Sherris Medical Microbiology 5th Edition

With this 5th edition, Sherris Medical Microbiology, passes the quarter century mark. This longevity carries with it some need for evolution of authorship as well as text. We are pleased to welcome to the fold, Nafees Ahmad, a virologist with extensive success in teaching medical students. For those authors not continuing with this edition, we direct your attention to a special recognition on the Acknowledgments page. John Sherris, the founding editor, continues to act as an advisor to all of us.

The goal of Sherris Medical Microbiology remains unchanged from that of the first edition (1984). This book is intended to be the primary text for students of medicine and medical science who are encountering microbiology and infectious diseases for the first time. Part I opens with a chapter that explains the nature of infection and the infectious agents at the level of a general reader. The following four chapters give more detail on the immunologic, diagnostic, and epidemiologic nature of infection with minimal detail about the agents themselves. Parts II–V form the core of the text with chapters on the major viral, bacterial, fungal, and parasitic diseases, and each now begins with its own chapters on basic biology, pathogenesis, and antimicrobial agents. In the specific organism/disease chapters, the presentation sequence of Organism (structure, replication, genetics, etc.) followed by Disease (epidemiology, pathogenesis, immunity), and concluding with Clinical Aspects (manifestations, diagnosis, treatment, prevention) is maintained throughout the book. The opening of each section is marked with an icon and the Clinical Capsule, a snapshot of the disease, is placed at the juncture of the Organism and Disease sections. A Clinical Case followed by questions in USMLE format concludes each of these chapters. The 10 brief chapters of Part VI re-sort the material in the rest of the book into infectious syndromes. It is hoped these chapters will be of particular value when the student prepares for case discussions or sees patients.

In Sherris Medical Microbiology, the emphasis is on the text narrative, which is designed to be read comprehensively, not as a reference work. Considerable eff ort has been made to supplement this text with other learning aids such as the above-mentioned cases and questions as well as tables, photographs, and illustrations. These are now in full color, including over 300 new figures. The marginal notes, a popular feature since the first edition, are nuggets of information designed as an aid for the student during review. If a marginal note is unfamiliar, the relevant text is immediately adjacent. Many additional cases, questions, and study aids can be found in our online learning center. Visit www.LangeTextbooks.com to see the additional resources available.

For any book, lecture, case study, or other materials aimed at students, dealing with the onslaught of new information is a major challenge. In this edition, much new material has been included, but to keep the student from being overwhelmed, older or less important information has been deleted to keep the size of this book approximately the same as that of the 4th edition. As a rule of thumb, material on classic microbial structures, toxins, and the like in the Organism section has been trimmed unless its role is clearly explained in the Disease section. At the same time, we have tried not to eliminate detail to the point of becoming synoptic and uninteresting. Genetics is one of the greatest challenges in this regard. Without doubt this is where major progress is being made in understanding infectious diseases, but an intelligent discussion may require using the names of genes, their products, and multiple regulators to tell the complete story. Here we have tried to fully describe some of the major mechanisms and refer to them later when they reappear with other organisms. For example, Neisseria gonorrhoeae is used as an example of genetic mechanisms for antigenic variation in bacterial pathogenesis (Chapter 22), but how it may infl uence its disease, gonorrhea, is taken up in Chapter 30.

A saving grace is that our topic is important, dynamic, and fascinating—not just to us but to the public at large. Newspaper headlines now carry not only the name but the antigenic formula of E coli O157:H7 when it is the cause of a national outbreak of hemorrhagic colitis and kidney failure. Who could have predicted that HIV/AIDS, which occupied less than a page in the first edition of this book, would rival tuberculosis as the leading cause of premature death in the world; or that the Nobel Prize would be awarded for showing that gastritis and ulcers that were attributed to stress in the past are in fact an infection with the bacterium Helicobacter pylori. Just as we hit the presses, a new infectious threat has emerged in the form of Influenza virus H1N1 (another antigenic formula), or swine flu. We will keep you apprised of these developments in our online learning center, but we are confident that the basis for understanding them has already been laid out in the pages of this book. If you can't wait, read Chapter 9.

- Kenneth J. Ryan and C. George Ray

Key Features

• 66 chapters that simply and clearly describe the strains of viruses, bacteria, fungi, and parasites that can bring about infectious diseases.
• Core sections on viral, bacterial, fungal, and parasitic diseases open with new chapters detailing basic biology, pathogenesis, and antimicrobial agents and feature a consistent presentation covering Organism (structure, replication, genetics, etc.), Disease (epidemiology, pathogenesis, immunity), and Clinical Aspects (manifestations, diagnosis, treatment, prevention).
• Explanations of host-parasite relationship, dynamics of infection, and host response.
• USMLE-style questions and a clinical case conclude each chapter on the major viral, bacterial, fungal, and parasitic diseases.
• All tables, photographs, and illustrations are now in full color.
• Clinical Capsules cover the essence of the disease(s) caused by major pathogens.
• Marginal Notes highlight key points within a paragraph to facilitate review.

Contents

Part I. The Nature of Infection

Part Editors: Kenneth J. Ryan and C. George Ray

• Chapter 1 Infection
• Chapter 2 Immune Response to Infection
• Chapter 3 Sterilization, Disinfection, and Infection Control
• Chapter 4 Principles of Laboratory Diagnosis of Infectious Diseases
• Chapter 5 Emergence and Global Spread of Infection

Part II. Pathogenic Viruses

Part Editors: Nafees Ahmad, C. George Ray and W. Lawrence Drew

• Chapter 6 The Nature of Viruses
• Chapter 7 Pathogenesis of Viral Infection
• Chapter 8 Antiviral Antimicrobics and Resistance
• Chapter 9 Influenza, Parainfluenza, Respiratory Syncytial Virus, Adenovirus, and Other Respiratory Viruses
• Chapter 10 Mumps Virus, Measles, Rubella, and Other Childhood Exanthems
• Chapter 11 Poxviruses
• Chapter 12 Enteroviruses
• Chapter 13 Hepatitis Viruses
• Chapter 14 Herpesviruses
• Chapter 15 Viruses of Diarrhea
• Chapter 16 Arthropod-Borne and Other Zoonotic Viruses
• Chapter 17 Rabies
• Chapter 18 Retroviruses: Human T-Lymphotropic Virus, Human Immunodeficiency Virus, and Acquired Immunodeficiency Syndrome
• Chapter 19 Papilloma and Polyoma Viruses
• Chapter 20 Persistent Viral Infections of the Central Nervous System

Part III. Pathogenic Bacteria

Part Editors: Kenneth J. Ryan and W. Lawrence Drew

• Chapter 21 The Nature of Bacteria
• Chapter 22 Pathogenesis of Bacterial Infections
• Chapter 23 Antibacterial Agents and Resistance
• Chapter 24 Staphylococci
• Chapter 25 Streptococci and Enterococci
• Chapter 26 Corynebacterium, Listeria, and Bacillus
• Chapter 27 Mycobacteria
• Chapter 28 Actinomyces and Nocardia
• Chapter 29 Clostridium, Peptostreptococcus, Bacteroides, and Other Anaerobes
• Chapter 30 Neisseria
• Chapter 31 Haemophilus and Bordetella
• Chapter 32 Vibrio, Campylobacter, and Helicobacter
• Chapter 33 Enterobacteriaceae
• Chapter 34 Legionella
• Chapter 35 Pseudomonas and Other Opportunistic Gram-negative Bacilli
• Chapter 36 Plague and Other Bacterial Zoonotic Diseases
• Chapter 37 Spirochetes
• Chapter 38 Mycoplasma and Ureaplasma
• Chapter 39 Chlamydia
• Chapter 40 Rickettsia, Ehrlichia, Coxiella, and Bartonella

Part IV. Pathogenic Fungi

Part Editor: Kenneth J. Ryan

• Chapter 41 The Nature of Fungi
• Chapter 42 Pathogenesis of Fungal Infection
• Chapter 43 Antifungal Agents and Resistance
• Chapter 44 Dermatophytes, Sporothrix, and Other Superficial and Subcutaneous Fungi
• Chapter 45 Candida, Aspergillus, Pneumocystis, and Other Opportunistic Fungi
• Chapter 46 Cryptococcus, Histoplasma, Coccidioides, and Other Systemic Fungal Pathogens

Part V. Pathogenic Parasites

Part Editors: C. George Ray and James J. Plorde

• Chapter 47 The Nature of Parasites
• Chapter 48 General Principles of Pathogenesis, Immunology, and Diagnosis of Parasitic Infection
• Chapter 49 Antiparasitic Antimicrobics and Resistance
• Chapter 50 Sporozoa
• Chapter 51 Rhizopods
• Chapter 52 Flagellates
• Chapter 53 Intestinal Nematodes
• Chapter 54 Tissue Nematodes
• Chapter 55 Cestodes
• Chapter 56 Trematodes

Part VI. Clinical Aspects of Infection

Part Editors: C. George Ray, Kenneth J. Ryan, and W. Lawrence Drew

• Chapter 57 Skin and Wound Infections
• Chapter 58 Bone and Joint Infections
• Chapter 59 Eye, Ear, and Sinus Infections
• Chapter 60 Dental and Periodontal Infections
• Chapter 61 Respiratory Tract Infections
• Chapter 62 Enteric Infections and Food Poisoning
• Chapter 63 Urinary Tract Infections
• Chapter 64 Genital Infections
• Chapter 65 Central Nervous System Infections
• Chapter 66 Intravascular Infections, Bacteremia, and Endotoxemia

Glossary

Book Details 
 

• Hardcover: 1040 pages
• Publisher: McGraw-Hill Medical; 5 edition (January 11, 2010)
• Language: English
• ISBN-10: 0071604022
• ISBN-13: 978-0071604024
• Product Dimensions: 11.1 x 8.7 x 1.6 inches

List Price: $88.95