In the 4 years since the publication of the first edition of this book an explosion in our understanding of the molecular genetics of breast cancer has occurred. This has been accelerated by the advent of genomic technologies following the sequencing of the human genome. In this second edition, for which we are delighted to act as editors, we have added a new chapter that describes the major genomic approaches used today. The authors also discuss how these technologies are predicted to change the way we understand and treat breast cancer. Throughout the remainder of the text we have maintained the original format and comprehensive approach of the first edition, but have updated many chapters. For example, a section on handling specimens postneoadjuvant therapy has been added to Chapter 2, and discussions on multigene prognostic assays, including Oncotype DX and MammaPrint, have been included in Chapter 20. An in-depth discussion of the updated seventh edition of the American Joint Committee on Cancer (AJCC) staging of breast cancer, with a focus on handling and reporting sentinel lymph nodes, is included in Chapters 22 and 23, and Chapter 24. Chapter 22 Chapter 23 Chapter24 on breast cancer biomarkers includes a detailed discussion on external quality assurance, an important topic for all laboratories that perform these tests.
We are again indebted to the many internationally renowned breast pathologists and clinical and scientific experts from around the world who have contributed to this book, and we are sincerely grateful for the time and effort they have put forth. We are delighted to share their words of wisdom with you, our readers, and we hope that you find this book a useful resource in your practice of breast pathology.
-- Authors --
Key Features
- Reference key information quickly and easily with a consistent, user-friendly format and at-a-glance boxes and tables throughout the text.
- Examine all aspects of a pathologic entity, including clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnosis, and prognostic and therapeutic considerations.
- Catch all the nuances of how pathological lesions present through over 400 full-color illustrations.
- Practice with confidence and overcome your toughest challenges with advice from the top minds in breast pathology.
- Access the fully searchable text online at www.expertconsult.com, along with a downloadable image bank, illustrations, boxes, tables, and more.
- Apply the latest molecular diagnostic techniques to recognize newly identified classifications in breast disease.
- Get more of the information you need from new and expanded chapters covering a broad range of diseases and topics including fine needle aspiration cytology and the physical handling of core biopsy specimens; handling and evaluation of sentinel lymph nodes; diseases of the male breast; and state-of-the-art coverage of molecular advances in malignant breast disease.
- Prepare for the future of breast pathology with a new chapter dedicated to gene profiling and stem cell diagnostic techniques.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
Contents
- Chapter 1 - Diagnostic Methodologies: Fine Needle Aspiration Cytology
- Chapter 2 - Handling of Surgical Specimens
- Chapter 3 - Core Biopsy: Methodologies, Reporting, and Management Issues
- Chapter 4 - Overview of Clinical Aspects of Breast Disease
- Chapter 5 - Overview of Radiologic Aspects of Breast Disease
- Chapter 6 - Normal Breast
- Chapter 7 - Inflammatory Lesions, Infections, and Silicone Granulomas
- Chapter 8 - Sclerosing Lesions: Sclerosing Adenosis, Radial Scar/Complex Sclerosing Lesion, and Microglandular Adenosis
- Chapter 9 - Papillary Lesions
- Chapter 10 - Fibroepithelial Lesions, Including Fibroadenoma and Phyllodes Tumors
- Chapter 11 - Benign Stromal Lesions of the Breast
- Chapter 12 - Diseases of the Nipple
- Chapter 13 - Fibrocystic Change and Columnar Cell Lesions
- Chapter 14 - Usual Epithelial Hyperplasia and Atypical Ductal Hyperplasia
- Chapter 15 - Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ
- Chapter 16 - Molecular Genetics of Ductal Carcinoma In Situ and Lobular Carcinoma In Situ
- Chapter 17 - Morphology of Ductal Carcinoma In Situ
- Chapter 18 - Invasive Carcinoma: Special Types
- Chapter 19 - Histologic Grade
- Chapter 20 - Invasive Carcinoma: Other Histologic Prognostic Factors, Prognostic Indices, and Application of Prognostic Information for Patient Management
- Chapter 21 - Familial Breast Cancer
- Chapter 22 - Handling and Evaluation of Sentinel Lymph Nodes
- Chapter 23 - Sentinel Node Biopsy and Lymph Node Classification in the 7th Edition Staging Manual
- Chapter 24 - Breast Cancer Biomarkers: Prognostic and Predictive Value and External Quality Assurance
- Chapter 25 - An Overview of Immunohistochemistry in Diagnosis of Breast Lesions
- Chapter 26 - Other Malignant Lesions of the Breast
- Chapter 27 - Diseases of the Male Breast
- Chapter 28 - Breast Cancer: Emerging Methods for the Assessment of Primary Tumors, Including Genomic and Stem Cell Characterization in Breast Cancer
About the Authors
- Frances P O’Malley, MB, FRCPC, Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto; Surgical Pathologist, Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
- Sarah E Pinder, MB ChB, FRCPath, Professor of Breast Pathology, Department of Cellular Pathology, King's College London; Lead Consultant Breast Pathologist, Guy's and St. Thomas’ Hospitals, London, United Kingdom.
- Anna Marie Mulligan, MB BCh, MSc, FRCPath, Assistant Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto; Surgical Pathologist, Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Series Editor
- John R Goldblum, MD, FCAP, FASCP, FACG, Chairman, Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Book Reviews
Drs. Frances O’Malley, Sarah Pinder, and Anna Marie Mulligan, world-renowned breast pathologists from Canada and the United Kingdom, have edited an outstanding, state-of-the-art book on breast pathology. The list of contributors is impressive, and includes eminent pathologists from the United States, Canada, the United Kingdom, Australia, and New Zealand, all of whom have built national and international reputations in the field of breast pathology. The content in each chapter is practical, well-organized, and concisely written, focusing on the thorough evaluation of fine needle aspirates, core biopsies, wire localization biopsies, and resection specimens. Overviews of the clinical and radiologic aspects of breast diseases provide a thoughtful background for the practicing pathologist, since these aspects go hand in hand with the histologic features.
This edition is organized into 28 chapters covering all the major problems encountered in breast pathology. Several new chapters in this second edition provide the most up-to-date information on the histologic, immunohistochemical, and molecular genetic aspects of breast diseases. Separate chapters describe the normal breast, inflammatory conditions, sclerosing lesions of the breast, papillary lesions, fibroadenomas and phyllodes tumors, stromal lesions, diseases of the nipple, and fibrocystic changes. Chapters 14 through 20Chapter 14 Chapter 15 Chapter 16 Chapter 17 Chapter 18 Chapter 19 Chapter 20 are dedicated to the ductal and lobular proliferations of the breast, describing in great detail the subtle changes that occur in the spectrum from hyperplasia to atypical hyperplasia to in-situ and invasive carcinoma. Separate chapters are dedicated to familial breast cancer, the handling and evaluation of sentinel lymph nodes, immunohistochemical diagnosis of breast lesions, and molecular markers in invasive breast cancer.
I wish to extend my sincerest gratitude to Drs. O’Malley, Pinder, and Mulligan for editing a superb edition of Foundations in Diagnostic Pathology. I would also like to congratulate all the authors who contributed to this outstanding edition. I sincerely hope you enjoy this volume of the series.
-- John R Goldblum, MD --
Product Details
- Hardcover: 400 pages
- Publisher: Saunders; 2 edition (2011)
- Language: English
- ISBN-10: 1437717578
- ISBN-13: 978-1437717570
- Product Dimensions: 11 x 8.7 x 0.9 inches
List Price: $179.00