Established since 1942 as the leading hematology textbook, Wintrobe's Clinical Hematology is now in its thoroughly revised Twelfth Edition. The text continues its tradition of correlating basic science with the clinical practice of hematology and is organized to help physicians find clinical answers quickly and easily.
The Twelfth Edition is in full color for the first time, includes more international contributors, and has two new editors, Daniel A. Arber, MD and Robert T. Means, Jr., MD. Highlights include expanded coverage of molecular genetics and pathogenesis, more hematopathology illustrations, and current information on new medications and their rapid bench-to-bedside development. Four new chapters cover anemias unique to the newborn period, pathology of LHC and other histiocytic disorders, tumors of the spleen, and pathology and classification of myeloproliferative disorders and mast cell disease.
A companion Website will offer the fully searchable text and an image bank.
Key Features
- The most comprehensive hematology book on the market.
- Effectively bridges the gap between the basic science and clinical practice in hematology.
- Chapters are arranged logically to best serve physicians in search of clinical answers.
- Full-color halftones and 2-color, computer-generated illustrations spread throughout the book.
New to this edition
- NEW! Two new editors: Robert Means, MD, Professor of Hematology/Oncology at Vanderbilt (red cell material) and Daniel Arber, MD, Professor of Pathology and Laboratory Medicine at Stanford (hematopathology material)
- NEW! Greater emphasis on molecular genetics and pathogenesis, as well as an increased number of hematopathology illustrations
- NEW! Further expansion of contributor base including international contributors
- NEW! Clinical chapters detail new medications and their rapid bench-to-bedside development, especially those under development for chronic myeloid leukemia
- NEW! Four new chapters:
- Anemias Unique to the Newborn Period;
- Pathology of LHC and Other Histiocytic Disorders;
- Tumors of the Spleen; and
- Pathology and Classification of Myeloproliferative Disorders and Mast Cell Disease
- NEW! Thirty-one chapters with major changes (combined/reconfigured and/or new contributors).
Contents
VOLUME 1
PART I Laboratory Hematology - CH 1. Examination of the Blood and Bone Marrow
- CH 2. Clinical Flow Cytometry
- CH 3. Cytogenetics
- CH 4. Molecular Biology and Hematology
PART II The Normal Hematologic System
Section 1. Hematopoiesis
- CH 5. Origin and Development of Blood Cells
Section 2. The Erythrocyte
- CH 6. Erythropoiesis
- CH 7. The Mature Erythrocyte
- CH 8. Destruction of Erythrocytes
Section 3. Granulocytes and Monocytes
- CH 9. Neutrophilic Leukocytes
- CH 10. The Human Eosinophil
- CH 11. Basophilic Leukocytes: Mast Cells and Basophils
- CH 12. Mononuclear Phagocytes
- CH 13. Phagocytosis
Section 4. The Lymphocytes
- CH 14. Lymphocytes and Lymphatic Organs
- CH 15. B Lymphocytes
- CH 16. T Lymphocytes and Natural Killer Cells
- CH 17. Effector Mechanisms in Immunity
Section 5. Hemostasis
- CH 18. Megakaryocytes
- CH 19. Platelet Structure and Function in Hemostasis and Thrombosis
- CH 20. Blood Coagulation and Fibrinolysis
- CH 21. Endothelium: Angiogenesis and the Regulation of Hemostasis
PART III Therapeutic Modalities
- CH 22. Red Cell, Platelet, and White Cell Antigens
- CH 23. Transfusion Medicine
- CH 24. Hematopoietic Stem Cell Transplantation
- CH 25. Gene Therapy for Hematologic Disorders
PART IV Disorders of Red Cells
Section 1. Introduction
- CH 26. Anemia: General Considerations
Section 2. Disorders of Iron Metabolism and Heme Synthesis
- CH 27. Iron Deficiency and Related Disorders
- CH 28. Sideroblastic Anemias
- CH 29. Hemochromatosis
- CH 30. Porphyria
Section 3. Hemolytic Anemia
- CH 31. Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the Erythrocyte Membrane
- CH 32. Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders
- CH 33. Autoimmune Hemolytic Anemia
- CH 34. Alloimmune Hemolytic Disease of the Fetus and Newborn
- CH 35. Paroxysmal Nocturnal Hemoglobinuria
- CH 36. Acquired Nonimmune Hemolytic Disorders
Section 4. Hereditary Disorders of Hemoglobin Structure and Synthesis
- CH 37. Sickle Cell Anemia and Other Sickling Syndromes
- CH 38. Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis
- CH 39. Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias
Section 5. Other Red Cells Disorders
- CH 40. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis
- CH 41. Inherited Aplastic Anemia Syndromes
- CH 42. Acquired Aplastic Anemia
- CH 43. Red Cell Aplasia
- CH 44. Congenital Dyserythropoietic Anemias
- CH 45. Anemias Secondary to Chronic Disease and Systemic Disorders
- CH 46. Anemias During Pregnancy and the Postpartum Period
- CH 47. Anemias Unique to the Newborn Period
- CH 48. Erythrocytosis
VOLUME 2
PART V Disorders of Hemostasis and Coagulation
- Section 1. Introduction
- Section 2. Thrombocytopenia
- Section 3. Other Disorders of Primary Hemostasis
- Section 4. Coagulation Disorders Platelet Destruction
- Section 5 Thrombosis
PART VI Nonmalignant Disorders of Leukocytes,the Spleen, and/or Immunoglobins
PART VII Hematologic Malignancies
- Section 1. General Aspects
- Section 2. The Acute Leukemias
- Section 4. Lymphoproliferative Disorders
- Section 5. Plasma Cell Dyscrasias
Appendices
Index
Product Details
- Hardcover: 3232 pages
- Publisher: Lippincott Williams & Wilkins; Twelfth edition (December 17, 2008)
- Language: English
- ISBN-10: 0781765072
- ISBN-13: 978-0781765077
- Product Dimensions: 12 x 9.4 x 5.6 inches
List Price: $359.50