deGroot and Jameson Endocrinology: Adult and Pediatric 6th edition 2 Volume Set (Expert Consult Series)

Endocrinology is now in its fortieth year and Sixth Edition, and it continues to evolve. After all, evolution to fit a changing environment is a law of nature that applies equally well to medical publishing as it does to the biological systems we seek to understand. Indeed, the rapid changes in information dissemination are necessary to keep pace with progress in science and medicine. In this Sixth Edition, we have retained the founding goals of this text while responding to the innovative means by which students, practicing clinicians, and researchers now acquire information.

As in the five prior editions, we provide a comprehensive, contemporary textbook that spans basic and clinical aspects of endocrinology. In addition to the traditional gland-based structure, readers will recognize a focus on the clinical presentations of disease, and an emphasis on multi-hormonal integration of endocrine function, perhaps a prime example of “systems biology.” Another change in this edition is more complete coverage of pediatric endocrinology because the division of pediatric and adult endocrinology is largely arbitrary and many physicians care for patients from all age groups.

A striking feature of our field is the explosion of knowledge ranging from the discovery of new hormones and drugs to the impact of genomics, proteomics, and metabolomics on how we classify diseases and conceptualize signaling pathways. These advances are all the more reason to seek information sources that synthesize and prioritize subject matter. We are proud to work with the most accomplished international authorities in the preparation of this text. Armed with electronic means to write, revise, edit, and update topics, this group of authors has succeeded in keeping pace with the latest advances in their specialty areas.

We also aspire to make the text interesting to read, relevant, and accessible in clinical practice settings. We have streamlined the book noticeably, so that it now fits within two sets of covers of reasonable weight. There is a hard-cover version for those who feel most comfortable with the book in hand, perhaps idyllically relaxing in a comfortable chair, and an online version for more “contemporary” readers who prefer the immediacy of online access to www.expertconsult.com between patient visits. The online version also provides direct links to original reference sources and monthly sectional updates so that important new ideas can be presented during the lifetime of this edition to keep it current.

In closing, the editors express their gratitude to the several hundred authors who have balanced their many other obligations to prepare truly masterful presentations for this Sixth Edition.

J. Larry Jameson, Leslie J. De Groot

Key Feature

• Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field.
• Access the full text online at expertconsult.com, fully searchable, with regular updates, case studies, links to PubMed abstracts, and more.
• Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors . brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis . expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration . and the newest discoveries in genetics and how they affect patient care.
• Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion.
• Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations.
• Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography.
• Locate information more quickly, while still getting the complete coverage you expect, with two streamlined, manageable volumes.

Website Features

• Consult the book from any computer at home, in your office, or at any practice location.
• Instantly locate the answers to your clinical questions via a simple search query.
• Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
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• Drugs: Quickly find reliable information on drug dosages and indications, listed both by brand and generic names.

Contents

VOLUME 1

PART I - Principles of Endocrinology and Hormone Signaling

• Chapter 1 - Endocrinology: Impact on Science and Medicine
• Chapter 2 - Control of Hormone Gene Expression
• Chapter 3 - Control of Hormone Secretion
• Chapter 4 - Insulin and Growth Factor Signaling Pathways
• Chapter 5 - Hormone Signaling Via G Protein–Coupled Receptors
• Chapter 6 - Nuclear Receptors: Structure, Function, and Coregulators
• Chapter 7 - Applications of Genetics in Endocrinology

PART II - Neuroendocrinology and Pituitary Disease

• Chapter 8 - Development of the Pituitary
• Chapter 9 - Prolactin
• Chapter 10 - Adrenocorticotropic Hormone
• Chapter 11 - Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
• Chapter 12 - Hypothalamic Syndromes
• Chapter 13 - Hypopituitarism and Growth Hormone Deficiency
• Chapter 14 - Acromegaly
• Chapter 15 - Cushing's Syndrome
• Chapter 16 - Clinically Nonfunctioning Sellar Masses
• Chapter 17 - TSH-Producing Adenomas
• Chapter 18 - Disorders of Prolactin Secretion and Prolactinomas
• Chapter 19 - Pituitary Surgery
• Chapter 20 - Evaluation and Management of Childhood Hypothalamic and Pituitary Tumors
• Chapter 21 - Vasopressin, Diabetes Insipidus, and the Syndrome of Inappropriate Antidiuretic Hormone Secretion
• Chapter 22 - The Pineal Gland and Melatonin

PART III - Growth and Maturation

• Chapter 23 - Regulation of Growth Hormone and Action (Secretagogues)
• Chapter 24 - Insulin-Like Growth Factor-1 and Its Binding Proteins
• Chapter 25 - Somatic Growth and Maturation
• Chapter 26 - Growth Hormone Deficiency in Children

PART IV - Obesity, Anorexia, and Nutrition

• Chapter 27 - Appetite Regulation and Thermogenesis
• Chapter 28 - Obesity: The Problem and Its Management
• Chapter 29 - Genetic Syndromes Associated with Obesity
• Chapter 30 - Anorexia Nervosa, Bulimia Nervosa, and Other Eating Disorders

PART V - Diabetes Mellitus

• Chapter 31 - Development of the Endocrine Pancreas
• Chapter 32 - Biosynthesis, Processing, and Secretion of the Islet Hormones: Insulin, Islet Amyloid Polypeptide (Amylin), Glucagon, Somatostatin, and Pancreatic Polypeptide
• Chapter 33 - Insulin Secretion
• Chapter 34 - The Mechanisms of Insulin Action
• Chapter 35 - Glucagon and the Glucagon-Like Peptides
• Chapter 36 - Regulation of Intermediatory Metabolism During Fasting and Feeding
• Chapter 37 - Role of the Adipocyte in Metabolism and Endocrine Function
• Chapter 38 - Lipodystrophy Syndromes
• Chapter 39 - Classification and Diagnosis of Diabetes Mellitus
• Chapter 40 - Type 1 (Insulin-Dependent) Diabetes Mellitus: Etiology, Pathogenesis, Prediction, and Prevention
• Chapter 41 - Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History
• Chapter 42 - Lipoprotein Metabolism and the Treatment of Lipid Disorders
• Chapter 43 - Hyperglycemia Secondary to Nondiabetic Conditions and Therapies
• Chapter 44 - The Metabolic Syndrome
• Chapter 45 - Treatment of Type 1 Diabetes Mellitus in Adults
• Chapter 46 - Ketoacidosis and Hyperosmolar Coma
• Chapter 47 - Hypoglycemia and Hypoglycemic Syndromes
• Chapter 48 - Management of Type 2 Diabetes Mellitus
• Chapter 49 - Management of Diabetes Mellitus in Children
• Chapter 50 - Pancreatic and Islet Transplantation
• Chapter 51 - Diabetes Control, Long-Term Complications, and Large Vessel Disease
• Chapter 52 - Diabetic Eye Disease
• Chapter 53 - Diabetes Mellitus: Neuropathy
• Chapter 54 - Diabetic Nephropathy
• Chapter 55 - Diabetic Foot and Vascular Complications

PART VI - Parathyroid Gland, Calciotropic Hormones, and Bone Metabolism

• Chapter 56 - Parathyroid Hormone and Parathyroid Hormone–Related Peptide in the Regulation of Calcium Homeostasis and Bone Development
• Chapter 57 - Calcitonin
• Chapter 58 - Vitamin D: From Photosynthesis, Metabolism, and Action to Clinical Applications
• Chapter 59 - Bone Development and Remodeling
• Chapter 60 - Calcium Regulation, Calcium Homeostasis, and Genetic Disorders of Calcium Metabolism
• Chapter 61 - Genetic Disorders of Phosphate Homeostasis
• Chapter 62 - Primary Hyperparathyroidism
• Chapter 63 - Malignancy-Associated Hypercalcemia and Medical Management
• Chapter 64 - Surgical Management of Hyperparathyroidism
• Chapter 65 - Pseudohypoparathyroidism, Albright's Hereditary Osteodystrophy, and Progressive Osseous Heteroplasia: Disorders Caused by Inactivating GNAS Mutations
• Chapter 66 - Genetic Defects in Vitamin D Metabolism and Action
• Chapter 67 - Hereditary Disorders of the Skeleton
• Chapter 68 - Bone Density and Imaging of Osteoporosis
• Chapter 69 - Chronic Kidney Disease Mineral and Bone Disorder
• Chapter 70 - Disorders of Calcification: Osteomalacia and Rickets
• Chapter 71 - Paget's Disease of Bone

VOLUME 2

PART VII - Thyroid

• Chapter 72 - Anatomy and Development of the Thyroid
• Chapter 73 - Thyroid-Stimulating Hormone: Physiology and Secretion
• Chapter 74 - Thyroid Regulatory Factors
• Chapter 75 - Thyroid Hormone Metabolism
• Chapter 76 - Mechanisms of Thyroid Hormone Action
• Chapter 77 - Thyroid Function Testing
• Chapter 78 - Thyroid Imaging
• Chapter 79 - Autoimmune Thyroid Disease
• Chapter 80 - Graves’ Disease
• Chapter 81 - Graves’ Ophthalmopathy
• Chapter 82 - Autonomously Functioning Thyroid Nodules and Other Causes of Thyrotoxicosis
• Chapter 83 - Chronic (Hashimoto's) Thyroiditis
• Chapter 84 - Subacute and Riedel's Thyroiditis
• Chapter 85 - Hypothyroidism and Myxedema Coma
• Chapter 86 - Nonthyroidal Illness Syndrome: A Form of Hypothyroidism
• Chapter 87 - Multinodular Goiter
• Chapter 88 - Iodine Deficiency Disorders
• Chapter 89 - Thyroid Neoplasia
• Chapter 90 - Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2
• Chapter 91 - Thyroid-Stimulating Hormone Receptor Mutations
• Chapter 92 - Genetic Defects in Thyroid Hormone Synthesis and Action
• Chapter 93 - Thyroid Hormone Binding and Variants of Transport Proteins
• Chapter 94 - Resistance to Thyroid Hormone
• Chapter 95 - Surgery of the Thyroid

PART VIII - Adrenal Gland and Adrenal Hormones

• Chapter 96 - The Principles, Enzymes, and Pathways of Human Steroidogenesis
• Chapter 97 - Glucocorticoid Action: Physiology
• Chapter 98 - Glucocorticoid Receptors: Their Mechanisms of Action and Glucocorticoid Resistance
• Chapter 99 - Aldosterone: Secretion and Action
• Chapter 100 - Glucocorticoid Therapy
• Chapter 101 - Adrenal Insufficiency
• Chapter 102 - Adrenal Causes of Hypercortisolism
• Chapter 103 - Defects of Adrenal Steroidogenesis
• Chapter 104 - Adrenarche and Adrenopause
• Chapter 105 - Adrenal Gland Imaging
• Chapter 106 - Adrenocortical Carcinoma
• Chapter 107 - Primary Mineralocorticoid Excess Syndromes and Hypertension
• Chapter 108 - Mineralocorticoid Deficiency
• Chapter 109 - Pheochromocytoma
• Chapter 110 - Adrenal Surgery

PART IX - Cardiovascular Endocrinology

• Chapter 111 - Hormones of the Cardiovascular System
• Chapter 112 - Hyponatremia and Hypernatremia
• Chapter 113 - Orthostatic Hypotension and Orthostatic Intolerance

PART X - Endocrine Changes in Critically III Patients

• Chapter 114 - Endocrine Aspects of Critical Care Medicine

PART XI - Reproductive Endocrinology and Sexual Function

• Chapter 115 - Gonadotropin-Releasing Hormones
• Chapter 116 - Gonadal Peptides: Inhibins, Activins, Follistatin, Mollerian-Inhibiting Substance (Antimollerian Hormone)
• Chapter 117 - Gonadotropins—Regulation of Synthesis and Secretion
• Chapter 118 - Genetic Basis of Gonadal and Genital Development
• Chapter 119 - Diagnosis and Treatment of Disorders of Sexual Development
• Chapter 120 - Endocrinology of Sexual Maturation and Puberty
• Chapter 121 - Precocious Puberty
• Chapter 122 - Delayed Puberty
• Chapter 123 - Hormonal Control of Breast Development
• Chapter 124 - The Endocrinology of Sexual Behavior and Gender Identity

PART XII - Female Reproduction

• Chapter 125 - Folliculogenesis, Ovulation, and Luteogenesis
• Chapter 126 - Ovarian Hormone Synthesis
• Chapter 127 - Estrogen and Progesterone Action
• Chapter 128 - Hormonal Regulation of the Menstrual Cycle, Mechanisms of Ovulation, Premenstrual Syndromes
• Chapter 129 - Amenorrhea, Anovulation, and Dysfunctional Uterine Bleeding
• Chapter 130 - Endometriosis
• Chapter 131 - Female Subfertility: Evaluation and Management
• Chapter 132 - Hyperandrogenism, Hirsutism, and Polycystic Ovary Syndrome
• Chapter 133 - Ovulation Induction and Assisted Reproduction
• Chapter 134 - Contraception
• Chapter 135 - Menopause

PART XIII - Male Reproduction

• Chapter 136 - Functional Morphology of the Testis
• Chapter 137 - Androgen Physiology, Pharmacology, and Abuse
• Chapter 138 - Testicular Dysgenesis Syndrome, Cryptorchidism, Hypospadias, and Testicular Tumors
• Chapter 139 - Androgen Deficiency Disorders
• Chapter 140 - Gynecomastia
• Chapter 141 - Clinical Management of Male Infertility
• Chapter 142 - Male Contraception
• Chapter 143 - Endocrinology of the Prostate

PART XIV - Endocrinology of Pregnancy

• Chapter 144 - The Endocrinology of Human Pregnancy and Parturition
• Chapter 145 - Fetal and Neonatal Endocrinology
• Chapter 146 - Diabetes Mellitus and Pregnancy
• Chapter 147 - Diagnosis and Treatment of Thyroid Disease During Pregnancy
• Chapter 148 - Hormonal Changes and Endocrine Testing in Pregnancy

PART XV - Polyglandular Syndromes

• Chapter 149 - Autoimmune Polyglandular Syndromes
• Chapter 150 - Multiple Endocrine Neoplasia Type 1
• Chapter 151 - Multiple Endocrine Neoplasia Type 2
• Chapter 152 - Gastrointestinal Hormones and Tumor Syndromes
• Chapter 153 - Carcinoid Syndrome
• Chapter 154 - Ectopic Hormone Syndromes

PART XVI - Endocrine Testing

• In Vitro Endocrine Tests
• Adrenal Dynamic Tests
• Carbohydrate Metabolic Dynamic Tests
• Gonadal Dynamic Tests
• Growth Hormone Dynamic Tests
• Multiple Endocrine Neoplasia Dynamic Test
• Posterior Pituitary Dynamic Tests
• Thyroid Dynamic Tests
• Additional Dynamic Testing and Interpretive Information

Product Details

• Hardcover: 3064 pages
• Publisher: Saunders; 6 edition (2011)
• Language: English
• ISBN-10: 1416055835
• ISBN-13: 978-1416055839
• Product Dimensions: 11.9 x 9.7 x 5.8 inches

List Price: $435.00