The antiphospholipid syndrome (Hughes syndrome) is now over a quarter of a century old. Although most of the major clinical features were described in the original papers between 1983 and 1985, the ensuing 25 years have seen a filling out of the clinical detail and recognition that the syndrome is of major medical importance.
More significantly, much has been learnt of the prevalence and epidemiology of the syndrome as well as the biology of the thrombotic process so central to the condition. Sadly, all that lags behind is treatment, the choice of drugs still very limited.
The syndrome now embraces all disciplines. It is now regarded as the commonest treatable cause of recurrent pregnancy loss, and has changed the face of obstetrics. It has become a major chapter in the field of neurology, being an important cause of stroke, migraine, seizures, and memory loss. In cardiology, it is at last becoming recognized as an important cause of young heart attacks, as well as providing leads in the study of accelerated atheroma.
And so the list goes on – idiopathic bone fracture, abdominal angina, renal vascular hypertension, leg ulcers…
This book, produced by clinical leaders in the field, brings together the many strands of another “great mimic”.
Contents
1 History
2 Epidemiology
3 Antiphospholipid Antibodies
3.1 Anticardiolipin Antibodies
3.2 Lupus Anticoagulant
3.3 Other aPL
3.3.1 Anti-b2GPI Antibodies
3.3.2 Antiprothrombin Antibodies
3.3.3 Other Specificities
3.4 Antiphospholipid Antibodies as Diagnostic Markers
3.5 Indications for aPL Testing
References
4 Classification Criteria for APS
References
5 Mortality, Morbidity, and Damage Associated with aPL
More significantly, much has been learnt of the prevalence and epidemiology of the syndrome as well as the biology of the thrombotic process so central to the condition. Sadly, all that lags behind is treatment, the choice of drugs still very limited.
The syndrome now embraces all disciplines. It is now regarded as the commonest treatable cause of recurrent pregnancy loss, and has changed the face of obstetrics. It has become a major chapter in the field of neurology, being an important cause of stroke, migraine, seizures, and memory loss. In cardiology, it is at last becoming recognized as an important cause of young heart attacks, as well as providing leads in the study of accelerated atheroma.
And so the list goes on – idiopathic bone fracture, abdominal angina, renal vascular hypertension, leg ulcers…
This book, produced by clinical leaders in the field, brings together the many strands of another “great mimic”.
1 History
2 Epidemiology
3 Antiphospholipid Antibodies
3.1 Anticardiolipin Antibodies
3.2 Lupus Anticoagulant
3.3 Other aPL
3.3.1 Anti-b2GPI Antibodies
3.3.2 Antiprothrombin Antibodies
3.3.3 Other Specificities
3.4 Antiphospholipid Antibodies as Diagnostic Markers
3.5 Indications for aPL Testing
References
4 Classification Criteria for APS
References
5 Mortality, Morbidity, and Damage Associated with aPL
6 Differences Between Primary and Secondary APS
7 Clinical Features
7.1 Central Nervous System Involvement
7.1.1 Cerebral Ischemia
7.1.2 Subcortical High-Intensity Lesions on Brain MRI
7.1.3 Epilepsy
7.1.4 Multiple Sclerosis-Like Syndrome
7.1.5 Headache
7.2 Cardiac Manifestations
7.2.1 Valvular Disease
7.2.2 Coronary Artery Disease
7.3 Skin Manifestations
7.3.1 Livedo Reticularis
7.3.2 Skin Ulcers
7.4 Renal Disease
7.4.1 Thrombotic Microangiopathy (TMA)
7.4.2 Renal Artery Lesions
7.4.3 Kidney Transplant
7.5 Hemocytopenia
7.5.1 Autoimmune Thrombocytopenia
7.5.2 Autoimmune Hemolytic Anemia (AIHA)
7.6 Obstetric Manifestations
7.7 Catastrophic Antiphospholipid Syndrome
7.8 Pulmonary Hypertension
7.9 Systemic Hypertension
7.10 Osteoarticular Manifestations
7.10.1 Osteonecrosis, Avascular Necrosis or Aseptic Necrosis
7.11 The Ear
7.12 The Eye
8 aPL and Transplantation
9 Differential Diagnosis
10 Management of APS
10.1 Introduction
10.2 Primary Thromboprophilaxis in aPL-Positive Patients
10.3 Management of Thrombosis
10.4 Management of Pregnancy Morbidity
10.4.1 Aspirin
10.4.2 Heparin
10.4.3 Warfarin
10.4.4 Corticosteroids
10.4.5 Other Drugs
10.5 Management of Thrombocytopenia
Appendix: Photographic Examples of Clinical Manifestations of APS
A.1 Skin Manifestations
A.2 Renal Disease
A.3 Obstetric Manifestations
A.4 Systemic Hypertension
A.5 Osteoarticular Manifestations
Index
Book Details
- Paperback: 93 pages
- Publisher: Springer; 1st edition (February 18, 2010)
- Language: English
- ISBN-10: 1846285224
- ISBN-13: 978-1846285226
- Product Dimensions: 7.7 x 5 x 0.3 inches