Papadakos: Mechanical Ventilation: Clinical Applications and Pathophysiology

Mechanical ventilation has become the most commonly used mode of life support in medicine today. It is widely used in management of acutely ill surgical and ICU patients; it is also used in the chronic support of patients with a wide spectrum of chronic diseases that can cause respiratory failure. For many years the impact of this commonly preformed procedure was not fully understood, either in how it modulated lung function or how it affected other organ function. In recent years researchers have made great strides in understanding how respiratory failure and mechanical ventilation affect the complex interaction of gas exchange, cytokine release and cellular immunity.
The contributors span the globe and constitute a renowned group of experts who have contributed much to our basic knowledge and patient care. Through many years of researching, writing, lecturing and caring for patients they have created the framework for this book.
The primary aim of this text is to cover the breadth of the topic in a practical yet organized fashion. Its primary use will be as a practical everyday reference, but it will also be a useful foundation for further reading and research. It begin with chapters that review the myriad diseases and conditions that lead to respiratory failure, including common restrictive and obstructive diseases.
There are review current knowledge on acute lung injury and ventilator-induced lung injury. All important aspects of the anatomy and ventilation mechanics are reviewed to allow the reader to better understand their importance patient care. New aspects of acid–base balance are discussed to give us the ability to better recognize derangements of cellular function due to failure to deliver oxygen and remove waste products. Various interactions between the pulmonary system and other organ systems are presented in such a way to reinforce the elegant concept of cell–cell interaction.
The many modalities of monitoring and diagnosing respiratory failure are necessary to rapidly observe changes in disease states and provide benchmarks and endpoints in the care of those patients. The book reviews all modes of ventilatory support currently used in all age groups, but it also introduces computer-guided therapies and other cutting-edge technologies. Special care had been taken to review the many unique environments in which patients are supported, from prehospital sites to specialized units of the tertiary medical centers.
Information on adjunctive therapy, both pharmacologic and special device therapy, is integrated throughout to provide a complete information package that it intended to reduce complications and decrease time on ventilatory support. New aspects and guidelines for use of antibiotics are presented to educate clinicians on the latest in bacterial resistance that plagues the modern ICUs. The importance of sedation and neuromuscular blockade in titrating mechanical ventilation is emphasized to provide bedside clinicians with further cost- and time-effective tools to develop protocols and guidelines. Case reports and discussions are used to illustrate and reinforce the multiple topics covered. They will also serve as a basis for training in the care of common disease states.
Economic and ethical aspects of mechanical ventilation are important core topics. The high cost of ICU patient care greatly affects individual hospital budgets as well as broader health care budgets. The ability to provide cost effective care is key to both the developed and developing world as the information highway leads to rapid sharing of techniques and care plans. The care provided at the end of life has become a cornerstone of ethical care.
The editors hope that their twenty-year collaboration between Rotterdam and Rochester will serve to illustrate how investigators and clinicians look for common ground to increase their understanding of pulmonary pathophysiology and apply this knowledge at the bedside. Researchers and bedside clinicians should work together to provide patient care supported by strong scientific evidence. All levels of readers can learn from this group of authors and their impressive knowledge of the many diverse aspects of this ever-growing field.

Contents 

• Chapter 1 Restrictive Diseases
• Chapter 2 Chronic Obstructive Pulmonary Disease
• Chapter 3 Acute Lung Injury: Injury from Drugs
• Chapter 4 Acute Lung Injury: Acute Respiratory Distress Syndrome
• Chapter 5 Ventilator-Induced Lung Injury
• Chapter 6 Role of Changes in Body Temperature in Acute Lung Injury
• Chapter 7 Severe Acute Respiratory Syndrome (SARS)
• Chapter 8 Anatomy
• Chapter 9 Lung Mechanics in Health
• Chapter 10 Lung Mechanics in Disease
• Chapter 11 Muscle Function
• Chapter 12 Surfactant Therapy
• Chapter 13 Diffusion and Mechanical Ventilation
• Chapter 14 Acid-Base Balance and Kidney-Lung Interaction
• Chapter 15 Heart-Lung Interactions
• Chapter 16 Gastrointestinal-Lung Interactions
• Chapter 17 Kidney-Lung Interactions
• Chapter 18 Genetic Basis of Acute Lung Injury
• Chapter 19 Cytokine Release 
• Chapter 20 Lung Imaging in Acute Respiratory Distress Syndrome by Computed Tomography
• Chapter 21 Flexible Bronchoscopy in Mechanically Ventilated Patients
• Chapter 22 Basic Modes of Mechanical Ventilation
• Chapter 23 Inverse Ratio Ventilation
• Chapter 24 Airway Pressure Release Ventilation
• Chapter 25 Open Lung Management
• Chapter 26 Liquid Ventilation
• Chapter 27 Extracorporeal Life Support in Acute Respiratory Distress Syndrome
• Chapter 28 Prehospital Care
• Chapter 29 Mechanical Ventilation During General Anesthesia
• Chapter 30 Independent Lung Ventilation and Bronchopleural Fistula
• Chapter 31 Intrahospital Transport of the Ventilator-Supported Patient
• Chapter 32 Air Embolism and Diving Injury
• Chapter 33 Blunt Thoracic Trauma
• Chapter 34 Airway Management and Physiologic Control of Ventilation
• Chapter 35 Current Sedation Practices in the Intensive Care Unit
• Chapter 36 Use of Special Beds
• Chapter 37 Oxygen Therapy in Acutely Ill Patients
• Chapter 38 Respiratory Pharmacology and Aerosol Therapy
• Chapter 39 Antibiotic Use in the Mechanically Ventilated Patient
• Chapter 40 Blood Gas Analysis
• Chapter 41 Hemodynamic Monitoring
• Chapter 42 In-Line Blood Gas Monitoring
• Chapter 43 Cytokine Modulation Therapy in Acute Respiratory Failure and ARDS
• Chapter 44 Gene Transfer in the Lung
• Chapter 45 Weaning through Noninvasive Ventilation
• Chapter 46 Neonatal Mechanical Ventilation
• Chapter 47 Ventilator Management for Congenital Abnormalities
• Chapter 48 Extracorporeal Membrane Oxygenation (ECMO) in Pediatric and Neonatal Patients
• Chapter 49 Noninvasive Ventilation in Children
• Chapter 50 Ethical Issues in the Termination of Ventilator Treatment
• Chapter 51 Economics of Ventilator Care
• Chapter 52 Ventilator Care in the Developing World
• Chapter 53 Ventilator-Induced Lung Injury
• Chapter 54 Weaning
• Chapter 55 Mechanical Ventilation in Severe Chest Trauma
• Chapter 56 Pneumonia
• Chapter 57 Ventilator-Associated Pneumonia
• Index

Book Details

• Hardcover: 688 pages
• Publisher: Saunders; 1 edition (2008) 
• Language: English
• ISBN-10: 0721601863
• ISBN-13: 978-0721601861
• Product Dimensions: 11.1 x 8.4 x 1.2 inches

Price: $177.00