Bender: Oxford American Handbook of Cardiology






Despite major advances in prevention and treatment, cardiovascular disease remains the leading cause of death in the United States. There are greater than 1.4 million myocardial infarcts per year. Furthermore, the incidence of atrial fi brillation and of heart failure is rising, in part due to increased survival following acute coronary events, to our aging population, and to other undetermined factors. Management of cardiovascular disease spans a wide range, from acute care of the hemodynamically unstable patient, interventions directed at acute coronary obstructions and electrically unstable rhythms, to disease prevention and care of the chronically ill. In an era of genome-wide scans and growing lists of cardiovascular disease genes, we still require a careful and detailed understanding of disease pathophysiology and management.
In this Handbook, represent wide range of cardiovascular disease. The chapters of this Handbook provide the pathophysiological basis for many of evidence based medicine, followed by delineation of management. Although these chapters will not replace the time-dependent accumulation of experience in clinical care, this Handbook provides easy and rapid access to many major day-to-day management approaches to patients with cardiovascular problems. It will appeal to a broad range of clinicians in many settings, including the coronary care unit, interventional laboratories, emergency departments, and medicine units, both inpatient and outpatient. It is designed to be a rapid reference guide for practicing cardiologists, internists, and relevant trainees. Pearls of cardiovascular care will be easily removed from these white pockets and extracted from our Handbook of Cardiology.

Contents 
1 Cardiovascular emergencies and practical procedures 1

Cardiovascular emergencies
  • Adult basic life support 2
  • Adult advanced life support 5
  • Universal treatment algorithm 7
  • Acute pulmonary edema: assessment 9
  • Pulmonary edema: causes 11
  • Pulmonary edema: management 12
  • Pulmonary edema: specifi c conditions 15
  • Acute aortic regurgitation 16
  • Acute mitral regurgitation 18
  • Deep vein thrombosis: assessment 20
  • Deep vein thrombosis: management 22
  • Pulmonary embolism (PE): assessment 24
  • Pulmonary embolism: investigations 25
  • Pulmonary embolism: management 27
  • Fat embolism 29
  • Hypertensive emergencies 31
  • Hypertensive emergencies: management 33
  • Drugs for hypertensive emergencies 35
  • Hypertensive emergency with retinopathy (accelerated and malignant hypertension) 37
  • Hypertensive encephalopathy 39
  • Aortic dissection: assessment 40
  • Aortic dissection: investigations 43
  • Aortic dissection: management 45
  • Acute pericarditis: assessment 48
  • Acute pericarditis: management 50
  • Cardiac tamponade: presentation 51
  • Cardiac tamponade: management 53

Practical procedures
  • Central line insertion 55
  • Internal jugular vein cannulation 57
  • Subclavian vein cannulation 59
  • Pulmonary artery catheterization 61
  • Indications for temporary pacing 66
  • Temporary ventricular pacing 68
  • Temporary atrial pacing 71
  • AV sequential pacing 72
  • Temporary pacing: complications 73
  • Pericardiocentesis 75
  • DC cardioversion 78
  • Intra-aortic balloon counterpulsation 80

2 Coronary artery disease 85
  • Angina pectoris 86
  • Acute coronary syndromes 89
  • ST elevation myocardial infarction (STEMI) 91
  • STEMI: diagnosis 93
  • STEMI: general measures 96
  • STEMI: reperfusion therapy (thrombolysis) 98
  • STEMI: reperfusion by primary PCI 101
  • Surgery for acute STEMI 103
  • STEMI: additional measures 104
  • Right ventricular (RV) infarction 105
  • STEMI: predischarge risk stratification 107
  • STEMI: complications 109
  • Ventricular septal defect post-MI 111
  • Acute mitral regurgitation post-MI 113
  • Pseudoaneurysm and free wall rupture 114
  • Cocaine-induced MI 115
  • Ventricular tachyarrhythmias post-MI 117
  • Atrial tachyarrhythmia post-MI 117
  • Bradyarrhythmias and indications for pacing 118
  • Bradyarrhythmias post-MI 118
  • Hypotension and shock post-MI 119
  • Cardiogenic shock 120
  • Non-ST elevation myocardial infarction (NSTEMI)/unstable angina (UA) 122
  • NSTEMI/UA: diagnosis 124
  • NSTEMI/UA: risk stratification 125
  • NSTEMI/UA: late risk stratification 127
  • NSTEMI/UA: medical management 128
  • NSTEMI: invasive vs. noninvasive strategies 131
  • Discharge and secondary prevention 132

3 Peripheral vascular disease 133
  • Introduction 134
  • Epidemiology 135
  • Risk factors 136
  • Natural history 137
  • Pathophysiology 139
  • Clinical presentation 140
  • Testing for peripheral artery disease 141
  • Prognosis in peripheral artery disease 147
  • Acute limb ischemia 152
  • Cerebrovascular disease 155
  • Renovascular disease 157
  • Aortic disease 161
  • Noninvasive and invasive vascular diagnostic tools 166

4 Valvular heart disease 173
  • General considerations 174
  • Acute rheumatic fever 176
  • Mitral stenosis 179
  • Mitral regurgitation 183
  • Mitral valve prolapse 186
  • Aortic stenosis 188
  • Aortic stenosis: management 190
  • Aortic regurgitation 193
  • Right heart valve lesions 197
  • Prosthetic heart valves 200
  • Prosthetic heart valves: complications 203
  • Infective endocarditis 204

5 Heart failure 211
  • Introduction 212
  • Forms of heart failure 215
  • Causes and precipitants 217
  • Diagnosis and initial workup 219
  • Management 222
  • Diuretics in heart failure 224
  • ACE inhibitors for heart failure 226
  • B-Blockers for heart failure 229
  • Angiotensin II receptor antagonists for heart failure 232
  • Aldosterone receptor antagonists in heart failure 233
  • Digoxin in heart failure 235
  • Vasodilators in heart failure 235
  • Phosphodiesterase inhibitors in heart failure 236
  • Positive inotropic support 236
  • Antiplatelet agents and anticoagulants 236
  • Miscellaneous drugs for heart failure 236
  • Device therapy for heart failure 237
  • Surgery for heart failure 238
  • Palliative care for heart failure 240
  • Worsening heart failure 241
  • Diastolic heart failure 242
  • High-output heart failure 244

6 Preventive cardiology 245
  • Background 246
  • Atherosclerosis: pathophysiology 247
  • Development of atherosclerotic plaques 249
  • Epidemiology 251
  • Assessment of atherosclerotic risk 252
  • Risk factors for coronary artery disease 256
  • Hypertension 262
  • Treatment of high blood pressure 264
  • Combining antihypertensive drugs 267
  • Lipid management in atherosclerosis 269
  • Lipid-lowering medications 272
  • Goals of lipid-lowering therapy 274
  • Diabetes and atherosclerosis 277
  • The metabolic syndrome 280
  • Metabolic syndrome: management 282
  • Aspirin for primary prevention 283

7 Diseases of the myocardium and pericardium 285
Myocardial diseases
  • Classification 286
  • Dilated cardiomyopathy 288
  • Hypertrophic cardiomyopathy 290
  • Restrictive cardiomyopathy 295
  • Arrhythmogenic right ventricular cardiomyopathy 297
  • Ischemic cardiomyopathy 299
  • Valvular cardiomyopathy 299
  • Hypertensive cardiomyopathy 299
  • Alcoholic cardiomyopathy 299
  • Metabolic cardiomyopathy 299
  • Takotsubo cardiomyopathy (“broken heart syndrome”) 300
  • General system disease 301
  • Nutritional cardiomyopathy 301
  • Muscular dystrophies 301
  • Neuromuscular disorders 302
  • Sensitivity or toxic reactions 302
  • Peripartum 302
  • Myocarditis 303

Pericardial diseases
  • Etiology 305
  • Syndromes of pericardial disease 306
  • Acute pericarditis without effusion 307
  • Pericardial effusion ± tamponade 309
  • Constrictive pericarditis 311
  • Effusive–constrictive pericarditis 312
  • Calcifi c pericarditis without constriction 312
  • Viral pericarditis 313
  • Tuberculous pericarditis 313
  • TB constrictive pericarditis 314
  • TB effusive–constrictive pericarditis 314
  • TB pericardial effusion 315
  • Uremic pericarditis 317
  • Neoplastic pericardial disease 318
  • Myxedematous effusion 319
  • Nontuberculous bacterial (purulent) pericarditis 320
  • Radiation pericarditis 321
  • Drug- or toxin-induced pericarditis 321
  • Postcardiotomy syndrome 322
  • Postinfarction pericarditis 322
  • Rheumatic fever 322
  • Autoimmune pericarditis 323
  • Traumatic pericarditis 323
  • Fungal pericarditis 323
  • Amoebic pericarditis 324
  • Constrictive pericarditis vs. restrictive myocardial disease 325
  • Pericardial fluid analysis 326
  • Pericardiocentesis 326

8 Congenital heart disease 329
  • Introduction 330
  • Assessment of patients with CHD 332
  • Specific signs in patients with CHD 336
  • Surgical operations for CHD 337
  • Percutaneous transcatheter interventions for CHD 341
  • Specifi c management issues 343
  • Atrial septal defect 346
  • Ventricular septal defect 346
  • Atrioventricular septal/canal defect (endocardial
  • cushion defect) 346
  • Pulmonary stenosis 347
  • Left ventricular outfl ow tract (LVOT) obstruction 347
  • Coarctation of the aorta 347
  • Anomalous pulmonary venous drainage 348
  • Transposition of the great arteries 348
  • Tetralogy of Fallot 349
  • Fontan patients 349
  • Congenitally corrected transposition of the great arteries 350
  • Ebstein’s anomaly of the tricuspid valve 350
  • Extracardiac complications 351

9 Arrhythmias 353
  • The cardiac conduction system 354
  • Bradyarrhythmias: general approach 356
  • Sinus bradycardia 358
  • Sinus pause 359
  • Sick sinus syndrome 359
  • Atrioventricular block 360
  • Bundle branch block 362
  • Tachyarrhythmias: general approach 363
  • Tachyarrhythmias: classifi cation 365
  • ECG diagnosis of tachyarrhythmias 367
  • Tachycardia: emergency management 369
  • Drug treatment of tachyarrhythmias 371
  • Supraventricular tachycardia 372
  • Sinus tachycardia 373
  • Sinus nodal reentrant tachycardia 373
  • Atrial tachycardia 374
  • Atrioventricular nodal reentrant tachycardia (AVNRT) 375
  • Atrioventricular reentrant tachycardia (AVRT) 376
  • Junctional tachycardia 377
  • Atrial fi brillation 377
  • Atrial fi brillation: evaluation 379
  • Atrial fi brillation: management 381
  • Ventricular tachycardia 384
  • VT in the normal heart (“benign” VT) 385
  • VT with impaired LV function 387
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC) 388
  • Brugada syndrome 389
  • Bundle branch tachycardia 390
  • Long QT syndrome 391
  • Long QT syndrome: management 395
  • Arrhythmia in special situations 396
  • Permanent pacemakers 398
  • Which pacing modality? 400
  • Complications of pacing 401
  • Pacemakers for chronic heart failure 403

10 Heart disease in pregnancy 405
  • Basic principles 406
  • Physiological changes in pregnancy 407
  • Normal fi ndings in pregnancy 409
  • General considerations in pregnancy 410
  • Pulmonary hypertension and pregnancy 411
  • Marfan’s syndrome and pregnancy 413
  • Valvular heart disease in pregnancy 414
  • Mitral stenosis and pregnancy 415
  • Other valve lesions 416
  • Mechanical heart valves in pregnancy 417
  • Ischemic heart disease 419
  • Hypertrophic obstructive cardiomyopathy (HOCM) 420
  • Peripartum cardiomyopathy 421
  • Arrhythmias in pregnancy 423
  • Cardiac arrest in pregnancy 424
  • Endocarditis prophylaxis 425

11 Multisystem disorders 427
  • Libman–Sacks endocarditis 428
  • Marfan’s syndrome 430
  • Ghent criteria for Marfan’s syndrome 431
  • Ehlers–Danlos syndrome 432
  • Kawasaki disease 434
  • Takayasu arteritis 436
  • Polyarteritis nodosa and other systemic vasculitides 438
  • Ankylosing spondylitis 440
  • Polymyositis and dermatomyositis 442
  • Rheumatoid disease 443

12 Stress testing and cardiac imaging 445
  • Exercise ECG 446
  • Transthoracic echocardiography (TTE) 449
  • Transthoracic Doppler imaging 453
  • The standard TTE 456
  • Assessment of wall motion 460
  • Assessment of LV systolic function 462
  • Assessment of LV diastolic function 464
  • Echocardiography in aortic stenosis 468
  • Transesophageal echocardiography (TEE) 470
  • TEE for a cardiac source of embolism 474
  • TEE in aortic dissection 475
  • TEE in endocarditis 476
  • TTE/TEE in mitral regurgitation (MR) 478
  • Mitral valve prolapse 480
  • TEE in chronic ischemic MR 482
  • TTE/TEE for mitral stenosis 482
  • TEE for prosthetic valve dysfunction 483
  • TEE assessment of mitral valve prosthesis 484
  • Echocardiography in aortic regurgitation 486
  • TEE for aortic valve prosthesis 487
  • Intraoperative TEE 489
  • Echocardiographic assessment of cardiac masses 491
  • SPECT perfusion imaging 492
  • PET scanning 497
  • Equilibrium radionuclide angiography (ERNA) 501
  • Cardiac CT 503
  • Cardiac magnetic resonance imaging (CMR) 505
  • Metallic prostheses and CMR 508

13 Invasive electrophysiology 511
  • Mechanism of tachycardias 512
  • Mechanism of arrhythmias 514
  • The electrophysiology study (EPS) 516
  • Uses of the EPS 518
  • Programmed ventricular stimulation 522
  • New technologies 524
  • Catheter ablation 525
  • Catheter ablation: complications 527
  • Atrial tachyarrhythmias: mechanism 528
  • Ablation of atrial tachycardias 530
  • Catheter ablation of atrial fi brillation 532
  • Mechanism of AV reentry tachycardias 534
  • AV reentry tachycardias: ablation 536
  • Ablation of ventricular tachycardia 538
  • Accessory pathways (Wolff–Parkinson–White syndrome) 540
  • Accessory pathways: localization 542
  • Accessory pathways: management 543
  • Implantable cardioverter defi brillators (ICDs) 544
  • Indications for ICD implantation 545
  • ICD therapies 546
  • ICD: trouble shooting and follow-up 547

14 Cardiac catheterization and coronary intervention 549
  • Radiation protection in the catheter laboratory 550
  • Vascular access: the femoral artery 551
  • Vascular access: the radial artery 553
  • Vascular access: site management 555
  • Coronary angiography 556
  • Interpreting the coronary angiogram 558
  • Angiographic study of grafts 560
  • Complications of angiography 561
  • Right heart catheterization 564
  • Cardiac output and LV function 566
  • Cardiac catheterization in valve disease 567
  • Intravascular ultrasound 569
  • Angioplasty and coronary stenting 571
  • Restenosis following PTCA 573
  • Drug-eluting stents 574
  • Stent thrombosis 576
  • Physiological assessment of coronary fl ow 578
  • Primary angioplasty for STEMI 580
  • Primary angioplasty: procedure 581
  • Invasive assessment of vulnerable plaque 583
  • Complex coronary angioplasty 584
  • Left main stem angioplasty 586
  • Adjunctive therapy for angioplasty and stenting 587
  • Embolic protection devices 589
  • Thrombectomy 591
  • Mitral valvuloplasty 592
  • Glossary of terms and abbreviations 594

15 Major trials in cardiology 597
  • ACUITY 598
  • ADMIRAL 598
  • AFCAPS/TexCAPS 598
  • AFFIRM 599
  • AHEFT 599
  • AIRE 600
  • AIREX 600
  • ALLHAT 601
  • ASCOT-LLA 601
  • ASSENT-1 602
  • ASSENT-2 602
  • ASSENT-3 and ASSENT-3 PLUS 603
  • BARI 603
  • CADILLAC 604
  • CAMIAT 604
  • CAPRIE 605
  • CAPTURE 605
  • CARE 605
  • CARE HF 606
  • CARMEN 606
  • CHARM 607
  • CIBIS 607
  • CIBIS II 607
  • COMET 608
  • COMPANION 608
  • COPERNICUS 609
  • COURAGE 609
  • CREDO 610
  • CTOPP 610
  • CURE 611
  • DANAMI 611
  • DANAMI II 612
  • DAVID 612
  • DIAMOND 613
  • DIG 613
  • DIGAMI 613
  • DINAMIT 614
  • EMIAT 614
  • EPILOG 614
  • EPISTENT 615
  • ENHANCE 615
  • EUROPA 616
  • FRISC 616
  • FRISC II 617
  • GISSI-I 617
  • GISSI-2 617
  • GISSI-3 618
  • GISSI-Prevenzione 618
  • GUSTO-1 619
  • GUSTO IV-ACS 619
  • HOPE 620
  • HORIZONS-AMI 620
  • HPS 621
  • ICTUS 622
  • ISAR REACT 622
  • ISIS-1 623
  • ISIS-2 623
  • ISIS-3 624
  • ISIS-4 624
  • JUPITER 624
  • LIFE 625
  • LIPID 626
  • MADIT 626
  • MADIT II 626
  • MERIT-HF 627
  • MICRO-HOPE 627
  • MIRACL 627
  • MIRACLE 628
  • MIRACLE ICD 628
  • MOST 629
  • MUSTIC 629
  • MUSTT 630
  • OPTIMAAL 630
  • PASE 630
  • PCI-CURE 631
  • PRAGUE Trials 631
  • PRISM 632
  • PRISM PLUS 632
  • PROGRESS 633
  • PURSUIT 633
  • RACE 634
  • RALES 634
  • RAVEL 635
  • REVERSAL 635
  • RITA-2 636
  • SAFE T 636
  • SAPPHIRE 637
  • SAVE 637
  • SIRIUS 638
  • SOLVD 638
  • SSSS (4S) 639
  • TAXUS 639
  • TIMI 1 640
  • TIMI 2A 640
  • TIMI 2B 640
  • TIMI 3A 641
  • TIMI 3B 641
  • TIMI 4 641
  • TIMI 5 641
  • TIMI 6 641
  • TIMI 7 641
  • TIMI 8 641
  • TIMI 9A 642
  • TIMI 9B 642
  • TIMI 10A 642
  • TIMI 10B 642
  • TIMI 11A 642
  • TIMI 11B 642
  • TIMI 12 642
  • TIMI 14 642
  • TIMI 15A 642
  • TIMI 15B 642
  • TIMI 16 643
  • TIMI 17 643
  • TIMI 18 643
  • TIMI 22 643
  • TIMI 28 CLARITY 644
  • VANQWISH 644
  • V-HEFT II 645
  • WOSCOPS 645

16 Special populations: women and elderly 647
  • Women and heart disease 648
  • The elderly and heart disease 656
Index 659

Book Details

  • Paperback: 708 pages
  • Publisher: Oxford University Press, USA; 1 edition (October 27, 2010)
  • Language: English
  • ISBN-10: 0195389697
  • ISBN-13: 978-0195389692
  • Product Dimensions: 7.1 x 4 x 1.1 inches
List Price: $49.95 
 

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