As illustrated by the chapters in this book, autoimmune disorders are diverse and the same. At the heart of these diseases are specific alleles of genes of the major histocompatibility complex favoring the targeting of specific antigens, with diseases differing in the specific alleles favoring or preventing autoimmunity. The fine balance between self tolerance and autoimmunity is upset by major mutations in a few families, and multiple polymorphisms in most families. Large scale genetic (research involving the screening of hundreds of thousands of newborns) and then immunologic prediction of many autoimmune disorders is now a reality for both families and the general population. With the exception of celiac disease, environmental factors essential for disease and contributing to the marked increase in many of these disorders are undefined. Despite our lack of comprehensive knowledge, multiple immunotherapeutic clinical trials are underway.
It is my hope that our current knowledge base for Immunoendocrinology presented here will prove sufficient to design and test preventive paradigms. Nevertheless, it is my belief that our current basic research knowledge, also presented here, is insufficient to be assured of disease prevention with current trials. Contained within each of the chapters are incomplete drafts of maps that should eventually lead to disease prevention for specific disorders that in combination provide a comprehensive draft of our knowledge and ignorance of the continent of autoimmunity.
- The Editor -
Contents
Part I Immunoendocrinology: Scientific and Clinical Aspects
- 1 Primer on Immunoendocrinology
- 2 Discovering Novel Antigens
- 3 Developing and Validating High Sensitivity / Specificity Autoantibody Assays
- 4 Characterizing T-Cell Autoimmunity
- 5 Metabolic Syndrome and Inflammation
Part II Syndromes
- 6 The Mouse Model of Autoimmune Polyglandular Syndrome Type 1
- 7 Autoimmune Polyendocrine Syndrome Type I: Man
- 8 IPEX Syndrome: Clinical Profile, Biological Features, and Current Treatment
- 9 Autoimmune Polyendocrine Syndrome Type 2: Pathophysiology, Natural History, and Clinical Manifestations
- 10 Drug-Induced Endocrine Autoimmunity
- Part III Specific Dis eases
- 11 The BB Rat
- 12 Immunopathogenesis of the NOD Mouse
- 13 Virus-Induced Type 1 Diabetes in the Rat
- 14 Autoimmune Pathology of Type 1 Diabetes
- 15 Genetics of Type 1 Diabetes
- 16 Epidemiology of Type 1 Diabetes
- 17 Natural History of Type 1 Diabetes
- 18 Immunotherapy of Type-1 Diabetes: Immunoprevention and Immunoreversal
- 19 Latent Autoimmune Diabetes in Adults
- 20 Fulminant Type 1 Diabetes Mellitus
- 21 Insulin Autoimmune Syndrome (Hirata Disease)
- 22 Lessons from Patients with Anti-Insulin Receptor Autoantibodies
- 23 Islet and Pancreas Transplantation
- 24 Addison’s Disease
- 25 Animal Models of Autoimmune Thyroid Disease
- 26 Genetics of Thyroid Autoimmunity
- 27 Immunopathogenesis of Thyroiditis
- 28 Immunopathogenesis of Graves’ Disease
- 29 Graves’ Ophthalmopathy
- 30 Hypoparathyroidism
- 31 Premature Gonadal Insufficiency
- 32 Celiac Disease and Intestinal Endocrine Autoimmunity
- 33 Pituitary Autoimmunity
Index
About the Editor
- George S. Eisenbarth, University of Colorado Health Sciences Center, Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
Product Details
- Hardcover: 579 pages
- Publisher: Humana Press; 1st Edition (2011)
- Language: English
- ISBN-10: 1603274774
- ISBN-13: 978-1603274777
- Product Dimensions: 10.1 x 7.1 x 1.6 inches
List Price: $189.00