Cohen: Infectious Diseases 3rd Edition (Expert Consult Series)






These are extraordinary times in the fields of microbiology and infectious diseases. The genomes of essentially all the major bacterial and viral pathogens known to infect humankind have now been sequenced and are available on public databases. The human genome project is now complete and whole genome sequencing of the major malaria parasite Plasmodium falciparum and the common fungal pathogen Candida albicans are now available on line. We have learned an enormous amount of new information about the molecular mechanisms that underlie microbial pathogenesis and the host response to pathogens since the second edition of this book some five years ago. An expanding number of antiviral and antifungal agents are now available to clinicians, and new generations of vaccine constructs and adjuvants are now entering clinical practice.
Despite these advances, progress has been uneven with very little in the developmental pipeline for novel antibacterial agents, anti-tuberculosis drugs, or chemotherapeutic agents against parasitic infection. We find ourselves increasingly on the defensive against a variety of newly emerging and remerging pathogens. The specter of progressive antimicrobial resistance now threatens the long-term viability of the very foundation of our primary treatment approach against bacterial pathogens, including extensively drug resistant tuberculosis (XDR-TB). Our collective vulnerability to airborne pathogens within our highly mobile and crowded global community has become poignantly evident with the H1N1 swine flu pandemic of 2009 and ongoing threats of human dissemination of H5N1 avian influenza strains. Environmental disruption and global warming largely attributable to our ever expanding human population is likely to have adverse health consequences; among them with be the spread of vector-borne, water-borne and airborne pathogens.
In preparing this third edition we have continued the themes that initially inspired the creation of this textbook of Infectious Diseases. The book maintains its tradition of well illustrated and tightly referenced chapters with an emphasis on clinical practicality along with a detailed review of disease pathogenesis and microbiology. Practice points are found throughout the text that highlight common, and not so common, clinical scenarios that require specific and targeted information to provide informed responses. The interactive website, complete with its frequently updated information sources and a downloadable set of illustrations, will continue to support the print version of the text and now includes a number of innovative new functions. The whole text has been carefully reviewed, many chapters have been totally re-written with new figures added, and new authors and editors have been commissioned to ensure that the material is fresh, up to date and relevant.
We are indebted to the superb group of section editors and the extensive collection of highly skilled, international, contributors for each chapter, without whom the third edition of this book would not have been possible. We would especially like to extend our sincere gratitude to Sue Hodgson, Sven Pinczewski, Poppy Garraway and the staff at Elsevier for their unflappable spirit and their attention to detail throughout this considerable undertaking. Finally, we thank the Section Editors from the second edition who have now stood down: Steven Holland, Dennis Maki, Ragnar Norrby, Allan Ronald, Claus Solberg and Jan Verhoef without whom we would never have been in the position of preparing a third edition. We trust that our readers will find the readily accessible knowledge distilled into these pages to have been well worth the effort in generating the Third Edition of Infectious Diseases.
Jon Cohen, William Powderly, Steven Opal

Key Features
  • Find a diagnosis quickly with the popular Diseases by Body System Section.
  • Stay well informed with expanded and updated coverage of nonsocomial infections and much more.
  • Receive unparalleled visual guidance from hundreds of full-color photographs and figures.
  • Quickly search information with a consistent chapter organization and colorful page layouts.
  • Get clinically-focused guidance from "Practice Points," which demonstrate how to diagnose and treat complicated problems encountered in practice.
  • Make effective diagnoses with a more efficient approach to differential diagnosis-discussions of conditions are presented in proportion to their incidence.
  • Gain a more international view from editors and authors, patient photographs, and treatment perspectives from around the world.

Website Features
  • Consult the book from any computer at home, in your office, or at any practice location.
  • Instantly locate the answers to your clinical questions via a simple search query.
  • Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
  • Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
  • Lancet articles: Selected articles from The Lancet and the The Lancet Infectious Diseases are presented.

Contents
Volume 1
Section 1 - Introduction to Infectious Diseases
  • Chapter 1 - Nature and pathogenicity of micro-organisms
  • Chapter 2 - Host responses to infection
  • Chapter 3 - Vaccines and vaccination
  • Chapter 4 - Emerging and re-emerging pathogens and diseases
  • Chapter 5 - Mathematical models in infectious disease epidemiology
  • Chapter 6 - History of infection prevention and control
  • Chapter 7 - Bacterial genomes

Section 2 - Syndromes by Body System
  • Chapter 8 - Viral exanthems
  • Chapter 9 - Cellulitis, pyoderma, abscesses and other skin and subcutaneous infections
  • Chapter 10 - Necrotizing fasciitis, gas gangrene, myositis and myonecrosis
  • Chapter 11 - Arthropods and ectoparasites
  • Chapter 12 - Dermatologic manifestations of systemic infections
  • Chapter 13 - Superficial fungal infections
  • Chapter 14 - Lymphadenopathy
  • Chapter 15 - Conjunctivitis, keratitis and infections of periorbital structures
  • Chapter 16 - Endophthalmitis
  • Chapter 17 - Infectious retinitis and uveitis
  • Chapter 18 - Acute and chronic meningitis
  • Chapter 19 - Encephalitis and myelitis
  • Chapter 20 - Brain abscess and other focal pyogenic infections of the central nervous system
  • Chapter 21 - Tetanus and botulism
  • Chapter 22 - Prion diseases of humans and animals
  • Chapter 23 - Infections in hydrocephalus shunts
  • Chapter 24 - Laryngitis, epiglottitis and pharyngitis
  • Chapter 25 - Otitis, sinusitis and related conditions
  • Chapter 26 - Bronchitis, bronchiectasis and cystic fibrosis
  • Chapter 27 - Community-acquired pneumonia
  • Chapter 28 - Hospital-acquired pneumonia
  • Chapter 29 - Lung abscesses and pleural abscesses
  • Chapter 30 - Tuberculosis and other mycobacterial infections
  • Chapter 31 - Fungal pneumonias
  • Chapter 32 - Orocervical infection
  • Chapter 33 - Gastritis, peptic ulceration and related conditions
  • Chapter 34 - Food-borne diarrheal illness
  • Chapter 35 - Acute diarrhea
  • Chapter 36 - Chronic diarrhea
  • Chapter 37 - Intra-abdominal sepsis, peritonitis and pancreatitis
  • Chapter 38 - Viral hepatitis
  • Chapter 39 - Hepatobiliary and splenic infection
  • Chapter 40 - Infective and reactive arthritis
  • Chapter 41 - Acute and chronic osteomyelitis
  • Chapter 42 - Infections of prosthetic joints and related problems
  • Chapter 43 - Lyme disease
  • Chapter 44 - Sepsis
  • Chapter 45 - Infections associated with intravascular lines, grafts and devices
  • Chapter 46 - Myocarditis and pericarditis
  • Chapter 47 - Endocarditis and endarteritis
  • Chapter 48 - Rheumatic fever
  • Chapter 49 - Vaginitis, vulvitis, cervicitis and cutaneous vulval lesions
  • Chapter 50 - Infections of the female pelvis including septic abortion
  • Chapter 51 - Complications of pregnancy: maternal perspectives
  • Chapter 52 - Implications for the fetus of maternal infections in pregnancy
  • Chapter 53 - Cystitis and urethral syndromes
  • Chapter 54 - Prostatitis, epididymitis and orchitis
  • Chapter 55 - Pyelonephritis and abscesses of the kidney
  • Chapter 56 - Complicated urinary infection, including postsurgical and catheter-related infections
  • Chapter 57 - Syphilis
  • Chapter 58 - Genital herpes
  • Chapter 59 - Papillomavirus infections
  • Chapter 60 - Lymphogranuloma venereum, chancroid and granuloma inguinale
Section 3 - Special Problems in Infectious Disease Practice
  • Chapter 61 - Pathogenesis of fever
  • Chapter 62 - Clinical approach to acute fever
  • Chapter 63 - Fever of unknown origin
  • Chapter 64 - The potential role of infectious agents in diseases of unknown etiology
  • Chapter 65 - Infectious complications following surgery and trauma
  • Chapter 66 - Recreational infections
  • Chapter 67 - Occupational infections
  • Chapter 68 - Infections from pets
  • Chapter 69 - Infections acquired from animals other than pets
  • Chapter 70 - Chronic fatigue syndrome
  • Chapter 71 - Bioterrorism and biodefense
Section 4 - Infections in the Immunocompromised Host
  • Chapter 72 - Immunodeficiencies
  • Chapter 73 - Infections in the neutropenic cancer patient
  • Chapter 74 - Infections in hematopoietic stem cell transplant recipients
  • Chapter 75 - Infection in solid organ transplantation
  • Chapter 76 - Heart, lung and heart–lung transplantation
  • Chapter 77 - Liver transplantation
  • Chapter 78 - Pancreatic transplantation
  • Chapter 79 - Intestinal transplantation
  • Chapter 80 - Kidney transplant patients
  • Chapter 81 - Vasculitis and other immunologically mediated diseases
  • Chapter 82 - Splenectomy and splenic dysfunction
  • Chapter 83 - Vaccination of the immunocompromised patient

Volume 2
Section 5 - HIV and AIDS
  • Chapter 84 - Epidemiology of HIV infection
  • Chapter 85 - Prevention of HIV transmission through behavioral change and sexual means
  • Chapter 86 - Preventing occupational HIV infection in the health-care environment
  • Chapter 87 - HIV vaccines: past failures and future scientific challenges
  • Chapter 88 - The immunopathogenesis of HIV-1 infection
  • Chapter 89 - Primary HIV infection
  • Chapter 90 - Prevention of opportunistic infections
  • Chapter 91 - Opportunistic infections
  • Chapter 92 - Disorders of immune reconstitution in patients with HIV infection
  • Chapter 93 - Tuberculosis in HIV
  • Chapter 94 - Neoplastic disease
  • Chapter 95 - Dermatologic manifestations of HIV infection
  • Chapter 96 - HIV/AIDS-related problems in developing countries
  • Chapter 97 - HIV infection in children
  • Chapter 98 - Special problems in women who have HIV disease
  • Chapter 99 - Principles of management of HIV in the developed world
  • Chapter 100 - Antiviral therapy
Section 6 - International Medicine
  • Chapter 101 - Geography of infectious diseases
  • Chapter 102 - Pretravel advice and immunization
  • Chapter 103 - Leprosy
  • Chapter 104 - Endemic treponematoses
  • Chapter 105 - African trypanosomiasis
  • Chapter 106 - Other parasitic infections of the central nervous system
  • Chapter 107 - Eye infections in the tropics

  • Chapter 108 - Parasitic infections of the gastrointestinal tract
  • Chapter 109 - Typhoid fever and other enteric fevers
  • Chapter 110 - Amebic infections
  • Chapter 111 - Malaria
  • Chapter 112 - Schistosomiasis
  • Chapter 113 - Cestode and trematode infections
  • Chapter 114 - Hydatid disease
  • Chapter 115 - Filariasis
  • Chapter 116 - Infections in sickle cell disease
  • Chapter 117 - Leishmaniasis
  • Chapter 118 - Chagas disease (American trypanosomiasis)
  • Chapter 119 - Melioidosis
  • Chapter 120 - Plague
  • Chapter 121 - Tularemia
  • Chapter 122 - Scrub typhus and other tropical rickettsioses
  • Chapter 123 - Brucellosis
  • Chapter 124 - Leptospirosis
  • Chapter 125 - Relapsing fevers
  • Chapter 126 - Viral hemorrhagic fevers
  • Chapter 127 - Dengue
  • Chapter 128 - Anthrax
Section 7 - Anti-Infective Therapy
  • Chapter 129 - Principles of anti-infective therapy
  • Chapter 130 - Mechanisms of action
  • Chapter 131 - Mechanisms of antibacterial resistance
  • Chapter 132 - Antibiotic prophylaxis
  • Chapter 133 - Non-inpatient parenteral antimicrobial therapy
  • Chapter 134 - β-Lactam antibiotics
  • Chapter 135 - Macrolides, ketolides, lincosamides and streptogramins
  • Chapter 136 - Oxazolidinones
  • Chapter 137 - Aminoglycosides
  • Chapter 138 - Folate inhibitors
  • Chapter 139 - Quinolones
  • Chapter 140 - Glycopeptides
  • Chapter 141 - Tetracyclines and chloramphenicol
  • Chapter 142 - Nitroimidazoles: metronidazole, ornidazole and tinidazole
  • Chapter 143 - Antituberculosis agents
  • Chapter 144 - Miscellaneous agents: fusidic acid, nitrofurantoin and spectinomycin
  • Chapter 145 - Antiretroviral agents
  • Chapter 146 - Drugs for herpesvirus infections
  • Chapter 147 - Antiviral agents against respiratory viruses
  • Chapter 148 - Drugs to treat viral hepatitis
  • Chapter 149 - Antifungal agents
  • Chapter 150 - Antiparasitic agents
Section 8 - Clinical Microbiology
  • Chapter 151 - Acute gastroenteritis viruses
  • Chapter 152 - Measles, mumps and rubella viruses
  • Chapter 153 - Human enteroviruses
  • Chapter 154 - Hepatitis viruses
  • Chapter 155 - Herpesviruses
  • Chapter 156 - Papillomaviruses
  • Chapter 157 - Polyomaviruses
  • Chapter 158 - Parvoviruses
  • Chapter 159 - Poxviruses
  • Chapter 160 - Rabies and rabies-related viruses
  • Chapter 161 - Influenza viruses
  • Chapter 162 - Respiratory viruses
  • Chapter 163 - Retroviruses and retroviral infections
  • Chapter 164 - Zoonotic viruses
  • Chapter 165 - Staphylococci and micrococci
  • Chapter 166 - Streptococci, enterococci and other catalase-negative cocci
  • Chapter 167 - Aerobic Gram-positive bacilli
  • Chapter 168 - Neisseria
  • Chapter 169 - Enterobacteriaceae
  • Chapter 170 - Pseudomonas spp., Acinetobacter spp. and miscellaneous Gram-negative bacilli
  • Chapter 171 - Curved and spiral bacilli
  • Chapter 172 - Gram-negative coccobacilli
  • Chapter 173 - Anaerobic bacteria
  • Chapter 174 - Mycobacteria
  • Chapter 175 - Mycoplasma and Ureaplasma
  • Chapter 176 - Rickettsia and rickettsia-like organisms
  • Chapter 177 - Chlamydia
  • Chapter 178 - Opportunistic and systemic fungi
  • Chapter 179 - Superficial and subcutaneous fungal pathogens
  • Chapter 180 - Protozoa: intestinal and urogenital amebae, flagellates and ciliates
  • Chapter 181 - Protozoa: intestinal coccidia and microsporidia
  • Chapter 182 - Protozoa: free-living amebae
  • Chapter 183 - Blood and tissue protozoa
  • Chapter 184 - Helminths


Product Details
  • Hardcover: 2070 pages
  • Publisher: Mosby; 3 edition (May 11, 2010)
  • Language: English
  • ISBN-10: 0723435030
  • ISBN-13: 978-0723435037
List Price: $435.00
 

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