Most organs have a limited repertoire of responses to injury, and recognition of these patterns forms the cornerstone of our daily practice of surgical pathology; a “good eye,” as we know, is the defining attribute of a good pathologist. However, the limited morphologic expression of injury means that there is overlap of patterns and histopathologic findings among different diseases and that more than one pattern or feature may exist at any given time. The “good eye,” therefore, does not simply recognize a pattern or finding, but seeks out the dominant pattern while simultaneously ignoring distracting secondary features. This process is best exemplified by the ubiquitous eosinophil, which receives a lot of press in drug-induced hepatitis and allograft rejection, but which may be present in a wide variety of other conditions. The bright granules scream for attention and promise a peg to hang one's hat on, but the astute eye looks past them if they are not pertinent to the underlying pattern. Once the primary pattern is identified, the roving (but still “good”!) eye next hunts for additional features that help to formulate the final diagnosis.
This seemingly effortless and intuitive approach, honed over years of training and experience, has been recapitulated in the present book, as it is in every other volume of this series. The dominant patterns of injury recognized under low magnification are listed, followed by additional findings that lead to the specific diagnosis. Detailed information on the diagnostic entity is found in the cross-referenced chapter along with a discussion of differential diagnoses, which further guides the pathologist down the right path. The chapters themselves are not intended to be encyclopedic in their approach but rather are oriented toward those who want to learn enough about liver disease without reaching dizzying heights of scholarship. The text is further embellished with ample tables, boxes, and images to make this process as straightforward and rewarding as possible.
Section I of this volume starts off with a chapter that supplies the basic framework for microscopic examination of liver biopsies, including basic terms and elemental lesions. The subsequent three chapters cover pathophysiologic processes most relevant to liver injury and disease processes; the explosion of knowledge about the molecular processes involved in bile formation and secretion (Chapter 2) has led to a redefinition of several cholestatic diseases (Chapter 11). Similarly, a better understanding of metabolism of drugs and xenobiotics (Chapter 4) aids in understanding drug-induced liver disease (Chapter 24), the incidence of which is rising due to the availability of an ever-increasing number of pharmaceutical compounds to treat various conditions as well as the growing popularity of herbal therapies and products.
A practical diagnostic pathology textbook would be incomplete without basic clinical and radiologic information essential for the interpretation of liver biopsies. Chapter 5 details the interpretation of liver tests while Chapter 6 covers clinical features of liver diseases. Chapter 7 discusses radiologic findings in liver diseases, including strengths and weaknesses of various imaging modalities as well as emerging technologies that aim to change the practice of hepatology.
Liver diseases of childhood provide unique diagnostic challenges by constantly raising the specter of those nebulous “metabolic diseases.” Because not all metabolic diseases are common and not all childhood diseases are metabolic in nature, this text adopts a pragmatic approach by discussing the common childhood diseases in Chapter 8 and the most common metabolic diseases individually in Chapters 11, Chapter 12, Chapter 13, Chapter 14, and Chapter 15. The rest of the metabolic disease spectrum is outlined as a pattern-based diagnostic approach in Chapter 10, which is complemented by Chapter 9 that details biochemical and genetic methodologies that are often necessary to establish the final diagnosis. With the same principle in mind, the most common liver diseases (inflammatory, biliary, and so on) are detailed in their own individual chapters.
Finally, because liver transplantation is being performed in an ever-increasing number of centers, and biopsies from allografts are more common, this text includes a section detailing the clinical aspects (Chapter 41) and pathology (Chapter 42) of liver transplantation.
The style and organization of this volume, along with its text and images, hope, at best, to entice the hepatophile that might be surreptitiously residing in the general surgical pathologist and, at worst, to aid the nonhepatophile in the diagnosis of liver biopsies that may surreptitiously creep under his or her microscope. In these twin goals, I hope we have achieved some measure of success.
Romil Saxena, MD, FRCPath
Key Features
- Access the fully searchable contents online at www.expertconsult.com, along with a downloadable image bank and access to PathConsult.
- Recognize the basic patterns of liver injury through an algorithmic approach and establish diagnosis by a pttern-based visual index present at the beginning of the book.
- Evaluate and interpret biopsy samples using superb, high-quality, full-color images that illustrate pathognomonic features and common variations.
- Get comprehensive information on major adult and childhood liver diseases, hepatic neoplasms and pre-neoplastic nodules including clinical features, laboratory tests, imaging findings and differential diagnosis.
- Understand the pathology and practice of liver transplantation with coverage of the clinical aspects of this procedure.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
Contents
SECTION I - Applied Anatomy and Pathophysiology
- Chapter 1 - Microscopic Anatomy, Basic Terms, and Elemental Lesions
- Chapter 2 - Immunobiology of the Liver
- Chapter 3 - Bile Physiology and Transporter Proteins
- Chapter 4 - Metabolism of Drugs and Xenobiotics
SECTION II - Clinical Features, Laboratory Tests, and Imaging
- Chapter 5 - Laboratory Tests in Liver Disease
- Chapter 6 - Clinical Features of Liver Disease
- Chapter 7 - Investigative Imaging of the Liver
SECTION III - Common Liver Diseases of Childhood
- Chapter 8 - Common Liver Diseases of Childhood
SECTION IV - Inherited Metabolic Disorders
- Chapter 9 - Medical Genetics and Biochemistry in Diagnosis and Management
- Chapter 10 - Histologic Patterns of Metabolic Disease
- Chapter 11 - Intrahepatic Cholestasis: Inherited Disorders
- Chapter 12 - Wilson Disease
- Chapter 13 - Alpha-1 Antitrypsin Deficiency
- Chapter 14 - Hemochromatosis
- Chapter 15 - Cystic Fibrosis
SECTION V - Infectious Diseases
- Chapter 16 - Chronic Hepatitis: Grading and Staging
- Chapter 17 - Hepatitis B
- Chapter 18 - Hepatitis C
- Chapter 19 - Acute Viral Hepatitis
- Chapter 20 - Nonviral Infections
- Chapter 21 - Human Immunodeficiency Virus Infection
SECTION VI - Granulomatous Diseases
- Chapter 22 - Hepatic Granulomas: Differential Diagnosis
- Chapter 23 - Hepatic Sarcoidosis
SECTION VII - Drug-Induced Liver Injury
- Chapter 24 - Liver Injury Due to Drugs and Herbal Agents
Section VIII - Disorders of Bile Ducts
- Chapter 25 - Fibrocystic Liver Diseases
- Chapter 26 - Primary Biliary Cirrhosis
- Chapter 27 - Primary Sclerosing Cholangitis
- Chapter 28 - Loss of Intrahepatic Bile Ducts in Adults
SECTION IX - Autoimmune Hepatitis
- Chapter 29 - Autoimmune Hepatitis and Overlap Syndromes
SECTION X - Fatty Liver Disease
- Chapter 30 - Alcohol-Induced Liver Disease
- Chapter 31 - Nonalcoholic Fatty Liver Disease
SECTION XI - Vascular Disorders
- Chapter 32 - Vascular Disorders of the Liver
SECTION XII - Liver Tumors and Tumor-Like Lesions
- Chapter 33 - Premalignant Hepatocellular Lesions
- Chapter 34 - Benign Hepatocellular Tumors
- Chapter 35 - Hepatocellular Carcinoma
- Chapter 36 - Benign and Malignant Tumors of Bile Ducts
- Chapter 37 - Mixed Hepatobiliary Carcinoma
- Chapter 38 - Liver Tumors of Childhood
- Chapter 39 - Miscellaneous Tumors and Tumor-like Lesions
SECTION XIII - Systemic Diseases and Diseases of Other Organs
- Chapter 40 - Liver Pathology in Systemic Diseases and Diseases of Other Organs
SECTION XIV - Liver Transplantation
- Chapter 41 - Clinical Aspects of Liver Transplantation
- Chapter 42 - Pathology of Liver Transplantation
Product Details
- Hardcover: 728 pages
- Publisher: Saunders; 1 edition (February 4, 2011)
- Language: English
- ISBN-10: 0443068038
- ISBN-13: 978-0443068034
- Product Dimensions: 11.2 x 8.7 x 1.4 inches
List Price: $279.00