The skin is a portal of knowledge on aging. From its softness and smoothness in infancy, through its suppleness in youth, to its wrinkled texture in elders, the skin displays the most visible and accessible manifestations of aging. Due to falling birth rates and rising life expectancies in industrialized countries, the average age of the population is increasing. Research interest in the process of aging has grown and people are becoming obsessed with looking and “staying” young.
Although excellent compendia exist on the subject of aging skin, the body of knowledge is burgeoning. Consequently, this handbook compiles information into one comprehensive reference. It covers a range of topics, from the basics of skin structure and function, to the cellular and molecular mechanisms of aging, to the latest bioengineering instruments used to assess age-related changes in the skin. The Nobel Prize in Physiology and Medicine awarded in 2009 to Drs. E. H. Blackburn, C. W. Greider and J. W. Szostak will stimulate research that will ameliorate the effects of aging on the organ systems of both humans and animals.
This textbook will simplify approaches when the skin may be an efficient approach to aging based on Dr. Blackburn’s team research. The skin approachability and the opportunities to work on humans will provide us in the near future with rapid therapeutic and preventive applications. Contributors are internationally recognized experts from multiple disciplines germane to this topic. This handbook to be valuable to researchers and students with an interest in aging skin.
Although excellent compendia exist on the subject of aging skin, the body of knowledge is burgeoning. Consequently, this handbook compiles information into one comprehensive reference. It covers a range of topics, from the basics of skin structure and function, to the cellular and molecular mechanisms of aging, to the latest bioengineering instruments used to assess age-related changes in the skin. The Nobel Prize in Physiology and Medicine awarded in 2009 to Drs. E. H. Blackburn, C. W. Greider and J. W. Szostak will stimulate research that will ameliorate the effects of aging on the organ systems of both humans and animals.
This textbook will simplify approaches when the skin may be an efficient approach to aging based on Dr. Blackburn’s team research. The skin approachability and the opportunities to work on humans will provide us in the near future with rapid therapeutic and preventive applications. Contributors are internationally recognized experts from multiple disciplines germane to this topic. This handbook to be valuable to researchers and students with an interest in aging skin.
Part 1 Basic Sciences
Histology
- 1 Skin Aging in Animal Models: Histological Perspective
- 2 Histology of Microvascular Aging of Human Skin
- 3 Basophilic (Actinic) Degeneration of the Dermis: An Easy Histological Scoring Approach in Dermal Photoaging
- 4 Degenerative Changes in Aging Skin
- 5 Skin Aging: A Brief Summary of Characteristic Changes
- 6 Physiological Variations During Aging
- 7 The Stratum Corneum and Aging
- 8 The Importance of Extracellular Matrix Protein 1 as Basement Membrane Protein in Maintaining Skin Function
- 9 Pathomechanisms of Endogenously Aged Skin
- 10 Pathomechanisms of Photoaged Skin
- 11 Proteoglycans in Skin Aging
- 12 Possible Involvement of Basement Membrane Damage by Matrix Metalloproteinases and Serine Proteinases in Skin Aging Process
- 13 Aging and Intrinsic Aging: Pathogenesis and Manifestations
- 14 Buffering Capacity Considerations in the Elderly
- 15 Neurotrophins and Skin Aging
- 16 Considerations for Thermal Injury: The Elderly as a Sensitive Population
- 17 Skin Reactivity of the Human Face: Functional Map and Age Related Differences
- 18 Cluster of Differentiation 1d (CD1d) and Skin Aging
- 19 Aging of Epidermal Stem Cells
- 20 Adipose-derived Stem Cells and their Secretory Factors for Skin Aging
- 21 Peroxisome Proliferator-activated Receptors: Role in Skin Health and Appearance of Photoaged Skin
- 22 Hyaluronan and the Process of Aging in Skin
- 23 Changes in Nail in the Aged
- 24 Vaginal Secretions with Age
- 25 Unique Skin Immunology of the Lower Female Genital Tract with Age
- 26 Aging Genital Skin and Hormone Replacement Therapy Benefits
- 27 Facial Skin Rheology
- 28 Pathology of Aging Skin
- 29 Alterations of Energy Metabolism in Cutaneous Aging
- 30 Cellular Energy Metabolism and Oxidative Stress
- 31 DNA Damage and Repair in Skin Aging
- 32 Fibulin-5 Deposition in Human Skin: Decrease with Aging and UVB Exposure and Increase in Solar Elastosis
- 33 Sebum Production
- 34 Climacteric Aging and Oral Hormone Replacement Therapy
- 35 Biological Effects of Estrogen on Skin
- 36 Corneocyte Size and Cell Renewal: Effects of Aging and Sex Hormones
- 37 Stratum Corneum Cell Layers
- 38 Aging and Melanocytes Stimulating Cytokine Expressed by Keratinocyte and Fibroblast
- 39 Cyanoacrylate Skin Surface Strippings
- 40 Biology of Stratum Corneum: Tape Stripping and Protein Quantification
- 41 Effect of Ozone on Cutaneous Tissues
- 42 Infrared A-induced Skin Aging
- 43 Global Warming and its Dermatologic Impact on Aging Skin
- 44 Skin Photodamage Prevention: State of the Art and New Prospects
- 45 Environmental and Genetic Factors in Facial Aging in Twins
- 46 Tobacco Smoke and Skin Aging
- 47 DNA Biomarkers in Aging Skin
- In vitro Techniques
- 48 The Use of Reconstructed Skin to Create New In Vitro Models of Skin Aging with Special Emphasis on the Flexibility of Reconstructed Skin
- 49 In vitro Method to Visualize UV-induced Reactive Oxygen Species in a Skin Equivalent Model
- 50 Aging of Skin Cells in Culture
- 51 Hyperpigmentation in Aging Skin
- 52 Pigmentation in Ethnic Groups
- 53 The New Face of Pigmentation and Aging
Part 2 Disease State/Conditions with Aging
Diseases Associated with Aging
- 54 Non-neoplastic Disorders of the Aging Skin
- 55 Neoplastic Skin Lesions in the Elderly Patient
- 56 Carcinogenesis: UV Radiation
- 57 Melanoma and Skin Aging
- 58 Aging-associated Non-melanoma Skin Cancer: A Role for the Dermis
- 59 Non-surgical Modalities of Treatment for Primary Cutaneous Cancers
- 60 Sunlight Exposure and Skin Thickness Measurements as a Function of Age: Risk Factors for Melanoma
- Non-Malignant Skin Conditions
- 61 Influence of Race, Gender, Age, and Diabetes on the Skin Circulation
- 62 Atopic Dermatitis in the Aged
- 63 Dry Skin in Diabetes Mellitus and in Experimental Models of Diabetes
- 64 Cutaneous Effects and Sensitive Skin with Incontinence in the Aged
Part 3 Techniques and Methods
Bioengineering Methods and Tools
- 65 Bioengineering Methods and Skin Aging
- 66 Hydration of the Skin Surface
- 67 Transepidermal Water Loss and Aging
- 68 Corneocyte Analysis
- 69 The Structural and Functional Development of Skin During the First Year of Life: Investigations Using Non-invasive Methods
- 70 Structure of Stratum Corneum Lipid Studied by Electron Paramagnetic Resonance
- 71 Molecular Concentration Profiling in Skin Using Confocal Raman Spectroscopy
- 72 The Measurement and Perception of Uneven Coloration in Aging Skin
- 73 Assessing Quality of Life in Older Adult Patients with Skin Disorders
- Percutaneous Penetration
- 74 Percutaneous Penetration of Chemicals and Aging Skin
- 75 Animal Models
- 76 Skin Aging: A Generalization of the Micro-inflammatory Hypothesis
- 77 The Potential of Probiotics and Prebiotics for Skin Health
- 78 Probiotics in Aging Skin
Part 4 Toxicological/Safety and General Considerations
Safety Evaluation for the Elderly Population
- 79 Irritant Contact Dermatitis
- 80 Susceptibility to Irritation in the Elderly: New Techniques
- 81 Safety Evaluation in the Elderly via Dermatological Exposure
- 82 Dermal Safety Evaluation: Use of Disposable Diaper Products in the Elderly
- 83 Aging Skin Microbiology
- 84 The Vaginal Microbiota in Menopause
- 85 Impaired Wound Repair and Delayed Angiogenesis
- 86 Facial Wrinkling: The Marquee Clinical Sign of Aging Skin
- 87 Assessing Quality of Ordinal Scales Depicting Skin Aging Severity
- 88 The Baumann Skin Typing System
Part 5 Global Skin Aging and its Management: Perception, Needs, Differences and Responses to Skin Aging
Psychosocial Implications
- 89 Psychological and Social Implications of Aging Skin: Normal Aging and the Effects of Cutaneous Disease
- 90 Aging Skin: Some Psychosomatic Aspects
- 91 Facial Skin Attributes and Age Perception
- 92 Determinants in the Rate of Skin Aging: Ethnicity, Gender, and Lifestyle Influences
- 93 Gender Differences in Skin
- 94 Aging in Asian Skin
- 95 Perceptions of Sensitive Skin with Age
- 96 Aging and Skin Sensitivity
- 97 Aging and Anti-aging Strategies
- 98 Cosmetics and Aging Skin
- 99 Cosmetic Anti-aging Ingredients
- 100 Topical Growth Factors for Skin Rejuvenation
- 101 Topical Peptides and Proteins for Aging Skin
- 102 Solutions and Products for Managing Female Urinary Incontinence
- 103 Changes in Vulvar Physiology and Skin Disorders with Age and Benefits of Feminine Wipes in Postmenopausal Women
- 104 A New Paradigm for the Aging Face
- 105 Cosmetic Surgery in the Elderly
- 106 Facial Rejuvenation: A Chronology of Procedures
Part 6 Global Market Place for the Aged
- 107 Marketing and Product Design of Anti-aging Skin Care Products
- 108 Key Trends Driving Anti-aging Skin Care in 2009 and Beyond
Product Details
- Hardcover: 1256 pages
- Publisher: Springer; 2nd Printing. edition (January 22, 2010)
- Language: English
- ISBN-10: 3540896554
- ISBN-13: 978-3540896555
- Product Dimensions: 10.5 x 8.7 x 2 inches