More than 6 years have elapsed since the third edition of Rossi’s Principles of Transfusion Medicine was published. During that time, the field has continued to be dynamic and many advances have been made. Molecular techniques are increasingly utilized; measurements of cell kinetics have been further refined; new treatments for bleeding disorders have been developed; progenitor cell transplantation protocols have matured; hemovigilance efforts have become more organized globally; pathogen inactivation and apheresis techniques have advanced; new treatments have emerged for iron overload; gene therapy and regenerative medicine are having an impact on the field; and regulation has become more complex in a global environment.
As expected, some controversies remain unresolved. For example, the effect of red cell age on clinical outcome and whether transfusion itself affects patient recovery are at the center of recent articles that commanded attention from both professionals and the public. At the same time, pharmacologic agents intended to reduce the need for transfusion have also become subjects of controversy. Whether recombinant human erythropoietin has deleterious effects on patients, the potential for cell-free hemoglobin solutions to cause more harm than good, and the balance between efficacy and toxicity of recombinant Factor VIIa are being discussed at the national level of health-care decision-making.
This edition provides updated comprehensive assessments of the subjects that remain important to the daily work of those who practice transfusion medicine today. The contents include information on controversies that are still percolating, as well as those new developments that have been widely adopted in practice. This volume also features those scientific areas that represent the frontiers of transfusion medicine such as cellular and gene therapy and regenerative medicine. Section I reviews the preparation and use of components and derivatives of blood used in clinical practice. Section II provides information and approaches to the major clinical issues related to transfusion in medical, obstetric, pediatric, oncology, and surgery patients, including transplant recipients. Section III focuses attention on both donor and patient apheresis. Section IV introduces the major concerns related to hazards of transfusion and covers the infectious and noninfectious risks in separate chapters. Section V covers the broad issues related to cells and tissue therapy in our field. Section VI contains an overview of the logistic and regulatory aspects of the profession.
The fourth edition is an example of both continuity and change. The comprehensive scope has been retained with emphasis on the scientific and clinical over the technical. The objective is to create the best single reference for the professional who is managing transfusion issues both at the bedside and at the interface of the laboratory and the clinic. Yet at the same time, the volume is intended to provide a helpful resource for trainees.
New chapters that have either combined material from several chapters in prior editions or ventured into new areas include cell kinetics, obstetric practice, cord blood, transfusion alternatives, regenerative medicine, hemovigilance, iron overload, and transplant organization and regulation. Once again, case studies have been included to enhance the educational aspects, but with this edition they are in an electronic format. In addition to the CD-ROM containing the case studies a second CD-ROM contains the 66 book chapters as searchable pdf files.
Four of the editors from the last edition have returned along with many of the expert chapter authors. This edition also welcomes new chapter contributors with fresh approaches and two new editors—Bjarte G. Solheim, who has led the effort to include more international perspectives, and Marian Petrides, who developed the software for, and managed the transition to, the interactive case study format. Joining the team effort for this edition are publishing staff at AABB Press and Wiley-Blackwell.
This book will help support those who can make a difference in transfusion medicine and serve as an example of the teamwork so urgently needed to move all of health care forward for the benefi t of the global community.
Contents
1 Transfusion in the New Millennium
Section I. Blood Components and Derivatives
Part I. Red Blood Cells
2 Red Cell Production and Kinetics
3 Regulation of Oxygen Delivery by Red Cells and Red Cell Substitutes
4 Red Cell Metabolism and Preservation
5 Red Cell Immunology and Compatibility Testing
6 Carbohydrate Blood Groups
7 Rh and LW Blood Group Antigens
8 Other Protein Blood Groups
9 Anemia and Red Blood Cell Transfusion
Part II. Platelets
10 Platelet Production, Kinetics, and Hemostasis
11 Platelet Immunology and Alloimmunization
12 Preparation, Preservation, and Storage of Platelet Concentrates
13 Thrombocytopenia and Platelet Transfusion
Part III. White Blood Cells
14 Neutrophil Production and Kinetics: Neutropenia and Neutrophilia
15 Neutrophil Collection and Transfusion
16 Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects
Part IV. Plasma
17 Composition and Mechanisms of Blood Coagulation and Fibrinolysis
18 Immunoglobulins
19 Preparation of Plasma Derivatives
20 Plasma Transfusion and Use of Albumin
Part V. Cell Kinetics
21 Applications of Cellular Radiolabeling in Transfusion Medicine
Section II. Clinical Practice
Part I. Medical Patients
22 Autoimmune Hemolytic Anemia and Paroxysmal Nocturnal Hemoglobinuria
23 Management of Immune Thrombocytopenia
24 Bleeding from Acquired Coagulation Defects and Antithrombotic Therapy
Part II. Obstetric and Pediatric Patients
25 Fetal and Neonatal Hematopoiesis
26 Obstetric Transfusion Practice
27 Hemolytic Disease of the Fetus and Newborn
28 Congenital Disorders of Clotting Proteins and Hypercoagulable States in Pediatrics
29 Management of Congenital Hemolytic Anemias
30 Blood Component Transfusions for Infants
Part III. Oncology Patients
31 Transfusion Support for the Oncology Patient
32 Hematopoietic Growth Factors (Cytokines)
33 Hematopoietic Progenitor Cells: Biology and Processing
34 Hematopoietic Progenitor Cells: Autologous Transplantation
35 Hematopoietic Progenitor Cells: Allogeneic Transplantation
36 Umbilical Cord Blood: A Reliable Source of Stem and Progenitor Cells for Human Transplantation
Part IV. Surgery Patients
37 Alternatives to Transfusion: Perioperative Blood Management
38 Blood Components to Achieve Hemostasis for Surgery and Invasive Procedures
39 Transfusion Therapy in the Care of Trauma and Burn Patients
40 Transfusion Therapy in Solid-Organ Transplantation
Section III. Apheresis
41 Apheresis: Principles and Technology of Hemapheresis
42 Therapeutic Plasma Exchange
43 Specialized Therapeutic Hemapheresis and Phlebotomy
Section IV. Hazards of Transfusion
Part I. Hemovigilance
44 Overview of Hemovigilance
45 Immunomodulatory and Proinfl ammatory Effects of Allogeneic Blood Transfusion
Part II. Infectious Hazards of Transfusion
46 Transfusion-Transmitted Hepatitis
47 Retroviruses and Other Viruses
48 Transfusion Transmission of Parasites
49 Bacterial Contamination of Blood Products
50 Prion Diseases
51 Pathogen Inactivation
Part III. Noninfectious Hazards
52 Hemolytic Transfusion Reactions
53 Febrile, Allergic, and Nonimmune Transfusion Reactions
54 Transfusion-Associated Graft-vs-Host Disease
55 Transfusional Iron Overload
56 Transfusion-Related Acute Lung Injury
Section V. Cell and Tissue Therapy
57 HLA Antigens and Alleles
58 Tissue Banking
59 Adoptive Immunotherapy
60 Gene Therapy in Transfusion Medicine
61 Tissue Engineering and Regenerative Medicine
Section VI. Delivery of Transfusion and Transplantation Services
62 Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood
63 Current Legal Issues in Transfusion Medicine
64 Current Good Manufacturing Practice
65 Transplant Organizations and Networks in the Regulation of Cellular Therapy Programs
66 Hospital Transfusion Committee and Quality Assurance
Index
As expected, some controversies remain unresolved. For example, the effect of red cell age on clinical outcome and whether transfusion itself affects patient recovery are at the center of recent articles that commanded attention from both professionals and the public. At the same time, pharmacologic agents intended to reduce the need for transfusion have also become subjects of controversy. Whether recombinant human erythropoietin has deleterious effects on patients, the potential for cell-free hemoglobin solutions to cause more harm than good, and the balance between efficacy and toxicity of recombinant Factor VIIa are being discussed at the national level of health-care decision-making.
The fourth edition is an example of both continuity and change. The comprehensive scope has been retained with emphasis on the scientific and clinical over the technical. The objective is to create the best single reference for the professional who is managing transfusion issues both at the bedside and at the interface of the laboratory and the clinic. Yet at the same time, the volume is intended to provide a helpful resource for trainees.
New chapters that have either combined material from several chapters in prior editions or ventured into new areas include cell kinetics, obstetric practice, cord blood, transfusion alternatives, regenerative medicine, hemovigilance, iron overload, and transplant organization and regulation. Once again, case studies have been included to enhance the educational aspects, but with this edition they are in an electronic format. In addition to the CD-ROM containing the case studies a second CD-ROM contains the 66 book chapters as searchable pdf files.
Four of the editors from the last edition have returned along with many of the expert chapter authors. This edition also welcomes new chapter contributors with fresh approaches and two new editors—Bjarte G. Solheim, who has led the effort to include more international perspectives, and Marian Petrides, who developed the software for, and managed the transition to, the interactive case study format. Joining the team effort for this edition are publishing staff at AABB Press and Wiley-Blackwell.
This book will help support those who can make a difference in transfusion medicine and serve as an example of the teamwork so urgently needed to move all of health care forward for the benefi t of the global community.
Contents
1 Transfusion in the New Millennium
Section I. Blood Components and Derivatives
Part I. Red Blood Cells
2 Red Cell Production and Kinetics
3 Regulation of Oxygen Delivery by Red Cells and Red Cell Substitutes
4 Red Cell Metabolism and Preservation
5 Red Cell Immunology and Compatibility Testing
6 Carbohydrate Blood Groups
7 Rh and LW Blood Group Antigens
8 Other Protein Blood Groups
9 Anemia and Red Blood Cell Transfusion
Part II. Platelets
10 Platelet Production, Kinetics, and Hemostasis
11 Platelet Immunology and Alloimmunization
12 Preparation, Preservation, and Storage of Platelet Concentrates
13 Thrombocytopenia and Platelet Transfusion
Part III. White Blood Cells
14 Neutrophil Production and Kinetics: Neutropenia and Neutrophilia
15 Neutrophil Collection and Transfusion
16 Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects
Part IV. Plasma
17 Composition and Mechanisms of Blood Coagulation and Fibrinolysis
18 Immunoglobulins
19 Preparation of Plasma Derivatives
20 Plasma Transfusion and Use of Albumin
Part V. Cell Kinetics
21 Applications of Cellular Radiolabeling in Transfusion Medicine
Section II. Clinical Practice
Part I. Medical Patients
22 Autoimmune Hemolytic Anemia and Paroxysmal Nocturnal Hemoglobinuria
23 Management of Immune Thrombocytopenia
24 Bleeding from Acquired Coagulation Defects and Antithrombotic Therapy
Part II. Obstetric and Pediatric Patients
25 Fetal and Neonatal Hematopoiesis
26 Obstetric Transfusion Practice
27 Hemolytic Disease of the Fetus and Newborn
28 Congenital Disorders of Clotting Proteins and Hypercoagulable States in Pediatrics
29 Management of Congenital Hemolytic Anemias
30 Blood Component Transfusions for Infants
Part III. Oncology Patients
31 Transfusion Support for the Oncology Patient
32 Hematopoietic Growth Factors (Cytokines)
33 Hematopoietic Progenitor Cells: Biology and Processing
34 Hematopoietic Progenitor Cells: Autologous Transplantation
35 Hematopoietic Progenitor Cells: Allogeneic Transplantation
36 Umbilical Cord Blood: A Reliable Source of Stem and Progenitor Cells for Human Transplantation
Part IV. Surgery Patients
37 Alternatives to Transfusion: Perioperative Blood Management
38 Blood Components to Achieve Hemostasis for Surgery and Invasive Procedures
39 Transfusion Therapy in the Care of Trauma and Burn Patients
40 Transfusion Therapy in Solid-Organ Transplantation
Section III. Apheresis
41 Apheresis: Principles and Technology of Hemapheresis
42 Therapeutic Plasma Exchange
43 Specialized Therapeutic Hemapheresis and Phlebotomy
Section IV. Hazards of Transfusion
Part I. Hemovigilance
44 Overview of Hemovigilance
45 Immunomodulatory and Proinfl ammatory Effects of Allogeneic Blood Transfusion
Part II. Infectious Hazards of Transfusion
46 Transfusion-Transmitted Hepatitis
47 Retroviruses and Other Viruses
48 Transfusion Transmission of Parasites
49 Bacterial Contamination of Blood Products
50 Prion Diseases
51 Pathogen Inactivation
Part III. Noninfectious Hazards
52 Hemolytic Transfusion Reactions
53 Febrile, Allergic, and Nonimmune Transfusion Reactions
54 Transfusion-Associated Graft-vs-Host Disease
55 Transfusional Iron Overload
56 Transfusion-Related Acute Lung Injury
Section V. Cell and Tissue Therapy
57 HLA Antigens and Alleles
58 Tissue Banking
59 Adoptive Immunotherapy
60 Gene Therapy in Transfusion Medicine
61 Tissue Engineering and Regenerative Medicine
Section VI. Delivery of Transfusion and Transplantation Services
62 Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood
63 Current Legal Issues in Transfusion Medicine
64 Current Good Manufacturing Practice
65 Transplant Organizations and Networks in the Regulation of Cellular Therapy Programs
66 Hospital Transfusion Committee and Quality Assurance
Index
Book Details
- Hardcover: 1112 pages
- Publisher: Wiley-Blackwell; 4 edition (February 4, 2009)
- Language: English
- ISBN-10: 1405175885
- ISBN-13: 978-1405175883
- Product Dimensions: 11.2 x 9 x 2.3 inches