In the time since the first edition of Blood and Bone Marrow Pathology was published in 2002, major advances have been made in all facets of the field of hematology. Much of this has resulted from progress in molecular genetics which has enhanced our understanding of the pathological basis of hematological disorders. The knowledge of the molecular basis of hematological diseases is now being used to both diagnose and classify non-malignant and malignant hematological disorders. This has had a major impact on the hemopoietic tumors where the World Health Organization classification is in large part based on this new biological information.
This second edition of Blood and Bone Marrow Pathology has therefore been significantly updated and revised to incorporate these advances. Many chapters have been totally rewritten to encapsulate the advances in the understanding of the fundamentals of the pathology of blood and bone marrow in health and disease. This book truly focuses on the pathology of blood and bone marrow. Although clinical aspects of disease are alluded to along with treatment approaches, this is only given as a guide to the reader. The book is aimed at bridging pure cytology and histology with clinical hematology diagnostics.
The book was originally to be co-edited by Professor Sunitha Wickramasinghe, co-editor of the first edition and a major driving force behind Blood and Bone Marrow Pathology. It is with immense sadness we note the untimely death of Sunitha during the production of this second edition. His death has been a tremendous loss to hematology.
The book is divided into sections on normal blood and bone marrow, pathology of the bone marrow, disorders of erythroid cells and leukocytes, abnormalities of hemostasis and immunohematology. Within each section there are chapters devoted to specific aspects of each of these areas and which have been written by internationally recognized experts. We are most grateful to them for their outstanding contributions and the time they have devoted to this project.
We are also immensely grateful to the publishers and especially Michael Houston, Ben Davie and Rachael Harrison for their enormous help in bringing this project to fruition. We hope this second edition of Blood and Bone Marrow Pathology will be of benefit to clinical and laboratory hematologists, hematopathologists and those in training in gaining a better understanding of the pathology of blood and bone marrow.
-- Authors --
Key Features
- Chapters have been totally rewritten and some new chapters have been added especially on myeloid malignancies, in line with the WHO 2008 Classification
- All chapters have been revised to include new aspects of molecular biology and updated concerning flow cytometry diagnostics
- Greater emphasis on practical diagnostic aspects for all disorders
- Brand new editorial and contributing author team.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
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Contents
Section A - Normal blood and bone marrow cells
- CHAPTER 1 - Normal blood cells
- CHAPTER 2 - Normal bone marrow cells
- CHAPTER 3 - Normal bone marrow histology
- CHAPTER 4 - Regulation of hematopoiesis
Section B - Pathology of the marrow
- CHAPTER 5 - Pathology of the marrow
Section C - Disorders affecting erythroid cells
- CHAPTER 6 - Investigation and classification of anemia
- CHAPTER 7 - Abnormalities of the red cell membrane
- CHAPTER 8 - Erythroenzyme disorders
- CHAPTER 9 - Abnormalities of the structure and synthesis of hemoglobin
- CHAPTER 10 - Acquired hemolytic anemia
- CHAPTER 11 - Iron deficiency anemia, anemia of chronic disorders and iron overload
- CHAPTER 12 - Macrocytic anemia
- CHAPTER 13 - Aplastic anemia and pure red cell aplasia
- CHAPTER 14 - Sideroblastic anemia
- CHAPTER 15 - Congenital dyserythropoietic anemias
Section D - Disorders affecting the leukocyte lineages
- CHAPTER 16 - Abnormalities in leukocyte morphology and number
- CHAPTER 17 - Disorders of phagocyte function
- CHAPTER 18 - Acute myeloid leukemias
- CHAPTER 19 - Acute lymphoblastic leukemia/lymphoma and mixed phenotype acute leukemias
- CHAPTER 20 - Myelodysplastic syndromes
- CHAPTER 21 - Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
- CHAPTER 22 - Erythrocytosis and polycythemia
- CHAPTER 23 - Essential thrombocythemia and primary myelofibrosis
- CHAPTER 24 - Chronic myelogenous leukemia
- CHAPTER 25 - Myeloproliferative neoplasms with eosinophilia
- CHAPTER 26 - Systemic mastocytosis
- CHAPTER 27 - Myelodysplastic/myeloproliferative neoplasms
- CHAPTER 28 - The chronic lymphoid leukemias
- CHAPTER 29 - Lymphoma
- CHAPTER 30 - Abnormalities in immunoglobulin synthesizing cells
Section E - Abnormalities of Hemostasis
- CHAPTER 31 - Hemostasis
- CHAPTER 32 - Disorders affecting megakaryocytes and platelets
- CHAPTER 33 - Acquired disorders affecting megakaryocytes and platelets
- CHAPTER 34 - Inherited disorders of coagulation
- CHAPTER 35 - Acquired bleeding disorders
- CHAPTER 36 - Natural anticoagulants and thrombophilia
Section F - Immunohematology
- CHAPTER 37 - Blood groups on red cells, platelets and neutrophils
- CHAPTER 38 - Transfusion medicine for pathologists
- CHAPTER 39 - Histocompatibility
About the Authors
- Anna Porwit MD, PhD, Professor, Department of Pathology, Karolinska University Hospital and Institute, Stockholm, Sweden; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
- Jeffrey McCullough MD, Professor of Laboratory Medicine and Pathology, American Red Cross Professor of Transfusion Medicine, University of Minnesota, Minneapolis, MN, USA.
- Wendy N. Erber MD, DPhil, FRCPA, FRCPath, Consultant Hematologist, Addenbrooke's Hospital; Hematology Department, University of Cambridge, Cambridge, UK.
Product Details
- Hardcover: 722 pages
- Publisher: Churchill Livingstone; 2 edition (2011)
- Language: English
- ISBN-10: 070203147X
- ISBN-13: 978-0702031472
- Product Dimensions: 11.1 x 9 x 1.5 inches
List Price: $319.95