Although over a decade passed between the publication of the first and second editions of the Atlas of Liver Pathology, the rapid development in understanding the pathophysiologic concepts of diseases and identifying variations in morphologic features of these diseases necessitates a third edition over a much shorter time span.
The new diagnostic tools leading to more sophisticated laboratory testing have been a hallmark in learning the etiology and pathophysiology of diseases. Where before morphologic changes were ascribed to various liver disorders without a good understanding of their significance, the advent of new testing procedures such as genome sequencing much better helps us understand what we see under light microscopy. An excellent example is the ongoing research in liver tumors that examines cellular signaling pathways and molecular profiling, identifies individual genes and gene groups associated with higher instances of the development of hepatocellular carcinoma in cirrhotic livers, and correlates all of the above with the morphology seen in liver biopsy specimens.
The changes in the updated third edition include the use of gross images of various liver diseases with direct correlation with the light microscopy. In addition, the total number of images has increased by approximately 50% from the second edition. What has also been added is a second section addressing specific morphologic changes in table format and listing the various liver diseases associated with these changes. This section, which has been updated from our previous book, Liver Biopsy Evaluation, specifically aids the reader in arriving at diagnoses and differential possibilities solely on morphology, then referring the reader to the text and images of the specific diseases in the first part of the book.
We hope that this new edition will be successful in providing pathologists, clinicians, and students a better understanding of liver pathology and disease concepts and will be a useful practical tool. The overall aim does not change from the previous editions: to offer a concise illustrative text in liver and hepatobiliary pathology.
-- Gary Kanel, Jacob Korula
Key Features
- Interpret liver specimens systematically by first considering the morphology, the differential diagnoses, and then the clinical features, including descriptions of the clinical and biologic behavior, treatment, and prognosis.
- Quickly and easily retrieve the information you need using a templated format that includes concise, bulleted text and abundant tables.
- Ensure accurate diagnoses with the help of 900+ full-color, high-quality images which capture the gross and histological presentation of liver pathology.
- Keep up with the latest findings on newly recognized liver diseases as well as rare disorders such as:
- Langerhans cell histiocytosis,
- Leishmaniasis,
- Niemann-Pick disease,
- Lymphangioma,
- Pheochromocytoma,
- Infection-associated (reactive) hemophagocytic syndrome, and
- Glycogen storage diseases.
- Find tables that cover rare diseases and disorders throughout the book.
- Obtain assistance with liver biopsy interpretation through greatly expanded coverage including differential diagnostic tables in a new section of the book, increased images, and more.
- Confidently recognize the major characteristics and distinguishing features of various diseases by examining the revised section on "Clinical and Biologic Behavior."
- Search the complete text online and download all of the illustrations at www.expertconsult.com.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
Contents
Part I - Liver and Hepatobiliary Pathology with Clinical Correlations
Chapter 1 - General Aspects of the Liver and Liver Diseases- The Normal Liver
- Embryology
- Gross Anatomy
- Microanatomy
- Stem Cells
- Common Pigments
- Systematic Approach in Liver Biopsy Interpretation
- General Clinical Considerations of Acute and Chronic Liver Diseases
- Major Hepatotropic Viruses: A, B, δ, C, E, G, “Non-A Through Non-G”
- Systemic Viral Infections with Hepatic Involvement
- Epstein-Barr Virus
- Cytomegalovirus
- Herpes Simplex Virus
- Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
- Rare Systemic Viral Infections with Hepatic Involvement
- Lassa Fever
- Yellow Fever
- Echovirus (Enterovirus)
- Other Viruses that May Cause Liver Damage
- Extrahepatic (Mechanical) Bile Duct Obstruction
- Early Stage
- Early Stage to Mid-Stage
- Late Stage
- Primary Biliary Cirrhosis
- Major morphologic features
- Other features
- Special stains
- Differential diagnosis
- Clinical and biologic behavior
- Treatment and prognosis
- Primary Sclerosing Cholangitis
- Recurrent Pyogenic Cholangiohepatitis
- Other Cholestatic Disorders
- Alcoholic Liver Disease
- Alcoholic Fatty Liver
- Perivenular Alcoholic Fibrosis
- Acute Alcoholic Liver Disease
- Non-Alcoholic Fatty Liver Disease (NAFLD)
- Non-Alcoholic Fatty Liver (NAFL)
- Non-Alcoholic Steatohepatitis (NASH)
- Classification
- Basic Mechanisms of Disease
- Predominant Morphologic Features
- Hepatocellular Necrosis with Minimal to Absent Inflammation
- Acetaminophen
- Cocaine
- Hepatocellular Necrosis with Inflammation
- Isoniazid
- Phenytoin
- Halogenated Hydrocarbons (Halothane)
- Nitrofurantoin
- Lobular Confluent Necrosis with Inflammation
- Troglitazone
- Niacin (Nicotinic Acid)
- Sertraline
- Fatty Change
- Tetracycline
- Mushrooms
- Sulfasalazine
- Vitamin A
- Granulomas
- Sulfonamides and Derivatives
- Mineral Oil
- Mallory Bodies
- Amiodarone
- Cholestasis, Simple
- Oral Contraceptives
- Methyltestosterone
- Cholestasis with Inflammation
- Ketoconazole
- Clarithromycin
- Bupropion
- Bile Ducts: Inflammation and Injury
- Chlorpromazine
- Allopurinol
- Vascular
- Busulfan (Conditioning Regimen for Bone Marrow Transplants)
- Fibrosis
- Methotrexate
- Neoplasms and Related Lesions
- Miscellaneous Drug-Induced Lesions
- Hepatic Venous Outflow Obstruction
- Venous Congestion Secondary to Right-Sided Heart Failure
- Hepatic Vein Thrombosis (Budd-Chiari Syndrome)
- Veno-Occlusive Disease (VOD) (Sinusoidal Obstruction Syndrome)
- Portal Vein Thrombosis
- Decreased Arterial Blood Flow
- Hypoxic Injury Secondary to Hypotension
- Hypoxic Injury Secondary to Left-Sided Heart Failure without Hypotension (Red Blood Cell–Trabecular Lesion)
- Inflammatory Lesions of the Portal and Hepatic Veins
- Pylephlebitis and Sublobular, Hepatic Vein Phlebitis
- Inflammatory Lesions of the Hepatic Artery (Vasculitis)
- Polyarteritis Nodosa and Churg-Strauss Syndrome
- Miscellaneous
- Peliosis Hepatitis
- Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease)
- Non-Cirrhotic Portal Fibrosis (Idiopathic Portal Hypertension, Hepatoportal Sclerosis)
- Other causes of vascular disorders
- Bacteria
- Reactive Changes and Pyogenic (Abscess)
- Brucellosis
- Salmonellosis (Typhoid Fever)
- Spirochetes
- Syphilis
- Mycobacterium
- Tuberculosis
- Mycobacterium Avium Complex (MAC)
- Leprosy
- Rickettsia
- Q Fever
- Rocky Mountain Spotted Fever
- Fungi
- Histoplasmosis
- Coccidioidomycoses
- Cryptococcosis
- Candidiasis
- Parasites
- Amebiasis
- Malaria
- Leishmaniasis
- Echinococcosis (Hydatid Cyst)
- Clonorchiasis
- Visceral Larva Migrans
- Toxoplasmosis
- Schistomosiasis
- Other non-viral infectious disorders that may cause liver damage
- Neonatal Hepatitis
- Biliary Atresia
- Extrahepatic
- Intrahepatic
- Inherited Cholestatic Disorders
- Progressive Familial Intrahepatic Cholestasis (Byler Syndrome)
- Benign Recurrent Intrahepatic Cholestasis
- Fibrocystic Diseases
- Biliary Microhamartoma (von Meyenburg Complex)
- Peribiliary Cysts
- Choledochal Cyst
- Solitary Unilocular (Nonparasitic) Cyst
- Polycystic Disease
- Congenital Hepatic Fibrosis (Juvenile/Adult Type)
- Caroli Disease
- Autosomal Dominant Variant
- Cystic Fibrosis (Mucoviscoidosis)
- Alpha-1 Antitrypsin Deficiency
- Hereditary Hyperbilirubinemias
- Gilbert Syndrome
- Dubin-Johnson Syndrome
- Disorders of Amino Acid Metabolism
- Hereditary Tyrosinemia
- Storage Disorders
- Glycogen Storage Diseases
- Gaucher Disease
- Niemann-Pick Disease
- Myoclonus Epilepsy (Lafora Disease)
- Mitochondrial Fatty Acid Oxidation Disorders
- Medium-Chain Acyl CoA Dehydrogenase Deficiency (MCAD)
- Porphyrias
- Porphyria Cutanea Tarda
- Erythropoietic Protoporphyria
- Sickle Cell Anemia
- Other Developmental, Familial and Metabolic Disorders that may Cause Liver Damage
- Iron Storage Disorders
- Basic Iron Metabolism
- Conditions Associated with Increased Hepatic Iron
- Secondary Iron Overload
- Hereditary Hemochromatosis
- Hepatic Iron Quantitation (Hepatic Iron Index)
- Copper Storage Disorders
- Basic Copper Metabolism
- Conditions Associated with Elevated Copper Levels
- Wilson Disease
- Indian Childhood Cirrhosis
- Primary Neoplasms, Benign
- Epithelial Benign Tumors
- Bile Duct Adenoma (Peribiliary Gland Hamartoma)
- Hepatobiliary Cystadenoma
- Mesenchymal Benign Tumors
- Angiomyolipoma
- Mesenchymal Hamartoma
- Rare Benign Mesenchymal Tumors
- Miscellaneous Benign Tumors: Teratoma
- Primary Neoplasms, Malignant
- Basic Pathophysiologic Concepts
- Epithelial Malignant Tumors
- Cholangiocarcinoma
- Hepatoblastoma
- Mesenchymal Malignant Tumors
- Rare Mesenchymal Malignant Tumors
- Miscellaneous Malignant Tumors
- Squamous Cell Carcinoma
- Yolk Sac Tumor
- Hematopoietic Diseases
- Hodgkin’s Lymphoma
- Non-Hodgkin’s Lymphoma
- Leukemia, Myeloproliferative Disorders
- Langerhans Cell Histiocytosis
- Plasma Cell, Lymphoplasma Cell Dyscrasias
- Alpha-Heavy Chain Disease (Macroglobulinemia)
- Metastatic Neoplasms
- Tumor-Like Lesions: Focal Nodular Hyperplasia
- Regenerative Lesions
- Introduction
- Timeframe of Pathologic Changes
- Preservation (Harvesting, Reperfusion) Injury
- Acute Graft Failure (Primary Nonfunction)
- Rejection
- Hyperacute (Humoral) Rejection
- Acute (Cellular) Rejection
- Chronic (Ductopenic) Rejection
- Post-Transplant Complications
- Bile Duct Strictures
- Hepatic Artery Thrombosis
- Post-Transplant Opportunistic Infections
- Bacterial, Fungal Infections
- Cytomegalovirus
- Herpes Simplex Virus
- Post-Transplant Lymphoproliferative Disorder, PTLD (EBV- and Non–EBV-Related)
- Recurrent Diseases
- Viral Hepatitis (HBV and HCV)
- Primary Biliary Cirrhosis
- Primary Sclerosing Cholangitis
- Autoimmune Hepatitis
- Alcoholic Liver Disease
- De Novo Liver Disease
- Hepatic Changes After Bone Marrow Transplants: Graft Versus Host Disease
- Granulomatous Liver Disease
- Description and Causes
- Sarcoidosis
- Liver in Inflammatory Bowel Disease
- Nonspecific Reactive Changes (50% Frequency)
- Biliary Tract Disorders (5% Frequency)
- Chronic Hepatitis (1% to 2% Frequency)
- Cirrhosis (2% to 5% Frequency)
- Autoimmune Hepatitis
- Amyloidosis
- Conditions Seen in Pregnancy
- Acute Fatty Liver of Pregnancy
- Toxemia of Pregnancy
- Hyperalimentation (Total Parenteral Nutrition)
- Infection-Associated (Reactive) Hemophagocytic Syndrome
- Hyperpyrexia and Heat Stroke
- Reye Syndrome
- Other Miscellaneous Conditions Associated with Liver Diseases
Part II - Liver Biopsy Evaluation: Morphology with Differential Diagnoses
- Introduction
- Tables of Morphology
- Abscess Formation
- Bile Ducts: Inflammation by Neutrophils (Acute Cholangitis)
- Bile Ducts: Inflammation by Lymphocytes (Nonsuppurative Cholangitis)
- Bile Ducts: Reduplication/Ectasia, Biliary Concretions
- Bile Ducts: Periductal Fibrosis
- Bile Ducts: Cytologic Atypia, Duct Loss (Ductopenia)
- Calcification, Ossification
- Cholestasis, Simple
- Cystic Lesions
- Diagnostic Lesions
- Extracellular Deposits (Not Collagen)
- Fatty Change
- Granulomas
- Inclusions: Hepatocytes
- Inclusions: Kupffer Cells, Portal Macrophages
- Lobular Necrosis with Inflammation
- Lobular Confluent Necrosis with Inflammation
- Lobular Necrosis with Minimal to Absent Inflammation
- Mallory Bodies
- Space Occupying (Noncystic) Lesions, Benign
- Space Occupying (Noncystic) Lesions, Malignant
- Pigments
- Portal Lymphocytes
- Portal Neutrophils
- Portal Plasma Cells
- Portal Eosinophils
- Portal Fibrosis
- Sinusoids: Fibrosis
- Sinusoids: Dilatation, Congestion, Hemorrhage
- Sinusoids: Peliotic Lesions
- Sinusoids: Circulating Cells
- Sinusoids: Extramedullary Hematopoiesis
- Syncytial Giant Cells
- Vessels (Excluding Sinusoids): Inflammation
- Vessels (Excluding Sinusoids): Thrombosis, Occlusion
Appendix: Chronic Liver Diseases: Staging and Grading Systems
Product Details
- Hardcover: 528 pages
- Publisher: Saunders; 3 edition (2011)
- Language: English
- ISBN-10: 1437707653
- ISBN-13: 978-1437707656
- Product Dimensions: 11.1 x 8.8 x 1 inches
List Price: $274.00