As we launch the 8th edition of Pathologic Basis of Disease we pause to look back 50 years ago, when the first edition of this book, entitled “Pathology with Clinical Correlations” was published. (For those who may not know, the first three editions were published under this name and so the current “8th edition” is really the 11th edition of this book.)
In the preface of the first edition, Stanley Robbins wrote:
- “But the study of morphology is only one facet of pathology. Pathology contributes much to clinical medicine. The pathologist is interested not only in the recognition of structural alterations, but also in their significance, i.e., the effects of these changes on cellular and tissue function and ultimately the effect of these changes on the patient. It is not a discipline isolated from the living patient, but rather a basic approach to a better understanding of disease and therefore a foundation of sound clinical medicine.”
- “The why's and how's are as important as the what's.”
In today's vocabulary, what Robbins said in 1957 was that pathology is the study of the mechanism of diseases and morphology is a tool (the only one available at that time) to gain insight into pathogenesis and clinical correlations. Over the past 50 years, this focus has not changed and it remains the guiding principle for the current edition. The main difference is that now we have many more tools to supplement morphology, including molecular biology, genetics, and informatics, to name a few. Indeed, it might be said that this book presents the molecular basis of human disease with clinical correlations. This edition, like all previous ones, has been extensively revised, and some areas have been completely rewritten. A few examples of significant changes are as follows:
- Chapter 1 has been completely reorganized to include the entire spectrum of cellular responses to injury, from adaptations and sublethal injury to cell death.
- Chapter 3 covering tissue repair and wound healing, has been extensively revised to include new and exciting information on stem cell biology, growth factor signaling, and the mechanisms that underlie fibrosis.
- Chapter 5 includes a completely rewritten section on molecular diagnosis that reflects rapid advances in DNA sequencing technology. The principles of genome-wide analysis, now becoming a powerful tool in the study of complex human diseases like cancer and diabetes, have also been added.
- Chapter 9 has been completely revised and reorganized in view of the increasing importance of environmental factors in human diseases.
- Chapter 17 has been completely rewritten and highlights new insights into the pathogenesis of inflammatory bowel disease and gastrointestinal cancers.
- Chapter 22 covering diseases of the female genital tract, includes discussion of the molecular basis of cancer, endometriosis, and preeclampsia.
- In addition to the revision and reorganization of the text, many new photographs and schematics have been added and a large number of the older “gems” have been enhanced by digital technology. Thus, we hope that even the veterans of Robbins Pathology will find the illustrations and figures sparkling and fresh.
Wherever appropriate, we have blended new discoveries into the discussion of pathogenesis and pathophysiology, while never losing sight that the “state of the art” has little value if it does not enhance the understanding of disease mechanisms. As in the past, we have not avoided discussions of “unsolved” problems because of our belief that many who read the text might be encouraged to embark on a path of discovery.
Despite the changes highlighted above, our goals remain the same as those articulated by Robbins and Cotran over the past many years.
- To integrate into the discussion of pathologic processes and disorders the newest established information available—morphologic as well as molecular.
- To organize information into logical and uniform presentations, facilitating readability, comprehension, and learning.
- To maintain the book at a reasonable size and yet provide adequate discussion of the significant lesions, processes, and disorders. Indeed, we have reduced the girth and the weight of this book by trimming out about 80 pages (making it less useful for weight lifting).
- To place great emphasis on clarity of writing and proper use of language in the recognition that struggling to comprehend is time-consuming and wearisome and gets in the way of the learning process.
- To make this first and foremost a student text—used by students throughout all years of medical school and into their residencies—but, at the same time, to provide sufficient detail and depth to meet the needs of more advanced readers.
We have been repeatedly told by readers that up-todatedness is a special feature that makes this book very valuable. We have strived to remain current by providing new information and references from recent literature, many published in 2008 and some from the early part of 2009. However, older classics have also been retained to provide original source material for advanced readers.
We are now into the digital age and so the text will be available online to those who own the print version. Such access gives the reader the ability to search across the entire text, bookmark passages, add personal notes, and use PubMed to view references, and has many other exciting features. In addition, also available online are case studies, previously available separately as the Interactive Case Study Companion developed by one of us (VK) in collaboration with Herb Hagler, PhD, and Nancy Schneider, MD, PhD, at the University of Texas Southwestern Medical School in Dallas. The cases are designed to enhance and reinforce learning by challenging students to apply their knowledge to solve clinical cases. A virtual microscope feature enables the viewing of selected images at various magnifications.
This edition is also marked by the addition of a new coauthor, Jon Aster. All four of us have reviewed, critiqued, and edited each chapter to ensure the uniformity of style and flow that have been the hallmarks of the book. Together, we hope that we have succeeded in equipping the readers with the scientific basis for the practice of medicine and in whetting their appetite for learning beyond what can be offered in any textbook.
-- VK, AKA, NF, JCA
Key Features
- Delivers a state-of-the-art understanding of the pathologic basis of disease through completely updated coverage, including the latest cellular and molecular biology.
- Demonstrates every concept visually with over 1,600 full-color photomicrographs and conceptual diagrams - many revised for even better quality.
- Facilitates learning with an outstanding full-color, highly user-friendly design.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
- Interactive Case Studies: Browse over 100 case studies, complete with learning objectives, and interactive figures and review questions.
- Virtual Microscope: See both standard and magnified views of over 150 high-quality pathology slides showing both normal and diseased states.
Contents
General Pathology
Chapter 1 - Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
- Introduction to Pathology
- Overview: Cellular Responses to Stress and Noxious Stimuli
- Adaptations of Cellular Growth and Differentiation
- Overview of Cell Injury and Cell Death
- Causes of Cell Injury
- Morphologic Alterations in Cell Injury
- Mechanisms of Cell Injury
- Clinico-Pathologic Correlations: Selected Examples of Cell Injury and Necrosis
- Apoptosis
- Autophagy
- Intracellular Accumulations
- Pathologic Calcification
- Cellular Aging
Chapter 2 - Acute and Chronic Inflammation
- Overview of Inflammation
- Historical Highlights
- Acute Inflammation
- Mediators of Inflammation
- Outcomes of Acute Inflammation
- Morphologic Patterns of Acute Inflammation
- Summary of Acute Inflammation
- Chronic Inflammation
- Systemic Effects of Inflammation
- Consequences of Defective or Excessive Inflammation
Chapter 3 - Tissue Renewal, Regeneration, and Repair
- Control of Normal Cell Proliferation and Tissue Growth
- Cell Cycle and the Regulation of Cell Replication
- Mechanisms of Tissue and Organ Regeneration
- Extracellular Matrix and Cell-Matrix Interactions
- Healing by Repair, Scar Formation and Fibrosis
Chapter 4 - Hemodynamic Disorders, Thromboembolic Disease, and Shock
- Edema
- Hyperemia and Congestion
- Hemorrhage
- Hemostasis and Thrombosis
- Embolism
- Infarction
- Shock
Chapter 5 - Genetic Disorders
- Human Genetic Architecture
- Genes and Human Diseases
- Mendelian Disorders
- Complex Multigenic Disorders
- Chromosomal Disorders
- Single-Gene Disorders with Nonclassic Inheritance
- Molecular Diagnosis of Genetic Diseases
Chapter 6 - Diseases of the Immune System
- The Normal Immune Response
- Hypersensitivity and Autoimmune Disorders
- Rejection of Tissue Transplants
- Immunodeficiency Syndromes
- Amyloidosis
Chapter 7 - Neoplasia
- Nomenclature
- Characteristics of Benign and Malignant Neoplasms
- Epidemiology
- Molecular Basis of Cancer
- Molecular Basis of Multistep Carcinogenesis
- Carcinogenic Agents and Their Cellular Interactions
- Host Defense against Tumors—Tumor Immunity
- Clinical Aspects of Neoplasia
Chapter 8 - Infectious Diseases
- General Principles of Microbial Pathogenesis
- Viral Infections
- Bacterial Infections
- Fungal Infections
- Parasitic Infections
Chapter 9 - Environmental and Nutritional Diseases
- The Global Burden of Disease
- Health Effects of Climate Change
- Toxicity of Chemical and Physical Agents
- Environmental Pollution
- Occupational Health Risks: Industrial and Agricultural Exposures
- Effects of Tobacco
- Effects of Alcohol
- Injury by Therapeutic Drugs and Drugs of Abuse
- Injury by Physical Agents
- Nutritional Diseases
Chapter 10 - Diseases of Infancy and Childhood
- Congenital Anomalies
- Disorders of Prematurity
- Perinatal Infections
- Fetal Hydrops
- Inborn Errors of Metabolism and Other Genetic Disorders
- Sudden Infant Death Syndrome (SIDS)
- Tumors and Tumor-like Lesions of Infancy and Childhood
Systemic Pathology: Diseases of Organ Systems
Chapter 11 - Blood Vessels
- The Structure and Function of Blood Vessels
- Vessel Development, Growth, and Remodeling
- Congenital Anomalies
- Vascular Wall Cells and Their Response to Injury
- Hypertensive Vascular Disease
- Arteriosclerosis
- Atherosclerosis
- Aneurysms and Dissection
- Vasculitis
- Raynaud Phenomenon
- Veins and Lymphatics
- Tumors
- Pathology of Vascular Interventions
Chapter 12 - The Heart
- Cardiac Structure and Specializations
- Effects of Aging on the Heart
- Heart Disease: Overview of Pathophysiology
- Heart Failure
- Congenital Heart Disease
- Ischemic Heart Disease
- Hypertensive Heart Disease
- Valvular Heart Disease
- Cardiomyopathies
- Pericardial Disease
- Tumors of the Heart
- Cardiac Transplantation
Chapter 13 - Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus
- Development and Maintenance of Hematopoietic Tissues
DISORDERS OF WHITE CELLS
- Leukopenia
- Reactive (Inflammatory) Proliferations of White Cells and Lymph Nodes
- Neoplastic Proliferations of White Cells
SPLEEN
- Splenomegaly
- Neoplasms
- Congenital Anomalies
- Rupture
THYMUS
- Developmental Disorders
- Thymic Hyperplasia
- Thymomas
Chapter 14 - Red Blood Cell and Bleeding Disorders
- Anemias
- Polycythemia
- Bleeding Disorders: Hemorrhagic Diatheses
Chapter 15 - The Lung
- Congenital Anomalies
- Atelectasis (Collapse)
- Pulmonary Edema
- Acute Lung Injury and Acute Respiratory Distress Syndrome (Diffuse Alveolar Damage)
- Obstructive versus Restrictive Pulmonary Diseases
- Obstructive Pulmonary Diseases
- Chronic Diffuse Interstitial (Restrictive) Diseases
- Diseases of Vascular Origin
- Pulmonary Infections
- Lung Transplantation
- Tumors
- Pleura
Chapter 16 - Head and Neck
ORAL CAVITY
- Teeth and Supporting Structures
- Inflammatory/Reactive Tumor-like Lesions
- Infections
- Oral Manifestations of Systemic Disease
- Tumors and Precancerous Lesions
- Odontogenic Cysts and Tumors
UPPER AIRWAYS
- Nose
- Nasopharynx
- Tumors of the Nose, Sinuses, and Nasopharynx
- Larynx
EARS
- Inflammatory Lesions
- Otosclerosis
- Tumors
NECK
- Branchial Cyst (Cervical Lymphoepithelial Cyst)
- Thyroglossal Duct Cyst
- Paraganglioma (Carotid Body Tumor)
SALIVARY GLANDS
- Xerostomia
- Inflammation (Sialadenitis)
- Neoplasms
Chapter 17 - The Gastrointestinal Tract
CONGENITAL ABNORMALITIES
- Atresia, Fistulae, and Duplications
- Diaphragmatic Hernia, Omphalocele, and Gastroschisis
- Ectopia
- Meckel Diverticulum
- Pyloric Stenosis
- Hirschsprung Disease
ESOPHAGUS
- Esophageal Obstruction
- Esophagitis
- Barrett Esophagus
- Esophageal Tumors
STOMACH
- Acute Gastritis
- Chronic Gastritis
- Complications of Chronic Gastritis
- Hypertrophic Gastropathies
- Gastric Polyps and Tumors
SMALL INTESTINE AND COLON
- Intestinal Obstruction
- Ischemic Bowel Disease
- Angiodysplasia
- Malabsorption and Diarrhea
- Infectious Enterocolitis
- Irritable Bowel Syndrome
- Inflammatory Bowel Disease
- Other Causes of Chronic Colitis
- Sigmoid Diverticulitis
- Polyps
- Familial Syndromes
- Adenocarcinoma
- Tumors of the Anal Canal
- Hemorrhoids
- Acute Appendicitis
- Tumors of the Appendix
PERITONEAL CAVITY
- Inflammatory Disease
- Tumors
Chapter 18 - Liver and Biliary Tract
THE LIVER
- General Features of Hepatic Disease
- Infectious Disorders
- Autoimmune Hepatitis
- Drug- and Toxin-Induced Liver Disease
- Metabolic Liver Disease
- Intrahepatic Biliary Tract Disease
- Circulatory Disorders
- Hepatic Complications of Organ or Bone Marrow Transplantation
- Hepatic Disease Associated with Pregnancy
- Nodules and Tumors
THE BILIARY TRACT
- Congenital Anomalies
- Disorders of the Gallbladder
- Disorders of the Extrahepatic Bile Ducts
- Tumors
Chapter 19 - The Pancreas
Congenital Anomalies
Pancreatitis
Non-Neoplastic Cysts
Neoplasms
Chapter 20 - The Kidney
Clinical Manifestations of Renal Diseases
Glomerular Diseases
Tubular and Interstitial Diseases
Vascular Diseases
Congenital Anomalies
Cystic Diseases of the Kidney
Urinary Tract Obstruction (Obstructive Uropathy)
Urolithiasis (Renal Calculi, Stones)
Tumors of the Kidney
Chapter 21 - The Lower Urinary Tract and Male Genital System
THE LOWER URINARY TRACT
- Ureters
- Urinary Bladder
- Urethra
THE MALE GENITAL TRACT
- Penis
- Testis and Epididymis
- Prostate
Chapter 22 - The Female Genital Tract
- Development
- Anatomy
- Infections of the Female Genital Tract
VULVA
- Bartholin Cyst
- Non-Neoplastic Epithelial Disorders
- Benign Exophytic Lesions
- Squamous Neoplastic Lesions
- Glandular Neoplastic Lesions
- Malignant Melanoma
VAGINA
- Developmental Anomalies
- Premalignant and Malignant Neoplasms
CERVIX
- Inflammations
- Endocervical Polyps
- Premalignant and Malignant Neoplasms
BODY OF UTERUS AND ENDOMETRIUM
- Endometrial Histology in the Menstrual Cycle
- Functional Endometrial Disorders (Dysfunctional Uterine Bleeding)
- Inflammation
- Endometriosis and Adenomyosis
- Endometrial Polyps
- Endometrial Hyperplasia
- Malignant Tumors of the Endometrium
- Tumors of the Endometrium with Stromal Differentiation
- Tumors of the Myometrium
FALLOPIAN TUBES
- Inflammations
- Tumors and Cysts
OVARIES
- Non-Neoplastic and Functional Cysts
- Ovarian Tumors
GESTATIONAL AND PLACENTAL DISORDERS
- Disorders of Early Pregnancy
- Disorders of Late Pregnancy
- Gestational Trophoblastic Disease
Chapter 23 - The Breast
THE FEMALE BREAST
- Disorders of Development
- Clinical Presentations of Breast Disease
- Inflammatory Disorders
- Benign Epithelial Lesions
- Carcinoma of the Breast
THE MALE BREAST
- Gynecomastia
- Carcinoma
Chapter 24 - The Endocrine System
PITUITARY GLAND
- Clinical Manifestations of Pituitary Disease
- Pituitary Adenomas and Hyperpituitarism
- Hypopituitarism
- Posterior Pituitary Syndromes
- Hypothalamic Suprasellar Tumors
THYROID GLAND
- Hyperthyroidism
- Hypothyroidism
- Thyroiditis
- Graves Disease
- Diffuse and Multinodular Goiters
- Neoplasms of the Thyroid
- Congenital Anomalies
PARATHYROID GLANDS
- Hyperparathyroidism
- Hypoparathyroidism
- Pseudohypoparathyroidism
THE ENDOCRINE PANCREAS
- Diabetes Mellitus
- Pancreatic Endocrine Neoplasms
ADRENAL GLANDS
- Adrenal Cortex
- Adrenal Medulla
MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES
PINEAL GLAND
- Pinealomas
Chapter 25 - The Skin
- The Skin: More Than a Mechanical Barrier
- Disorders of Pigmentation and Melanocytes
- Benign Epithelial Tumors
- Premalignant and Malignant Epidermal Tumors
- Tumors of the Dermis
- Tumors of Cellular Migrants to the Skin
- Disorders of Epidermal Maturation
- Acute Inflammatory Dermatoses
- Chronic Inflammatory Dermatoses
- Blistering (Bullous) Diseases
- Disorders of Epidermal Appendages
- Panniculitis
- Infection
Chapter 26 - Bones, Joints, and Soft-Tissue Tumors
BONES
- Bone Modeling, Remodeling, and Peak Bone Mass
- Bone Growth and Development
- Developmental Abnormalities in Bone Cells, Matrix, and Structure
- Fractures
- Osteonecrosis (Avascular Necrosis)
- Infections—Osteomyelitis
- Bone Tumors and Tumor-Like Lesions
- Miscellaneous Tumors
JOINTS
- Arthritis
- Tumors and Tumor-Like Lesions
SOFT-TISSUE TUMORS AND TUMOR-LIKE LESIONS
- Pathogenesis and General Features
- Fatty Tumors
- Fibrous Tumors and Tumor-Like Lesions
- Fibrohistiocytic Tumors
- Tumors of Skeletal Muscle
- Tumors of Smooth Muscle
- Synovial Sarcoma
Chapter 27 - Peripheral Nerve and Skeletal Muscle
- General Reactions of the Motor Unit
- Diseases of Peripheral Nerve
- Diseases of Skeletal Muscle
Chapter 28 - The Central Nervous System
- Cellular Pathology of the Central Nervous System
- Cerebral Edema, Hydrocephalus, and Raised Intracranial Pressure and Herniation
- Malformations and Developmental Diseases
- Perinatal Brain Injury
- Trauma
- Cerebrovascular Diseases
- Infections
- Transmissible Spongiform Encephalopathies (Prion Diseases)
- Demyelinating Diseases
- Degenerative Diseases
- Genetic Metabolic Diseases
- Toxic and Acquired Metabolic Diseases
- Tumors
Chapter 29 - The Eye
- Orbit
- Eyelid
- Conjunctiva
- Sclera
- Cornea
- Anterior Segment
- Uvea
- Retina and Vitreous
- Optic Nerve
- The End-Stage Eye: Phthisis Bulbi
About the Authors
- VINAY KUMAR, MBBS, MD FRCPath, Alice Hogge and Arthur Baer Professor, Chairman, Department of Pathology; Executive Vice Dean, Division of Biologic Sciences and, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois.
- ABUL K. ABBAS, MBBS, Professor and Chairman, Department of Pathology, University of California, San Francisco, San Francisco, California.
- NELSON FAUSTO, MD, Professor and Chairman, Department of Pathology, University of Washington School of Medicine, Seattle, Washington.
- JON C. ASTER, MD, PhD, Professor of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
Book Reviews
"This book is even shorter than before. That is really impressive. I cannot but admire this book, which I keep re-reading since I entered Pathology in 1966. Wow, it shows that even a first class book can be improved - hard to believe but true.It is very readable and even funny in some places. The text is nicely laid out and the book looks less bulky than the previous edition. The illustrations are excellent. Even though the book is definitely for the new generations, I am sure that it will be welcomed by senior pathologists trying to keep up with the times - I doubt that I am the only old timer eager to re-read it."
-- Ivan Damjanov, MD, PhD, author of Pathology Secrets and Pathophysiology
"Pathologic Basis of Disease continues to be the most appropriate text for all students of pathology, be they in medical or health curricula, studying medical sciences in the context of another field such as engineering or business, and for professionals requiring a rapid reference to common pathologic conditions and pathways. Anyone who interfaces with human illness should have a copy of this book."
-- Michael A. Seidman, M.D., Ph.D.Department of Pathology, Brigham & Women's Hospital, Boston, MA
Product Details
- Hardcover: 1464 pages
- Publisher: Saunders; 8 edition (June 2, 2009)
- Language: English
- ISBN-10: 1437707920
- ISBN-13: 978-1437707922
- Product Dimensions: 11.2 x 8.7 x 2.2 inches
List Price: $165.00