Edited by internationally acclaimed experts in the field, this authoritative 2-volume Gold Standard comprehensively covers the neurobiology and diseases of the peripheral nervous system. It encompasses neurobiology, clinical neurophysiology, molecular genetics, and clinical diagnosis and management. The 4th Edition has been rewritten and updated to provide a fresh account of all subjects, with an emphasis on new information about cell biology, genetics, proteomics, clinical manifestations, and new treatments. And, a user-friendly organization allows readers to quickly find specific information, or access more in-depth coverage when needed.
Key Features
- Provides authoritative, in-depth information on neurobiology and diseases of the peripheral nervous system.
- Presents complete coverage of development - anatomy - physiology - pharmacology -special testing (nerve conduction and EMG), autonomic testing, and testing of impairment and disability - and the diagnosis, management, and outcomes for peripheral neuropathies.
- Includes information on epidemiologic survey and pharmaceutical industry trials, with coverage of the complications of diabetes mellitus and other metabolic diseases.
New to This Edition
- Features new clinically oriented sections that discuss key areas such as pain management - peripheral neuropathies and cancer - pediatric management issues - new diagnostic techniques.
- Discusses new developments in molecular genetics, new manifestations of altered immunity, metabolic disease, and course.
- Covers the many new treatment and management techniques now available, including strategies for patients with infections, altered immunity, lymphoma and paraneoplastic neuropathies, and metabolic neuropathies.
- Includes new coverage of the enteric nervous system, management of gut dysmotility, cutaneous receptors and their function, cutaneous innervation, and quantitative sensation testing.
Contents
I. Introduction
- 1. Introduction
II. Structure Of The Peripheral Nervous System
- 2. Gross Anatomy of the PNS
- 3. Microscopic Anatomy of the PNS
III. Function Of The Peripheral Nervous System
- 4. Channel Function in Axons and Sheath Cells
- 5. Nerve Excitability Measures: Biophysical Basis and Use in the Investigation of Peripheral Nerve Disease
- 6. The Muscle Spindle
- 7. The Golgi Tendon Organ
- 8. The Peripheral Sensory Nervous System: Dorsal Root Ganglion Neurons
- 11. Neurologic Control of Cardiac Function
- 12. Neurobiology of Autonomic Peripheral Ganglia
- 13. Neurobiology of the Enteric Nervous System
- 14. Autonomic and Somatic Systems to the Anorectum and Pelvic Floors
- 15. Autonomic Systems to the Urinary Bladder & Sexual Organs
- 16. Sympathetic nerves and control of blood vessels to human limbs
IV. Neurobiology Of The Peripheral Nerve System
- 17. Molecular Signaling in Schwann Cell Development
- 18. Growth Factors of the PNS
- 19. Axonal Flow
- 20. Myelination
- 21. The Control of Axonal Caliber
- 22. Guidance of Axons to Targets in Development and in Disease
- 23. Aging of the PNS
- 24. Oxidative Stress and Excitatory Neurotoxins
- 25. Transgenic Models of Nerve Degeneration
V. Neuroimmunology Of The Peripheral Nervous System
- 26. Introduction to Immune Reactions in the PNS
- 27. Peripheral Nerve Antigens
- 28. Experimental Autoimmune Neuritis (EAN)
- 29. Fundamentals of Immune Therapy
VI. Functional Compartments And Nerve-fiber Environment
- 30. The Blood Nerve Barrier
- 31. Nerve Blood Flow and Nerve Fiber Microenvironment
VII. Pathology
- 32. Pathology of Peripheral Neuron Cell Bodies
- 33. Pathologic Alterations of Nerves
- 34. Pathology of the Neuromuscular Junction
- 35. Pathology and Quantitation of Cutaneous Innervation
VIII. Nerve Conduction And Electromyography
- 36. Nerve Conduction and Needle Electromyography
- 37. Nerve Tests Expressed as Percentiles, Normal Deviates and Composite Scores
- 38. Single Fiber Electromyography
- 39. Single-unit Recordings of Afferent Human Peripheral Nerves by Microneurography
- 40. Compound Action Potential of Sural Nerves in Vitro
IX. Quantitating Symptoms, Impairments And Outcomes
- 41. Quantitating Neuropathic Symptoms, Impairments and Outcomes
- 42. Health Outcomes and Quality of Life
- 43. Quantitation of Sensory Abnormality
- 44. Quantitation of Muscle Contraction & Strength
- 45. Quantitation of Autonomic Impairment
X. Diseases Of The Peripheral Nervous System
Part A. Differential Diagnoses and Epidemiology
- 46. Clinical Patterns
- 47. Differential Diagnoses of Polyneuropathy
- 48. Epidemiologic Approaches to Peripheral Neuropathy
Part B. Diseases of Cranial Nerves
- 49. Diseases of the Third, Fourth, and Sixth Cranial Nerves
- 50. Diseases of the Fifth Cranial Nerve
- 51. Diseases of the Seventh Cranial Nerve
- 52. Diseases of the Eighth Cranial Nerve
- 53. Diseases of the Ninth, Tenth, Eleventh, and Twelfth Cranial Nerves
Part C. Diseases of Spinal Cord, Spinal Roots, and Limb Girdle Plexuses
- 54. Myelopathies Affecting Anterior Horn Cells and Centrally Directed Afferent Axons in Posterior
- Horns and Columns
- 55. Diseases of Spinal Roots
- 56. Mechanical Compression, Traction, Electrical Radiation and Neoplastic Infiltration of the Brachial Plexus
- 57. Diseases of Spinal Cord, Spinal Roots, and Limb-Girdle Plexuses
Part D. Neuropathy Due to Compression, Entrapment or Physical Injury
- 58. Mechanisms of Nerve Injury from Compression, Entrapment, Traction and Ischemia
- 59. Mechanisms of Repair After Traumatic Injury
- 60. Median Neuropathy
- 61. Upper Limb Neuropathies: suprascapular, axillary, nerve to serratus anterior, radial and ulnar
- 62. Lower Limb Neuropathies
- 63. Operating on Peripheral Nerves
Part E. Sporadic Motor Neuron Disease
- 64. Sporadic Motor Neuron Degeneration
Part F. Basis of Inherited Disease
- 65. Mendelian and Mitochondrial Inheritance, Gene Identification, and Clinical Testing
- 66. Transgenic Models of Inherited Neuropathy
Part G. Inherited Motor Neuron Degeneration
- 67. Transgenic Models of ALS
- 68. Inherited Motor Neuron Degeneration
- 69. Hereditary Motor Neuropathies (Spinal Muscular Atrophies)
Part H. Hereditary Motor and Sensory Neuropathies
- 70. Principles of Classifications, Clinical Syndromes
- 71. Disorders Related to PMP22 Mutations
- 72. The Hereditary Motor and Sensory Neuropathies (HMSN)
About the Authors
- Peter James Dyck, MD, Professor of Neurology, Department of Neurology, Mayo Clinic, Rochester, MN.
- P. K. Thomas, DSc MD FRCP LRCP FRCPath, Department of Neurological Science, Royal Free Hospital, London, UK.
Product Details
- Hardcover: 2992 pages
- Publisher: Saunders; 4 edition (March 24, 2005)
- Language: English
- ISBN-10: 0721694918
- ISBN-13: 978-0721694917
- Product Dimensions: 11.5 x 9.2 x 5.7 inches
List Price: $490.00