The authors and publisher are pleased to present the twenty-seventh edition of Harper’s Illustrated Biochemistry. First published as Review of Physiological Chemistry in 1939 and revised in 1944, it quickly gained a wide readership. In 1951, the third edition appeared with Harold A. Harper, University of California at San Francisco, as author. Dr. Harper remained the sole author until the ninth edition and co-authored eight subsequent editions. Peter Mayes and Victor Rodwell joined as authors in the tenth edition, Daryl Granner in the twentieth, and Rob Murray in the twenty-first edition. We now bid a fond and grateful farewell to our long-time colleague Peter Mayes, who retired from active authorship after the previous edition. Asked by Harold Harper to review portions of the ninth edition, Peter joined as an author for the tenth through twenty-sixth editions. Peter contributed a unique ability to design diagrams that integrate all key aspects of a metabolic pathway: the enzymes, intermediates, and the mechanisms that guide and regulate metabolic flow. Such skills, his concise and informative prose, and his collegial relationships with the other authors contributed significantly to the continued success of this text. He will be greatly missed by his fellow authors and by readers.
The Twenty-Eighth Edition has undergone sweeping changes - including a conversion to full-color artwork and every chapter being substantially revised and updated - all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.
Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference.
NEW to this edition:
- Every chapter now opens with a summary of Biomedical Importance and concludes with a summary reviewing the topics covered.
- Two all-new chapters: Free Radicals and Antioxidant Nutrients, and Biochemical Case Histories offer an extensive presentation of 16 pathophysical conditions.
- An Expanded Appendix containing a list of important biochemistry websites, data bases, and online journals.
- NEW or updated coverage of important topics such as: The influence of the Human Genome Project on the; biomedical fields; Computer-aided drug delivery; The attachment of influenza virus to human cells; Next Generation Gene Sequencing platforms; Methods of assaying enzymes; Advanced glycation end-products and their importance in diabetes mellitus; The major challenges facing medicine.
- Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters.
New Key Features in This Edition!
- Influence of the Human Genome Project on various biomedical fields.
- Revision of the use of enzymes in medical diagnosis.
- New material on computer-aided drug discovery.
- Compilation of some conformational diseases.
- New material on advanced glycation end-products and their importance in diabetes mellitus.
- New material on the attachment of influenza virus to human cells.
- Some major challenges facing medicine.
Important biochemical updates include:
- Expanded coverage of mass spectrometry, a key analytical method in contemporary biochemistry.
- New figures revealing various aspects of protein structure.
- Expanded coverage of active sites of enzymes and transition states.
- New information on methods of assaying enzymes.
- Expanded coverage of aspects of enzyme kinetics.
- New information on micro- and silencing RNAs.
- New information on eukaryotic transcription mechanisms, including the biogenesis of mRNA and the role of nucleosomes.
- Description of activities of miRNAs.
- New material on next generation sequencing (NGS) platforms.
- New material on chromatin immunoprecipitation (CHIP) technology and its uses.
- New information on subcellular localization of key signaling enzymes (kinases, phosphatases).
- New information on how hormones affect gene transcription.
Contents
1. Biochemistry and Medicine
2. Water & PH
3. Amino Acids and Peptides
4. Proteins: Determination of Primary Structure
5. Proteins: Higher Orders of Structure
6. Proteins: Myoglobin and Hemoglobin
7. Enzymes: Mechanisms of Action
8. Enzymes: Kinetics
9. Enzymes: Regulation of Activities
10. Bioenergetics: The Role of ATP
11. Biologic Oxidation
12. The Respiratory Chain & Oxidative Phosphorylation
13. Carbohydrates of Physiologic Significance
14. lipids of Physiologic Significance
15. Overview of Metabolism
16. The Citric acid Cycle: The Catabolism of Acetyl-CoA
17. Glycolysis and Oxidation of Pyruvate
18. Metabolism of Glycogen
19. Gluconeogenesis and Control of the Blood Glucose
20. The Pentose Phosphate Pathway & other Pathways of Hexose Metabolism
21. Biosynthesis of Fatty Acids
22. Oxidation of Fatty Acids: Ketogenesis
23. Metabolism of Unsaturated Fatty Acids & Eicosanoids
24. Metabolism of Acyglycerols and Sphingolipids
25. Lipid Transport And Storage
26. Cholesterol Synthesis, Transport and Excretion
27. Integration of Metabolism- the Provision of Metabolic Fuels
28. Biosynthesis of Nutritionally Nonessential Amino Acids
29. Catabolism of Proteins & of Amino Acid Nitrogen
30. Catabolism of the Carbon Skeletons of Amino Acids
31. Conversion of Amino Acids
32. Porphyrins & Bile Pigments
33. Nucleotides
34. Metabolism of Purine & Pyrimidine Nucleotides
35. Nucleic Acid Structure and Function
36. DNA Organization, Replication and Repair
37. RNA Synthesis, Processing and Modifications
38. Protein Synthesis and Genetic Code
39. Regulation of Gene Expression
40. Molecular Genetics, Recombinant DNE and Genomic Technology
41. Membranes: Structure and Function
42. The Diversity of Endocrine System
43. Hormone Action and Signal Transduction
44. Nutrition, Digestion and Absorption
45. Vitamins and Minerals
46. Intracellular Traffic and Sorting of Proteins
47. Glycoprotein
48. The Extracellular Matrix
49. Muscle and the Cytoskeleton
50. Plasma Proteins and Immunoglobulins
51. Homeostasis and Thrombosis
52. The Red and White Blood Cells
53. Metabolism of Xenobiotics
54. The Human Genome Project
Product Details
- Paperback: 704 pages
- Publisher: McGraw-Hill Medical; 28 edition (June 2, 2009)
- Language: English
- ISBN-10: 0071625917
- ISBN-13: 978-0071625913
- Product Dimensions: 10.9 x 8.5 x 1.1 inches
List Price: $60.95