAL-INDUCED INFLAMMATION
- 87 - Gout and Hyperuricemia
- 88 - Diseases Associated with Articular Deposition of Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate Crystals
PART 15 - CARTILAGE, BONE, AND HERITABLE CONNECTIVE TISSUE DISORDERS
- 89 - Pathogenesis of Osteoarthritis
- 90 - Clinical Features of Osteoarthritis
- 91 - Management of Osteoarthritis
- 92 - Metabolic Bone Disease
- 93 - Proliferative Bone Diseases
- 94 - Osteonecrosis
- 95 - Relapsing Polychondritis
- 96 - Heritable Diseases of Connective Tissue
PART 16 - RHEUMATIC DISEASES OF CHILDHOOD
- 97 - Juvenile Idiopathic Arthritis
- 98 - Systemic Lupus Erythematosus, Juvenile Dermatomyositis, Scleroderma, and Vasculitis
PART 17 - INFECTION AND ARTHRITIS
- 99 - Bacterial Arthritis
- 100 - Lyme Disease
- 101 - Mycobacterial Infections of Bones and Joints
- 102 - Fungal Infections of the Bones and Joints
- 103 - Rheumatic Manifestations of Human Immunodeficiency Virus Infection
- 104 - Viral Arthritis
- 105 - Poststreptoccocal Arthritis and Rheumatic Fever
PART 18 - ARTHRITIS ACCOMPANYING SYSTEMIC DISEASE
- 106 - Amyloidosis
- 107 - Sarcoidosis
- 108 - Hemochromatosis
- 109 - Hemophilic Arthropathy
- 110 - Rheumatic Manifestations of Hemoglobinopathies
- 111 - Arthritis Accompanying Endocrine and Metabolic Disorders
- 112 - Musculoskeletal Syndromes in Malignancy
- 113 - Familial Autoinflammatory Syndromes
- 114 - Tumors and Tumor-like Lesions of Joints and Related Structures
Staying current in a field that's advancing rapidly is difficult. Now more than ever, Kelley's Textbook of Rheumatology, 8th Edition helps you better understand today's scientific underpinnings of rheumatic diseases, so that you can better manage your patients. With its new full-color design, scholarly approach to scientific concepts, and sweeping updates, you'll have a source of knowledge at your disposal to help you face even your toughest challenges. And, as an Expert Consult title, this thoroughly updated 8th edition comes with access to the complete contents online, fully searchable-enabling you to consult it rapidly from any computer with an Internet connection.
Key Features
- Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection.
- Features state-of-the-art, evidence-based guidance to help you offer your patients the best possible outcomes.
- Provides an increased understanding of mechanisms and molecules involved in the pathogenesis of disease.
New to this edition
- Includes detailed coverage of the very latest breakthroughs and the newest clinical algorithms to help you gain a thorough understanding of the whys as well as the hows of rheumatic disease management.
- Features new expert authors and new chapters that help you identify key effector mechanisms in autoimmune diseases and inflammation and apply the newest therapeutic modalities.
- Provides fresh, cutting-edge perspectives from the newest addition to the editorial team, Dr. Iain McInnes.
- Offers expanded coverage of imaging modalities so you can diagnose, monitor, and manage rheumatic disease more effectively.
- Incorporates a new full-color design-complete with more than 900 full-color illustrations-for quick access to the answers you need.
Product Details
- Hardcover: 2064 pages
- Publisher: Saunders; 8 edition (September 16, 2008)
- Language: English
- ISBN-10: 1416032851
- ISBN-13: 978-1416032854
List Price: $415.00