Flynn: Pediatric Hypertension (Clinical Hypertension and Vascular Diseases Series)

While hypertension in children and adolescents has a significant impact on adult cardiovascular disease as it transitions into adulthood, it also directly causes target organ damage and is associated with early atherosclerosis in children. The second edition of Pediatric Hypertension is an excellent reference textbook for any clinician or clinical researcher interested in this area as it provides a thorough review of what is known about childhood blood pressure based on the evidence from clinical studies, trials, and outcome research. The new edition has been substantially updated from the first edition of the book that was published in 2004—there are several new chapters and some old chapters have been modified or replaced. The second edition of Pediatric Hypertension is now a comprehensive textbook in 32 chapters that remain divided into 4 broad themes:

• (I) regulation of blood pressure and pathophysiology of hypertension in children; 
• (II) assessment of blood pressure including measurement, normative data, and epidemiology; 
•  (III) definitions, predictors, risk factors, and comorbid conditions in childhood hypertension; and 
• (IV) evaluation and treatment of hypertension in neonates and children. 

As in the first edition of the book, the chapters are written by experts in their respective fields and remain nicely organized and easy to read and understand. The first section has been enlarged substantially and now includes chapters on vasoactive peptides, ion transport, and inflammatory mediators of vascular function. An excellent genomics chapter that was in edition 1 of the book has been moved into this section as well. The second section of the book now focuses not only on the epidemiology of hypertension in children but on cardiovascular diseases in general as well as on important comorbidities of obesity, diabetes, and metabolic syndromes in children and adolescents. The third section has also been expanded to encompass more in-depth discussion of perinatal programming, cardiovascular reactivity, and social environments as well as important clinical subpopulations of chronic and end-stage renal diseases and obstructive sleep apnea. In this second edition, there are also discrete new chapters on the impact of exercise on blood pressure and the utility of ambulatory blood pressure monitoring in assessing children with elevated blood pressure. The material in each chapter is presented in a logical manner, with clearly interpreted results and extensive referencing. Clinical applications are given so that the clinician can better incorporate this material into their understanding of the pathophysiology of hypertension in neonates, children, and adolescents.
It is pleasing to see the detail given in the section of the book on the management and treatment of hypertension in children. These chapters are destined to be very helpful for trainees in pediatrics and its subspecialties as well as practicing clinicians due to their pragmatic nature. The updated chapter on pediatric antihypertensive trials (Chapter 33) is particularly unique as it differentiates the issues of clinical trials for new antihypertensive medications in children versus adults and provides summary information from the US FDA.

Contents
PART I. REGULATION OF BLOOD PRESSURE IN CHILDREN
1. Neurohumoral Regulation of Blood Pressure in EarlyDevelopment
2. Vasoactive Factors and Blood Pressure in Children
3. Cardiovascular and Autonomic Influences on Blood Pressure
4. Ion and Fluid Dynamics in Hypertension
5. CRP, Uric Acid, and Other Novel Factors in the Pathogenesis of Hypertension
6. Monogenic and Polygenic Genetic Contributions to Hypertension
PART II. ASSESSMENT OF BLOOD PRESSURE IN CHILDREN: MEASUREMENT, NORMATIVE DATA, AND EPIDEMIOLOGY
7. Casual Blood Pressure Methodology
8. Development of Blood Pressure Norms in Children
9. Definitions of Hypertension in Children
10. Ambulatory Blood Pressure Monitoring Methodology and Norms in Children
11. Epidemiology of Essential Hypertension in Children: The Bogalusa Heart Study
12. Epidemiology of Cardiovascular Disease in Children
PART III. HYPERTENSION IN CHILDREN: PREDICTORS, RISK FACTORS, AND SPECIAL POPULATIONS
13. Perinatal Programming and Blood Pressure
14. Familial Aggregation of Blood Pressure
15. Influence of Dietary Electrolytes on Childhood Blood Pressure
16. Ethnic Differences in Childhood Blood Pressure
17. Childhood Obesity and Blood Pressure Regulation
18. Hypertension in Children with the Metabolic Syndrome or Type 2 Diabetes
19. Primary Hypertension
20. Secondary Forms of Hypertension
21. Neonatal Hypertension
22. Hypertension in Chronic Kidney Disease
23. Hypertension in End-Stage Renal Disease
24. Sequelae of Hypertension in Children and Adolescents
25. Sleep Apnea and Hypertension
26. Hypertension and Exercise
27. Hypertension in the Developing World
PART IV. EVALUATION AND MANAGEMENT OF PEDIATRIC HYPERTENSION
28. Evaluation of the Hypertensive Pediatric Patient
29. The Role of Ambulatory Blood Pressure Monitoring in Diagnosis of Hypertension and Evaluation of Target Organ Damage
30. Nonpharmacologic Treatment of Pediatric Hypertension
31. Pharmacotherapy of Pediatric Hypertension
32. Management of Hypertensive Emergencies
33. Pediatric Antihypertensive Clinical Trials
Subject Index

Book Details

• Hardcover: 700 pages
• Publisher: Humana Press; 2nd edition (December 2, 2010)
• Language: English
• ISBN-10: 1603278230
• ISBN-13: 978-1603278232
• Product Dimensions: 10.1 x 7.1 x 1.6 inches

List Price: $239.00