The challenge addressed by this book has not changed since the Preface to the First Edition was written in 1982: The amazing advances in fundamental biology that have occurred within the past two decades have brought hepatology and other disciplines into new, uncharted and exciting waters. The dramatic changes in biology will profoundly influence our ability to diagnose, treat, and prevent liver disease. How can a student of the liver and its disease maintain a link to these exciting advances? Most physicians lack the time to take post-graduate courses in basic biology; most basic researchers lack an understanding of liver physiology and disease. This book strives to bridge the ever-increasing gap between the amazing advances in basic biology and their application to liver structure, function, and disease.
Previous editions included a section entitled “Horizons”, which presented advances of extraordinary nature in areas of potentially major importance to the liver. Virtually all of these fields have rapidly expanded and become topics for future chapters. Fifteen new “Horizons” are presented in this edition. One may safely predict that their impact on hepatology will also be considerable.
Contents
PART ONE INTRODUCTION
1 Organizational Principles of the Liver
2 Embryonic Development of the Liver
PART TWO THE CELLS
3 Microtubules, Actin Filaments and Motor-mediated Vesicular Transport
4 Molecular Motors
5 Ion Pumps and Molecular Motors: P-, F-, and V-type ATPases
6 Hepatocyte Surface Polarity: Its Dynamic Maintenance and Establishment
7 Endocytosis as an Essential Process in Liver Function and Pathology
8 Membrane Transport in Hepatocellular Secretion
9 Mitochondria
10 Nuclear Pore Complex
11 Protein Maturation and Processing at the Endoplasmic Reticulum
12 Protein Degradation and the Lysosomal System
13 Peroxisome Assembly, Degradation, and Disease
14 Gap and Tight Junctions in Liver: Composition, Regulation, and Function
SECTION A HEPATOCYTE
15 Copper Metabolism and the Liver
16 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis
17 Disorders of Bilirubin Metabolism
18 Hepatic Fatty Acid Metabolism and Dysfunction
19 Lipoprotein Metabolism and Cholesterol Balance
SECTION B BILE SECRETION
20 Bile Acids and the Enterohepatic Circulation
21 Hepatocyte Basolateral Membrane Organic Anion Transporters
22 Nuclear Receptors Regulate Bile Acid Synthesis
23 The Function of the Canalicular Membrane in Bile Formation and Secretion
24 Apical Recycling of Canalicular ABC Transporters
25 Cholangiocyte Functions in Health and Disease: The Ciliary Connection
SECTION C SINUSOIDAL CELLS
26 The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology
27 Fenestrations in the Liver Sinusoidal Endothelial Cell
28 Hepatic Stellate Cells
29 Hepatic Fibrosis
30 Matrix
PART THREE INTERRELATED CELL FUNCTIONS
31 Insulin Resistance
32 Ca2+ Signaling in the Liver
33 Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury
34 Regulatory Pathways of Liver Gene Expression: The Central Role of Cyclic AMP
35 AMPK: Central Regulator of Glucose and Lipid Metabolism
36 Liver Regeneration
37 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver
38 Liver Repopulation by Cell Transplantation and the Role of Stem Cells
PART FOUR RELATION TO OTHER ORGANS
39 Hepatic Encephalopathy
40 The Kidney in Liver Disease
41 Critical Role of the Liver in Coagulation
PART FIVE PATHOBIOLOGICAL ANALYSIS
42 Inheritable Cholestatic Disorders
43 Adaptive Regulation of Hepatocyte Transporters in Cholestasis
44 Pathogenesis of Portal Hypertension
45 Non-alcoholic Fatty Liver Disease: A Pathophysiological Perspective
46 Pathophysiology of Alcoholic Liver Disease
47 Inflammation and Drug-induced Liver Injury
48 Hepatocyte Apoptosis
49 Back to the Future: A Backward Glance at the Forward Progress of Hepatitis Virus Research
50 Molecular Biology of Hepatitis Viruses
51 Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis
52 Clinical Implications of the Molecular Biology of Hepatitis B Virus
53 Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection
54 Current and Future Therapy for Hepatitis B and C
55 Biological Principles and Clinical Issues Underlying Liver Transplantation for Virus-induced End-stage Liver Disease
PART SIX HORIZONS
56 Tissue Engineering of the Liver
57 Aging and the Uncertain Roles of Sirtuins
58 The Liver Proteome
59 Liver-directed Gene Therapy
60 Decoding the Liver Cancer Genome
61 Genome-wide Expression Profiling of Human Hepatocellular Carcinoma
62 Cell Cycle Control in the Liver
63 miRNAs and Liver Biology
64 Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster
65 Zebrafish as a Model System for the Study of Liver Development and Disease
66 The Hepatocyte and the Cancer Cell: Dr Jekyll and Mr Hyde
67 The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions
68 Telomeres and Aging, Cancer, and Hepatic Fibrosis
69 Treatment of Cirrhosis with Vitamin A-coupled Liposomes Carrying siRNA against Heat Shock Protein 70 The “Green Liver” and Transcriptional Regulation of Phase II Detoxification Genes
Index
Book Details
- Hardcover: 1216 pages
- Publisher: Wiley; 5 edition (January 26, 2010)
- Language: English
- ISBN-10: 0470723130
- ISBN-13: 978-0470723135
- Product Dimensions: 11.3 x 8.8 x 2.8 inches