Causes of Rickets Disease






VITAMIN D DISORDERS
Nutritional vitamin D deficiency
Congenital vitamin D deficiency
Secondary vitamin D deficiency
 Malabsorption
 Increased degradation
 Decreased liver 25-hydroxylase
Vitamin D–dependent rickets type 1
Vitamin D–dependent rickets type 2
Chronic renal failure
CALCIUM DEFICIENCY
Low intake
 Diet
 Premature infants (rickets of prematurity)
Malabsorption
 Primary disease
 Dietary inhibitors of calcium absorption
PHOSPHORUS DEFICIENCY
Inadequate intake
 Premature infants (rickets of prematurity)
 Aluminum-containing antacids
RENAL LOSSES
X-linked hypophosphatemic rickets
Autosomal dominant hypophosphatemic rickets
Hereditary hypophosphatemic rickets with hypercalciuria
Overproduction of phosphatonin
 Tumor-induced rickets
 McCune-Albright syndrome
 Epidermal nevus syndrome
 Neurofibromatosis
Fanconi syndrome
Dent disease
DISTAL RENAL TUBULAR ACIDOSIS

Reference:
Nelson Textbook of Pediatrics 18th Edition
 

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