The present edition of this book is the first without the direct imprimature of its founding and longtime author Professor Peter J. Scheuer, who very sadly died in 2006. The younger reader may not know that Liver Biopsy Interpretation was the first book of its kind, a fairly slender volume written by Peter when he was Senior Lecturer in Morbid Anatomy at the Royal Free Hospital Medical School, London, and published just over 40 years ago in 1968. At the time the percutaneous needle liver biopsy technique of Menghini had been in regular use only for a decade, so Peter's concept of a book ‘intended as a practical aid to liver biopsy diagnosis’ (as he wrote in the Preface to the first edition) was both timely and prescient.
Preparation of the subsequent editions was a source of great satisfaction to him, particularly the integration of advances in the fields of hepatology and hepatic pathology. Peter's unique ability to distill the essence of a diagnostic problem to its crystalline core, both conceptually and in writing, was a quality much in evidence in his lectures and publications. Many friends, trainees and colleagues benefited from his generously given advice and counsel, myself included. Peter's optimistic view of the world and the pursuit of academe were informed by his gentle good humour and love of music (a prodigiously talented cellist and chamber music enthusiast), the Italian language and the arts. He is greatly missed. The book's new title, Scheuer's Liver Biopsy Interpretation, honours Peter Scheuer and his many contributions to the way we think about pathology of the liver.
Preparation of the subsequent editions was a source of great satisfaction to him, particularly the integration of advances in the fields of hepatology and hepatic pathology. Peter's unique ability to distill the essence of a diagnostic problem to its crystalline core, both conceptually and in writing, was a quality much in evidence in his lectures and publications. Many friends, trainees and colleagues benefited from his generously given advice and counsel, myself included. Peter's optimistic view of the world and the pursuit of academe were informed by his gentle good humour and love of music (a prodigiously talented cellist and chamber music enthusiast), the Italian language and the arts. He is greatly missed. The book's new title, Scheuer's Liver Biopsy Interpretation, honours Peter Scheuer and his many contributions to the way we think about pathology of the liver.
For this edition there are both new illustrations and references which address recently described entities as well as current diagnostic problems in practice including chronic hepatitis and fatty liver disease. The principle of a concise ‘bench’ book for use by the microscope has been kept to the fore and the reader is encouraged to take advantage of larger textbooks and Internet sources for new information. It is to be hoped that the material in this book will serve not only as a foundation for interpreting liver biopsies, but also to stimulate encorporation of the many advances in genomic and molecular diagnostics that are now available.
-- Jay H. Lefkowitch
Contents
CHAPTER 1 - General Principles of Biopsy Assessment - Introduction
- Type and adequacy of liver biopsy specimen
- The specimen at the bedside and in the laboratory
- References
- Processing of the specimen
- Choice of stains
- References
- General reading
- Structures and components
- Normal appearances in childhood
- Ageing
- Biopsy of the normal liver
- Initial examination and reporting
- Basic patterns of injury
- Differential diagnosis of individual findings
- Introduction
- Cholestasis
- Large bile-duct obstruction
- Cholangitis: infection of the biliary tree
- Primary sclerosing cholangitis
- Primary biliary cirrhosis
- Other disorders with intrahepatic bile-duct loss
- Introduction
- Pathological features
- Individual causes of viral hepatitis
- Differential diagnosis of acute viral hepatitis
- Fate and morphological sequelae of acute viral hepatitis
- Steatosis
- Alcoholic and non-alcoholic fatty liver disease
- Steatohepatitis, alcoholic and non-alcoholic
- Other alcohol-related liver lesions
- Introduction
- Classification and mechanisms
- Morphological categories
- Definition and causes
- Classification and nomenclature
- Use of liver biopsy in chronic hepatitis
- Histological features of chronic hepatitis
- Individual causes of chronic hepatitis
- Differential diagnosis of chronic hepatitis
- Semi-quantitative scoring: grading and staging
- Introduction
- Diagnosis of cirrhosis by liver biopsy
- Assessment of cause
- Stage of development
- Histological activity
- Complications
- Introduction
- Neoplasms and nodules in adults
- Extrahepatic malignancy and the liver
- Neoplasms and nodules in children
- Cytopathological diagnosis
- The hepatic arteries
- The portal veins
- The hepatic sinusoids
- Venous congestion and outflow obstruction
- Introduction
- Diagnostic approach to neonatal liver biopsy
- Neonatal hepatitis
- Extrahepatic biliary atresia
- Paucity of intrahepatic bile ducts in childhood
- Fibropolycystic diseases
- Inherited metabolic disorders
- Reye's syndrome
- Parenteral nutrition
- Hyperbilirubinaemias
- Inherited cholestatic syndromes
- Cirrhosis in childhood
- Wilson's disease (hepatolenticular degeneration)
- Iron overload
- Primary iron overload disorders
- Secondary iron overload disorders
- Introduction
- Granulomas
- Viral diseases
- Rickettsial, bacterial and fungal infections
- Parasitic diseases
- Gastrointestinal disorders and the liver
- Haematological disorders and the liver
- The liver in rheumatoid, immune-complex and collagen diseases
- Amyloidosis and light chain deposition
- The liver in the porphyrias
- Non-specific reactive changes
- The liver in pregnancy
- Introduction
- Liver transplantation
- Renal transplantation
- Bone marrow transplantation
- Introduction
- Electron microscopy of liver biopsies
- The normal liver and examples of ultrastructural changes in disease
- Immunoelectron microscopy
- Scanning electron microscopy
- Immunohistochemistry
- In situ hybridisation
- Flow cytometry of lymphocytes from liver biopsies
- Confocal laser scanning microscopy
- Polymerase chain reaction
- Laser capture microdissection
- Gene array analysis
Key Features
- A well-written, complete, and concise quick reference that helps the practicing and trainee pathologist solve diagnostic problems at the mircroscope.
- High-quality color images complement the text throughout and provide the user with a complete visual guide to each entity and assist in the recognition and diagnosis of any tissue sample under the microscope.
- Practical tips and “hands on” advice are offered from two of the world’s leading experts in liver pathology, providing the trainee and general surgical pathologist with time-saving diagnostic clues when dealing with difficult specimens.
- A glossary of frequently used terms and descriptions used in the pathology report is contained at the end of the book, which is a useful quick reference for trainee pathologists and clinical hepatologists who may be unfamiliar with many of the terms and descriptions. This glossary will assist in the writing and reading of a pathology report.
- A selection of a few general reading references is provided at the end of each chapter, directing the trainee or practitioner to the most relevant and authoritative sources of further information and study.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
New to this edition
- A brand new chapter: "Practical Principles in Biopsy Assessment". Focus is on interpretation rather than a mere listing of pathological changes. The initial overview of the biopsy specimen provides critical clues to diagnosis and a highly illustrated guide to ddx will be of enormous help in avoiding diagnostic errors.
- Expanded coverage throughout, especially of liver tumours, pediatric fatty liver disease, neonatal cholestasis. Keeps the user apprised of the key areas of growth and development in diagnosis and interpretation.
- Histopathology correlated with molecular genetics and immunohistochemistry whenever clinically relevant. Keeps the user up-to-date with all of the latest tools for performing a complete and accurate diagnosis.
- Many new high-quality colour illustrations. Helps the user identify a wide variety of pathologic lesions.
- Text and images available online via Expert Consult.
Product Details
- Hardcover: 416 pages
- Publisher: Saunders Ltd.; 8 edition (July 28, 2010)
- Language: English
- ISBN-10: 070203410X
- ISBN-13: 978-0702034107
- Product Dimensions: 9.9 x 7.7 x 0.9 inches
List Price: $170.00