Pathology of the Female Reproductive Tract, by design, is dynamic, comprehensive and thorough, but pithy and easy to read. A decision we made when planning the 1st edition was to give the book multi-continental flavor. This was to acknowledge the reality that a common medicine is today practiced on an international scale and that the standard of care is no longer local, but global. The many advances discussed throughout the book emanate from many different countries. In this newest edition, 41 authors have been invited to participate, again representing many of the leading institutions throughout the world. As with the 1st edition, we have tried to make the text appear seamless as if prepared by a single author, yet retaining the flavor and indeed the differences that a multitude of authors and editors bring when viewing the same area. The positive response from our readers has reaffirmed the value of this approach.
Several aspects of the second edition are new. By involving many new authors, perspectives on presentation for individual organs by necessity have differed. In some instances, this is because medicine has evolved. Emerging new concepts about the pathogenesis of endometrial carcinoma have led to an entire new body of work on separating those lesions that are precancerous, now called endometrial intraepithelial neoplasia, from those that have histologic appearances of hyperplasia, but are biologically benign (Chapter 15). Knowledge has also exploded in our understanding of the relation between human papilloma virus (HPV) and the pathogenesis of cervical neoplasia, with new understanding about the biology of those precancerous lesions that themselves might regress spontaneously (Chapters 7 and 8). We see the beginning of major insights being made in endometrial cancer and ovarian cancer. To the extent possible, these insights are incorporated into this edition, although we anticipate a plethora of new findings in the next decade. The development of reliable immunohistochemical techniques, some borrowing from molecular diagnostics, have provided pathologists with new tools to explore what until recently was considered classical pathology. Both chapters 1 (embryology) and 34 (disorders of sexual development, also abnormal sexual development or intersex) heavily explore the histochemical, biochemical and genetic changes that take place over time.
A goal of this book, although never explicitly stated in the first edition, is that all of the concepts and findings presented could be used today in everyday practice. The book was not written to discuss theory, but rather what could be put into practice today. Hence, many pearls are included that we use in our daily practices. Further, a new chapter (chapter 36) was added that systematically details the many immunohistochemical markers useful in gynecologic pathology. We hope this proves a useful reference.
If there is one area in which the editors have strayed into the future, it regards the importance of both synoptic reporting and coding, both of which make the reports rendered useful to the clinicians and managers of the electronic record in which the reports appear. Since publication of the first edition of this book, the College of American Pathologists (CAP) has entered into two key agreements that are having a major impact on all of medicine. The College has authorized the American College of Surgeons (ACS) to utilize CAP derived standardized data elements and synoptic report formats. In turn, the American College of Surgeons now requires that for an institutional tumor registry to be ACS certified, all pathology reports must incorporate pathology reporting elements deemed critical by the CAP. Synoptic reports ensure that all relevant information is included in the diagnosis rendered, allowing for better treatment of patients and easier comparison of findings across institutions. The elements of synoptic reporting are covered in Appendix C. The second major event occurred in 2005 when the coding system the CAP developed (SNOMED, or Systematized Nomenclature of Medicine) which also incorporated the United Kingdom's Clinical Terms Version 3) was adopted by the US National Library of Medicine as the major language of healthcare. The importance of this language and its role as a critical element of electronic healthcare is described in appendix D.
To keep the volume current and manageable for the reader, the authors have emphasized inclusion of references published since 2000. To the extent feasible, earlier articles have been pruned as they are now general knowledge and easily accessible from various databases. Further, current review articles have been given preference rather than the original older articles. The review articles often provide new insights and advances not present in the original.
Finally, during the intense multiyear endeavor required to prepare both the prior and this edition, your editors have enjoyed a buoyant spirit and have tried to portray this in the various chapters. Except where deemed outrageous by either the editors from Elsevier or our wives, we have left several purposeful elements of humor embedded in the text. Like the children's series, “Where's Elmo”, we challenge the reader to find these inclusions.
Stanley J. Robboy, George L. Mutter, Jaime Prat, Rex C. Bentley, Peter Russell, Malcolm C. Anderson
Contents
- Chapter 1 - Embryology
- Chapter 2 - Vulvar dermatoses and infections
- Chapter 3 - Vulvar cysts, neoplasms, and related lesions
- Chapter 4 - Vulvar mesenchymal neoplasms and tumor-like conditions
- Chapter 5 - Vagina
- Chapter 6 - Cervical benign and non-neoplastic conditions
- Chapter 7 - Cervix: epidemiology of squamous neoplasia
- Chapter 8 - Cervical precancer (intraepithelial neoplasia), including functional biomarkers and colposcopy
- Chapter 9 - Cervical squamous cell carcinoma
- Chapter 10 - Cervical glandular neoplasia
- Chapter 11 - Miscellaneous cervical neoplasms
- Chapter 12 - The normal endometrium
- Chapter 13 - Exogenous hormones and their effects on the endometrium
- Chapter 14 - Endometritis, metaplasias, polyps, and miscellaneous changes
- Chapter 15 - Benign endometrial hyperplasia and EIN
- Chapter 16 - Endometrial adenocarcinoma
- Chapter 17 - Mesenchymal uterine tumors, other than pure smooth muscle neoplasms, and adenomyosis
- Chapter 18 - Uterine smooth muscle tumors
- Chapter 19 - Fallopian tube
- Chapter 20 - Endometriosis
- Chapter 21 - Normal ovaries, inflammatory and non-neoplastic conditions
- Chapter 22 - Ovarian cysts, tumor-like, iatrogenic and miscellaneous conditions
- Chapter 23 - Ovarian neoplasia: epidemiology and etiology
- Chapter 24 - Ovarian serous and mucinous epithelial–stromal tumors
- Chapter 25 - Ovarian endometrioid, clear cell, Brenner, and rare epithelial–stromal tumors
- Chapter 26 - Ovarian sex cord-stromal and steroid cell tumors
- Chapter 27 - Ovarian germ cell tumors
- Chapter 28 - Ovarian lymphoid and hematopoietic neoplasms
- Chapter 29 - Ovarian tumors: miscellaneous and metastatic
- Chapter 30 - Nidation and placenta
- Chapter 31 - Placenta – clinical scenarios
- Chapter 32 - Gestational trophoblastic disease
- Chapter 33 - The peritoneum
- Chapter 34 - Disorders of sexual development
- Chapter 35 - Cutup – gross description and processing of specimens
- Chapter 36 - Immunohistochemical and functional biomarkers of value in female genital tract lesions
APPENDICES
- Appendix A: FIGO staging rules of cancers of the female genital tract
- Appendix B: Histologic classification of tumors and precursor conditions of the female genital tract
- Appendix C: Synoptic reports/checklists
- Appendix D: Coding with SNOMED CT (Systematized Nomenclature of Medicine-Clinical Terminology)
- Appendix E: Abbreviations
Key Features
- Covers all benign and malignant disorders of the female genital tract to provide you with a comprehensive resource for use in the reporting room or in formal study.
- Offers a complete visual guide to each tumor or tumor-like lesion to assist you in the recognition and diagnosis of any tissue sample under the microscope with over 2500 high-quality, full-color illustrations.
- Provides expert advice on how to avoid diagnostic errors with practical advice on pitfalls in differential diagnosis.
- Integrates histopathologic features with data from ancillary techniques such as immunohistochemistry and cytogenetics and discussions of the relevant clinical manifestations of gynecological diseases to provide you with the necessary tools to make a comprehensive diagnostic workup.
- Features summary tables, diagnostic flow charts, and analytic tables to facilitate rapid interpretation and accurate diagnosis.
- Approaches definitions, clinical features, gross features, microscopic features, and differential diagnosis consistently and uniformly for quick and easy access to the information you need.
- Readers praise its readability and practicality for both daily and reference use by both the novice and experienced pathologist.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
- Path Consult DDX Fundamentals Maximize clinical efficiency and productivity with Path Consult, an easy-to-use online resource that will help you quickly and easily confirm diagnoses.
New to this edition
- Features a "Road map" at the beginning of each chapter to help you navigate and access the material more quickly.
- Provides you with the latest advances in immunohistochemistry to reflect the development of reliable techniques.
- Covers cytology more extensively, including cytologic/histologic correlations, additional cytologic images, and additional material on differential diagnosis to reflect modern diagnostic practice.
- Includes the latest classification and staging systems for all diseases and disorders of the female genital tract, so you can provide the referring physicians with the most accurate and up-to-date diagnostic and prognostic indicators possible.
- Uses more bullet points, diagnostic flowcharts, decision-making algorithms, and summary tables to make it even easier to find what you need.
Product Details
- Hardcover: 1104 pages
- Publisher: Churchill Livingstone; 2 edition (October 29, 2008)
- Language: English
- ISBN-10: 0443074771
- ISBN-13: 978-0443074776
List Price: $350.00