Clinical trial and guideline basis for compelling indications for antihypertensive drugs

1. Hipertension with Heart failure

Recommended Drugs:

• ACE Inhibitors
• Aldosterone Antagonist
• ARB
• β-Blockers
• CCB
• Diuretic

Clinical Trial Basis:

• ACC/AHA Heart Failure Guideline
• MERIT-HF
• COPERNICUS
• CIBIS
• SOLVD
• AIRE
• TRACE
• ValHEFT
• RALES

2. Hipertension with Post-myocardial infarction

Recommended Drugs:

• ACE Inhibitors
• Aldosterone Antagonist
• β-Blockers

Clinical Trial Basis:

• ACC/AHA Post-MI Guideline
• BHAT
• SAVE
• Capricorn
• EPHESUS

3. Hipertension with High coronary disease risk

Recommended Drugs:

• ACE Inhibitors
• ARB
• β-Blockers
• CCB
• Diuretic

Clinical Trial Basis:

• ALLHAT
• HOPE
• ANBP2
• LIFE
• CONVINCE

4. Hipertension with Diabetes mellitus

Recommended Drugs:

• ACE Inhibitors
• ARB
• β-Blockers
• CCB
• Diuretic

Clinical Trial Basis:

• NKF-ADA Guideline
• UKPDS
• ALLHAT

5. Hipertension with Chronic kidney disease

Recommended Drugs:

• ACE Inhibitors
• ARB

Clinical Trial Basis:

• NKF Guideline
• Captopril Trial
• RENAAL
• IDNT
• REIN
• AASK

6. Hipertension with Recurrent stroke prevention

Recommended Drugs:

• ACE Inhibitors
• Diuretic

Clinical Trial Basis:

• PROGRESS

Source: CMDT 2013