Over thirty years ago, Elliott Middleton, Jr., Charles E. Reed, and Elliot F. Ellis conceived of the idea for a new comprehensive textbook of asthma and allergic disorders, and they set about to publish the first edition of Allergy: Principles and Practice. The seventh edition of the now classic Middleton's Allergy: Principles and Practice is an ongoing tribute to the original editors’ foresight in bringing their innovative vision to fruition, subsequent wide acceptance, and preeminence. As stated in their original preface, which is traditionally reprinted in each edition, ‘it is our opinion that some chapters in this book represent the most comprehensive summaries of the subject material found in print. Thus, Allergy: Principles and Practice serves as not only a textbook, but as a reference book.’ Moreover, it was their goal that ‘the final product … turns out to be a book we hope will be useful to all students of allergy, practitioners, clinical investigators, other researchers, allergy trainees, and medical students.’ Each subsequent edition has also achieved this goal. It is the design and hope of the current editors that our efforts have produced a worthy sequel that provides updated and new authoritative information on every important aspect of allergic inflammation, and associated allergic disorders.
To accomplish this, we have adhered to the successful strategy developed by our original forebears to provide information on the basic science underpinnings of allergy (principles) and integrate this information into clinical applications (practice). Our approach follows current efforts in ‘translational’ research to follow findings or knowledge in basic science discoveries through to their applications in clinical medicine. Fundamental ‘principles’ of allergic inflammation and its origins is addressed in Volume 1 with sections for immunology (including the cellular biology of immunology, as it relates to allergic processes), aerobiology and allergens; and then physiology, which reflects the functional interactions of the sensitized host with its environment. Volume 2 presents the ‘practice’ implications of these basic sciences as they are translated to clinical sciences, the diagnostic approach to the patient, and finally therapeutics. Within this structure, we have attempted to infuse the clinical sciences with evidence-based medicine for best practices in the specialty of allergy and clinical immunology.
The achievement of these ambitious goals was a collaborative venture undertaken with our knowledgeable and dedicated authors of the various chapters. As in the past, authors were chosen not only because they are experts in their subject matter, but also because they are able to ‘tell the story’ in a comprehensive, integrated and understandable manner. We are grateful for the care, dedication and knowledge of the 174 authors and co-authors who contributed to the 97 chapters of this 7th edition. Of these authors 90 are new to the 7th edition and reflect the editors’ commitment to find the best contributors within an increasingly global scientific and medical community. Another aspect of this commitment to the inclusion of new and fresh perspectives is our longstanding policy of turning over the authorship of even the most excellent chapters every second or third edition.The growth of knowledge in biomedical science during the past decade has been nothing short of stupendous, and allergy and clinical immunology have been no exceptions to this. To recognize these advances, 14 new chapters have been added to Middleton's seventh edition. These include the new scientific arenas of innate immunity, stem cells, and dendritic cell biology. A new chapter reviews the factors associated with the increasing prevalence of allergic disorders and asthma. New clinical chapters detail current knowledge of eosinophilic gastroenteropathies, immunologic non-asthmatic lung diseases, oral challenge testing, approach to the patient with chronic cough, and approach to the patient requiring emergency treatment for acute asthma. Other new chapters on therapeutics in the seventh edition include the important topics of environmental controls for allergic diseases, adherence to medical regimens, and pharmacogenomics, as well as the evolving role of anti-IgE therapy. Noteworthy is chapter 27 , ‘Protease-activated Pathways of Inflammation,’ contributed by founding editor Charles Reed along with Hirohito Kita and Catherine Weiler. Although the final application of this new field to allergic diseases and asthma has yet to be fully defined, Charles Reed's vision of new horizons of importance to allergy has always been keen, and we are delighted to include his ‘cutting edge’ viewpoint.
This edition of Middleton's Allergy: Principles and Practice is for the first time printed in full-color format. The design includes color coding and accenting to further enhance organizational structure. And there are more than 400 new illustrations (700 in all) to bring home the message graphically on virtually every page. Appendix A has been thoroughly updated and now covers all 334 CD surface markers and their cellular expression patterns. This seventh edition has also expanded its appendix of Internet Resources useful in the science and practice of allergology. Appendix C summary tables from the new Expert Panel 3 Report outlining US Guidelines for the Diagnosis and Management of Asthma, and the corresponding GINA (Global Initiative for Asthma) guidelines that we hope will be of use and benefit to our readership. A new feature at the beginning of each chapter: a bulleted list of the salient scientific or clinical principles highlighted in the chapter. These principles should make the text more useful for a wide range of readers seeking information at differing levels of detail. Overall these innovations are intended to make this seventh edition the best yet.
John Yunginger stepped down as an editor with the completion of the sixth edition and his immense contributions have been missed. Dr. Yunginger was a seasoned and savvy member of the editorial team to which he brought understanding and knowledge in insect hypersensitivity, latex allergy, and allergen structure, as well as an important pediatric perspective. Equally important were his uncanny ability to encapsulate key points, and his dogged insistence on clarity and brevity. We thank him for his years of service and leadership. Robert F. Lemanske, Jr., is our new pediatric editor who brings valuable special interests and expertise to this enterprise, particular in the arenas of pediatric asthma and the origins of asthma and allergic diseases.
Contents
VOLUME 1
SECTION A - IMMUNOLOGY
- 1 - The Immune System: an Overview
- 2 - Innate Immunity
- 3 - Molecular Biology and Genetic Engineering
- 4 - Principles of Genetics in Allergic Diseases and Asthma
- 5 - Immunoglobulin Structure and Function
- 6 - The Complement System
- 7 - Immunobiology of IgE
- 8 - Signal Transduction
- 9 - Cellular Adhesion in Inflammation
- 10 - Cytokines in Allergic Inflammation
- 11 - Chemokines in Cell Movement and Allergic Inflammation
- 12 - Lipid Mediators of Hypersensitivity and Inflammation
- 13 - Neuronal Control of Airway Function in Allergy
- 14 - Biochemical Events in Basophil/Mast Cell Activation and Mediator Release
- 15 - Stem Cells: What Are They and Why Do We Need Them?
- 16 - Biology of Lymphocytes
- 17 - Biology of Neutrophils
- 18 - Biology of Eosinophils
- 19 - Biology of Mast Cells and Their Mediators
- 20 - Biology of Basophils
- 21 - Antigen-Presenting Dendritic Cells
- 22 - The Biology of Monocytes and Macrophages
- 23 - Biology of Epithelial Cells
- 24 - Biology of Endothelial Cells
- 25 - Biology of Airway Smooth Muscle Cells
- 26 - Regulation of Cell Survival
- 27 - Protease-Activated Pathways of Inflammation
- 28 - Animal Models of Allergen-Induced Asthma
- 29 - Pathophysiology of Allergic Inflammation
- 30 - Immunopathology of Allergic Airway Inflammation
Section B - AEROBIOLOGY AND ALLERGENS
- 31 - Air Pollution: Indoor and Outdoor
- 32 - Aerobiology of Outdoor Allergens
- 33 - Indoor Allergens
- 34 - Preparation and Standardization of Allergen Extracts
- 35 - The Structure and Function of Allergens
Section C - PHYSIOLOGY
- 36 - Structural and Functional Cutaneous Immunology
- 37 - Airway Smooth Muscle and Related Extracellular Matrix in Normal and Asthmatic Lung
- 38 - Development, Structure, and Physiology in Normal Lung and in Asthma
- 39 - Airway Mucus and the Mucociliary System
- 40 - Aerosols and Aerosol Drug Delivery Systems
- 41 - Anatomy and Physiology of the Nose and Control of Nasal Airflow
VOLUME 2
SECTION D - CLINICAL SCIENCE
- 42 - Epidemiology of Asthma and Allergic Diseases
- 43 - Factors Underlying the Increasing Incidence and Prevalence of Allergic Diseases
- 44 - Development and Prevention of Atopic Disease in Childhood
- 45 - Immune Complexes and Allergic Disease
- 46 - Primary Immunodeficiency Diseases
- 47 - Human Immunodeficiency Virus and Allergic Disease
- 48 - Clinical Significance of Immunoglobulin E
- 49 - Eosinophilia and Eosinophil Related Disorders
- 50 - Eosinophilic Gastroenteropathies
- 51 - Asthma Pathogenesis
- 52 - Pathology of Asthma Compared with Chronic Obstructive Pulmonary Disease
- 53 - Occupational Asthma
- 54 - Immunologic Non-Asthmatic Diseases of the Lung
- 55 - Allergic and Non-Allergic Rhinitis
- 56 - Nasal Polyps and Rhinosinusitis
- 57 - Insect Allergy
- 58 - Natural Rubber Latex Allergy
- 59 - Anaphylaxis
- 60 - Mastocytosis
- 61 - Urticaria and Angioedema
- 62 - Atopic Dermatitis
- 63 - Contact Dermatitis
- 64 - Allergic and Immunologic Diseases of the Eye
- 65 - Adverse Reactions to Foods
- 66 - Adverse Reactions to Food and Drug Additives
- 67 - Adverse Reactions to Vaccines for Infectious Diseases
- 68 - Drug Allergy
- 69 - Hypersensitivity to Aspirin and Non-Steroidal Antiinflammatory Drugs
SECTION E - DIAGNOSIS AND APPROACH TO THE PATIENT
- 70 - Laboratory Tests for Allergic and Immunodeficiency Diseases: Principles and Interpretations
- 71 - In Vivo Methods for the Study of Allergy
- 72 - Nasal Provocation Testing
- 73 - Bronchial Challenge Testing
- 74 - Oral Food Challenge Testing
- 75 - Approach to Infants and Children with Asthma
- 76 - Approach to Adults with Asthma
- 77 - Emergency Treatment and Approach to the Patient with Acute Asthma
- 78 - Approach to the Patient with Exercise-Induced Airway Narrowing
- 79 - Approach to the Patient with Chronic Cough
- 80 - Approach to the Patient with Recurrent Infections
- 81 - Asthma and Allergic Diseases during Pregnancy
SECTION F - THERAPEUTICS
- 82 - Allergen Control in the Prevention and Management of Allergic Disease
- 83 - Principles of Pharmacotherapeutics
- 84 - Adherence
- 85 - Beta-Adrenergic Agonists
- 86 - Theophylline and Phosphodiesterase Inhibitors
- 87 - Histamine and H1-Antihistamines
- 88 - Pharmacology of Glucocorticoids in Allergic Disease
- 89 - Glucocorticoids: Clinical Pharmacology
- 90 - The Chromones: Cromolyn Sodium and Nedocromil Sodium
- 91 - Cholinergic Mechanisms and Anticholinergic Therapy in Respiratory Diseases
- 92 - Antileukotriene Therapy in Asthma
- 93 - Pharmacogenomics of Asthma Therapies
- 94 - Immunomodulators
- 95 - Immunotherapy for Inhalant Allergens
- 96 - Anti-IgE Therapy
- 97 - Unconventional Theories and Unproven Methods in Allergy
APPENDICES
- Appendix A: CD Molecules
- Appendix B:: Internet Resources
- Appendix C: National Asthma Education and Prevention Program (NAEPP) and Global Initiative for Asthma (GINA) Guidelines
Key features
- Includes a glossary of allergy and immunology for quick and easy reference.
- Contains keypoints and clinical pearls highlighted to find important information quickly.
- links to useful online resources both for you and for your patients.
- Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge.
New to this edition
- Contains 400 new illustrations, 700 in all, to better illustrate complex immunology.
- Covers the very latest in the field, including hot topics such as food allergy and immunotherapy.
- Includes the latest guidelines from The National Asthma Education and Prevention Program (NAEPP).
- Utilizes a new, more user-friendly full-color format for easier reference.
- Includes online access to the entire contents of the book, fully searchable, with links to MEDLINE abstracts for all of the references.
Book Details
- Hardcover: 1924 pages
- Publisher: Mosby; 7 edition (November 19, 2008)
- Language: English
- ISBN-10: 0323056598
- ISBN-13: 978-0323056595
- Product Dimensions: 10.5 x 10.2 x 3.9 inches
List Price: $342.00