Hypertension and Stroke: Pathophysiology and Management reviews the pathophysiologic relationship between hypertension and cerebrovascular disease and the management of blood pressure in a variety of settings such as primary stroke prevention, acute ischemic and hemorrhagic stroke, secondary stroke prevention, and vascular cognitive impairment.
Hypertension is one of the most important global public health challenges, and there is a close linkage between hypertension and cerebrovascular disease. Hypertension is the most significant modifiable risk factor for cerebrovascular disease. The importance of adequately treating elevated blood pressure in the primary prevention of stroke and management of cerebrovascular disease is widely accepted. It is estimated that about 25% and up to 50% of strokes could be prevented by blood pressure control. In the course of clinical practice, however, questions arise about the management of blood pressure in the acute, subacute, and chronic phases of stroke. For example, when is it safe to initiate blood pressure-lowering therapy after acute ischemic stroke? Is it dangerous to lower blood pressure in elderly persons who have had a stroke? What is the blood pressure-lowering target after a stroke has occurred to maximize recurrent stroke prevention? Which blood pressure-lowering agents are most efficacious and safe for persons who have had a stroke or for those in the general population to prevent a first stroke? In this book the authors explore answers to these and many more important aspects of hypertension and stroke. In recent years, several large clinical trials which address blood pressure management for cerebrovascular disease have been published. In this book they have attempted to collate and synthesize this rapidly expanding knowledge base in a form that can be easily accessed and utilized by treating physicians.
Hypertension and Stroke provides a broad approach to the understanding of this topic from the perspectives of leading experts in the fields of vascular neurology, preventive medicine, nephrology and other cardiovascular diseases, epidemiology, pharmacology, neuropsychology and cognitive function, brain imaging, and nursing. In addition, the authors have recruited international experts who are well-versed in the area of stroke management, and who provide a unique clinical and epidemiological viewpoint from geographic regions where stroke risk is high.
The book consists of five sections and corresponding chapters which provide insights about the following:
(1) epidemiology of blood pressure and hypertension in relation to measurement, definition, diagnosis, and observational epidemiological studies and clinical trials in relation to stroke;
(2) mechanisms of hypertension and how hypertension may cause stroke;
(3) acute management of blood pressure after hemorrhagic and ischemic stroke, hypertensive encephalopathy, management of blood pressure to prevent recurrent stroke, non-blood-pressure-lowering effects of some antihypertensive agents, and a guide to overall cardiovascular risk factor assessment and management for prevention of recurrent stroke;
(4) importance of blood pressure in cognitive function, newer brain imaging modalities to elucidate brain structure and function in hypertension, and the role of cerebral amyloid angiopathy and brain microhemorrhages on cognitive function; and
(5) organization of stroke care to improve blood pressure control and overall stroke prevention.
This text will provide the most up-to-date and expert information on a myriad of important aspects relating to hypertension and stroke.We anticipate that primary care physicians, neurologists, physician extenders, residents and medical students, and epidemiologists, stroke and other cardiovascular researchers, and public health specialists will benefit from this treatise. The global public health challenge of elevated blood pressure will continue to increase. Hypertension and Stroke is designed to help meet these challenges.
Contents
PART I. BLOOD PRESSURE AND HYPERTENSION AS ANTECEDENTS OF STROKE
1. Blood Pressure: Definition, Diagnosis, and Management
2. The Link Between Hypertension and Stroke: Summary of Observational Epidemiological Studies
3. Blood Pressure Control and Primary Prevention of Stroke: Summary of Clinical Trial Data
PART II. MECHANISMS OF HYPERTENSION AND HYPERTENSION-RELATED STROKE
4. Mechanisms Underlying Essential Hypertension: Neurogenic and Nonneurogenic Contributors
5. Pathophysiology and Mechanisms Whereby Hypertension May Cause Stroke
PART III. MANAGEMENT OF BLOOD PRESSURE FOR FIRST STROKE PREVENTION, IMMEDIATELY AFTER ACUTE STROKE, AND FOR RECURRENT STROKE PREVENTION
6. Cardiovascular Risk Assessment and Summary of Guidelines for the Management of Hypertension
7. Acute Blood Pressure Management After Ischemic Stroke
8. Hypertensive Encephalopathy and Acute Blood Pressure Management After Hemorrhagic Stroke
9. Recurrent Stroke Prevention I: Diuretic and Angiotensin-Converting Enzyme Inhibitors (ACEIs) – The PROGRESS Trial
10. Recurrent Stroke Prevention II: Angiotensin Receptor Blockers—The LIFE, MOSES, PRoFESS, and Other Trials
11. A Practical Guide to Recurrent Stroke Prevention
PART IV. MECHANISMS AND SEQUELAE OF ELEVATED BLOOD PRESSURE ON BRAIN FUNCTION AND COGNITION
12. Vascular Cognitive Impairment and Alzheimer Disease: Are These Disorders Linked to Hypertension and Other Cardiovascular Risk Factors?
13. Cerebral Small Vessel Disease, Hypertension, and Cognitive Function
14. Cerebral Microbleeds, Small-Vessel Disease of the Brain, Hypertension, and Cognition
15. Imaging Effects of Hypertension on the Brain: A Focus on New Imaging Modalities and Options
PART V. ORGANIZATION OF STROKE CARE
16. The Joint Commission’s Initiatives to Improve Stroke Care and What It Means for Acute Stroke Care and Prevention
Index
Book Details
- Hardcover: 293 pages
- Publisher: Humana Press; 1st Edition. edition (November 12, 2010)
- Language: English
- ISBN-10: 1607610094
- ISBN-13: 978-1607610090
- Product Dimensions: 10.1 x 7.1 x 0.9 inches
List Price: $189.00