The second edition of Applied Clinical Pharmacokinetics includes new methods to dose immunosuppressants (2-hour post dose cyclosporine concentrations, area under the curve methods for cyclosporine and tacrolimus), and the elevation of what were new methods of dosing antibiotics to the mainstream (extended interval and area under the curve methods for aminoglycosides, trough-only monitoring for vancomycin). Other additions include more complete coverage of pediatric patients, dosing during hemoperfusion, an overview of methods preceding the initial and dosage adjustment sections, and a dosing strategies section that groups together initial and dosage adjustment techniques into a logical sequence. Of course, relevant sections, examples, problems, and references have been updated as needed for each chapter. However, one thing that remains unchanged is the general organization and philosophy of the book.
Depending on one’s point of view, the discipline of therapeutic drug monitoring is entering its fifth decade. Some brilliant scientists and practitioners who have made significant contributions to the area (and whose names are in the reference list or attached to the methods recommended in this text) and changed the lives of countless patients are no longer with us.
Book Features
- NEW! High-yield sections on dosing strategies in all chapters
- NEW! Up-to-date, ready-to-use information on monitored drugs
- Valuable coverage of drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure and patients on dialysis
- All the information that you need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants
- Tools that simplify learning throughout, such as an introductory chapter on clinical pharmacokinetic and pharmacodynamic concepts, examples of calculations, and problems with answers and explanations at the end of each chapter
About the Author
Larry A. Bauer, PharmD, is a Professor at the University of Washington School of Pharmacy and has been on the faculty since 1980. He also holds an adjunct appointment at the same rank in the Department of Laboratory Medicine where he is a toxicology consultant. He received his Bachelor of Science in Pharmacy degree (1977) from the University of Washington and his Doctor of Pharmacy degree (1980) from the University of Kentucky under the supervision of Dr. Robert Blouin. He also completed an ASHP accredited hospital pharmacy residency (1980) specializing in clinical pharmacokinetics from A. B. Chandler Medical Center at the University of Kentucky under the preceptorship of Dr. Paul Parker. Dr. Bauer is a fellow of the American College of Clinical Pharmacology and the American College of Clinical Pharmacy.
Dr. Bauer’s specialty area is in clinical pharmacokinetics; he teaches courses and offers clinical clerkships in this area. His research interests include the pharmacokinetics and pharmacodynamics of drug interactions, the effects of liver disease and age on drug metabolism, and computer modeling of population pharmacokinetics. He has over 155 published research papers, abstracts, books, and book chapters. Dr. Bauer is a member of several clinical pharmacology and clinical pharmacy professional organizations. He was consulting editor of Clinical Pharmacy (1981–1990), field editor of ASHP Signal (1981–1983), and a member of the editorial board of Clinical Pharmacology and Therapeutics. Currently, he is on the editorial board of Antimicrobial Agents and Chemotherapy and reviews for many other scientific publications. Dr. Bauer has precepted three postdoctoral fellows in clinical pharmacokinetics who currently have faculty appointments in schools of pharmacy or positions in the pharmaceutical industry.
Contents
PART I BASIC CONCEPTS
PART I BASIC CONCEPTS
1 Clinical Pharmacokinetic and Pharmacodynamic Concepts
2 Clinical Pharmacokinetic Equations and Calculations
Drug Dosing in Special Populations: Renal and Hepatic Disease, Dialysis, Heart Failure, Obesity, and Drug Interactions
PART II ANTIBIOTICS
4 The Aminoglycoside Antibiotics
5 Vancomycin
PART III CARDIOVASCULAR AGENTS
6 Digoxin
7 Lidocaine
8 Procainamide/N-Acetyl Procainamide
9 Quinidine
PART IV ANTICONVULSANTS
10 Phenytoin
11 Carbamazepine
12 Valproic Acid
13 Phenobarbital/Primidone
14 Ethosuximide
PART V IMMUNOSUPPRESSANTS
15 Cyclosporine
16 Tacrolimus
PART VI OTHER DRUGS
17 Lithium
18 Theophylline
Index
Product Details
- Hardcover: 840 pages
- Publisher: McGraw-Hill Medical; 2 edition (June 24, 2008)
- Language: English
- ISBN-10: 9780071476287
- ISBN-13: 978-0071476287
- Product Dimensions: 9.4 x 7.6 x 1.5 inches
List Price: $68.95
