The aim of Stockley’s Drug Interactions is to inform busy doctors, pharmacists, surgeons, nurses and other healthcare professionals, of the facts about drug interactions, without their having to do the time-consuming literature searches and full assessment of the papers for themselves. These therefore are the practical questions which this book attempts to answer:
- Are the drugs and substances in question known to interact or is the interaction only theoretical and speculative?
- If they do interact, how serious is it?
- Has it been described many times or only once?
- Are all patients affected or only a few?
- Is it best to avoid these two substances altogether or can the interaction be accommodated in some way?
- And what alternative and safer drugs can be used instead?
To precis the mass of literature into a concise and easy-to-read form, the text has been organized into a series of individual monographs, all with a common format. If you need some insight into the general philosophy underlying the way all this information is handled in this publication, you should have a look at the section, ‘Before using this book. . .’.
There have been several changes for the 8th edition. All of the existing monographs have, as with each edition, been reviewed, revalidated and updated, and many new ones have been added, making a total in excess of 3100 monographs. Many new monographs on herbal interactions have been added, although good quality human studies remain sparse. A new chapter has been added to cover the growing number of interactions about anorectics, and the chapter on sympathomimetics has been removed, with the information redistributed according to the therapeutic use of the drugs in question, to give a better indication of precisely which drugs from this disparate group are likely to interact. We have continued to add information provided by regulatory bodies outside of the UK, which further enhances the international flavour of the publication.
This edition has also seen the growth in our editorial team, with two practicing clinical pharmacists recruited to help us ensure we maintain the practical nature of the information given. This has also allowed us to develop our product range, with the publication of the first Stockley’s Drug Interactions Pocket Companion, which we have developed for delivery on PDA.
As always, the Editorial team have had assistance from many other people in developing this publication , and the Editor gratefully acknowledges the assistance and guidance that they have provided. The Martindale team continue to be a great source of advice and support, and particular thanks is due to the editor, Sean Sweetman. Thanks are also due to John Wilson and Tamsin Cousins, who handle the various aspects of producing our publications in print. We are also grateful for the support of both Paul Weller and Charles Fry. Ivan Stockley remains an important part of the publication, taking a keen interest in the development of new products, and as ever, we find his advice invaluable.
Stockley’s Drug Interactions continues to be available on the Pharmaceutical Press platform, Medicines Complete, as well as being available on other platforms, both in English and Spanish. With the further development of the integratable Alerts product and the new PDA, we remain indebted to Julie McGlashan, Michael Evans, Elizabeth King, and all those involved in the development of these products, for their advice and support. For more details about these digital products please visit: www.pharmpress.com/Stockley.
The monographs
This publication has over 3100 monographs with a common format, which are subdivided into sections like these:
- An abstract or summary for quick reading.
- Clinical evidence, detailing one, two or more illustrative examples of the interaction, followed by most or all of other supportive clinical evidence currently available.
- Mechanism, in brief.
- Importance and management, a short discussion designed to aid rapid clinical decision making. For example:
- Is the interaction established or not?
- What is its incidence?
- How important is it?
- How can it be managed?
- And what, if any, are the non-interacting alternatives?
- References, a list of all of the relevant references. The length of the references list gives a very fair indication of the extent of the documentation. A long list indicates a well documented interaction, whereas a short list indicates poor documentation.
Some of the monographs have been compressed into fewer subsections instead of the more usual five, simply where information is limited or where there is little need to be more expansive.
The monographs do not carry the drug interaction Hazard/Severity ratings as used in the electronic Stockley Interactions Alerts because of the difficulties of applying them to monographs that cover multiple pairs of drug–drug interactions, but what is written in each monograph should speak for itself.
Contents
- 1. General considerations and an outline survey of some basic interaction mechanisms 1
- 2. ACE inhibitors and Angiotensin II receptor antagonists 12
- 3. Alcohol 40
- 4. Alpha blockers 83
- 5. Anaesthetics and Neuromuscular blockers 90
- 6. Analgesics and NSAIDs 133
- 7. Anorectics and Stimulants 199
- 8. Anthelmintics, Antifungals and Antiprotozoals 207
- 9. Antiarrhythmics 243
- 10. Antibacterials 285
- 11. Anticholinesterases 352
- 12. Anticoagulants 358
- 13. Antidiabetics 468
- 14. Antiepileptics 517
- 15. Antihistamines 582
- 16. Antimigraine drugs 597
- 17. Antineoplastics 609
- 18. Antiparkinsonian and related drugs 672
- 19. Antiplatelet drugs and Thrombolytics 697
- 20. Antipsychotics, Anxiolytics and Hypnotics 706
- 21. Antivirals 772
- 22. Beta blockers 833
- 23. Calcium-channel blockers 860
- 24. Cardiovascular drugs, miscellaneous 878
- 25. Digitalis glycosides 903
- 26. Diuretics 944
- 27. Gastrointestinal drugs 960
- 28. Hormonal contraceptives and Sex hormones 975
- 29. Immunosuppressants 1009
- 30. Lipid regulating drugs 1086
- 31. Lithium 1111
- 32. MAOIs 1130
- 33. Respiratory drugs 1158
- 34. SSRIs, Tricyclics and related antidepressants 1203
- 35. Miscellaneous drugs 1247
- Index
Product Details
- Hardcover: 1464 pages
- Publisher: Pharmaceutical Press; 8 edition (November 8, 2008)
- Language: English
- ISBN-10: 085369754X
- ISBN-13: 978-0853697541
- Product Dimensions: 14.8 x 9.7 x 3.2 inches
List Price: $250.00