Several prominent members of our institution, San Camillo-Forlanini Hospital of Rome, and of the University Faculty of Medicine of Rome, La Sapienza of Rome, joined together to present a book intended to provide a comprehensive discussion of Crohn's disease. The result, “Crohn’s Disease: A Multidisciplinary Approach”, attempts to systematically review all medical and surgical aspect of the disease. The first group of chapters deals with problems regarding the etiology, pathogenesis, and clinical manifesta-tions of Crohn's disease, while the second group concentrates on diagnostic techniques and clinical practice. This is followed by chapters addressing current concepts of medical and surgical treatment. The selected topics are those wherein recent developments have altered previous practices.
The goals of this book are to offer general practitioners basic knowledge of Crohn’s disease, to provide the specialist with more detailed information, and to stimulate students, residents, and fellows in their search for knowledge of this challenging but satisfying field.
The Editors express their thanks to all of the book’s authors and to the Italian Society of Surgery.
-- Roberto Tersigni MD, Department of Surgery San Camillo-Forlanini Hospital Rome, Italy
Foreword
In 1761, J.B. Morgagni described the clinical case of a young man who died from an ileal perforation. The patient’s clinical presentation included ileal ulceration and inflammation of the mesenteric lymphonodes with splenomegaly. This was the first description of Crohn’s disease (CD).
In 1904, a Polish physician, Lesmowski, wrote a case report for a local medical journal, describing a patient with symptoms similar to those of CD. In 1913, an English author, C. Combe, and a Scottish colleague, T.K. Daziel, reported several cases of “chronic interstitial enteritis” with the features of CD. However, these descriptions were completely ignored by the academic world.
The pathology became known only after the classic description of Crohn, Ginzburg, and Oppenheimer in 1932. They described a “chronic granulomatous inflammation of the ileal ansa.” Nevertheless, it was only in 1960, after the wellknown publication of Lockhart-Mummery and Morson, that the existence of the disease entity, by then known as CD, was accepted.
While CD can affect any part of the digestive tract, without distinction, from the mouth to the anus, it shows very different localizations. The etiopathology of CD remains controversial; the disease has a variable clinical presentation and thus a number of therapeutic options, both medical and surgical. However, treatment of the frequent precocious and late complications of CD remains problematic.
More recently, research has focused on the immunological origins of the disease, specifically, on the humoral and cell-mediated responses of the immune system to sensitizing agents. Furthermore, environmental factors acting in concert with a genetic predisposition have been considered and may explain the increased incidence of CD in certain geographical areas over the past few decades.
The Italian Society of Surgery has recognized the need for an authoritative update on the subject and has entrusted this task to Roberto Tersigni, in recognition of his extensive experience in the field of CD and the inflammatory bowel diseases, and taking advantage of his numerous case files. The result is an exceedingly interesting scientific work, rich in details and in critical analyses of all the important issues related to CD. In addition, the book presents a wealth of new information that will certainly be of interest to physicians and researchers seeking to broaden their knowledge of this disease.
As President of the Society and as someone who is passionately involved in this field of surgery, my compliments to Roberto and his co-workers for this excellent work. I am convinced it is destined to attain a prestigious place for itself in the world of international surgical knowledge.
-- Enrico De Antoni, President of Italian Society of Surgery
Contents
- Chapter 01 Etiology of Crohn's Disease
- Chapter 02 Epidemiology of Crohn's Disease
- Chapter 03 Genetics
- Chapter 04 The Role of the Pathologist in the Management of Patients with Crohn's Disease
- Chapter 05 Clinical Presentation of Crohn's Disease
- Chapter 06 Diagnostic and Therapeutic Role of Endoscopy
- Chapter 07 Laboratory Tests of Crohn's Disease
- Chapter 08 Imaging of Crohn's Disease
- Chapter 09 Diagnosis of Anorectal Disease
- Chapter 10 Role of Interventional Radiology of Crohn's Disease
- Chapter 11 Standard Therapeutic Approach of Crohn's Disease
- Chapter 12 New Therapies of Crohn's Disease
- Chapter 13 Cell and Stem-Cell Therapies of Crohn’s Disease and Complications
- Chapter 14 Surgical Treatment
- Chapter 15 Crohn’s Disease in Children
- Chapter 16 Perianal Disease
- Chapter 17 Crohn’s Disease and Pregnancy
- Chapter 18 Rheumatological Manifestations of Crohn’s Disease
- Chapter 19 Cutaneous Manifestations
- Chapter 20 Ocular Manifestations
- Chapter 21 Hepatopathologies
- Chapter 22 Infectious Complications
- Chapter 23 Kidney Disease
- Chapter 24 Crohn’s Disease and Cancer
- Chapter 25 Crohn’s Disease and Malignant Lymphomas
- Chapter 26 Psychological and Social Aspects
- Subject Index
Book Details
- Hardcover: 304 pages
- Publisher: Springer; 1 edition (December 15, 2009)
- Language: English
- ISBN-10: 8847014719
- ISBN-13: 978-8847014718
List Price: $169.00