As in prior editions, the book is designed to provide a comprehensive, authoritative, and readable pharmacology textbook for students in the health sciences. Frequent revision is necessary to keep pace with the rapid changes in pharmacology and therapeutics; the 2–3 year revision cycle of the printed text is among the best in the field and the availability of an online version provides even greater currency. In addition to the full-color illustrations, other new features have been introduced. The Case Study at the beginning of chapters and the Drug Summary Table at the end of chapters will make the learning process even more interesting and efficient. The book also offers special features that make it a useful reference for house officers and practicing clinicians.
Within each chapter, emphasis is placed on discussion of drug groups and prototypes rather than offering repetitive detail about individual drugs. Selection of the subject matter and the order of its presentation are based on the accumulated experience of teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.
Major features that make this book particularly useful in integrated curricula include sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects—in other words, clinical pharmacology is an integral part of this text. Lists of the commercial preparations available, including trade and generic names and dosage formulations, are provided at the end of each chapter for easy reference by the house officer or practitioner writing a chart order or prescription.
Significant revisions in this edition include:
- A Case Study is used to open many chapters, providing an introduction to the clinical applications of the drugs discussed. Explicit answers are provided at the end of some chapters but discussion of the concepts involved will be found in the text of all chapters.
- A Drug Summary Table is placed at the conclusion of most chapters; these provide a concise recapitulation of the most important drugs
- Many new illustrations in full color provide significantly more information about drug mechanisms and effects and help to clarify important concepts
- Major revisions of the chapters on sympathomimetic, sympathoplegic, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, nitric oxide, hypothalamic and pituitary hormones, and immunopharmacology
- Continued expansion of the coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters
- Descriptions of important new drugs released through December 2008, including numerous new immunopharmacologic agents
This edition marks the 27th year of publication of Basic and Clinical Pharmacology. The widespread adoption of the first ten editions indicates that this book fills an important need. We believe that the eleventh edition will satisfy this need even more successfully. Spanish, Portuguese, Italian, French, Indonesian, Japanese, Korean, and Turkish translations are available. Translations into other languages are under way; the publisher may be contacted for further information.
I wish to acknowledge the prior and continuing efforts of my contributing authors and the major contributions of the staff at Lange Medical Publications, Appleton and Lange, and more recently at McGraw-Hill, and of our editors, Alison Kelley and Donna Frassetto. I also wish to thank my wife, Alice Camp, for her expert proofreading contributions since the first edition.
Special thanks and recognition are due James Ransom, PhD, the long-time Senior Editor at Lange Medical Publications, who provided major inspiration and invaluable guidance through the first eight editions of the book. Without him, this book would not exist.
Suggestions and comments about Basic and Clinical Pharmacology are always welcome. They may be sent to me at the Department of Cellular and Molecular Pharmacology, P.O. Box 0450, University of California, San Francisco, CA 94143-0450.
Bertram G. Katzung, MD, PhD
Contents
I. BASIC PRINCIPLES
1. Introduction
2. Drug Receptors and Pharmacodynamics
3. Pharmacokinetics and Pharmacodynamics: Rational Dosing and the Time Course of Drug Action
4. Drug Biotransformation
5. Development and Regulation of Drugs
II. AUTONOMIC DRUGS
6. Introduction to Autonomic Pharmacology
7. Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs
8. Cholinoceptor-Blocking Drugs
9. Adrenoceptor-Activating and Other Sympathomimetic Drugs
10. Adrenoceptor Antagonist Drugs
III. CARDIOVASCULAR-RENAL DRUGS
11. Antihypertensive Agents
12. Vasodilators and the Treatment of Angina Pectoris
13. Drugs Used in Heart Failure
14. Agents Used in Cardiac Arrhythmias
15. Diuretic Agents
IV. DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE
16. Histamine, Serotonin, and the Ergot Alkaloids
17. Vasoactive Peptides
18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Related Compounds
19. Nitric Oxide
20. Drugs Used in Asthma
V. DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM
21. Introduction to the Pharmacology of CNS Drugs
22. Sedative-Hypnotic Drugs
23. The Alcohols
24. Antiseizure Drugs
25. General Anesthetics
26. Local Anesthetics
27. Skeletal Muscle Relaxants
28. Pharmacologic Management of Parkinsonism and Other Movement Disorders
29. Antipsychotic Agents
30. Antidepressant Agents
31. Opioid Analgesics and Antagonists
32. Drugs of Abuse
VI. DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, and GOUT
33. Agents Used in Anemias; Hematopoietic Growth Factors
34. Drugs Used in Disorders of Coagulation
35. Agents Used in Hyperlipidemia
VII. ENDOCRINE DRUGS
37. Hypothalamic and Pituitary Hormones
38. Thyroid and Antithyroid Drugs
39. Adrenocorticosteroids and Adrenocortical Antagonists
40. The Gonadal Hormones and Inhibitors
41. Pancreatic Hormones and Antidiabetic Drugs
42. Agents That Affect Bone Mineral Homeostasis
VIII. CHEMOTHERAPEUTIC DRUGS
43. Beta-Lactam and Other Cell Wall- and Membrane-Active Antibiotics
44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, and Oxazolidinones
45. Aminoglycosides and Spectinomycin
46. Sulfonamides, Trimethoprim, and Quinolones
47. Antimycobacterial Drugs
48. Antifungal Agents
49. Antiviral Agents
50. Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, and Sterilants
51. Clinical Use of Antimicrobial Agents
52. Antiprotozoal Drugs
53. Clinical Pharmacology of the Antihelminthic Drugs
54. Cancer Chemotherapy
55. Immunopharmacology
IX. TOXICOLOGY
56. Introduction to Toxicology: Occupational and Environmental
57. Heavy Metal Intoxication and Chelators
58. Management of the Poisoned Patient
X. SPECIAL TOPICS
59. Special Aspects of Perinatal and Pediatric Pharmacology
60. Special Aspects of Geriatric Pharmacology
61. Dermatologic Pharmacology
62. Drugs Used in the Treatment of Gastrointestinal Diseases
63. Therapeutic and Toxic Potential of Over-the-Counter Agents
64. Botanicals (“Herbal Medications”) and Nutritional Supplements
65. Rational Prescribing and Prescription Writing
66. Important Drug Interactions and Their Mechanisms
Appendix: Vaccines, Immune Globulins, and Other Complex Biologic Products
Index
Product Details
- Paperback: 1232 pages
- Publisher: McGraw-Hill Medical; 11 edition (July 1, 2009)
- Language: English
- ISBN-10: 0071604057
- ISBN-13: 978-0071604055
- Product Dimensions: 10.8 x 8.5 x 1.4 inches