Book Features
- Cutting edge information on the science and practice of oncology
- Discusses in detail the growing importance of prevention, early screening, and quality of life issues for cancer patients
- Exhaustive coverage of combined modality cancer treatment
- Greater emphasis on the increasing role of biologic therapy in the treatment of cancer
- Over 300 1st rate contributors
- The single, most comprehensive oncology reference ever published
New in this edition
- NEW 11 new chapters
- NEW 25% new 4-color illustrations
- NEW completely revamped art program with new/redrawn pieces of art
- NEW updates to book posted quarterly (available with purchase of print book)
- NEW single volume text for greater portability
Contents PART ONE MOLECULAR BIOLOGY OF CANCER
1. The Cancer Genome
- Cancer Genes and Their Mutations
- Identification of Cancer Genes
- Cancer Genome Investigation: Tools and Quality Controls
- Somatic Alteration Classes Detected by Cancer Genome Analysis
- Pathway-Oriented Models of Cancer Genome Analysis
- Networks of Cancer Genome Projects
- The Genomic Landscape of Cancers
- The Cancer Genome and the New Taxonomy of Tumors
- Cancer Genomics and Drug Resistance
- Perspectives of Cancer Genome Analysis
- Basic Defenses Against Genomic Instability
- Barriers to Genomic Instability
- Mutations in Cancer
- Mechanisms of Genome Destabilization in Human Tumors
- What Causes Chromosomal Instability and Whole-Chromosome Aneuploidy?
- Does Whole-Chromosome Aneuploidy Cause Cancer?
- Perspectives and Implications for Cancer Therapeutics
- Epigenetic Processes
- Epigenomic Changes in Cancer
- The Timing of Epigenetic Alterations
- Epigenetic Biomarkers for Early Detection of Cancer
- Epigenetic Therapies
- Problems with Epigenetic Therapies
- Telomeres and Telomerase
- Senescence
- Telomere Maintenance and Cancer
- Cell Signaling Growth Factors
- Signal Transduction Systems
- Sensory Machinery: Ligands and Receptors
- Regulation of Protein Kinases
- Small-Molecule Second Messengers
- Efficiency and Specificity: Formation of Multiprotein Signaling Complexes
- Signaling Networks
- Cell-Cycle Engine
- Induction of Cell-Cycle Phase Transitions
- Ubiquitin-Mediated Proteolysis
- Regulation of the Cell Cycle
- Cell Cycle and Cancer
- MicroRNAs, the Cell Cycle, and Cancer
- The Cell Cycle and Cancer Therapy
- Apoptosis
- Autophagy
- Necrosis
- Altered Metabolism in Cancer Cells
- Energetics of Cell Proliferation
- Imaging Cancer Metabolism in Patients
- Genetic Events Important for Cancer Influence Metabolism
- Targeting Metabolism to Treat Cancer
- Introduction: Origins of the Concept of Antiangiogenic Therapy for Cancer
- Sequential Steps Involved in the Formation of Blood Vessel Capillaries in Tumors
- Pericytes
- Dysfunctional Nature of the Tumor Vasculature
- Molecular Mediators of Tumor Angiogenesis: Angiogenic Stimulators and Their Receptors
- Endogenous Inhibitors of Tumor Angiogenesis
- A Cooperative Regulator of Tumor Angiogenesis: The Notch Receptor- DLL4 Signaling Pathway in Endothelial Cells
- Strategies for Development of Antiangiogenic Drugs
- Enhancement of Chemotherapy Efficacy and Other Therapeutic Modalities by Antiangiogenic Drugs
- Resistance to Antiangiogenic Drugs or Treatments
- Biomarkers for Tumor Angiogenesis and Antiangiogenic Therapy
- Antiangiogenic/Anti-VEGF Drug-Based Clinical Trials
- Looking Ahead: New Targets, New Drugs, and New Strategies for Antiangiogenic Therapy
- The Evolution and Pathogenesis of Metastasis
- An Integrated Model for Metastasis
- Selective Pressures at the Primary Tumor Driving Acquisition of Metastasis Functions
- Coupling Tumorigenesis with Metastasis Initiation
- Coupling Tumorigenesis with Metastasis Progression
- From Metastasis Progression to Macrometastatic Colonization
- Micro-RNAs and Metastasis
- Tumor Heterogeneity
- Leukemia Stem Cells
- Cancer Stem Cells in Solid Tumors
- Genetic Diversity and Clonal Evolution in Cancer
- The Origins of Cancer Stem Cells
- Epithelial-Mesenchymal Transition
- Cancer Stem Cells: Targeted Therapy
- Cancer Predisposition
- Familial Adenomatous Polyposis
- Lynch Syndrome
- Other Polyposis Syndromes
- Association Studies
- Breast Cancer
- Early Detection
- Tumor Classification and Patient Stratification
- Treatment
- Development of Resistance to Tyrosine Kinase Inhibitors
- Alternative Mechanisms of Resistance
- BRAF Inhibitors
- The Future
- Changing Face of Personalized Medicine
- Summary
PART TWO ETIOLOGY AND EPIDEMIOLOGY OF CANCER
Section 1: Etiology of Cancer
13. Tobacco
- Epidemiology of Tobacco and Cancer
- Tumor Induction in Laboratory Animals by Tobacco Products
- Carcinogens in Tobacco Products
- Overview of Mechanisms of Tumor Induction by Tobacco Products
- Tobacco Carcinogen and Toxicant Biomarkers
- Principles of Cancer Susceptibility
- Genetic Testing
- Cancer Susceptibility Syndromes
- Future Directions
- History of Viral Oncology
- Hepadnaviruses and Hepatocellular Carcinoma
- Papillomaviruses
- Epstein-Barr Virus
- Kaposi's Sarcoma–Associated Herpesvirus
- Human Polyomaviruses
- Retroviruses: Background, Replication Cycle, and Molecular Genetics
- Human T-Lymphotropic Virus Type 1
- Human T-Lymphotropic Virus Type 2
- Human Immunodeficiency Virus
- Hepatitis C Virus
- Tumor Immune Surveillance
- Inflammation and Tumorigenesis
- Mechanisms of Cell Transformation and Cancer Initiation in the Inflammatory Environment 196 Inflammatory Cells and Stromal Cells in the Initiation of Neoplasia and in the Tumor Microenvironment
- The Nature of Chemical Carcinogens: Chemistry and Metabolism
- Animal Model Systems and Chemical Carcinogenesis
- DNA Repair Protects the Host from Chemical Carcinogens
- Genetic Susceptibility to Chemical Carcinogenesis
- Molecular Epidemiology, Chemical Carcinogenesis, and Cancer Risk in Human Populations
- Polyclic Aromatic Hydrocarbons as a Model for Gene-Environment Interaction
- Ionizing Radiation
- Ultraviolet Light
- Radiofrequency and Microwave Radiation
- Electromagnetic Fields
- Asbestos
- Nanoparticles
- Methodologic Challenges
- The Role of Individual Food and Nutrients in Cancer Etiology
- Other Foods and Nutrients
- Dietary Patterns
- Diet During Early Phases of Life
- Summary
- Limitations
Book Details
- Hardcover: 2800 pages
- Publisher: Lippincott Williams and Wilkins; Ninth, North American Edition (April 25, 2011)
- Language: English
- ISBN-10: 1451105452
- ISBN-13: 978-1451105452