Leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. Accurate diagnosis and classification are necessary for the identification of specific biological entities and underpin scientific advances in this field. The detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients. Many systems for the classification of leukaemia have been proposed.
Between 1976 and 1999, a collaborative group of French, American and British haematologists (the FAB group) proposed a number of classifications, which became widely accepted throughout the world. In 2001, a quarter of a century after the first FAB proposals, a World Health Organization (WHO) expert group proposed an updated system for the classification of leukaemia and lymphoma incorporating clinical features, haematological and histological features, immunophenotyping and the results of cytogenetic and, to a lesser extent, molecular genetic analysis. In 2008 a further updating of the WHO classification incorporated new knowledge and gave a greater importance to molecular genetic features.
Leukaemia Diagnosis 4th Edition by Barbara J. Bain illustrate and explain how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. This book discuss diagnosis and classification in a way that will be helpful to trainee haematologists and to laboratory scientists in haematology and related disciplines. However, this book also tried to provide a useful reference source and teaching aid for those who already have expertise in this field. In addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders.
As the diagnosis and classification of leukaemia comes to rely increasingly on sophisticated and expensive investigations there is a risk that some countries will be left behind. For the first time the author have therefore incorporated, as an appendix, some suggestions as to how leukaemia might be diagnosed in under-resourced laboratories. This may seem presumptuous from someone who has not worked in a developing country for more than 40 years but I thought that at least it should be attempted.
Since photographs have been taken of many different microscopes and exact magnifications differ slightly, magnifications of photomicrographs in this edition are given as the microscope objective used.
New to this edition
Contents
Product Details
Between 1976 and 1999, a collaborative group of French, American and British haematologists (the FAB group) proposed a number of classifications, which became widely accepted throughout the world. In 2001, a quarter of a century after the first FAB proposals, a World Health Organization (WHO) expert group proposed an updated system for the classification of leukaemia and lymphoma incorporating clinical features, haematological and histological features, immunophenotyping and the results of cytogenetic and, to a lesser extent, molecular genetic analysis. In 2008 a further updating of the WHO classification incorporated new knowledge and gave a greater importance to molecular genetic features.
Leukaemia Diagnosis 4th Edition by Barbara J. Bain illustrate and explain how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. This book discuss diagnosis and classification in a way that will be helpful to trainee haematologists and to laboratory scientists in haematology and related disciplines. However, this book also tried to provide a useful reference source and teaching aid for those who already have expertise in this field. In addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders.
As the diagnosis and classification of leukaemia comes to rely increasingly on sophisticated and expensive investigations there is a risk that some countries will be left behind. For the first time the author have therefore incorporated, as an appendix, some suggestions as to how leukaemia might be diagnosed in under-resourced laboratories. This may seem presumptuous from someone who has not worked in a developing country for more than 40 years but I thought that at least it should be attempted.
Since photographs have been taken of many different microscopes and exact magnifications differ slightly, magnifications of photomicrographs in this edition are given as the microscope objective used.
New to this edition - Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues.
- Includes 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma - 50 of which are completely new.
Contents
- The Nature of Leukaemia, Cytology, Cytochemistry and the FAB Classification of Acute Leukaemia
- Immunophenotyping and Cytogenetic/Molecular Genetic Analysis in Leukaemia and Related Conditions
- Acute Leukaemia: Integration of Morphological, Immunophenotypic and Genetic Information and the WHO Classification
- The Myelodysplastic Syndromes
- Chronic Myeloid Leukaemias
- Lymphoid Leukaemias of Mature T, B and Natural Killer Cells
- Appendix: Leukaemia Diagnosis in Resource-Poor Countries
- Index
Product Details
- Hardcover: 404 pages
- Publisher: Wiley-Blackwell; 4 edition (May 11, 2010)
- Language: English
- ISBN-10: 1405168048
- ISBN-13: 978-1405168045