The first edition of this book published in 1997 was written with the purpose of showing how the convergence of pharmacology and genetics in the new hybrid field of pharmacogenetics is complementary and how individuals more or less susceptible to a given chemical differ from each other by describing the genetics and molecular basis of specific traits of pharmacogenetic importance.
In the 10 or so years since that edition was published, much new pharmacogenetic information has been gathered and many conceptual and technological advances have occurred. To accommodate these changes, the current edition was divided into four sections: Foundations, Fundamentals, Futures, and Synthesis. Foundations describes the origins and defining features of the field. Fundamentals expands on the principles of pharmacogenetics with detailed discussions of the pharmacologic and genetic profiling of human drug response, the molecular aspects of pharmacogenetics, the tools available for pharmacogenomic research and testing, ethnicity in pharmacogenetics, and the modeling of human drug response in experimental systems. Futures discusses the prospects of pharmacogenetics relevant to drug discovery and predictive biology. Synthesis concludes the book with a brief overview of the field.
Contents
I. FOUNDATIONS
1. Beginnings
- Cellular foundations of early pharmacology and genetics
- Molecular foundations of early pharmacology and genetics
- Emergence of modern genetics and experimental pharmacogenetics
- Informational foundations of modern genetics
- The genomics era
- The effect of molecular biology on pharmacogenetics
2. Defining Pharmacogenetics
- The genetic profile of human drug response
- Evidence for individual variation in drug response
- Evidence that variation in drug response is inherited
- Interaction with other fields empowers pharmacogenetics
- Pharmacogenetics is a component of ecogenetics
- The scope of pharmacogenetics
- Strategies for gene identification
- Linking pharmacogenetics to clinical applications
- Summary
II. FUNDAMENTALS
3. Pharmacology of Human Drug Response
- Pharmacology and genetics of human drug response are complementary
- Dose–response relationships
- Pharmacokinetics in pharmacogenetics
- Pharmacogenetic mechanisms of human drug response
- Testing pharmacogenetic hypotheses
- Summary
4. Age-Related Pharmacology
- Age-related physiological variation
- Pharmacokinetic variation
- Pharmacodynamic variation
- Summary
5. Genetics in Pharmacology
- The fine structure of genetic profiling human drug response
- Some elementary features of the human genome
- Framework for dissecting genetic variation in human drug response
- Twin studies
- Inheritance patterns of monogenic traits
- Mathematical treatment of heterogeneity in human drug response
- Molecular pharmacogenetics
- Impediments to pharmacogenetic investigation
- Summary
6. Epigenetics
- The emergence of epigenetics
- The foundations of epigenetics
- The effect of molecular biology on epigenetics
- Epigenetics in health and disease
- Therapeutic potential for epigenetic disease
- Summary
7. Genomic Tools
- Charting the evolution of genomic tools
- Conventional analytical techniques
- Conventional analysis of genetic variants
- Advances in genomic technology
- Emerging technologies
- Summary
8. Ethnic Pharmacogenetics
- Marrying race and ethnicity to genetic variation
- Grappling with race and ethnicity during the twentieth century
- Ethnic specificity in drug response
- Frequency of pharmacogenetic ethnic specificities
- Ethnicity as a starting point for pharmacogenetic investigation
- Ethnic specificity in drug development
- Culturally specific risks of ethnic research
- Summary
9. Modeling Human Drug Response
- Mouse models of pharmacogenetic traits
- Constructing inbred mouse models
- Mouse models of the arylhydrocarbon receptor and N-acetyltransferase polymorphisms
- Creating mouse models by gene targeting
- Mouse models of human disorders created by gene targeting
- Quantitative trait locus (QTL) analysis
- Modeling with simple eukaryotic organisms
- Summary
III. FUTURES
10. Drug Discovery
- Changing pharmaceutical perspectives
- Human drug efficacy targets
- Applying genomics to drug discovery
- Small molecule drug discovery
- Protein therapeutics
- Genetic pathways to improved drug therapy
- Summary
11. Predictive Biology
- Indexing pharmacogenetic knowledge
- Edging toward personalized medicine
- Digging deeper into human genetic variation
- New dimensions in drug discovery
- When good drugs go bad, what to do?
- Summary
- Synthesis
Appendices
- Appendix A
- Appendix B
- Appendix C
Index
About the Author
- Wendell W. Weber, Ph.D., M.D., is Professor at the Pharmacology department at the University of Michigan, Ann Arbor. His teaching and research interests have been concentrated in the area of pharmacogenetics for the past 20 years.
Product Details
- Hardcover: 448 pages
- Publisher: Oxford University Press, USA; 2 edition (April 2, 2008)
- Language: English
- ISBN-10: 0195341511
- ISBN-13: 978-0195341515
- Product Dimensions: 9.3 x 6 x 0.9 inches
List Price: $79.50