A major challenge in assembling this text was finding a niche not already occupied by any of the other excellent books touching upon diagnostic virology. This inspired a significant reorganization. As in previous editions, the work is divided into two parts. Part one is similar in scope to that of the previous editions and provides a detailed description of the various techniques forming the foundation of modern diagnostic virology. Part two, on the other hand, presented a greater challenge. A simple listing of virus families and their various clinical manifestations was clearly the easiest option, but this approach has already been well traveled.
Instead, the authors have taken a syndromic approach, an idea originally suggested by my colleague, Dr. Yi-Wei Tang. Thus, if presented with a patient having symptoms of viral encephalitis, for example, readers can now refer to the chapter on CNS infections, where they will find a differential diagnosis of potential causative agents, along with suggestions for the appropriate diagnostic approach. While this reorganization has brought its own challenges in avoiding redundancy and omissions, this unique approach will make the book particularly valuable to students of infectious disease as well as laboratorians.
Clinical virology has changed at an astounding pace in the 10 years since publication of the previous edition, and this edition has been completely rewritten to reflect this new reality. Molecular techniques continue to grow in importance and are covered in depth by new chapters on a variety of topics, including the design of molecular tests, the importance of genotyping and viral sequence analysis, and the use of microarrays in diagnostic virology. Another emerging theme is the increased awareness of global health issues, reflected here by a new chapter regarding viral testing in resource-limited settings. Finally, new associations continue to be made between clinical disease and viruses, and these are discussed in the chapters on respiratory infections, polyomavirus infections, hemorrhagic fevers, and elsewhere throughout the book. Contents
1. Verification and Validation of Virological Laboratory Tests in the Routine Diagnostic Laboratory
2. Statistical Evaluation of Diagnostic Tests
3. Molecular Amplification Methods in Diagnostic Virology
4. Viral Genotyping and the Sequencing Revolution
5. Design of Molecular Virologic Tests
6. Microarray Detection of Viruses
7. Virus Isolation
8. Diagnosis by Viral Antigen Detection
9. Serologic Tests in Clinical Virology
10. Surgical Pathology and Diagnostic Cytology of Viral Infections
11. Electron Microscopy of Viral Infections
12. Laboratory Diagnosis of Viruses in Resource-Limited Settings
13. Antiviral Therapy
14. Common Viral Infections of Childhood
15. Respiratory Virus Infections
16. Gastrointestinal Tract Infections
17. Infections of the Skin and Mucosa
18. Cardiovascular Viral Infections
19. Viral Hepatitis
20. Viral Hemorrhagic Fevers
21. Infections of the Central Nervous System
22. Sexually Transmitted Infections
23. Human Immunodeficiency Viruses: HIV-1 and HIV-2
24. Diagnosis of Polyomavirus Infection, Replication, and Disease
25. Ocular Viral Infections
26. Arthropod-Borne Viruses
27. Viral Infections of the Immunocompromised Host
Index
Book Details
- Hardcover: 510 pages
- Publisher: Informa Healthcare; 4 edition (March 26, 2010)
- Language: English
- ISBN-10: 142008495X
- ISBN-13: 978-1420084955
- Product Dimensions: 10.1 x 7.1 x 1.5 inches