The observation that several of the topics discussed as emerging therapies in the first edition of Heart Failure: A Companion to Braunwald's Heart Disease have now become either the standard of care (e.g., cardiac resynchronization) or are being tested in multicenter, multinational clinical trials (e.g., stem cell therapy) could be viewed as the major justification for publishing a second edition of the Heart Failure Companion. Beyond updating the chapters covered in the first edition, the vision for the second edition was to provide an extremely broad educational platform that would serve to foster a more complete understanding and appreciation of the clinical syndrome of heart failure.
To that end, the second edition contains 20 entirely new chapters that were not included in the first edition. Particular emphasis has been given to the sections on clinical assessment and treatment of heart failure (see below), which have been expanded by 75% compared to the first edition. As with the first edition, the goal in organizing this text was to provide trainees, scientists, and practicing clinicians with a resource that would present a complete bench-to-bedside overview of the field of heart failure that could be read from start to finish, or section by section. The second edition retains the same organization as the first edition and is divided into five sections that progress logically from basic molecular and cellular mechanisms that underlie heart failure (Section 1), to the mechanisms that lead to disease progression in heart failure (Section 2), to the etiologic basis for heart failure (Section 3), and finally to the clinical assessment (Section 4) and treatment of heart failure (Section 5).As with the first edition, many of the chapters were designed to parallel one another, which should allow readers to focus on the aspects of heart failure that they find most interesting. For example, the second edition features chapters that cover the basic and clinical aspects of heart failure with a preserved ejection fraction as well as basic and clinical aspects of stem cell therapy and myocardial regeneration. The second edition also includes new chapters that reflect the overall growth in the field (e.g., biomarkers, cardiac devices, cardiac imaging, pharmacogenomics, palliative care in heart failure), as well as increased depth of understanding in the field (e.g., myocardial recovery, diabetic cardiomyopathy, heart failure as a consequence of chemotherapy, heart failure in special populations). In addition, this edition features several unique chapters that have not heretofore been covered in traditional textbooks on heart failure, including the important topic of heart failure in developing countries, the emerging issue of meaningfully measuring quality of outcomes in heart failure, and the neglected area of cognition in heart failure.The extent to which the second edition of Heart Failure: A Companion to Braunwald's Heart Disease provides readers with a comprehensive bench-to-bedside overview of the field of heart failure reflects the extraordinary expertise and scholarship of the authors who contributed their professional time and efforts to this undertaking. It has been a great pleasure to work with them and it has been my great fortune to learn from them. Although every attempt was made to make the content of individual chapters as up-to-date as possible and include all the changes that were occurring in the field while this text was in development, we recognize the challenge of capturing all the essential elements of a field that is evolving rapidly. Accordingly, this second edition will be accessible online as well as in print, on the same Expert Consult platform that houses the parent text, Braunwald's Heart Disease, which features regular content updates.
Douglas L. Mann, MD, FACC
Foreword In what seems on the surface to be a paradox, the prevalence, incidence, and mortality of heart failure are steadily climbing despite phenomenal progress in the diagnosis and treatment of all forms of cardiac disease. As we successfully manage -yet not cure— patients with heart disease, the damage to their cardiac muscles persists and sometimes progresses as adaptive compensatory mechanisms become maladaptive. With steadily increasing life spans and the growing “epidemics” of diabetes, obesity, and atrial fibrillation in the elderly, the stage is now set for a large increase in the number of heart failure cases. Thus we are facing great challenges in our quest to control cardiac disease.
How are we going to win this battle? Surely not with a single magic bullet, whether it is a gene, device, or drug. We believe Douglas Mann’s excellent book, Heart Failure, details the right plan. As with any battle, we must understand the terrain on which it will be fought. The first three sections of Heart Failure do just that. Section I delves into the basic underlying mechanisms on genetic, molecular, tissue, organ, and organismal levels, whereas Section II describes the pathophysiology of disease progression. These discussions involve not only the heart but also the vascular bed, neurohormonal systems, kidneys, and lungs. The most common etiologies of heart failure are described in Section III. Section IV provides a detailed description of the clinical manifestations and laboratory features of heart failure. Finally, the current armamentaria in the treatment of heart failure—drugs, devices, and surgery—and how each of these (and their combinations) can be optimally deployed are described in Section V.
A leader in the fight against one of humankind’s most stubborn enemies, Dr. Mann should be congratulated on selecting the right topics and the best authors to write about them. His skillful editing pulled everything together, making this book much greater than simply the sum of the excellent individual chapters.
This second edition builds on the first, which was warmly received. Fully one third of the chapters are new. Many chapters that appeared in the last edition have new authors and all have been updated to include the most current data and research.
This splendid second edition of Heart Failure will be enormously useful to cardiovascular specialists who care for the growing number of patients with heart failure; it will be equally useful to those who are training to deliver this care, as well as to their teachers. However, the ultimate beneficiaries of this book will be the millions of patients with heart failure worldwide.
We are proud that this second edition of Heart Failure is a valued and indispensable companion to Heart Disease: A Textbook of Cardiovascular Disease.
Eugene Braunwald, Robert Bonow, Peter Libby, Douglas P. Zipes
Key Features
- Access the very latest coverage of every aspect of managing and treating heart failure.
- Refer to the cutting-edge imagery, diagrams, and online illustrations to help you keep current with the latest research in the field.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
Section I: Basic Mechanisms of Heart Failure
Chapter 1 - Evolving Concepts in the Pathophysiology of Heart Failure
Chapter 2 - Molecular Basis for Heart Failure
Chapter 3 - Cellular Basis for Heart Failure
Chapter 4 - Cellular Basis for Myocardial Repair and Regeneration
Chapter 5 - Myocardial Basis for Heart Failure: Role of the Cardiac Interstitium
Chapter 6 - Myocardial Basis for Heart Failure: Role of Cell Death
Chapter 7 - Energetic Basis for Heart Failure
Chapter 8 - Molecular and Cellular Mechanisms for Myocardial Recovery
Section II: Mechanisms of Disease Progression in Heart Failure
Chapter 9 - Activation of the Renin-Angiotensin System in Heart Failure
Chapter 10 - Activation of the Adrenergic Nervous System in Heart Failure
Chapter 11 - Activation of Inflammatory Mediators in Heart Failure
Chapter 12 - Oxidative and Nitrosative Stress in Heart Failure
Chapter 13 - Alterations in Ventricular Function: Systolic Heart Failure
Chapter 14 - Alterations in Ventricular Function: Diastolic Heart Failure
Chapter 15 - Alterations in Ventricular Structure: Role of Left Ventricular Remodeling
Chapter 16 - Alterations in the Sympathetic and Parasympathetic Nervous Systems in Heart Failure
Chapter 17 - Alterations in the Peripheral Circulation in Heart Failure
Chapter 18 - Alterations in Renal Function in Heart Failure
Chapter 19 - Alterations in Diaphragmatic and Skeletal Muscle in Heart Failure
Chapter 20 - Alterations in Cardiac Metabolism
Chapter 21 - Alterations in Nutrition and Body Mass in Heart Failure
Section III: Etiological Basis for Heart Failure
Chapter 22 - Epidemiology of Heart Failure
Chapter 23 - Heart Failure as a Consequence of Ischemic Heart Disease
Chapter 24 - Heart Failure as a Consequence of Dilated Cardiomyopathy
Chapter 25 - Heart Failure as a Consequence of Restrictive Cardiomyopathy
Chapter 26 - Heart Failure as a Consequence of Diabetic Cardiomyopathy
Chapter 27 - Heart Failure as a Consequence of Genetic Cardiomyopathy
Chapter 28 - Heart Failure as a Consequence of Hypertension
Chapter 29 - Heart Failure as a Consequence of Valvular Heart Disease
Chapter 30 - Heart Failure as a Consequence of Congenital Heart Disease
Chapter 31 - Heart Failure as a Consequence of Viral and Nonviral Myocarditis
Chapter 32 - Heart Failure as a Consequence of Sleep-Disordered Breathing
Chapter 33 - Heart Failure in Developing Countries
Section IV: Clinical Assessment of Heart Failure
Chapter 34 - The Prognosis of Heart Failure
Chapter 35 - Clinical Evaluation of Heart Failure
Chapter 36 - Use of Cardiac Imaging in the Evaluation of Heart Failure
Chapter 37 - The Use of Biomarkers in the Evaluation of Heart Failure
Chapter 38 - Measuring Quality Outcomes in Heart Failure
Chapter 39 - Clinical Trial Design in Heart Failure
Section V: Therapy for Heart Failure
Chapter 40 - Development and Implementation of Practice Guidelines in Heart Failure
Chapter 41 - Disease Prevention in Heart Failure
Chapter 42 - Pharmacogenomics and Pharmacogenetics in Heart Failure
Chapter 43 - Management of Acute Decompensated Heart Failure
Chapter 44 - Management of Volume Overload in Heart Failure
Chapter 45 - Antagonism of the Renin-Angiotensin-Aldosterone System in Heart Failure
Chapter 46 - Antagonism of the Sympathetic Nervous System in Heart Failure
Chapter 47 - Device Therapy in Heart Failure
Chapter 48 - Treatment of Heart Failure with a Preserved Ejection Fraction
Chapter 49 - Heart Failure in Special Populations
Chapter 50 - Emerging Strategies in the Treatment of Heart Failure
Chapter 51 - Cell-Based Therapies and Tissue Engineering in Heart Failure
Chapter 52 - Management of Thrombosis in Heart Failure
Chapter 53 - Management of Arrhythmias in Heart Failure
Chapter 54 - Cardiac Transplantation
Chapter 55 - Surgical Treatment of Chronic Heart Failure
Chapter 56 - Circulatory Assist Devices in Heart Failure
Chapter 57 - Exercise in Heart Failure
Chapter 58 - Management of Heart Failure Patients with Malignancy
Chapter 59 - Disease Management in Heart Failure
Chapter 60 - Cognitive Impairment in Heart Failure
Chapter 61 - Management of End-Stage Heart Failure
Index
Book Details
- Hardcover: 928 pages
- Publisher: Saunders; 2 edition (2011)
- Language: English
- ISBN-10: 1416058958
- ISBN-13: 978-1416058953
- Product Dimensions: 11.1 x 8.9 x 1.6 inches
List Price: $174.00
Look for These Other Titles in the Braunwald's Heart Disease Family
Braunwald's Heart Disease Companions Series
- Acute Coronary Syndromes by Pierre Theroux
- Atlas of Cardiac Computed Tomography by Allen J. Taylor
- Clinical Lipidology by Christie M. Ballantyne
- Clinical Arrhythmology and Electrophysiology by Ziad Issa, John M. Miller and Douglas P. Zipes
- Heart Failure by Douglas L. Mann
- Preventive Cardiology by Roger S. Blumenthal, Joanne M. Foody and Nathan D. Wong