Medical Lecture Note: Kaushansky: Williams Hematology 8th Edition with CD

The rate of growth in our understanding of diseases of blood cells and coagulation proteins provides a challenge for the editors of a comprehensive textbook of hematology. The sequencing of individual genomes and the acquisition of knowledge in proteomics, metabolomics, and all the other burgeoning "-omics" fields as applied to hematologic disorders have accelerated the understanding of the pathogenesis of the diseases of our interest. The rate at which basic knowledge in molecular and cell biology and molecular immunology has been translated into improved diagnostic and therapeutic methods is equally impressive. Specific molecular targets for therapy in a myriad of hematological disorders have become reality, and it is not hyperbole to state that hematology has become the poster child for the rational design of therapeutics throughout all of medicine.

This edition of Williams Hematology includes many changes, for the better. Each chapter has been extensively revised or rewritten to provide the most current information available. Two new chapters have been added, Chapter 10 entitled Epigenetics and Genomics, to reflect the growing importance of this basic science in hematology, and Chapter 28 entitled Principles of Multipotential Cell Therapy for Tissue Replacement. In addition, several chapters have been divided, most notably the single chapter on non-Hodgkin lymphoma has been split into its constituent diseases, and the chapters on erythrocytosis and thrombocytosis have been divided into the myeloproliferative and reactive forms, to reflect our growing understanding of the pathophysiology of these disorders and more targeted approaches to their therapy. Recognizing that at the heart of hematology is blood and marrow cell morphology, the authors have incorporated most of the collection of 274 images that appeared in a separate section of color plates in the 7th edition (as well as additional images) into the relevant topics in each chapter, allowing far easier access to highly informative illustrations and cellular morphology.

Apropos the age of information, the new edition of Williams Hematology is also available online, as part of the popular www.accessmedicine.com website. With direct links to a comprehensive drug therapy database and to other important medical texts, including Harrison's Principles of Internal Medicine and Goodman and Gilman's The Pharmacological Basis of Therapeutics, Williams Hematology Online is part of a powerful resource covering all disciplines within medical education and practice. The online edition of Williams Hematology also includes PubMed links to journal articles cited in the references in our new edition.

For the first time, a CD accompanies the Williams Hematology book. The CD features a large selection of morphologies, illustrations, and drawings, from this new edition of Williams Hematology; these can be easily transported into PowerPoint™ format for use in lectures and presentations.

Finally, the Williams Manual of Hematology will once again be revised. The convenient Manual features the most clinically salient content from the parent text, and is perfect for use in time-restricted clinical situations. The Manual will be available for iPhone™ and other mobile formats.

The readers of the 8th edition of Williams Hematology will note the passing of a legend in hematology, Dr. Ernest Beutler. Ernie was a founding editor and the lead editor of Hematology for the 5th and 6th editions, continued to contribute as an editor for the 7th edition, and passed away in October 2008, while the 8th edition's revised and new chapters were being compiled. Ernie's thumbprint continues to permeate the 8th edition, including F1 and F2 generations of the Beutler pedigree, and it is to Ernie that dedicate this edition.

New to this Edition:

Full-color presentation conveniently integrates images of blood and tissue findings where they are cited in the text.
Two additional chapters, “Genomics and Epigenetics,” and “Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement,” offer insights into the application of genomic and monoclonal therapies to hematology and emphasize their role in improving diagnostic and therapeutic methods.
Expanded coverage of non-Hodgkin lymphoma includes separate chapters on its constituent diseases, providing an in-depth assessment of the diagnosis and management of these disorders.
A comprehensive discussion of erythrocytosis and thrombocytosis reviews reactive and malignant forms of myeloproliferation, encompassing new genetic advances in these disorders along with more targeted therapeutic approaches.
Companion CD includes a large selection of morphologies, illustrations, and drawings from the book, in a presentation-ready PowerPoint format.

Contents

Part I. Clinical Evaluation of the Patient

Chapter 1 Initial Approach to the Patient: History and Physical Examination
Chapter 2 Examination of Blood Cells
Chapter 3 Examination of the Marrow

Part II. The Organization of the Lymphohematopoietic Tissues

Chapter 4 Structure of the Marrow and the Hematopoietic Microenvironment
Chapter 5 The Organization and Structure of Lymphoid Tissues

Part III. Epochal Hematology

Chapter 6 Hematology of the Fetus and Newborn
Chapter 7 Hematology during Pregnancy
Chapter 8 Hematology in Older Persons

Part IV. Molecular and Cellular Hematology

Chapter 9 Genetic Principles and Molecular Biology
Chapter 10 Genomics and Epigenetics
Chapter 11 Cytogenetics and Molecular Abnormalities
Chapter 12 Apoptosis
Chapter 13 Cell-Cycle Regulation and Hematologic Disorders
Chapter 14 Signal Transduction Pathways
Chapter 15 The Cluster of Differentiation Antigens
Chapter 16 Hematopoietic Stem Cells, Progenitors, and Cytokines
Chapter 17 The Inflammatory Response
Chapter 18 Innate Immunity
Chapter 19 Dendritic Cells and the Control of Innate and Adaptive Immunity

Part V. Therapeutic Principles

Chapter 20 Pharmacology and Toxicity of Antineoplastic Drugs
Chapter 21 Principles of Hematopoietic Cell Transplantation
Chapter 22 Treatment of Infections in the Immunocompromised Host
Chapter 23 Principles of Antithrombotic Therapy
Chapter 24 Principles of Immune Cell Therapy
Chapter 25 Principles of Vaccine Therapy
Chapter 26 Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications
Chapter 27 Principles of Gene Transfer for Therapy
Chapter 28 Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement

Part VI. The Erythrocyte

Chapter 29 Morphology of the Erythron
Chapter 30 Composition of the Erythrocyte
Chapter 31 Production of Erythrocytes
Chapter 32 Destruction of Erythrocytes
Chapter 33 Clinical Manifestations and Classification of Erythrocyte Disorders
Chapter 34 Aplastic Anemia: Acquired and Inherited
Chapter 35 Pure Red Cell Aplasia
Chapter 36 Anemia of Chronic Renal Disease
Chapter 37 Anemia of Chronic Disease
Chapter 38 Anemia of Endocrine Disorders
Chapter 39 The Congenital Dyserythropoietic Anemias
Chapter 40 Paroxysmal Nocturnal Hemoglobinuria
Chapter 41 Folate, Cobalamin, and Megaloblastic Anemias
Chapter 42 Disorders of Iron Metabolism
Chapter 43 Anemia Resulting from Other Nutritional Deficiencies
Chapter 44 Anemia Associated with Marrow Infiltration
Chapter 45 The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseases
Chapter 46 Disorders of Red Cells Resulting from Enzyme Abnormalities
Chapter 47 The Thalassemias: Disorders of Globin Synthesis
Chapter 48 Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities
Chapter 49 Methemoglobinemia and Other Dyshemoglobinemias
Chapter 50 Hemolytic Anemia Resulting from Physical Injury to Red Cells
Chapter 51 Hemolytic Anemia Resulting from Chemical and Physical Agents
Chapter 52 Hemolytic Anemia Resulting from Infections with Microorganisms
Chapter 53 Hemolytic Anemia Resulting from Immune Injury
Chapter 54 Alloimmune Hemolytic Disease of the Fetus and Newborn
Chapter 55 Hypersplenism and Hyposplenism
Chapter 56 Primary and Secondary Polycythemias (Erythrocytosis)
Chapter 57 The Porphyrias
Chapter 58 Hereditary and Acquired Sideroblastic Anemias

Part VII. Neutrophils, Eosinophils, Basophils and Mast Cells

Chapter 59 Morphology of Neutrophils, Eosinophils, and Basophils
Chapter 60 Composition of Neutrophils
Chapter 61 Production, Distribution, and Fate of Neutrophils
Chapter 62 Eosinophils and Their Disorders
Chapter 63 Basophils and Mast Cells and Their Disorders
Chapter 64 Classification and Clinical Manifestations of Neutrophil Disorders
Chapter 65 Neutropenia and Neutrophilia
Chapter 66 Disorders of Neutrophil Function

Part VIII. Monocytes and Macrophages

Chapter 67 Morphology of Monocytes and Macrophages
Chapter 68 Biochemistry and Functions of Monocytes and Macrophages
Chapter 69 Production, Distribution, and Fate of Monocytes and Macrophages
Chapter 70 Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages
Chapter 71 Monocytosis and Monocytopenia
Chapter 72 Inflammatory and Malignant Histiocytosis
Chapter 73 Lipid Storage Diseases

Part IX. Lymphocytes and Plasma Cells

Chapter 74 Morphology of Lymphocytes and Plasma Cells
Chapter 75 Composition and Biochemistry of Lymphocytes and Plasma Cells
Chapter 76 Lymphopoiesis
Chapter 77 Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production
Chapter 78 Functions of T Lymphocytes: T-Cell Receptors for Antigen
Chapter 79 Functions of Natural Killer Cells
Chapter 80 Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders
Chapter 81 Lymphocytosis and Lymphocytopenia
Chapter 82 Immunodeficiency Diseases
Chapter 83 Hematologic Manifestations of Acquired Immunodeficiency Syndrome
Chapter 84 Mononucleosis Syndromes

Part X. Neoplastic Myeloid Diseases

Chapter 85 Classification and Clinical Manifestations of the Clonal Myeloid Disorders
Chapter 86 Polycythemia Vera
Chapter 87 Essential Thrombocythemia
Chapter 88 Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia)
Chapter 89 Acute Myelogenous Leukemia
Chapter 90 Chronic Myelogenous Leukemia and Related Disorders
Chapter 91 Primary Myelofibrosis

Part XI. Neoplastic Lymphoid Diseases

Chapter 92 Classification of Malignant Lymphoid Disorders
Chapter 93 Acute Lymphoblastic Leukemia
Chapter 94 Chronic Lymphocytic Leukemia and Related Diseases
Chapter 95 Hairy Cell Leukemia
Chapter 96 Large Granular Lymphocytic Leukemia
Chapter 97 General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease
Chapter 98 Pathology of Malignant Lymphomas
Chapter 99 Hodgkin Lymphoma
Chapter 100 Diffuse Large B-Cell Lymphoma
Chapter 101 Follicular Lymphoma
Chapter 102 Mantle Cell Lymphoma
Chapter 103 Marginal Zone B-Cell Lymphomas
Chapter 104 Burkitt Lymphoma
Chapter 105 Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome)
Chapter 106 Mature T-Cell and Natural Killer Cell Lymphomas
Chapter 107 Plasma Cell Neoplasms: General Considerations
Chapter 108 Essential Monoclonal Gammopathy
Chapter 109 Myeloma
Chapter 110 The Amyloidoses
Chapter 111 Macroglobulinemia
Chapter 112 Heavy-Chain Disease

Part XII. Hemostasis and Thrombosis

Chapter 113 Megakaryopoiesis and Thrombopoiesis
Chapter 114 Platelet Morphology, Biochemistry, and Function
Chapter 115 Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
Chapter 116 Control of Coagulation Reactions
Chapter 117 Vascular Function in Hemostasis
Chapter 118 Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
Chapter 119 Thrombocytopenia
Chapter 120 Reactive Thrombocytosis
Chapter 121 Hereditary Qualitative Platelet Disorders
Chapter 122 Acquired Qualitative Platelet Disorders
Chapter 123 The Vascular Purpuras
Chapter 124 Hemophilia A and Hemophilia B
Chapter 125 Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors
Chapter 126 Hereditary Fibrinogen Abnormalities
Chapter 127 von Willebrand Disease
Chapter 128 Antibody-Mediated Coagulation Factor Deficiencies
Chapter 129 Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation
Chapter 130 Disseminated Intravascular Coagulation
Chapter 131 Hereditary Thrombophilia
Chapter 132 The Antiphospholipid Syndrome
Chapter 133 Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia
Chapter 134 Venous Thrombosis
Chapter 135 Atherothrombosis: Disease Initiation, Progression, and Treatment
Chapter 136 Fibrinolysis and Thrombolysis

Part XIII. Transfusion Medicine

Chapter 137 Erythrocyte Antigens and Antibodies
Chapter 138 Human Leukocyte and Platelet Antigens
Chapter 139 Blood Procurement and Screening
Chapter 140 Red Cell Transfusion
Chapter 141 Preservation and Clinical Use of Platelets

Book Details

Hardcover: 2460 pages
Publisher: McGraw-Hill Professional; 8 edition (July 9, 2010)
Language: English
ISBN-10: 0071621512
ISBN-13: 978-0071621519
Product Dimensions: 11 x 9 x 3 inches

List Price: $275.00

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