A best-selling core textbook for medical students taking medical biochemistry, Marks' Basic Medical Biochemistry links biochemical concepts to physiology and pathophysiology, using hypothetical patient vignettes to illustrate core concepts. Completely updated to include full-color art, expanded clinical notes, and bulleted end-of-chapter summaries, the revised Third Edition helps medical students understand the importance of the patient and bridges the gap between biochemistry, physiology, and clinical care.
A new companion Website will offer the fully searchable online text, an interactive question bank with 250 multiple-choice questions, animations depicting key biochemical processes, self-contained summaries of patients described in the book, and a comprehensive list of disorders discussed in the text, with relevant Website links. An image bank, containing all the images in the text, will be available to faculty.
Key Features
New to this edition
Contents
Section One: FUEL METABOLISM
Section Two: CHEMICAL AND BIOLOGICAL FOUNDATIONS OF BIOCHEMISTRY
Section Three: GENE EXPRESSION AND THE SYNTHESIS OF PROTEINS
Section Four: FUEL OXIDATION AND THE GENERATION OF ATP
Section Five: CARBOHYDRATE METABOLISM
Section Six: LIPID METABOLISM
Section Seven: NITROGEN METABOLISM
Section Eight: TISSUE METABOLISM
Appendix: Answers to Review Questions
Index
Product Details
A new companion Website will offer the fully searchable online text, an interactive question bank with 250 multiple-choice questions, animations depicting key biochemical processes, self-contained summaries of patients described in the book, and a comprehensive list of disorders discussed in the text, with relevant Website links. An image bank, containing all the images in the text, will be available to faculty.
Key Features
- Patient-oriented approach: hypothetical patient vignettes illustrate core concepts. Patients have unique and humorous names that serve as mnemonics and help students remember the vignettes.
- A well-organized icon system provides quick navigation through the various elements of each chapter
- "Biochemical Comments" expand on a topic or introduce additional biochemical information.
- "Clinical Comments" provide additional clinical information, including treatment and outcome.
- Sidebars expand on clinical material mentioned in the text.
- Review and USMLE-style questions and answers at the end of each chapter and online provide ample opportunity for review and self-assessment.
- Cross-references between chapters speed navigation and enhance the continuity of the text.
New to this edition
- NEW: New full-color art program includes illustrations of chemical structures and biochemical pathways as well as conceptual diagrams.
- NEW: Molecular Techniques and Biochemistry of Cancer chapters have been expanded, as most advances in medical biochemistry have occurred in these areas.
- NEW: Measurement Notes explain the "why" of clinical measurements as they relate to biochemistry.
- NEW: Stethoscope Notes expanded in this edition to provide more clinical information.
- NEW: "Key Concept List" added to the end of each chapter.
Section One: FUEL METABOLISM
- 1: Metabolic Fuels and Dietary Components
- 2: The Fed or Absorptive State
- 3: Fasting
Section Two: CHEMICAL AND BIOLOGICAL FOUNDATIONS OF BIOCHEMISTRY
- 4: Water, Acids, Bases, and Buffers
- 5: Structures of the Major Compounds of the Body
- 6: Amino Acids in Proteins
- 7: Structure-Function Relationships in Proteins
- 8: Enzymes as Catalysts
- 9: Regulation of Enzymes
- 10: Relationship between Cell Biology and Biochemistry
- 11: Cell Signaling by Chemical Messengers
Section Three: GENE EXPRESSION AND THE SYNTHESIS OF PROTEINS
- 12: Structure of the Nucleic Acids
- 13: Synthesis of DNA
- 14: Transcription: Synthesis of RNA
- 15: Translation: Synthesis of Proteins
- 16: Regulation of Gene Expression
- 17: Use of Recombinant DNA Techniques in Medicine
- 18: The Molecular Biology of Cancer
Section Four: FUEL OXIDATION AND THE GENERATION OF ATP
- 19: Cellular Bioenergetics: ATP and O2
- 20: Tricarboxylic Acid Cycle
- 21: Oxidative Phosphorylation and Mitochondrial Function
- 22: Generation of ATP from Glucose: Glycosis
- 23: Oxidation of Fatty Acids and Ketone Bodies
- 24: Oxygen Toxicity and Free Radical Injury
- 25: Metabolism of Ethanol
Section Five: CARBOHYDRATE METABOLISM
- 26: Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other Hormones
- 27: Digestion, Absorption, and Transport of Carbohydrates
- 28: Formation and Degradation of Glycogen
- 29: Pathways of Sugar Metabolism: Pentose Phosphate Pathway, Fructose, and Galactose Metabolism
- 30: Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids
- 31: Gluconeogenesis and Maintenance of Blood Glucose Levels
Section Six: LIPID METABOLISM
- 32: Digestion and Transport of Dietary Lipids
- 33: Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
- 34: Cholesterol Absorption, Synthesis, Metabolism, and Fate
- 35: Metabolism of the Eicosanoids
- 36: Integration of Carbohydrate and Lipid Metabolism
Section Seven: NITROGEN METABOLISM
- 37: Protein Digestion and Amino Acid Absorption
- 38: Fate of Amino Acid Nitrogen: Urea Cycle
- L39: Synthesis and Degradation of Amino Acids
- 40: Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine
- 41: Purine and Pyrimidine Metabolism
- 42: Intertissue Relationships in the Metabolism of Amino Acids
Section Eight: TISSUE METABOLISM
- 43: Actions of Hormones Regulating Fuel Metabolism
- 44: The Biochemistry of the Erythrocyte and Other Blood Cells
- 45: Blood Plasma Proteins, Coagulation and Fibrinolysis
- 46: Liver Metabolism
- 47: Metabolism of Muscle at Rest and During Exercise
- 48: Metabolism of the Nervous System
- 49: The Extracellular Matrix and Connective Tissue
Appendix: Answers to Review Questions
Index
Product Details
- Paperback: 1024 pages
- Publisher: Lippincott Williams & Wilkins; Third Edition edition (April 21, 2008)
- Language: English
- ISBN-10: 078177022X
- ISBN-13: 978-0781770224
- Product Dimensions: 10.7 x 8.3 x 1.3 inches