Melanocytic pathology constitutes a large proportion of our everyday diagnostic practice. Lesions vary from the utterly banal and clinically insignificant such as a freckle or a lentigo through to melanoma with its attendant high mortality. The subject is fraught with potential diagnostic difficulty and as a consequence melanocytic lesions represent the commonest source of litigation in dermatopathology practice.
Clinicopathological correlation is of great importance. Before reporting a specimen it is essential to know the age of the patient and the site of the lesion. For example cytological atypia and pagetoid spread in an adult would automatically point towards a diagnosis of malignancy. However, these features might not be of concern in a congenital nevus in the neonate or young child. Similarly cytological atypia and pagetoid spread can be seen in nevi from the plantar/palmar surfaces and from the vulva where again they may have no prognostic significance.Features of melanoma are sometimes very subtle as for example in nevoid melanoma. The presence of multiple mitoses or slight cytological atypia seen at high power magnification represent important diagnostic features. It should thus be clear that nevi should never be examined solely at scanning or low power magnification. To do so is to risk potential misdiagnosis and court disaster for both the patient and the pathologist.Melanoma is a great mimic. It occasionally shows histological features that imitate a wide range of alternative tumors including carcinomas, lymphomas and sarcomas. Many of such lesions are amelanotic and the final diagnosis therefore depends upon immunohistochemistry. It is therefore critical that the possibility of melanoma is always considered in any malignant tumor that defies ready classification.This atlas is presented in a bulleted format to provide quick access to information. It includes all variations on the theme of melanocytic nevi and similarly describes and illustrates all of the variants of melanoma.
Book Features
- Discusses the clinical manifestations of melanocytic lesions to help you correlate clinical and pathologic findings to produce a more accurate diagnosis.
- Functions as a unique and invaluable diagnostic resource with over 1,000 full-color photographs to provide you with a visual summary of all the features of melanocytic lesions encountered on a daily basis.
- Highlights the main pathologic criteria for all commonly seen melanocytic lesions in a concise, user-friendly format so that you get the information you need quickly for immediate problem-solving.
- Features "diagnostic pearls" and "pitfalls," particularly emphasizing differential diagnosis, to help you avoid incorrect and inaccurate diagnoses.
- Presents the fully-searchable text online along with downloadable images for use in your electronic presentations.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
- Images Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
- Path Consult DDX Fundamentals Maximize clinical efficiency and productivity with Path Consult, an easy-to-use online resource that will help you quickly and easily confirm diagnoses.
Section 1 - Ephelides and Lentigo
- Ephelides
- Lentigo simplex
- Puva, sunbed and radiation lentigines
- Genital melanosis and lentigines
- Acral lentigo
- Solar lentigo (actinic lentigo, lentigo senilis, liver spot)
- Ink-spot lentigo (reticular lentigo, reticulated black solar lentigo)
- Becker's nevus (pigmented hairy epidermal nevus)
Section 2 - Melanocytic Nevus
- Junctional nevus
- Compound nevus
- Dermal nevus
- Banal nevus versus nevoid melanoma
- Banal nevus versus dysplastic nevus
- Banal nevus variants
- Balloon cell nevus
- Meyerson's nevus
- Halo (sutton's) nevus
- Recurrent nevus (pseudomelanoma)
- Inverted type a (clonal) nevus
- Cockarde nevus
- Nevus spilus
- Collision tumors
- Eccrine-centered (spotted grouped pigmented) nevus
- Acral nevus
- Atypical acral nevus versus acral lentiginous melanoma
- Atypical genital nevus
- Atypical genital nevus versus dysplastic nevus
- Atypical genital nevus versus vulval melanoma
- Banal nevi with atypia
Section 3 - Congenital Nevus
- Congenital nevi in neonates and young children
- Proliferation nodule (cellular nodule)
- Proliferation nodule – differential diagnosis
Section 4 - Spitz and Reed Nevus
- Pagetoid spitz nevus
- Junctional/intraepidermal spitz nevus
- Compound spitz nevus
- Dermal spitz nevus
- Desmoplastic spitz nevus
- Plexiform spitz nevus
- Pigmented spitz nevus
- Combined spitz nevus
- Atypical spitz nevus and spitz-like (spitzoid) melanoma
- Spitz-like (spitzoid) melanoma
- Spindle cell nevus of reed
Section 5 - Dysplastic Nevus
- Architectural abnormalities
- Cytological atypia
- Host responses
- Criteria for grading cytological atypia in dysplastic nevi
- Differential diagnosis
Section 6 - Dermal Melanocytoses
- Mongolian blue spot
- Nevi of ota, ito, hori and sun
- Common blue nevus
- Epithelioid blue nevus
- Neurocristic hamartoma
- Cellular blue nevus
- Atypical blue nevus
- Deep penetrating nevus
- Combined nevus
Section 7 - Melanoma General
- Histological features
- Radial and vertical growth phases
- Superficial spreading melanoma
- Lentigo maligna (melanoma)
- Acral lentiginous melanoma
- Nodular, polypoid and verrucous melanoma
- Subungual melanoma
- Melanoma: minimum histological data requirements
Section 8 - Melanoma Variants
- Melanoma variants
- Nevoid melanoma
- Differential diagnosis: nevoid melanoma vs banal nevus
- Small cell melanoma
- Desmoplastic melanoma
- Malignant blue nevus
- Pigment-synthesizing melanoma (animal type, equine type)
- Rhabdoid melanoma
- Myxoid melanoma
- Adenoid (pseudoglandular) melanoma
- Angiotropic and angiomatoid (pseudovascular) melanoma
- Signet-ring cell melanoma
- Balloon cell melanoma
- Clear cell melanoma
- Differential diagnosis of clear cell melanoma*
- Melanoma with heterologous differentiation (metaplastic melanoma)
- Spitzoid melanoma
- Giant cell melanoma
- Melanoma with neuroendocrine differentiation
- In-situ lentiginous melanoma
- Epidermotropic metastatic melanoma
- Childhood melanoma
Section 9 - Oral Mucosa Pigmented Lesions
- Amalgam tattoo
- Drug-induced oral pigmentation
- Melanocytic lesions
- Blue nevus
- Melanotic macule (labial and oral)
- Postinflammatory hypermelanosis
- Oral melanoacanthosis (oral melanoacanthoma)
- Oral melanoma
Section 10 - Conjunctival Melanocytic Lesions
- Freckle
- Acquired conjunctival nevi
- Stromal and episcleral melanocytoses
- Primary acquired melanosis without atypia
- Primary acquired melanosis with atypia
- Primary acquired melanosis with nevi
- Conjunctival melanoma
Product Details
- Hardcover: 440 pages
- Publisher: Mosby; 1 Har/Psc edition (January 21, 2009)
- Language: English
- ISBN-10: 0323048137
- ISBN-13: 978-0323048132
- Product Dimensions: 12.1 x 9.9 x 0.9 inches
- Author: Phillip H. McKee, J. Eduardo Calonje