Continuing Garrett and Grisham's innovative conceptual and organizing framework, "Essential Questions," BIOCHEMISTRY guides students through course concepts in a way that reveals the beauty and usefulness of biochemistry in the everyday world.The book's balanced presentation has been streamlined for increased clarity and readability--and to make it more interesting to visual learners, this edition also includes new photos and illustrations that show the subject matter consistently throughout the text. New end-of-chapter problems, MCAT practice questions, and the unparalleled text/media integration with the power of CengageNOW round out this exceptional package, giving students the tools they need to master course concepts and develop critical problem-solving skills they can draw upon long after the course ends.
The Audience
This biochemistry textbook is designed to communicate the fundamental principles governing the structure, function, and interactions of biological molecules to students encountering biochemistry for the first time. The aim to bring an appreciation of biochemistry to a broad audience that includes undergraduates majoring in the life sciences, physical sciences, or premedical programs, as well as medical students and graduate students in the various health sciences for whom biochemistry is an important route to understanding human physiology.
Features
- Each chapter in this book is framed around an Essential Question that engages students in the material and encourages curiosity about the subject matter.
- Human Biochemistry essays emphasize the central role of basic biochemistry in medicine and the health sciences with information on clinically important issues such as diet, diabetes, and cardiovascular health.
- Critical Developments in Biochemistry essays emphasize recent and historical advances in the field, while A Deeper Look essays expand on the text, highlighting selected topics or experimental observations.
- To promote more efficient study, each chapter includes in-text icons that direct students to interactive online tutorials and animations within CengageNOW, while end-of-chapter summaries review and briefly answer the key questions posed in each section.
- Active and Animated Figures are now available online through CengageNOW. Active Figures include corresponding test questions where students can quiz themselves on the concept conveyed in the figure, while Animated Figures allow students to watch the progress of an illustration.
New to this edition
- This edition's updated coverage includes new topics like protein folding and proteomics, as well as updates on the Human Genome Project, cellular signaling, and other important subjects.
- Streamlined for increased clarity and readability, this edition features shorter figure heads as well as the addition of more information directly within illustrations to aid visual readers.
- The richness of the Protein Data Bank (www.pdb.org) and availability of molecular graphics software has been exploited to enliven this edition with more than 330 images of prominent proteins and nucleic acids.
- Approximately 15% of the text's 600+ end-of-chapter problems are new to this edition. Each set of problems concludes with MCAT practice questions to aid students in their preparation for standardized examinations.
- Reference lists at the end of each chapter make it easy for students to find additional information about each topic.
About the Author
- Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.
- Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.
Contents
Part I: MOLECULAR COMPONENTS OF CELLS.
1. Chemistry is the Logic of Biological Phenomena.
2. Water – The Medium of Life.
3. Thermodynamics of Biological Systems.
4. Amino Acids.
5. Proteins: Their Primary Structure and Biological Functions.
6. Proteins: Secondary, Tertiary, and Quaternary Structure.
7. Carbohydrates and Glyco-Conjugates of the Cell Surface.
8. Lipids.
9. Membranes and Membrane Transport.
10. Nucleotides and Nucleic Acids.
11. Structure of Nucleic Acids.
12. Recombinant DNA: Cloning and Creation of Chimeric Genes.
Part II: PROTEIN DYNAMICS.
13. Enzyme Kinetics.
14. Mechanisms of Enzyme Action.
15. Enzyme Regulation.
16. Molecular Motors.
Part III: METABOLISM AND ITS REGULATION.
17. Nutrition and the Organization of Metabolism.
18. Glycolysis.
19. The Tricarboxylic Acid Cycle.
20. Electron Transport and Oxidative Phosphorylation.
21. Photosynthesis.
22. Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway.
23. Fatty Acid Catabolism.
24. Lipid Biosynthesis.
25. Nitrogen Acquisition and Amino Acid Metabolism.
26. The Synthesis and Degradation of Nucleotides.
27. Metabolic Integration and Organ Specialization.
Part IV: INFORMATION TRANSFER.
28. DNA Metabolism.
29.Transcription and the Regulation of Gene Expression.
30. Protein Synthesis.
31. Post-Translational Processing of Proteins and Protein Degradation.
32. The Reception and Transmission of Extracellular Information.
Product Details
- Hardcover: 1184 pages
- Publisher: Brooks Cole; 4 edition (2010)
- Language: English
- ISBN-10: 0495109355
- ISBN-13: 978-0495109358
- Product Dimensions: 11 x 9 x 1.7 inches
List Price: $277.95