The previous three editions of Diseases of the Breast were intended as up-to-date, single-source multidisciplinary compilations of important knowledge on breast diseases, with a focus on breast cancer, presented in a form accessible to practicing clinicians. We have been gratified by the success of this effort, and for the fourth edition, we have similarly invited a diverse and distinguished group of experts to summarize the current knowledge about benign and malignant breast diseases, including their biology and epidemiology, clinical features, and management. The underlying premise for this book has been that multidisplinary care of the breast cancer patient is critical to achieve the best outcomes; furthermore, effective communication between pathologists, breast imagers, medical geneticists, nurses, psychologists, social services, and rehabilitation specialists as well as surgical, medical, and radiation oncologists is essential.
This fourth edition comes at a time when considerable progress has been made in the treatment of breast cancer. In the United States and in Western Europe, there has been a substantial decrease in the death rate from the disease, attributable to early detection with screening mammography and increasingly effective systemic treatment. It is now established that effective local treatment is also essential to decrease breast cancer mortality in addition to optimal local control. A key contributor to this decrease in breast cancer mortality has been the willingness of many thousands of women with breast cancer to participate in clinical trials and this edition is dedicated to them.
Efforts have also been made to understand and improve the quality of life of breast cancer patients. The widespread use of sentinel node biopsy as an alternative to axillary lymph node dissection is a prominent example. Systemic therapy is increasingly targeted and less toxic, and advances in the molecular characterization of breast cancers have begun to explain the heterogeneity of the disease and allow for individualization of treatments. Radiation treatment has advanced by better incorporation of imaging modalities and more sophisticated irradiation techniques. While there has been progress in the treatment of breast cancer, many patients still die of the disease. Continued research into the biology, genetics, prevention, early diagnosis, and treatment of the disease is mandatory.
We hope that the Fourth Edition of Diseases of the Breast will be a useful resource for both clinicians and translational investigators. We highlight the rapid and substantial progress that has been made since the last edition that has reduced breast cancer mortality and provides optimism for additional advances in the near future.
-- Authors
Key Features
- NEW! Overall increase in number of clinical chapters and commensurate decrease in basic biology.
- NEW! Fourteen (14) new or reconstituted chapters: 36 new contributors.
- NEW! Chapters will contain "Key Points" summary (similar to Greenfield's).
- NEW! Book will print in full color.
- Comprehensive text on breast disease.
- Covers all aspects of breast disease.
- Contributors are top experts in the field.
Contents
Section I Breast Anatomy and Development
- Chapter 1 Breast Anatomy and Development
- Chapter 2 Molecular Mechanisms Regulating Breast Development
- Chapter 3 Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives
Section II Diagnosis and Management of Benign Breast Diseases
- Chapter 4 Physical Examination of the Breast
- Chapter 5 Management of the Palpable Breast Mass
- Chapter 6 Management of Disorders of the Ductal System and Infections
Section III Breast Imaging and Image-Guided Biopsy Techniques
- Chapter 11 Screening for Breast Cancer
- Chapter 12 Imaging Analysis: Mammography
- Chapter 13 Breast Ultrasound
Section IV Epidemiology and Assessing and Managing Risk
- Chapter 18 Inherited Genetic Factors and Breast Cancer
- Chapter 19 Genetic Testing and Management of Patients with Hereditary Breast Cancer
- Chapter 20 Nongenetic Factors in the Causation of Breast Cancer
Section V In Situ Carcinoma
- Chapter 23 Pathology and Biological Features of Premalignant Breast Disease
- Chapter 24 Lobular Carcinoma In Situ: Biology and Pathology
- Chapter 25 Lobular Carcinoma In Situ: Clinical Management
Section VI Pathology and Biological Markers of Invasive Breast Cancer
- Chapter 27 Breast Cancer Genomics
- Chapter 28 Pathology of Invasive Breast Cancer
- Chapter 29 Clinical Aspects of Estrogen and Progesterone Receptors
Section VII Management of Primary Invasive Breast Cancer
- Chapter 34 Evaluation of Patients for Metastasis Prior to Primary Therapy
- Chapter 35 Staging of Breast Cancer
- Chapter 36 Mastectomy
Section VIII Preoperative Systemic Therapy
- Chapter 58 Preoperative Therapy for Operable Breast Cancer
- Chapter 59 Preoperative Endocrine Therapy for Operable Breast Cancer
- Chapter 60 Local-Regional Therapy Considerations in Patients Receiving Preoperative Chemotherapy
Section IX Special Therapeutic Problems
- Chapter 64 Male Breast Cancer
- Chapter 65 Phyllodes Tumors
- Chapter 66 Paget's Disease
Section X Evaluation after Primary Therapy and Management of Recurrent Breast Cancer
- Chapter 70 Surveillance of Patients Following Primary Therapy
- Chapter 71 Surgery for the Primary in Patients with Distant Metastases
- Chapter 72 Local-Regional Recurrence after Breast-Conservation Treatment or Mastectomy
Section XI New Breast Cancer Therapeutic Approaches
- Chapter 78 Angiogenesis Inhibition in Breast Cancer
- Chapter 79 Tyrosine Kinase Inhibitors
- Chapter 80 Newer Targeted Therapy in Breast Cancer
Section XII Site-Specific Therapy of Metastatic Breast Cancer
- Chapter 81 Brain Metastases
- Chapter 82 Epidural Metastases
- Chapter 83 Leptomeningeal Metastasis
Section XIII Breast Cancer in Special Populations
- Chapter 91 Breast Cancer in Older Women
- Chapter 92 Breast Cancer in Younger Women
- Chapter 93 Breast Cancer in Minority Women
Section XIV Issues in Breast Cancer Survivorship
- Chapter 94 Nursing Care in Patient Management and Quality of Life
- Chapter 95 Psychosocial Adaptation During and After Breast Cancer
- Chapter 96 Reproductive Issues in Breast Cancer Survivors
Section XV Other Considerations
- Chapter 97 Medical Legal Aspects of Breast Cancer Evaluation
- Chapter 98 Cost and Cost-Effectiveness Considerations
Index
About the Editors
- Jay R. Harris MD, Professor, Department of Radiation Oncology, Harvard Medical School; Chair, Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham Women's Hospital, Boston, Massachusetts.
- Marc E. Lippman MD, Kathleen and Stanley Glaser Professor, Chairman, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida.
- Monica Morrow MD, Anne Burnett Windfohr Chair of Clinical Oncology, Chief, Breast Service, Memorial Sloan-Kettering Cancer Center; Professor of Surgery, Weill Medical College of Cornell University, New York, New York.
- C. Kent Osborne MD, The Tina and Dudley Sharp Chair of Oncology, Professor of Medicine and Molecular and Cellular Biology; Director, Dan L. Duncan Cancer Center; Director, Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Product Details
- Hardcover: 1200 pages
- Publisher: Lippincott Williams & Wilkins; Fourth edition (2010)
- Language: English
- ISBN-10: 0781791170
- ISBN-13: 978-0781791175
- Product Dimensions: 11.2 x 8.7 x 2.1 inches
List Price: $319.00