It is interesting to compare the first edition with the new, seventh edition of Principles and Practice of Infectious Diseases. Since 1979, when the first edition was published, there have been scores of new antimicrobial agents and newly recognized diseases and pathogens, such as legionnaires’ disease, Lyme disease, Kaposi's sarcoma, human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), multidrug-resistant tuberculosis, Clostridium difficile colitis, progressive multifocal leukoencephalopathy, severe acute respiratory syndrome (SARS), and the new H1N1 flu, to mention just a few. A comparison with the sixth edition, published in 2004, reveals a further increase in our knowledge of newly recognized diseases, microbes, and therapeutic agents. The developments in basic sciences have been astounding, with advances in genomics leading to rapid diagnoses and breakthrough therapies.
Principles and Practice of Infectious Diseases differs from other sources of information, such as many web-based resources, in that it is carefully edited and the content put into perspective by infectious diseases experts. The new edition combines the knowledge and experience of the world's authorities with the careful review of all chapters by all three editors.
This edition has been planned and designed for physicians (infectious diseases specialists, internists, family practitioners, travel medicine specialists, HIV/AIDS researchers), pharmacologists, public health experts, microbiologists, and basic scientists. Readers consulting the volumes can quickly find key clinical information to help in diagnosing and treating their patients. The text contains up-to-date information and includes numerous 2009 references. New chapters have been added, and all other chapters have been revised extensively, with tables, figures, and references updated.
Among the 330 chapters is excellent coverage of such topics as microbial pathogenesis, infections in cancer patients, emerging infections, new antimicrobial agents, antibiotic resistance, travel medicine, vaccines, infections related to exotic pets, and important aspects of agents of bioterrorism.
The online version of the book contains fully searchable text on the dedicated Expert Consult website. It will also allow us to present new developments in the field and advances in therapy via regular content updates. The website contains other added-value features such as a downloadable image library and drug database.
We could not have edited this book without the assistance and stoic patience of our wives, Judy Mandell, Shirley Bennett, and Kelly Dolin, who endured the many long hours their husbands spent at home, uncommunicative, laboring over yet another edition of this treatise. Our thanks also go to Janet Morgan for her invaluable assistance to Dr. Dolin.
-- Authors --
Book features
- Features online access of the entire book's content- fully searchable-as well as access to regular updates on new developments in the field and advances in therapy, such as the new strain of H1N1, a drug database, downloadable image library, and more at expertconsult.com.
- Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you'll find in any other ID resource so you can get the answers to any questions you have.
- Presents 1,100 exquisite color photographs that reflect real-life patient symptoms for enhanced visual guidance.
- Offers current and up-to-date information on the newly recognized and emerging influenza viruses including Swine and Avian influenzas so you are able to accurately diagnose and treat anything that comes your way.
- Uses a consistent chapter-to-chapter layout for easy navigation.
- Features updated coverage of the emerging influenza viruses, such as the Swine and Avian Influenzas, microbial pathogenesis, infections in cancer patients, MRSA, antibiotic resistance, travel medicine, importation of exotic pets, bioterrorism agents, and much more.
- Includes new chapters on Probiotics, Outbreak Investigation, Infection of Nonvalvular Cardiovascular Devices, and Chlamydophila Pneumonia to keep you up to date on today's hot topics.
- Incorporates many more new American and International contributors, giving you fresh perspectives and expanded global insights.
Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Contents
Part I Basic Principles in the Diagnosis and Management of Infectious Diseases
Section A. Microbial Pathogenesis
Section A. Microbial Pathogenesis
- 1 A Molecular Perspective of Microbial Pathogenicity
- 2 Microbial Adherence
- 3 Toxins
Section B. Host Defense Mechanisms
- 4 Innate (General or Nonspecific) Host Defense Mechanisms
- 5 Human Genetics and Infection
- 6 Antibodies
- 7 Complement
- 8 Granulocytic Phagocytes
- 9 Cell-Mediated Defense Against Infection
- 10 Nutrition, Immunity, and Infection
- 11 Probiotics
- 12 Evaluation of the Patient with Suspected Immunodeficiency
Section C. Epidemiology of Infectious Diseases
- 13 Epidemiologic Principles
- 14 Outbreak Investigation
- 15 Emerging and Reemerging Infectious Disease Threats
- 16 Hospital Preparedness for Emerging and Highly Contagious Infectious Diseases
Section D. Clinical Microbiology
- 17 The Clinician and the Microbiology Laboratory
Section E. Anti-Infective Therapy
- 18 Principles of Anti-infective Therapy
- 19 Molecular Mechanisms of Antibiotic Resistance in Bacteria
- 20 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
- 21 Penicillins
- 22 Cephalosporins
- 23 Other beta-Lactam Antibiotics
- 24 beta-Lactam Allergy
- 25 Fusidic Acid
- 26 Aminoglycosides
- 27 Tetracyclines and Chloramphenicol
- 28 Rifamycins
- 29 Metronidazole
- 30 Macrolides, Clindamycin, and Ketolides
- 31 Glycopeptides, Streptogramins, and Lipopeptides
- 32 Polymyxins (Polymyxin B and Colistin)
- 33 Oxazolidinones
- 34 Sulfonamides and TrimNitrofurantoin and Methenamine
- 38 Topical Antibacterials
- 39 Antimycobacterial Agents
- 40 Antifungal Agents
- 41 Antiviral Drugs (Other Than Antiretrovirals)
- 42 Immunomodulators
- 43 Hyperbaric Oxygen
- 44 Agents Active against Parasites and Pneumocystis
- 45 Complementary and Alternative Medicines for Infectious Diseases
- 46 Antimicrobial Management: Cost and Resistance
- 47 Interpretation of Clinical Trials of Antimicrobial Agents
- 48 Outpatient Parenteral Antimicrobial Therapy
- 49 Tables of Antimicrobial Agent Pharmacology
Part II Major Clinical Syndromes
Section A. Fever
Section A. Fever
- 50 Temperature Regulation and the Pathogenesis of Fever
- 51 Fever of Unknown Origin
- 52 The Acutely Ill Patient with Fever and Rash
Section B. Upper Respiratory Tract Infections
- 53 The Common Cold
- 54 Pharyngitis
- 55 Actue Laryngitis
- 56 Acute Laryngotracheobronchitis (Croup)
- 57 Otitis Externa, Otitis Media, and Mastoiditis
- 58 Sinusitis
- 59 Epiglottitis
- 60 Infections of the Oral Cavity, Neck, and Head
Section C. Pleuropulmonary and Bronchial Infections
- 61 Acute Bronchitis
- 62 COPD, Chronic Bronchitis, and Acute Exacerbations
- 63 Bronchiolitis
- 64 Acute Pneumonia
- 65 Empyema and Pleural Effusion
- 66 Lung Abscess
- 67 Chronic Pneumonia
- 68 Cystic Fibrosis
Section D. Urinary Tract Infections
- 69 Urinary Tract Infections
Section E. Sepsis
- 70 Sepsis, Severe Sepsis, and Septic Shock
Section F. Intra-abdominal Infection
- 71 Peritonitis and Intraperitoneal Infections
- 74 Splenic Abscess
- 75 Appendicitis
- 76 Diverticulitis and Typhlitis
Section G. Cardiovascular Infections
- 77 Endocarditis and Intravascular Infections
- 78 Prosthetic Valve Endocarditis
- 79 Infections of Non-Valvular Cardiovascular Devices
- 80 Prophylaxis of Infective Endocarditis
- 81 Myocarditis and Pericarditis
- 82 Mediastinitis
Section H. Central Nervous System Infections
- 83 Approach to the Patient with Central Nervous System Infection
- 84 Acute Meningitis
- 85 Infections of CSF Shunts
- 86 Chronic Meningitis
- 87 Encephalitis, Myelitis, and Neuritis
- 88 Brain Abscess
- 89 Subdural Empyema, Epidural Abscess, and Intracranial Suppurative Thrombophlebitis
Section I. Skin and Soft Tissue Infections
- 90 Cellulitis, Necrotizing Fasciitis and Subcutaneous Tissue Infections
- 91 Myositis
- 92 Lymphadenitis and Lymphangitis
Section J. Gastrointestinal Infections and Food Poisoning
- 93 Principles and Syndromes of Enteric Infection
- 94 Esophagitis
- 95 Nausea, Vomiting, and Noninflammatory Diarrhea
- 96 Antibiotic-Associated Colitis
- 97 Inflammatory Enteritides
- 98 Enteric Fever and Other Causes of Abdominal Symptoms with Fever
- 99 Foodborne Disease
- 100 Tropical Sprue/Enteropathy
- 101 Whipple's Disease
Section K. Bone and Joint Infections
- 102 Infectious Arthritis
- 103 Osteomyelitis
- 104 Infections in Prostheses in Bones and Joints
Secction L. Diseases of the Reproductive Organs and Sexually Transmitted Diseases
- 105 of the Female Pelvis
- 109 Prostatitis, Epididymitis, and Orchitis
Section M. Eye Infections
- 110 Microbial Conjunctivitis
- 111 Microbial Keratitis
- 112 Endophthalmitis
- 113 Infectious Causes of Uveitis
- 114 Periocular Infections
Section N. Hepatitis
- 115 Acutel Hepatitis
- 116 Chronic Viral Hepatitis
Section O. Acquired Immunodeficiency Syndrome
- 117 Global Perspectives on HIV Infection and Acquired Immunodeficiency Syndrome
- 118 Epidemiology and Prevention of AIDS and HIV Infection
- 119 Diagnosis of Human Immunodeficiency Virus Infection
- 120 The Immunology of Human Immunodeficiency Virus Infection
- 121 General Clinical Manifestations of Human Immunodeficiency Virus Infection
- 122 Pulmonary Manifestations of Human Immunodeficiency Virus Infection
- 123 GI and Hepatobiliary Manifestations of Human Immunodeficiency Virus Infection
- 124 Neurologic Diseases Caused by HIV-1 and Opportunistic Infections
- 125 Malignancies in Human Immunodeficiency Virus Infection
- 126 Human Immunodeficiency Virus Infection in Women
- 127 Pediatric Human Immunodeficiency Virus Infection
- 128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection
- 129 Management of Opportunistic Infections Associated with HIV Infection
- 130 Vaccines for Human Immunodeficiency Virus-1 Infection
Section P. Miscellaneous Syndromes
- 131 Chronic Fatigue Syndrome
Part III Infectious Diseases and Their Etiologic Agents
Section A. Viral Diseases
Section A. Viral Diseases
- 132 Introduction to Viruses and Viral Diseases - DNA Viruses - Poxviridae
- 134 Other Poxviruses: Parapoxviruses, Molluscum Contagiosum, and Tanapox Herpesviridae
- 135 Introduction to Herpesviridae
- 136 Herpes Simplex Virus
- 137 Varicella-Zoster Virus
- 138 Cytomegalovirus
- 139 Epstein-Barr Virus (Infectious Mononucleosis)
- 140 Human Herpesvirus Types 6 and 7
- 141 Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus Type 8)
- 142 Herpes B Virus - Adenoviridae
- 143 Adenovirus - Papovaviridae
- 144 Papillomaviruses
- 145 JC, BK, and Other Polyomaviruses; Progressive Multifocal Leukoencephalopathy - Hepadnaviridae
- 146 Hepatitis B Virus and Hepatitis Delta Virus - Parvoviridae
- 147 Human Parvoviruses - RNA Viruses - Reoviridae
- 148 Orthoreoviruses and Orbiviruses
- 149 Coltiviruses and Seadornaviruses (Colorado Tick Fever)
- 150 Rotaviruses - Togaviridae
- 151 Alphaviruses
- 152 Rubella Virus (German Measles) - Flaviviruses
- 153 Flaviviruses (Yellow Fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis)
- 154 Hepatitis C - Coronaviridae
- 155 Coronaviruses, Including SARS-Associated Coronavirus Paramyxoviridae
- 156 Parainfluenza Viruses
- 157 Mumps Virus
- 158 Respiratory Syncytial Virus
- 159 Human Metapneumovirus
- 160 Measles Virus (Rubeola)
- 161 Zoonotic Paramyxoviruses: Hendra, Nipah, and Menangle Viruses
- Rhabdoviridae
- 162 Vesicular Stomatitis Virus and Related Viruses
- 163 Rhabdoviruses - Filoviridae
- 164 Marburg and Ebola Virus Hemorrhagic Fevers - Orthomyxoviridae
- 165 Influenza Viruses Including Avia Hemorrhagic Fevers - Arenaviridae
- 167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers - Retroviridae
- 168 Human T-Cell Lymphotropic Virus Types I and II
- 169 Human Immunodeficiency Viruses - Picornaviridae
- 170 Introduction to the Enteroviruses
- 171 Poliovirus
- 172 Coxsackieviruses, Echoviruses, and Newer Enteroviruses
- 173 Hepatitis A Virus - Caliciviridae and Other Gastrointestinal Viruses
- 174 Rhinovirus
- 175 Noroviruses and Other Caliciviruses
- 176 Astroviruses and Picobirnaviruses - Unclassified Viruses
- 177 Hepatitis E Virus
- Section B. Prion Diseases
- 178 Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)
- Section C. Chlamydial Diseases
- 179 Introduction to Chlamydial Diseases
- 180 Chlamydia trachomatis (Trachoma, Perinatal Infections, Lymphogranuloma Venereum, and Other Genital Infections)
- 181 Chlamydophila (Chlamydia) psittaci (Psittacosis)
- 182 Chlamydophila (Chlamydia) pneumoniae
- 183 Introduction to Mycoplasma Diseases
- 184 Mycoplasma pneumoniae and Atypical Pneumonia
Section D. Mycoplasma Diseases
- 185 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species
Section E. Rickettsioses, Ehrlichioses, and Anaplasmosis
- 186 Introduction to Rickettsioses, Ehrlichioses and Anaplasmosis
- 187 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)
- 188 Rickettsia akari (Rickettsialpox)
- 189 Coxiella burneti Typhus)
- 191 Rickettsia typhi (Murine Typhus)
- 192 Orientia Tsutsugamushi
- 193 Ehrlichia Chaffeensis and Ehrlichia Phagocytophila
Section F. Bacterial Diseases
- 194 Introduction to Bacteria and Bacterial Diseases - Gram-Positive Cocci
- 195 Staphylococcus aureus (Including Staphylococcal Toxic Shock)
- 196 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
- 197 Classification of Streptococci
- 198 Streptococcus pyogenes
- 199 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis
- 200 Streptococcus pneumoniae
- 201 Enterococcus Species, Streptococcus bovis, and Leuconostoc Species
- 202 Streptococcus agalactiae (Group B Streptococcus)
- 203 Viridans Streptococci, Groups C and G Streptococci, and Gemella morbillorum
- 204 Streptococcus anginosus Group - Gram-Positive Bacilli
- 205 Corynebacterium diphtheriae
- 206 Corynebacteria other than Diphtheria and Rhodococcus
- 207 Listeria monocytogenes
- 208 Bacillus anthracis (Anthrax)
- 209 Bacillus Species and Other than Bacillus anthracis
- 210 Erysipelothrix rhusiopathiae - Gram-Negative Cocci
- 211 Neisseria meningitidis
- 212 Neisseria gonorrhoeae
- 213 Moraxella catarrhalis and Other Gram-Negative Cocci - Gram-Negative Bacilli
- 214 Vibrio cholerae
- 215 Other Pathogenic Vibrios
- 216 Campylobacter jejuni and Related Species
- 217 Helicobacter pylori and Other Gastric Helicobacter Species
- 218 Enterobacteriaceae
- 219 Pseudomonas species, including Ps. aeruginosa
- 220 Stenotrophomonas maltophilia and Burkholderia cepacia complex
- 221 Burkholderia pse Including Salmonella typhi
- 224 Shigella Species (Bacillary Dysentery)
- 225 Haemophilus species (incluing H. influenzae and chancroid)
- 226 Brucella Species
- 227 Francisella tularensis (Tularemia)
- 228 Pasteurella Species
- 229 Yersinia Species, Including Plague
- 230 Bordetella Pertussis
- 231 Rat-Bite Fever Streptobacillus moniliformis and Spirillum minus
- 232 Legionella
- 233 Other Legionella Species
- 234 Capnocytophaga
- 235 Bartonella, Including Cat-Scratch Disease
- 236 Calymmatobacterium granulomatis (Donovanosis, Granuloma Inguinale)
- 237 Other Gram-Negative and Gram-Variable Bacilli - Spirochetes
- 238 Treponema pallidum (Syphilis)
- 239 Endemic Treponematoses
- 240 Leptospira Species (leptospirosis)
- 241 Borrelia Species (Relapsing Fever)
- 242 Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis) - Anaerobic Bacteria
- 243 Anaerobic Infections: General Concepts
- 244 Clostridium tetani (Tetanus)
- 245 Clostridium botulinum (Botulism)
- 246 Gas Gangrene and Other Clostridium-Associated Diseases
- 247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species
- 248 Anaerobic Cocci; Anaerobic
- 249 Anaerobic Gram-Positive Non-sporulating Bacilli - Mycobacterial Diseases
- 250 Mycobacterium tuberculosis
- 251 Mycobacterium leprae
- 252 Mycobacterium Avium-intracellulare
- 253 Infections due to Mycobacteria other than M. tuberculosis and M. Avium Complex -Higher Bacterial Diseases
- 254 Nocardia Species
- 255 Agents of Actinomycosis
Section G. Mycoses
- 256 Introduction to Mycoses
- 257 Chromomycosis
- 262 Agents of Mycetoma
- 263 Cryptococcus neoformans
- 264 Histoplasma capsulatum
- 265 Blastomyces dermatitidis
- 266 Coccidioides Species
- 267 Dermatophytosis and Other Superficial Mycoses
- 268 Paracoccidioides brasiliensis
- 269 Uncommon Fungi and Prototheca
- 270 Pneumocystis
- 271 Microsporidiosis
Section H. Protozoal Diseases
- 272 Introduction to Protozoal Diseases
- 273 Entamoeba species including amoebiasis
- 274 Free-Living Amebas
- 275 Plasmodium Species (Malaria)
- 276 Leishmania Species: Visceral, Cutaneous, and Mucocutaneous Leishmaniasis
- 277 Biology of Trypanosoma Species
- 278 Agents of African Trypanosomiasis (Sleeping Sickness)
- 279 Toxoplasma gondii
- 280 Giardia lamblia
- 281 Trichomonas vaginalis
- 282 Babesia Species
- 283 Cryptosporidium Species
- 284 Isospora belli, Sarcocystis Species, Blastocystis hominis and Cyclospora
Section I. Diseases Due to Toxic Algae
- 285 Human Illness Associated with Harmful Algal Blooms
Section J. Diseases Due to Helminths
- 286 Introduction to Helminth Infections
- 287 Intestinal Nematodes (Roundworms)
- 288 Tissue Nematodes, Including Trichinosis, Dracunculiasis, and the Filariases
- 289 Trematodes (Schistosomes and Other Flukes)
- 290 Cestodes (Tapeworms)
- 291 Visceral Larva Migrans and Other Unusual Helminth Infections
Section K. Ectoparasitic Diseases
- 292 Introduction to Ectoparasitic Diseases
- 293 Lice (Pediculosis)
- 294 Scabies
- 295 Myiasis and Tungiasis
- 296 Mites (Including Chigger Syndrome
Part IV Special Problems
Section A. Nosocominal Infections
Section A. Nosocominal Infections
- 299 Organization for Infection Control
- 300 Isolation
- 301 Disinfection, Sterilization, and Control of Hospital Waste
- 302 Infections Caused by Percutaneous Intravascular Devices
- 303 Nosocomial Pneumonia
- 304 Nosocomial Urinary Tract Infections
- 305 Nosocomial Hepatitis and Other Infections Transmitted by Blood and Blood Products
- 306 Human Immunodeficiency Virus in Health Care Settings
- 307 Nosocomial Herpesvirus Infections
Section B. Infections in Special Hosts
- 308 Infections in the Immunocompromised Host: General Principles
- 309 Prophylaxis and Empirical Therapy of Infection in Cancer Patients
- 310 Risk Factors and Approaches to Infections in Transplant Recipients
- 311 Infections in Hematopoietic Stem Cell Transplant Recipients
- 312 Infections in Solid Organ Transplant Recipients
- 313 Infections in Patients with Spinal Cord Injury
- 314 Infections in the Elderly
- 315 Infections in Asplenic Patients
- 316 Infections in Injection Drug Users
- 317 Postoperative Infections and Antimicrobial Prophylaxis
Section C. Surgical and Trauma-Related Infections
- 318 Infections in Patients with Burns
- 319 Bites
Section D. Immunization
- 320 Immunization
Section E. Biodefense
- 321 Bioterrorism: An Overview
- 322 Plague as Bioterrorism Weapon
- 323 Tularemia as a Bioterrorism Weapon
- 324 Smallpox as an Agent of Bioterrorism
- 325 Anthrax as an Agent of Bioterrorism
- 328 Zoonoses
- Section G. Protection of Travelers
- 329 Protection of Travelers
- 330 Infections in Returning Travelers
Product Details
- Hardcover: 4320 pages
- Publisher: Churchill Livingstone; 7 edition (September 18, 2009)
- Language: English
- ISBN-10: 0443068399
- ISBN-13: 978-0443068393
- Product Dimensions: 11.5 x 9.2 x 5.4 inches
List Price: $415.00