Medical Lecture Note: Cohen: Infectious Diseases 3rd Edition (Expert Consult Series)

These are extraordinary times in the fields of microbiology and infectious diseases. The genomes of essentially all the major bacterial and viral pathogens known to infect humankind have now been sequenced and are available on public databases. The human genome project is now complete and whole genome sequencing of the major malaria parasite Plasmodium falciparum and the common fungal pathogen Candida albicans are now available on line. We have learned an enormous amount of new information about the molecular mechanisms that underlie microbial pathogenesis and the host response to pathogens since the second edition of this book some five years ago. An expanding number of antiviral and antifungal agents are now available to clinicians, and new generations of vaccine constructs and adjuvants are now entering clinical practice.

Despite these advances, progress has been uneven with very little in the developmental pipeline for novel antibacterial agents, anti-tuberculosis drugs, or chemotherapeutic agents against parasitic infection. We find ourselves increasingly on the defensive against a variety of newly emerging and remerging pathogens. The specter of progressive antimicrobial resistance now threatens the long-term viability of the very foundation of our primary treatment approach against bacterial pathogens, including extensively drug resistant tuberculosis (XDR-TB). Our collective vulnerability to airborne pathogens within our highly mobile and crowded global community has become poignantly evident with the H1N1 swine flu pandemic of 2009 and ongoing threats of human dissemination of H5N1 avian influenza strains. Environmental disruption and global warming largely attributable to our ever expanding human population is likely to have adverse health consequences; among them with be the spread of vector-borne, water-borne and airborne pathogens.

In preparing this third edition we have continued the themes that initially inspired the creation of this textbook of Infectious Diseases. The book maintains its tradition of well illustrated and tightly referenced chapters with an emphasis on clinical practicality along with a detailed review of disease pathogenesis and microbiology. Practice points are found throughout the text that highlight common, and not so common, clinical scenarios that require specific and targeted information to provide informed responses. The interactive website, complete with its frequently updated information sources and a downloadable set of illustrations, will continue to support the print version of the text and now includes a number of innovative new functions. The whole text has been carefully reviewed, many chapters have been totally re-written with new figures added, and new authors and editors have been commissioned to ensure that the material is fresh, up to date and relevant.

We are indebted to the superb group of section editors and the extensive collection of highly skilled, international, contributors for each chapter, without whom the third edition of this book would not have been possible. We would especially like to extend our sincere gratitude to Sue Hodgson, Sven Pinczewski, Poppy Garraway and the staff at Elsevier for their unflappable spirit and their attention to detail throughout this considerable undertaking. Finally, we thank the Section Editors from the second edition who have now stood down: Steven Holland, Dennis Maki, Ragnar Norrby, Allan Ronald, Claus Solberg and Jan Verhoef without whom we would never have been in the position of preparing a third edition. We trust that our readers will find the readily accessible knowledge distilled into these pages to have been well worth the effort in generating the Third Edition of Infectious Diseases.

Jon Cohen, William Powderly, Steven Opal

Key Features

Find a diagnosis quickly with the popular Diseases by Body System Section.
Stay well informed with expanded and updated coverage of nonsocomial infections and much more.
Receive unparalleled visual guidance from hundreds of full-color photographs and figures.
Quickly search information with a consistent chapter organization and colorful page layouts.
Get clinically-focused guidance from "Practice Points," which demonstrate how to diagnose and treat complicated problems encountered in practice.
Make effective diagnoses with a more efficient approach to differential diagnosis-discussions of conditions are presented in proportion to their incidence.
Gain a more international view from editors and authors, patient photographs, and treatment perspectives from around the world.

Website Features

Consult the book from any computer at home, in your office, or at any practice location.
Instantly locate the answers to your clinical questions via a simple search query.
Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
Lancet articles: Selected articles from The Lancet and the The Lancet Infectious Diseases are presented.

Contents
Volume 1
Section 1 - Introduction to Infectious Diseases

Chapter 1 - Nature and pathogenicity of micro-organisms
Chapter 2 - Host responses to infection
Chapter 3 - Vaccines and vaccination
Chapter 4 - Emerging and re-emerging pathogens and diseases
Chapter 5 - Mathematical models in infectious disease epidemiology
Chapter 6 - History of infection prevention and control
Chapter 7 - Bacterial genomes

Section 2 - Syndromes by Body System

Chapter 8 - Viral exanthems
Chapter 9 - Cellulitis, pyoderma, abscesses and other skin and subcutaneous infections
Chapter 10 - Necrotizing fasciitis, gas gangrene, myositis and myonecrosis
Chapter 11 - Arthropods and ectoparasites
Chapter 12 - Dermatologic manifestations of systemic infections
Chapter 13 - Superficial fungal infections
Chapter 14 - Lymphadenopathy
Chapter 15 - Conjunctivitis, keratitis and infections of periorbital structures
Chapter 16 - Endophthalmitis
Chapter 17 - Infectious retinitis and uveitis
Chapter 18 - Acute and chronic meningitis
Chapter 19 - Encephalitis and myelitis
Chapter 20 - Brain abscess and other focal pyogenic infections of the central nervous system
Chapter 21 - Tetanus and botulism
Chapter 22 - Prion diseases of humans and animals
Chapter 23 - Infections in hydrocephalus shunts
Chapter 24 - Laryngitis, epiglottitis and pharyngitis
Chapter 25 - Otitis, sinusitis and related conditions
Chapter 26 - Bronchitis, bronchiectasis and cystic fibrosis
Chapter 27 - Community-acquired pneumonia
Chapter 28 - Hospital-acquired pneumonia
Chapter 29 - Lung abscesses and pleural abscesses
Chapter 30 - Tuberculosis and other mycobacterial infections
Chapter 31 - Fungal pneumonias
Chapter 32 - Orocervical infection
Chapter 33 - Gastritis, peptic ulceration and related conditions
Chapter 34 - Food-borne diarrheal illness
Chapter 35 - Acute diarrhea
Chapter 36 - Chronic diarrhea
Chapter 37 - Intra-abdominal sepsis, peritonitis and pancreatitis
Chapter 38 - Viral hepatitis
Chapter 39 - Hepatobiliary and splenic infection
Chapter 40 - Infective and reactive arthritis
Chapter 41 - Acute and chronic osteomyelitis
Chapter 42 - Infections of prosthetic joints and related problems
Chapter 43 - Lyme disease
Chapter 44 - Sepsis
Chapter 45 - Infections associated with intravascular lines, grafts and devices
Chapter 46 - Myocarditis and pericarditis
Chapter 47 - Endocarditis and endarteritis
Chapter 48 - Rheumatic fever
Chapter 49 - Vaginitis, vulvitis, cervicitis and cutaneous vulval lesions
Chapter 50 - Infections of the female pelvis including septic abortion
Chapter 51 - Complications of pregnancy: maternal perspectives
Chapter 52 - Implications for the fetus of maternal infections in pregnancy
Chapter 53 - Cystitis and urethral syndromes
Chapter 54 - Prostatitis, epididymitis and orchitis
Chapter 55 - Pyelonephritis and abscesses of the kidney
Chapter 56 - Complicated urinary infection, including postsurgical and catheter-related infections
Chapter 57 - Syphilis
Chapter 58 - Genital herpes
Chapter 59 - Papillomavirus infections
Chapter 60 - Lymphogranuloma venereum, chancroid and granuloma inguinale

Section 3 - Special Problems in Infectious Disease Practice

Chapter 61 - Pathogenesis of fever
Chapter 62 - Clinical approach to acute fever
Chapter 63 - Fever of unknown origin
Chapter 64 - The potential role of infectious agents in diseases of unknown etiology
Chapter 65 - Infectious complications following surgery and trauma
Chapter 66 - Recreational infections
Chapter 67 - Occupational infections
Chapter 68 - Infections from pets
Chapter 69 - Infections acquired from animals other than pets
Chapter 70 - Chronic fatigue syndrome
Chapter 71 - Bioterrorism and biodefense

Section 4 - Infections in the Immunocompromised Host

Chapter 72 - Immunodeficiencies
Chapter 73 - Infections in the neutropenic cancer patient
Chapter 74 - Infections in hematopoietic stem cell transplant recipients
Chapter 75 - Infection in solid organ transplantation
Chapter 76 - Heart, lung and heart–lung transplantation
Chapter 77 - Liver transplantation
Chapter 78 - Pancreatic transplantation
Chapter 79 - Intestinal transplantation
Chapter 80 - Kidney transplant patients
Chapter 81 - Vasculitis and other immunologically mediated diseases
Chapter 82 - Splenectomy and splenic dysfunction
Chapter 83 - Vaccination of the immunocompromised patient

Volume 2
Section 5 - HIV and AIDS

Chapter 84 - Epidemiology of HIV infection
Chapter 85 - Prevention of HIV transmission through behavioral change and sexual means
Chapter 86 - Preventing occupational HIV infection in the health-care environment
Chapter 87 - HIV vaccines: past failures and future scientific challenges
Chapter 88 - The immunopathogenesis of HIV-1 infection
Chapter 89 - Primary HIV infection
Chapter 90 - Prevention of opportunistic infections
Chapter 91 - Opportunistic infections
Chapter 92 - Disorders of immune reconstitution in patients with HIV infection
Chapter 93 - Tuberculosis in HIV
Chapter 94 - Neoplastic disease
Chapter 95 - Dermatologic manifestations of HIV infection
Chapter 96 - HIV/AIDS-related problems in developing countries
Chapter 97 - HIV infection in children
Chapter 98 - Special problems in women who have HIV disease
Chapter 99 - Principles of management of HIV in the developed world
Chapter 100 - Antiviral therapy

Section 6 - International Medicine

Chapter 101 - Geography of infectious diseases
Chapter 102 - Pretravel advice and immunization
Chapter 103 - Leprosy
Chapter 104 - Endemic treponematoses
Chapter 105 - African trypanosomiasis
Chapter 106 - Other parasitic infections of the central nervous system
Chapter 107 - Eye infections in the tropics
Chapter 108 - Parasitic infections of the gastrointestinal tract
Chapter 109 - Typhoid fever and other enteric fevers
Chapter 110 - Amebic infections
Chapter 111 - Malaria
Chapter 112 - Schistosomiasis
Chapter 113 - Cestode and trematode infections
Chapter 114 - Hydatid disease
Chapter 115 - Filariasis
Chapter 116 - Infections in sickle cell disease
Chapter 117 - Leishmaniasis
Chapter 118 - Chagas disease (American trypanosomiasis)
Chapter 119 - Melioidosis
Chapter 120 - Plague
Chapter 121 - Tularemia
Chapter 122 - Scrub typhus and other tropical rickettsioses
Chapter 123 - Brucellosis
Chapter 124 - Leptospirosis
Chapter 125 - Relapsing fevers
Chapter 126 - Viral hemorrhagic fevers
Chapter 127 - Dengue
Chapter 128 - Anthrax

Section 7 - Anti-Infective Therapy

Chapter 129 - Principles of anti-infective therapy
Chapter 130 - Mechanisms of action
Chapter 131 - Mechanisms of antibacterial resistance
Chapter 132 - Antibiotic prophylaxis
Chapter 133 - Non-inpatient parenteral antimicrobial therapy
Chapter 134 - β-Lactam antibiotics
Chapter 135 - Macrolides, ketolides, lincosamides and streptogramins
Chapter 136 - Oxazolidinones
Chapter 137 - Aminoglycosides
Chapter 138 - Folate inhibitors
Chapter 139 - Quinolones
Chapter 140 - Glycopeptides
Chapter 141 - Tetracyclines and chloramphenicol
Chapter 142 - Nitroimidazoles: metronidazole, ornidazole and tinidazole
Chapter 143 - Antituberculosis agents
Chapter 144 - Miscellaneous agents: fusidic acid, nitrofurantoin and spectinomycin
Chapter 145 - Antiretroviral agents
Chapter 146 - Drugs for herpesvirus infections
Chapter 147 - Antiviral agents against respiratory viruses
Chapter 148 - Drugs to treat viral hepatitis
Chapter 149 - Antifungal agents
Chapter 150 - Antiparasitic agents

Section 8 - Clinical Microbiology

Chapter 151 - Acute gastroenteritis viruses
Chapter 152 - Measles, mumps and rubella viruses
Chapter 153 - Human enteroviruses
Chapter 154 - Hepatitis viruses
Chapter 155 - Herpesviruses
Chapter 156 - Papillomaviruses
Chapter 157 - Polyomaviruses
Chapter 158 - Parvoviruses
Chapter 159 - Poxviruses
Chapter 160 - Rabies and rabies-related viruses
Chapter 161 - Influenza viruses
Chapter 162 - Respiratory viruses
Chapter 163 - Retroviruses and retroviral infections
Chapter 164 - Zoonotic viruses
Chapter 165 - Staphylococci and micrococci
Chapter 166 - Streptococci, enterococci and other catalase-negative cocci
Chapter 167 - Aerobic Gram-positive bacilli
Chapter 168 - Neisseria
Chapter 169 - Enterobacteriaceae
Chapter 170 - Pseudomonas spp., Acinetobacter spp. and miscellaneous Gram-negative bacilli
Chapter 171 - Curved and spiral bacilli
Chapter 172 - Gram-negative coccobacilli
Chapter 173 - Anaerobic bacteria
Chapter 174 - Mycobacteria
Chapter 175 - Mycoplasma and Ureaplasma
Chapter 176 - Rickettsia and rickettsia-like organisms
Chapter 177 - Chlamydia
Chapter 178 - Opportunistic and systemic fungi
Chapter 179 - Superficial and subcutaneous fungal pathogens
Chapter 180 - Protozoa: intestinal and urogenital amebae, flagellates and ciliates
Chapter 181 - Protozoa: intestinal coccidia and microsporidia
Chapter 182 - Protozoa: free-living amebae
Chapter 183 - Blood and tissue protozoa
Chapter 184 - Helminths

Product Details

Hardcover: 2070 pages
Publisher: Mosby; 3 edition (May 11, 2010)
Language: English
ISBN-10: 0723435030
ISBN-13: 978-0723435037

List Price: $435.00

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