In 1982 the first edition of Hepatology: A Textbook of Liver Disease was published. The book was based on pathophysiologic principles in the belief that these “principles form the basis for interpreting concepts about disease and for evaluating the validity of research.” The first 12 chapters focused on normal hepatic function. The next 10 chapters focused on alterations of normal function leading to clinical illnesses, such as hepatic encephalopathy, and the last 24 chapters focused on specific disease states. There were only two chapters on viral hepatitis: one on the biology of hepatitis viruses and the second on clinical features of viral hepatitis. A single chapter on liver transplantation was included in the first edition. Over the next almost 30 years, the book has changed dramatically, largely as a reflection of the tremendous progress that has been achieved in the field of hepatology. Because we now understand better the abnormal pathophysiology seen in the patient with liver disease, this new edition focuses more on the abnormal, rather than the normal, physiology. However, the current editors, Drs. Boyer, Manns, and Sanyal, believe that a basic understanding of both normal and abnormal physiology present in the patient with liver disease is critical to provide a high level of care for this difficult patient population, as well as to advance the field of hepatology. We hope that this sixth edition of Zakim and Boyer's Hepatology: A Textbook of Liver Disease will serve practicing hepatologists and gastroenterologists; general physicians, such as internists and general practitioners; and basic scientists who want to know more about the clinical spectrum, therapeutic approaches, and unmet needs of the diseases they investigate and treat.
Teresa Wright and Michael Manns were new editors for the fifth edition of Zakim and Boyer's Hepatology: A Textbook of Liver Disease. Dr. Wright moved into industry; therefore, Dr. Arun Sanyal joined Drs. Boyer and Manns as the third editor for the sixth edition. Each of the editors brings unique expertise to the book, and we believe this experience and knowledge is reflected in the sixth edition.
The sixth edition contains five new chapters. Three cover new topics on viral hepatitis. One discusses hepatitis B and C infection in the non-liver transplant population, and the second discusses HIV and HCV co-infection and drug toxicity. The third new viral hepatitis chapter covers pathogenesis of liver injury in HBV and HCV. The fourth new chapter on the pathogenesis of hepatocellular carcinoma and the fifth new chapter on imaging techniques for the diagnosis of liver disease complete the new additions. As in the past, we have changed the authors on approximately one third of the chapters to provide fresh perspectives on subjects that have appeared in previous editions.
To keep the book at a reasonable size and reduce cost, each chapter has only 100 of the most current references in the printed book. Additional cited references will be on the Elsevier Expert Consult website, which will keep the tradition of the book being well referenced without being too large. The style that was used for the previous edition, including placing the color photomicrographs and photos within each chapter, is used again in this edition. We believe the book is more readable using this format.
Hepatology, like medicine in general and infectious diseases in particular, does not respect any borders. Liver diseases are a significant global health burden. Over the past 40 to 50 years, the discipline of hepatology has provided examples of discoveries in basic science that are immediately transformed into novel diagnostic procedures, molecular-based therapies, anti-toxins, and vaccines. The discovery of the five major hepatotropic viruses is an example of success for translational medicine. Effective treatment for acetaminophen overdose has been developed from basic studies of drug metabolism and toxicity. Liver transplantation has evolved into a routine, life-saving procedure. We have seen the global success of hepatitis A and B vaccination programs, and we are now following the clinical development of new generations of direct-acting anti- HCV drugs that hopefully will provide more effective and less toxic anti-HCV therapies. Finally, hepatocellular carcinoma, which is one of the top killers globally and one of the most important complications of end-stage liver disease, has become an area for innovative molecularly targeted anti-cancer therapies. We will be very pleased if this sixth edition is regarded as an international textbook for a global readership helping to combat a global health burden.
Key Features
- Effectively treat all liver diseases currently seen in clinical practice with authoritative guidance from leading international authorities.
- Reinforce your foundation in basic science with the concise Pathophysiology of Therapeutic Targets section.
- See clear presentations of liver disease through hundreds of detailed, color illustrations.
- Explore topics further with up-to-date references that direct you to the significant literature.
- Access the complete, fully searchable contents of the book online at www.expertconsult.com, along with a downloadable image bank and complete list of references.
- Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout.
- Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology.
- Reference key information more easily thanks to streamlined content that now fits into one volume.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
Contents
Section I - Pathophysiology of the Liver
- Chapter 1 - Anatomy of the Liver
- Chapter 2 - Liver Regeneration
- Chapter 3 - Mechanisms of Liver Cell Destruction
- Chapter 4 - Mechanisms of Bile Secretion
- Chapter 5 - Hepatic Fibrosis and Cirrhosis
- Chapter 6 - Replication of Hepatitis B Virus
- Chapter 7 - Replication of Hepatitis C Virus
- Chapter 8 - Immune Pathogenesis of Viral Hepatitis B and C
- Chapter 9 - Liver and Immune System
- Chapter 10 - Epidemiology and Molecular Mechanisms of Hepatocarcinogenesis
- Chapter 11 - Stem Cells and Hepatocyte Transplantation
Section II - Approach to the Patient with Liver Disease
- Chapter 12 - Liver Biopsy (Quality and Use of Gun)
- Chapter 13 - Liver Biopsy Interpretation
- Chapter 14 - Laboratory Testing for Liver Disease
- Chapter 15 - Imaging and Noninvasive Diagnosis of Liver Disease: Computerized Tomography, Ultrasound, Magnetic Resonance Imaging, and Emerging Techniques
- Chapter 16 - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Section III - Clinical Consequence of Liver Disease
- Chapter 17 - Hepatic Encephalopathy
- Chapter 18 - Ascites
- Chapter 19 - Portal Hypertension and Bleeding Esophageal Varices
- Chapter 20 - Acute Liver Failure
- Chapter 21 - Renal Failure in Cirrhosis, Hepatorenal Syndrome, and Hyponatremia
- Chapter 22 - Cardiovascular Complications of Cirrhosis
- Chapter 23 - Pulmonary Complications in Patients with Liver Disease
- Chapter 24 - Hematopoietic Abnormalities and Hemostasis
Section IV - Toxin-Mediated Liver Injury
- Chapter 25 - Drug-Induced Liver Injury
- Chapter 26 - Hepatotoxicity of Herbal Preparations
- Chapter 27 - Occupational and Environmental Hepatotoxicity
- Chapter 28 - Alcoholic Liver Disease
Section V - Liver Diseases Due to Infectious Agents
- Chapter 29 - Hepatitis A
- Chapter 30 - Hepatitis B
- Chapter 31 - Hepatitis C
- Chapter 32 - Hepatitis D
- Chapter 33 - Hepatitis E
- Chapter 34 - Liver Disease Associated with Viral Infections
- Chapter 35 - Parasitic Liver Disease
- Chapter 36 - Bacterial and Miscellaneous Infections of the Liver
- Chapter 37 - Granulomatous Diseases of the Liver
- Chapter 38 - HIV Co-Infection Drug Toxicity
- Chapter 39 - Hepatitis B and C in Non–Liver Transplant Patients
Section VI - Immune Diseases of the Liver
- Chapter 40 - Autoimmune Hepatitis
- Chapter 41 - Primary Biliary Cirrhosis
- Chapter 42 - Primary Sclerosing Cholangitis
- Chapter 43 - Overlap Syndromes
Section VII - Vascular Diseases of the Liver
- Chapter 44 - Budd-Chiari Syndrome and Sinusoidal Obstruction Syndrome (Hepatic Venoocclusive Disease)
- Chapter 45 - Portal and Splenic Vein Thrombosis
- Chapter 46 - Liver Involvement in Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia)
Section VIII - Liver Transplantation
- Chapter 47 - Pretransplant Evaluation and Care
- Chapter 48 - Transplantation of the Liver
- Chapter 49 - Post–Liver Transplantation Management
- Chapter 50 - Recurrent Viral Diseases after Liver Transplantation
- Chapter 51 - Treatment of Recurrent Nonviral Disease
Section IX - Liver Affected by Other Organs or Conditions (Diseases)
- Chapter 52 - The Liver in Pregnancy
- Chapter 53 - Nonalcoholic Fatty Liver Disease
- Chapter 54 - The Liver in Systemic Illness
- Chapter 55 - The Liver and Parenteral Nutrition
- Chapter 56 - Preoperative and Postoperative Hepatic Dysfunctions
Section X - Tumors of the Liver and Gallstones
- Chapter 57 - Hepatocellular Carcinoma
- Chapter 58 - Cholangiocarcinoma
- Chapter 59 - Benign Liver Tumors
- Chapter 60 - Surgery for Liver Tumors
- Chapter 61 - Management of Gallstones
Section XI - Inherited and Pediatric Liver Diseases
- Chapter 62 - Bilirubin Metabolism and Its Disorders
- Chapter 63 - Wilson Disease
- Chapter 64 - Hemochromatosis
- Chapter 65 - α1-Antitrypsin Deficiency
- Chapter 66 - Inborn Errors of Metabolism that Lead to Permanent Liver Injury
- Chapter 67 - Fibrocystic Diseases of the Liver
- Chapter 68 - Pediatric Cholestatic Syndromes
- Chapter 69 - Viral Hepatitis in Children
About the Authors
- Thomas D. Boyer, MD, Chairman of Medicine, Robert and Irene Flinn Professor of Medicine; Director, Liver Research Institute, University of Arizona College of Medicine, Tucson, Arizona.
- Michael P. Manns, MD, Professor and Chairman, Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.
- Arun J. Sanyal, MBBS, MD, Charles Caravati Professor of Medicine, Chairman, Division of Gastroenterology, Hepatology, and Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Product Details
- Hardcover: 1408 pages
- Publisher: Saunders; 6 edition (October 7, 2011)
- Language: English
- ISBN-10: 1437708811
- ISBN-13: 978-1437708813
List Price: $349.00