This third edition has brought about significant changes to the editorial team, which now includes friends and colleagues from the other side of the Atlantic, Andres Blei and Scott Friedman. This has achieved objective of making the Textbook more international.
The Textbook present the substantial scientific progress that has taken place over the last few years: concepts such as genomics, proteomics, gene arrays, metabolomics, bioinformatics, stem cells, molecular and cell biology, and genetics are now extensively covered throughout the book.
The most significant changes can probably be seen in the sections on functions of the liver, basic concepts of pathobiology, assessment of hepatobiliary disease, portal hypertension and its complications, congenital hepatic fibrosis and non-parasitic cystic diseases of the liver, hepatic non-alcoholic steatosis, tumours of the liver, liver transplantation, and mathematics in hepatology. The Textbook use tables and figures to aid interpretation and understanding. The scientific information is current and exhaustive and is essential for clinical decision making whether diagnostic or therapeutic. This book fulfils the requisites necessary for it to be highly useful for translational research.
Section 1 Architecture of the liver
1.1 Macroscopic anatomy of the liver
1.2 Liver and biliary tract histology
1.3 Ultrastructure of the hepatocyte
1.4 Liver sinusoidal endothelial cells
1.5 Kupffer cells
1.6 The hepatic stellate cell
1.7 Biliary epithelial cells
1.8 Hepatic stem cells
1.9 Embryology of the liver and intrahepatic biliary tract
Section 2 Functions of the liver
2.1 Hepatic circulation
2.1.1 Regulation of hepatic blood flow
2.1.2 Hepatic microcirculation
2.1.3 Hepatic lymph and lymphatics
2.2 Functions of the liver
2.2.1 Functional organization of the liver
2.2.2 Cell biology of the hepatocyte
2.2.3 Molecular biology of the liver cell
2.2.4 Hepatic transport processes
2.2.5 Modulation of liver function by hepatic nerves
2.2.6 In vitro techniques: isolated organ perfusion, slices, cells and subcellular elements
2.3 Metabolism : Intermediate metabolism
2.3.1 Carbohydrates and the liver
2.3.2 Lipoprotein metabolism
2.3.3 Protein and amino acid metabolism
2.3.4 Mitochondria and energy formation
Liver-specific functions
2.3.5 Bilirubin metabolism
2.3.6 Metabolism of bile acids
2.3.7 Ammonia, urea production and pH regulation
2.3.8 Protein synthesis and degradation in the liver
2.3.9 Glutathione
2.3.10 Haem biosynthesis and excretion of porphyrins
Metabolism of endo/xenobiotics
2.3.11 Vitamins and the liver (A and D)
2.3.12 Normal iron metabolism
2.3.13 Normal copper metabolism and reducing copper to subnormal levels for therapeutic purposes
2.3.14 Trace elements and the liver
2.3.15 Hepatic metabolism of drugs
2.4 Synthetic function
2.4.1 Albumin and other carrier proteins
2.4.2 The liver and coagulation
2.4.3 Function and metabolism of collagen and other extracellular matrix proteins
2.5 Regulation of the liver cell mass
2.5.1 Control of liver cell proliferation
2.5.2 Regeneration of chronically injured liver
2.6 Excretion
2.6.1 Physiology of bile formation
2.6.2 Motility of the biliary tree
2.7 Immunology of the liver
2.7.1 Cytokines in liver physiology and liver pathology
2.7.2 Intrahepatic lymphocytes
2.7.3 Antibody production and transport in the liver
Section 3 Basic concepts in pathobiology
3.1 Hepatocyte apoptosis and necrosis
3.2 Ischaemia-reperfusion injury to the liver
3.3 Genetics and liver diseases
3.3.1 Genetic polymorphisms in liver disease
3.3.2 Immunogenetics of liver disease
3.3.3 Genetic determinants of complex liver diseases: mouse models and quantitative trait locus analysis
3.4 Cellular cholestasis
3.5 Oncogenes and tumour suppressor genes
3.6 Genomics, gene arrays and proteomics in the study of liver disease
Section 4 Pathology
4.1 Histological features
4.2 Classifications, scoring systems and morphometry in liver pathology
Section 5 Investigation of hepatobiliary disease
5.1 Signs and symptoms of liver disease
5.2 Biochemical investigations in the management of liver disease
5.3 Hepatic removal kinetics: importance for quantitative measurements of liver function
5.4 Immunological investigations in liver diseases
5.5 Biopsy and laparoscopy
5.6 Imaging of the liver
5.6.1 Ultrasonography
5.6.2 Computerized tomography imaging of the liver
5.6.3 Magnetic resonance imaging
5.6.4 Angiography
5.6.5 Endoscopic retrograde cholangiopancreatography
5.7 Interventional radiology in hepatobiliary diseases
5.8 Positron emission tomography of the liver
5.9 Splanchnic haemodynamic investigations
5.10 The Cochrane Hepatobiliary Group
Section 6 Cirrhosis
6.1 The evolution of cirrhosis
6.2 Cellular and molecular pathobiology of liver fibrosis and its pharmacological intervention
6.3 Clinical and diagnostic aspects of cirrhosis
Section 7 Portal hypertension and its complications
7.1 Anatomy of the portal venous system in portal hypertension
7.2 Pathogenesis of portal hypertension
7.3 Clinical manifestions and management of bleeding episodes in cirrhotics
7.4 Haemodynamic assessment of portal hypertension
7.5 Pathogenesis, diagnosis and treatment of ascites in cirrhosis
7.6 Hepatorenal syndrome
7.7 Pulmonary complications of portal hypertension
7.8 Hepatic encephalopathy
7.9 Bacterial infections in portal hypertension
7.10 Hypersplenism
Section 8 Congenital hepatic fibrosis and non-parasitic cystic lesions of the liver and bile ducts
8.1 Congenital conditions
8.1.1 Congenital hepatic fibrosis
8.1.2 Simple cyst of the liver
8.1.3 Polycystic kidney disease
8.1.4 Polycystic liver disease
8.1.5 Biliary hamartomas
8.1.6 Peribiliary cysts
8.1.7 Caroli syndrome
8.1.8 Choledochal cyst
8.1.9 Ciliated hepatic foregut cyst
8.2 Acquired conditions
8.2.1 Inflammatory cystic diseases
8.2.2 Neoplasms including cystadenoma
8.2.3 Post-traumatic cystic diseases
Section 9 Viral infections of the liver
9.1 Viral hepatitis
9.1.1 Viral hepatitis
9.1.2 The viruses of hepatitis
i) Structure, replication and laboratory diagnosis of hepatitis B virus and hepatitis D virus
ii) Structure, replication and laboratory diagnosis of hepatitis C virus
iii) Hepatitis A
iv) Hepatitis B
v) Hepatitis D
vi) Hepatitis C
vii) Hepatitis E
9.1.3 Prevention and treatment of viral hepatitis
i) Vaccines against hepatitis A
ii) Hepatitis B vaccines and immunization
iii) Therapy of acute viral hepatitis
iv) Antiviral therapy of chronic hepatitis B
v) Therapy for chronic hepatitis C
9.2 Systemic virosis producing hepatitis
9.3 Human immunodeficiency virus and the liver
9.4 Exotic virus infections of the liver
Section 10 Other infections of the liver
10.1 Bacterial, rickettsial and spirochaetal infections
10.2 Fungal infections affecting the liver
10.3 Protozoal infections affecting the liver
10.3.1 Amoebiasis, giardiasis and cryptosporidiosis
10.3.2 Malaria
10.3.3 Visceral leishmaniasis
10.4 Helminthiasis
10.4.1 Blood flukes (schistosomes) and liver flukes
10.4.2 Echinococcosis of the liver
10.4.3 Ascariasis, visceral larva migrans, strongyloidiasis, capillariasis and pentastomiasis
Index
Colour plate section follows p. 72 Volume Two
Section 11 Immune disorders of the liver
11.1 Primary biliary cirrhosis
11.2 Autoimmune hepatitis
11.3 Sclerosing cholangitis
11.4 Vanishing bile duct syndrome
11.5 Overlap syndromes
Section 12 Alcoholic liver disease
12.1 Epidemiological aspects of alcoholic liver disease
12.2 Ethanol metabolism and pathogenesis of alcoholic liver injury
12.3 Pathology of alcoholic liver disease
12.4 Alcoholic liver disease: natural history, diagnosis, clinical features, evaluation, prognosis and management
12.5 Management of the alcoholic patient, including alcoholism and extrahepatic manifestations
Section 13 Hepatic non-alcoholic steatosis
13 Non-alcoholic fatty liver and non-alcoholic steatohepatitis
Section 14 Toxic liver injury
14.1 Drug-induced liver injury
14.2 Toxic liver injury
14.3 Hepatic injury due to physical agents
14.4 Hepatic toxicity induced by herbal medicines
Section 15 Acute liver failure
15 Acute liver failure and related syndromes
Section 16 Genetic and metabolic diseases
16.1 Wilson’s disease
16.2 Haemochromatosis
16.3 Alpha 1-antitrypsin deficiency and related disorders
16.4 The liver in cystic fibrosis
16.5 Human hereditary porphyrias
16.6 Hyperbilirubinaemia
16.7 The liver in intracellular and extracellular lipidosis
16.8 Glycogen storage diseases
16.9 Mitochondriopathies
16.10 Genetic cholestatic diseases
Section 17 Vascular diseases
17.1 Hepatic artery diseases
17.2 Obstruction of the portal vein
17.3 Disorders of the hepatic veins and hepatic sinusoids
17.4 Congenital vascular malformations
Section 18 Tumours of the liver
18.1 Benign hepatic tumours
18.1.1 Liver haemangioma
18.1.2 Benign hepatocellular tumours
18.2 Malignant tumours
18.2.1 Primary liver cell carcinoma
18.2.2 Malignant mesenchymal tumours of the liver
18.3 Metastatic tumours
18.3.1 Metastatic liver disease
18.3.2 Carcinoid tumours
Section 19 Biliary tract diseases
19.1 Intrahepatic cholestasis
19.2 Extrahepatic biliary obstruction: systemic effects, diagnosis and management
19.3 Gallstone disease
19.4 Cholangitis and biliary tract infections
19.5 Haemobilia
19.6 Biliary dyskinesia
19.7 Benign biliary tumours
19.8 Gallbladder carcinoma
19.9 Cholangiocarcinoma
Section 20 The liver in diseases of other systems
20.1 The liver in cardiovascular disease
20.2 The liver in lung diseases
20.3 The effect of gastrointestinal diseases on the liver and biliary tract
20.4 Total parenteral nutrition-related liver disease
20.5 The effect of skin diseases on the liver
20.6 The liver in urogenital diseases
20.7 The effect of haematological and lymphatic diseases on the liver
20.8 The liver in graft-vs.-host disease
20.9 The effect of endocrine diseases on liver function
20.10 Musculoskeletal diseases and the liver
20.11 Amyloidosis
20.12 Hepatic granulomas
Section 21 The impact of liver disease on other systems
21.1 The effect of liver disease on the cardiovascular system
21.2 The effect of liver disease on the endocrine system
21.3 Haematological abnormalities in liver disease
21.4 Haemostasis in liver disease
21.5 The effect of liver disease on the gastrointestinal tract
21.6 The effect of liver disease on the skin
21.7 Effect of liver on the urogenital tract
21.8 The nervous system in liver disease
21.9 The effect of liver disease on bone
21.10 The effect of liver disease on nutritional status and energy metabolism
Section 22 The liver in specific settings
22.1 Paediatric liver diseases
22.2 Liver diseases in the elderly
22.3 Liver diseases and pregnancy
Section 23 The management of liver diseases
23.1 The general management of liver diseases
23.2 Nutritional aspects of liver and biliary disease
23.3 Prescribing drugs in liver disease
23.4 Management of pretransplant patients
Section 24 Surgery, anaesthesia and the liver
24.1 General surgical aspects and the risks of liver surgery in patients with hepatic disease
24.2 Anaesthesia and liver disease
24.3 Postoperative jaundice
24.4 Hepatobiliary trauma
Section 25 Liver transplantation
25.1 Surgical techniques
25.1.1 Liver transplantation
25.1.2 Split-liver transplantation
25.1.3 The surgical technique of living donor liver transplantation using the right hepatic lobe
25.2 Liver transplantation: indications, contraindications and results
25.3 The perioperative care and complications of liver transplantation
25.4 Immunosuppression
25.5 Recurrent disease and management in liver transplantation
25.6 Post-transplantation management and complications
25.7 Liver transplantation and quality of life
25.8 Emerging therapies
25.8.1 Hepatocyte transplantation
25.8.2 Liver support
Section 26 Mathematics in hepatology
26.1 Models in clinical hepatology
26.2 Outcomes research in hepatology
26.3 Meta-analysis
26.4 Economic considerations in hepatology
26.5 Development of the liver interactome: mapping the regulatory networks
Section 27 Appendices
27.1 Geographic distribution of infections causing liver disease
27.2 Liver injury in man ascribed to non-drug chemicals and natural toxins
27.3 Rare diseases with hepatic abnormalities
Index
Book Details
- Hardcover: 2360 pages
- Publisher: Wiley-Blackwell; 3 edition (September 4, 2007)
- Language: English
- ISBN-10: 1405127414
- ISBN-13: 978-1405127417
- Product Dimensions: 11.8 x 10 x 5.8 inches