Goodman and Gilman's The Pharmacological Basis of Therapeutics 12th Edition with DVD

The publication of the twelfth edition of this book is a testament to the vision and ideals of the original authors, Alfred Gilman and Louis Goodman, who, in 1941 set forth the principles that have guided the book through eleven editions: to correlate pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the applications of pharmacodynamics to therapeutics, and to create a book that will be useful to students of pharmacology and to physicians. These precepts continue to guide the current edition.

As with editions since the second, expert scholars have contributed individual chapters. A multiauthored book of this sort grows by accretion, posing challenges to editors but also offering memorable pearls to the reader. Thus, portions of prior editions persist in the current edition, and I hasten to acknowledge the contributions of previous editors and authors, many of whom will see text that looks familiar. However, this edition differs noticeably from its immediate predecessors. Fifty new scientists, including a number from outside the U.S., have joined as contributors, and all chapters have been extensively updated. The focus on basic principles continues, with new chapters on drug invention, molecular mechanisms of drug action, drug toxicity and poisoning, principles of antimicrobial therapy, and pharmacotherapy of obstetrical and gynecological disorders. Figures are in full color. The editors have continued to standardize the organization of chapters; thus, students should easily find the basic physiology, biochemistry, and pharmacology set forth in regular type; bullet points highlight important lists within the text; the clinician and expert will find details in extract type under clear headings.

Online features now supplement the printed edition. The entire text, updates, reviews of newly approved drugs, animations of drug action, and hyperlinks to relevant text in the prior edition are available on the Goodman & Gilman section of McGraw-Hill's websites, AccessMedicine.com and AccessPharmacy.com. An Image Bank CD accompanies the book and makes all tables and figures available for use in presentations.

The process of editing brings into view many remarkable facts, theories, and realizations. Three stand out: the invention of new classes of drugs has slowed to a trickle; therapeutics has barely begun to capitalize on the information from the human genome project; and, the development of resistance to antimicrobial agents, mainly through their overuse in medicine and agriculture, threatens to return us to the pre-antibiotic era. We have the capacity and ingenuity to correct these shortcomings.

Contents

Section I. General Principles

• Chapter 1 Drug Invention and the Pharmaceutical Industry
• Chapter 2 Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination
• Chapter 3 Pharmacodynamics: Molecular Mechanisms of Drug Action
• Chapter 4 Drug Toxicity and Poisoning
• Chapter 5 Membrane Transporters and Drug Response
• Chapter 6 Drug Metabolism
• Chapter 7 Pharmacogenetics

Section II. Neuropharmacology

• Chapter 8 Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
• Chapter 9 Muscarinic Receptor Agonists and Antagonists
• Chapter 10 Anticholinesterase Agents
• Chapter 11 Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
• Chapter 12 Adrenergic Agonists and Antagonists
• Chapter 13 5-Hydroxytryptamine (Serotonin) and Dopamine
• Chapter 14 Neurotransmission and the Central Nervous System
• Chapter 15 Drug Therapy of Depression and Anxiety Disorders
• Chapter 16 Pharmacotherapy of Psychosis and Mania
• Chapter 17 Hypnotics and Sedatives
• Chapter 18 Opioids, Analgesia, and Pain Management
• Chapter 19 General Anesthetics and Therapeutic Gases
• Chapter 20 Local Anesthetics
• Chapter 21 Pharmacotherapy of the Epilepsies
• Chapter 22 Treatment of Central Nervous System Degenerative Disorders
• Chapter 23 Ethanol and Methanol
• Chapter 24 Drug Addiction

Section III. Modulation of Cardiovascular Function

• Chapter 25 Regulation of Renal Function and Vascular Volume
• Chapter 26 Renin and Angiotensin
• Chapter 27 Treatment of Myocardial Ischemia and Hypertension
• Chapter 28 Pharmacotherapy of Congestive Heart Failure
• Chapter 29 Anti-Arrhythmic Drugs
• Chapter 30 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
• Chapter 31 Drug Therapy for Hypercholesterolemia and Dyslipidemia

Section IV. Inflammation, Immunomodulation, and Hematopoiesis

• Chapter 32 Histamine, Bradykinin, and Their Antagonists
• Chapter 33 Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
• Chapter 34 Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout
• Chapter 35 Immunosuppressants, Tolerogens, and Immunostimulants
• Chapter 36 Pulmonary Pharmacology
• Chapter 37 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins

Section V. Hormones and Hormone Antagonists

• Chapter 38 Introduction To Endocrinology: The Hypothalamic-Pituitary Axis
• Chapter 39 Thyroid and Anti-Thyroid Drugs
• Chapter 40 Estrogens and Progestins
• Chapter 41 Androgens
• Chapter 42 ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex
• Chapter 43 Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia
• Chapter 44 Agents Affecting Mineral Ion Homeostasis and Bone Turnover

Section VI. Drugs Affecting Gastrointestinal Function

• Chapter 45 Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
• Chapter 46 Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease
• Chapter 47 Pharmacotherapy of Inflammatory Bowel Disease

Section VII. Chemotherapy of Microbial Diseases

• Chapter 48 General Principles of Antimicrobial Therapy
• Chapter 49 Chemotherapy of Malaria
• Chapter 50 Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections
• Chapter 51 Chemotherapy of Helminth Infections
• Chapter 52 Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for UrinaryTract Infections
• Chapter 53 Penicillins, Cephalosporins, and Other β-Lactam Antibiotics
• Chapter 54 Aminoglycosides
• Chapter 55 Protein Synthesis Inhibitorsand Miscellaneous Antibacterial Agents
• Chapter 56 Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy
• Chapter 57 Antifungal Agents
• Chapter 58 Antiviral Agents (Nonretroviral)
• Chapter 59 Antiretroviral Agents and Treatment of HIV Infection

Section VIII. Chemotherapy of Neoplastic Diseases

• Chapter 60 General Principles of Cancer Chemotherapy
• Chapter 61 Cytotoxic Agents
• Chapter 62 Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines
• Chapter 63 Natural Products in Cancer Chemotherapy: Hormones and Related Agents

Section IX. Special Systems Pharmacology

• Chapter 64 Ocular Pharmacology
• Chapter 65 Dermatological Pharmacology
• Chapter 66 Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders
• Chapter 67 Environmental Toxicology: Carcinogens and Heavy Metals

Section X. Appendices

• Appendix I Principles of Prescription Order Writing and Patient Compliance
• Appendix II Design and Optimization of Dosage Regimens: Pharmacokinetic Data

About the Editors

• Laurence L. Brunton, PhD, Professor of Pharmacology and Medicine, University of California San Diego, School of Medicine, La Jolla, CA.
• Bruce A. Chabner, MD, Clinical Director, MDF Cancer Center; Professor of Medicine, Harvard Medical School, Boston, MA.
• b, MD, PhD, Associate Professor of Medicine and Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Nashville, TN.

Product Details

• Hardcover: 1808 pages
• Publisher: McGraw-Hill Professional; 12 edition (2011)
• Language: English
• ISBN-10: 0071624422
• ISBN-13: 978-0071624428
• Product Dimensions: 10.1 x 8.3 x 2.7 inches

List Price: $179.00